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The map label for this gene is lpxK [H]

Identifier: 209548096

GI number: 209548096

Start: 503022

End: 504095

Strand: Direct

Name: lpxK [H]

Synonym: Rleg2_0490

Alternate gene names: 209548096

Gene position: 503022-504095 (Clockwise)

Preceding gene: 209548095

Following gene: 209548098

Centisome position: 11.08

GC content: 66.85

Gene sequence:

>1074_bases
ATGATATCCGAAGCGCCGCCGTTCTGGTGGAGGAAAGCCGACTGGCGGGCCTGGCTGCTGCTGCCTGTTTCCTTTCTCTA
CGGTCGTATCGCCGGCCACCGCATGGCCCATGGGCGCCGCGCCTCCGTGGCCATTCCGGTCATCTGCGTCGGCAATTTCA
CCGTCGGCGGCGCCGGCAAGACGCCGACGGCGCTGACCATTGCCCGCGCCGCCAAGGCGAAAGGGCTGAAGCCGGGCTTC
CTCAGCCGCGGTTACGGCGGCTCGCTCGACGTGACGACGGTGGTCGATCCCGATCATCACCGGGCGGTCGCCGTCGGCGA
TGAGCCGCTGCTGCTTGCCCGGGAGGCGCTGACGGTGATTTCGCGGAGGCGCGTCGACGGGGCTCAGCGTCTGGTCGCAG
AGGGCGCCGATCTCATCATCATGGATGACGGTTTCCAGAGCGCCCGGCTGGCGATCGACTATGCCCTGCTGGTCATCGAC
GCGACCCGAGGCCTCGGCAACGGCCATATCGTGCCGGCCGGCCCGGTGCGGGCCCCGATCCGCCAGCAGCTGCGTTCGGC
CACCGCCCTGTTGAAGGTCGGCGGCGGCAATGCCGCCGACAGGATCGTCCGCATGGCGGCGCGCGCCGCAAAGCCCTATT
TCACCGCCTCGCTGAAAGTGCGCGGCGACAATACGCTTGCCGGCATGAAGGTGCTCGCCTTCGCCGGCATTGCCGATCCC
GCCAAATTTTTCCGCACGGTCGAATCGCGCGGCGCCGAAATCACCGTCGCCAAGTCCTTCGGCGACCATGAGCATCTGAC
CGAGGACGAGATCGACGACATCCTGACGACCGCCGAGCGTCAGGACCTGCTGATCGTCACCACCTCAAAGGATTTCGTCC
GCCTCTCCGGCCATCCCGGCAAGGCGGCACAGCTCGCCGAAAAGTGCCGGGTGATCGAGGTCGACATGGTCTTCGAGGAT
CACCTCGCCCCGAGCCTGATCATCGACCGGGCGATTGTTGCCTGCCGCGAGCGGCGCCTAAGGGAGATGAAGGCCGGCAT
TAAAGCGATGCCCGGAAAGGCTGGGCCGCTCTAA

Upstream 100 bases:

>100_bases
GTAAGGGCTTGCATTTTCATTGATTTTGGCTTCTCAATCCGGCCGGTCGAAAAGCAAGAGGCTGGCTGCCGCAAGGCGGG
CAGGGGAGCGGAACGGCAAG

Downstream 100 bases:

>100_bases
AGACTTCTGCAAACTCGCGTTGGTTTTCGGAAGCTATCGATCAAAAACCACTTGTTCCGCTGGTTCGTCGGGCTTTCTCC
TACCCCCAATCGCAATGTGG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MISEAPPFWWRKADWRAWLLLPVSFLYGRIAGHRMAHGRRASVAIPVICVGNFTVGGAGKTPTALTIARAAKAKGLKPGF
LSRGYGGSLDVTTVVDPDHHRAVAVGDEPLLLAREALTVISRRRVDGAQRLVAEGADLIIMDDGFQSARLAIDYALLVID
ATRGLGNGHIVPAGPVRAPIRQQLRSATALLKVGGGNAADRIVRMAARAAKPYFTASLKVRGDNTLAGMKVLAFAGIADP
AKFFRTVESRGAEITVAKSFGDHEHLTEDEIDDILTTAERQDLLIVTTSKDFVRLSGHPGKAAQLAEKCRVIEVDMVFED
HLAPSLIIDRAIVACRERRLREMKAGIKAMPGKAGPL

Sequences:

>Translated_357_residues
MISEAPPFWWRKADWRAWLLLPVSFLYGRIAGHRMAHGRRASVAIPVICVGNFTVGGAGKTPTALTIARAAKAKGLKPGF
LSRGYGGSLDVTTVVDPDHHRAVAVGDEPLLLAREALTVISRRRVDGAQRLVAEGADLIIMDDGFQSARLAIDYALLVID
ATRGLGNGHIVPAGPVRAPIRQQLRSATALLKVGGGNAADRIVRMAARAAKPYFTASLKVRGDNTLAGMKVLAFAGIADP
AKFFRTVESRGAEITVAKSFGDHEHLTEDEIDDILTTAERQDLLIVTTSKDFVRLSGHPGKAAQLAEKCRVIEVDMVFED
HLAPSLIIDRAIVACRERRLREMKAGIKAMPGKAGPL
>Mature_357_residues
MISEAPPFWWRKADWRAWLLLPVSFLYGRIAGHRMAHGRRASVAIPVICVGNFTVGGAGKTPTALTIARAAKAKGLKPGF
LSRGYGGSLDVTTVVDPDHHRAVAVGDEPLLLAREALTVISRRRVDGAQRLVAEGADLIIMDDGFQSARLAIDYALLVID
ATRGLGNGHIVPAGPVRAPIRQQLRSATALLKVGGGNAADRIVRMAARAAKPYFTASLKVRGDNTLAGMKVLAFAGIADP
AKFFRTVESRGAEITVAKSFGDHEHLTEDEIDDILTTAERQDLLIVTTSKDFVRLSGHPGKAAQLAEKCRVIEVDMVFED
HLAPSLIIDRAIVACRERRLREMKAGIKAMPGKAGPL

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=290, Percent_Identity=31.3793103448276, Blast_Score=131, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 38412; Mature: 38412

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEAPPFWWRKADWRAWLLLPVSFLYGRIAGHRMAHGRRASVAIPVICVGNFTVGGAGK
CCCCCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECEEECCCCC
TPTALTIARAAKAKGLKPGFLSRGYGGSLDVTTVVDPDHHRAVAVGDEPLLLAREALTVI
CCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
SRRRVDGAQRLVAEGADLIIMDDGFQSARLAIDYALLVIDATRGLGNGHIVPAGPVRAPI
HHHHCCHHHHHHHCCCCEEEEECCCCCHHHHEEEEEEEEECCCCCCCCCEECCCCCCHHH
RQQLRSATALLKVGGGNAADRIVRMAARAAKPYFTASLKVRGDNTLAGMKVLAFAGIADP
HHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCCH
AKFFRTVESRGAEITVAKSFGDHEHLTEDEIDDILTTAERQDLLIVTTSKDFVRLSGHPG
HHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCC
KAAQLAEKCRVIEVDMVFEDHLAPSLIIDRAIVACRERRLREMKAGIKAMPGKAGPL
HHHHHHHHCEEEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
>Mature Secondary Structure
MISEAPPFWWRKADWRAWLLLPVSFLYGRIAGHRMAHGRRASVAIPVICVGNFTVGGAGK
CCCCCCCCCEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECEEECCCCC
TPTALTIARAAKAKGLKPGFLSRGYGGSLDVTTVVDPDHHRAVAVGDEPLLLAREALTVI
CCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
SRRRVDGAQRLVAEGADLIIMDDGFQSARLAIDYALLVIDATRGLGNGHIVPAGPVRAPI
HHHHCCHHHHHHHCCCCEEEEECCCCCHHHHEEEEEEEEECCCCCCCCCEECCCCCCHHH
RQQLRSATALLKVGGGNAADRIVRMAARAAKPYFTASLKVRGDNTLAGMKVLAFAGIADP
HHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCCH
AKFFRTVESRGAEITVAKSFGDHEHLTEDEIDDILTTAERQDLLIVTTSKDFVRLSGHPG
HHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCC
KAAQLAEKCRVIEVDMVFEDHLAPSLIIDRAIVACRERRLREMKAGIKAMPGKAGPL
HHHHHHHHCEEEEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA