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The map label for this gene is rnhA [H]

Identifier: 209548219

GI number: 209548219

Start: 637636

End: 638091

Strand: Direct

Name: rnhA [H]

Synonym: Rleg2_0613

Alternate gene names: 209548219

Gene position: 637636-638091 (Clockwise)

Preceding gene: 209548218

Following gene: 209548224

Centisome position: 14.05

GC content: 62.28

Gene sequence:

>456_bases
ATGAAACACGTCGATATCTTCACCGACGGCGCCTGCTCCGGCAATCCCGGCCCCGGCGGCTGGGGCGCCGTGCTGCGCTA
TGGCGACGTCGAAAAGGAGCTTTGCGGCGGCGAAGCGGATACGACCAACAACCGCATGGAACTGCTGGCGGCGATCTCCG
CGCTGCAGGCCTTGAAGAGCCCCTGCGAGGTCGACCTCTACACCGACAGCGCCTACGTCAAAGACGGCATCTCCAAATGG
ATTTTCGGCTGGAAGAAAAACGGCTGGAAGACCGCCGACAAGAAGCCGGTAAAAAATGCCGAACTCTGGCAGGCGCTCGA
AGAAGCCCGCAACCGCCACACCGTGACGCTGCACTGGGTCAAAGGCCACGCCGGCCACCCGGAAAACGAACGCGCCGATG
AACTCGCGCGCCGGGGCATGGAGCCTTTCAAGAAGGGCAAGGCGGTTTCGTTTTAG

Upstream 100 bases:

>100_bases
CTGAAGGCGCCATGGTCACCAAGAAGGACCCGCTCGAATATCTCCGCAAGCTGCGTTTCCACCGCCAGATCAAATCGCCG
GCCGAATACGGATTGAGCCT

Downstream 100 bases:

>100_bases
AAGCGCGGGGCGATTGTGGGGATTACGCCTGCGCCCTGAAGGCTGCCCCTCACCCTAACCCTCTCCCCGTAAAAACGGGG
CGAGGGGACGTGCCACGCGA

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MKHVDIFTDGACSGNPGPGGWGAVLRYGDVEKELCGGEADTTNNRMELLAAISALQALKSPCEVDLYTDSAYVKDGISKW
IFGWKKNGWKTADKKPVKNAELWQALEEARNRHTVTLHWVKGHAGHPENERADELARRGMEPFKKGKAVSF

Sequences:

>Translated_151_residues
MKHVDIFTDGACSGNPGPGGWGAVLRYGDVEKELCGGEADTTNNRMELLAAISALQALKSPCEVDLYTDSAYVKDGISKW
IFGWKKNGWKTADKKPVKNAELWQALEEARNRHTVTLHWVKGHAGHPENERADELARRGMEPFKKGKAVSF
>Mature_151_residues
MKHVDIFTDGACSGNPGPGGWGAVLRYGDVEKELCGGEADTTNNRMELLAAISALQALKSPCEVDLYTDSAYVKDGISKW
IFGWKKNGWKTADKKPVKNAELWQALEEARNRHTVTLHWVKGHAGHPENERADELARRGMEPFKKGKAVSF

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=144, Percent_Identity=38.8888888888889, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1786408, Length=137, Percent_Identity=66.4233576642336, Blast_Score=193, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI115532542, Length=145, Percent_Identity=36.551724137931, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17505482, Length=133, Percent_Identity=35.3383458646617, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45552509, Length=153, Percent_Identity=32.6797385620915, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17137476, Length=153, Percent_Identity=32.6797385620915, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16711; Mature: 16711

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVDIFTDGACSGNPGPGGWGAVLRYGDVEKELCGGEADTTNNRMELLAAISALQALKS
CCCCCEEECCCCCCCCCCCCHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
PCEVDLYTDSAYVKDGISKWIFGWKKNGWKTADKKPVKNAELWQALEEARNRHTVTLHWV
CCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEE
KGHAGHPENERADELARRGMEPFKKGKAVSF
ECCCCCCCCHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure
MKHVDIFTDGACSGNPGPGGWGAVLRYGDVEKELCGGEADTTNNRMELLAAISALQALKS
CCCCCEEECCCCCCCCCCCCHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
PCEVDLYTDSAYVKDGISKWIFGWKKNGWKTADKKPVKNAELWQALEEARNRHTVTLHWV
CCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEE
KGHAGHPENERADELARRGMEPFKKGKAVSF
ECCCCCCCCHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA