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The map label for this gene is ahcY [H]

Identifier: 209548053

GI number: 209548053

Start: 456933

End: 458090

Strand: Direct

Name: ahcY [H]

Synonym: Rleg2_0446

Alternate gene names: 209548053

Gene position: 456933-458090 (Clockwise)

Preceding gene: 209548052

Following gene: 209548055

Centisome position: 10.07

GC content: 63.73

Gene sequence:

>1158_bases
ATGGACAAGACCGCGACGCGCATCGACTGGATCGGCAGCAGCTGCAGGCTGCTGAAGGCGACGGCAGCCGAATTCGAGCG
GACGCGGCCCTTCGAAGGCCTGTCGATCGGCACCAGCATTCATCTGGAGCCGAAGACGGTGGCGCTCTTGATGACGCTTC
GCGCCGGCGGGGCGCGTCTCGTCTGCACCGGCAATCTCAACAGCACCCAGCCTTTGACGGTCGAATTTCTGCGTTCGCAG
GGTTTTACGGTCTTCGCCACGCAGACGACCGATCCGGCCGCCCATCATCAGAGCCTCGAAGCGGTGATTGCCGAAAGGCC
GGACCTGCTGCTCGACAATGGCGGCGATCTCTTCGCCATCGCGGCGGAAAAACCCTATGCCAATCTTCGCGGCGGTACCG
AGGAAACCACCTCGGGCCGCACCCGCCTGCTGCCGCTGCGCGAACGCCTCGCTATGCCGATCCTCGTCATCAACGACAGC
CCGATCAAGCAGTTCGCCGAAAACAGGCATGCCGTCGGACAGAGCCTGTTCGAAAGCTATTTGCGCTTCACCAACCGCTC
GACCAACGGCAAACGCGTGACGGTGTTCGGCTACGGCGCCTGCGGCAAGGGCACGGCCGCCTGTTTCCGCAATGCTTTTT
CCACCGTCAGCGTCGTCGATATCGACGCCGTGACGACACTCGAAGCCCATCTCGATGGTTTCGCCACGCCGCCGCGCGAG
GCGGCAATCCGCTCGGCCGATATAATCGTCACCGTCACCGGCTTTGCCGGCATCGTCACCGCAGCCGACCTGCCGCTCGT
CAAGGATGGCGCGATCCTGATGAATGGCGGCCATTTCCCCCATGAGATCGATGTCGAGGCCTTCCGCCGCCATCCCGATG
TCATCGGCATCGATCGCTACGAGGCCGATCAGATCGAGACCTTCCATCTAAGGGACGGCCGCTCTTTCCATGTGTTGGGC
GGTGGCCACATGGCCAATCTCGCCGGCCCGCGGCCGCTCGGCAACACGGTCGAATCGATGGATCTCGGCTTCACCCTGCA
GGCCCGCTGCCTGGAACGCATCGCCAGGGGCGAGGCCGGGCCCGAAGCCTGCGTCGTGCCGGTTCCCGGCGATATCGACG
CGATGGTGGCCAATGCTTATCTTGATCTGGCACGTTGA

Upstream 100 bases:

>100_bases
AAAGGGCAGATTTTCTGCCCTTTCGCCAGAATAACCTCCATATTCGCCGCCCTGTCGCTTCGCTAAAGATTGTTCGAGTA
TCGGCAACAGGGATGAAGTG

Downstream 100 bases:

>100_bases
GGATGATTCCGAAAAATGTGAGTGTTTTCAGACGACATCACGCGCCACTCTCTGATTTAGCAAAGGATTAGATTTAAGGC
CGACCGGGGCCTCAAATCAT

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDKTATRIDWIGSSCRLLKATAAEFERTRPFEGLSIGTSIHLEPKTVALLMTLRAGGARLVCTGNLNSTQPLTVEFLRSQ
GFTVFATQTTDPAAHHQSLEAVIAERPDLLLDNGGDLFAIAAEKPYANLRGGTEETTSGRTRLLPLRERLAMPILVINDS
PIKQFAENRHAVGQSLFESYLRFTNRSTNGKRVTVFGYGACGKGTAACFRNAFSTVSVVDIDAVTTLEAHLDGFATPPRE
AAIRSADIIVTVTGFAGIVTAADLPLVKDGAILMNGGHFPHEIDVEAFRRHPDVIGIDRYEADQIETFHLRDGRSFHVLG
GGHMANLAGPRPLGNTVESMDLGFTLQARCLERIARGEAGPEACVVPVPGDIDAMVANAYLDLAR

Sequences:

>Translated_385_residues
MDKTATRIDWIGSSCRLLKATAAEFERTRPFEGLSIGTSIHLEPKTVALLMTLRAGGARLVCTGNLNSTQPLTVEFLRSQ
GFTVFATQTTDPAAHHQSLEAVIAERPDLLLDNGGDLFAIAAEKPYANLRGGTEETTSGRTRLLPLRERLAMPILVINDS
PIKQFAENRHAVGQSLFESYLRFTNRSTNGKRVTVFGYGACGKGTAACFRNAFSTVSVVDIDAVTTLEAHLDGFATPPRE
AAIRSADIIVTVTGFAGIVTAADLPLVKDGAILMNGGHFPHEIDVEAFRRHPDVIGIDRYEADQIETFHLRDGRSFHVLG
GGHMANLAGPRPLGNTVESMDLGFTLQARCLERIARGEAGPEACVVPVPGDIDAMVANAYLDLAR
>Mature_385_residues
MDKTATRIDWIGSSCRLLKATAAEFERTRPFEGLSIGTSIHLEPKTVALLMTLRAGGARLVCTGNLNSTQPLTVEFLRSQ
GFTVFATQTTDPAAHHQSLEAVIAERPDLLLDNGGDLFAIAAEKPYANLRGGTEETTSGRTRLLPLRERLAMPILVINDS
PIKQFAENRHAVGQSLFESYLRFTNRSTNGKRVTVFGYGACGKGTAACFRNAFSTVSVVDIDAVTTLEAHLDGFATPPRE
AAIRSADIIVTVTGFAGIVTAADLPLVKDGAILMNGGHFPHEIDVEAFRRHPDVIGIDRYEADQIETFHLRDGRSFHVLG
GGHMANLAGPRPLGNTVESMDLGFTLQARCLERIARGEAGPEACVVPVPGDIDAMVANAYLDLAR

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI298286489, Length=366, Percent_Identity=30.6010928961749, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI195539349, Length=366, Percent_Identity=30.6010928961749, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI24308043, Length=366, Percent_Identity=30.6010928961749, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI195539337, Length=366, Percent_Identity=30.6010928961749, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI21361647, Length=366, Percent_Identity=29.5081967213115, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI9951915, Length=369, Percent_Identity=28.1842818428184, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI239937451, Length=369, Percent_Identity=28.1842818428184, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17506425, Length=323, Percent_Identity=31.5789473684211, Blast_Score=137, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320882, Length=322, Percent_Identity=29.8136645962733, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24656245, Length=378, Percent_Identity=29.1005291005291, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45553385, Length=309, Percent_Identity=29.7734627831715, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI45553387, Length=309, Percent_Identity=29.7734627831715, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24642172, Length=321, Percent_Identity=28.6604361370716, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 41495; Mature: 41495

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTATRIDWIGSSCRLLKATAAEFERTRPFEGLSIGTSIHLEPKTVALLMTLRAGGARL
CCCCCCEEEECCCCCCEEHHHHHHHHHCCCCCCEEECCEEEECCCEEEEEEEEECCCEEE
VCTGNLNSTQPLTVEFLRSQGFTVFATQTTDPAAHHQSLEAVIAERPDLLLDNGGDLFAI
EEECCCCCCCCEEHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEE
AAEKPYANLRGGTEETTSGRTRLLPLRERLAMPILVINDSPIKQFAENRHAVGQSLFESY
EECCCCHHCCCCCCCCCCCCEEEEEHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LRFTNRSTNGKRVTVFGYGACGKGTAACFRNAFSTVSVVDIDAVTTLEAHLDGFATPPRE
HHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCEEEEEEECHHEEHHHHHCCCCCCCHH
AAIRSADIIVTVTGFAGIVTAADLPLVKDGAILMNGGHFPHEIDVEAFRRHPDVIGIDRY
HHHCCCCEEEEECCCHHHHHHCCCCEEECCEEEEECCCCCCCCCHHHHHCCCCEEECCCC
EADQIETFHLRDGRSFHVLGGGHMANLAGPRPLGNTVESMDLGFTLQARCLERIARGEAG
CCCCEEEEEECCCCEEEEEECCEEECCCCCCCCCCCHHHHCCCEEHHHHHHHHHHCCCCC
PEACVVPVPGDIDAMVANAYLDLAR
CCEEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDKTATRIDWIGSSCRLLKATAAEFERTRPFEGLSIGTSIHLEPKTVALLMTLRAGGARL
CCCCCCEEEECCCCCCEEHHHHHHHHHCCCCCCEEECCEEEECCCEEEEEEEEECCCEEE
VCTGNLNSTQPLTVEFLRSQGFTVFATQTTDPAAHHQSLEAVIAERPDLLLDNGGDLFAI
EEECCCCCCCCEEHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEE
AAEKPYANLRGGTEETTSGRTRLLPLRERLAMPILVINDSPIKQFAENRHAVGQSLFESY
EECCCCHHCCCCCCCCCCCCEEEEEHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
LRFTNRSTNGKRVTVFGYGACGKGTAACFRNAFSTVSVVDIDAVTTLEAHLDGFATPPRE
HHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHCCEEEEEEECHHEEHHHHHCCCCCCCHH
AAIRSADIIVTVTGFAGIVTAADLPLVKDGAILMNGGHFPHEIDVEAFRRHPDVIGIDRY
HHHCCCCEEEEECCCHHHHHHCCCCEEECCEEEEECCCCCCCCCHHHHHCCCCEEECCCC
EADQIETFHLRDGRSFHVLGGGHMANLAGPRPLGNTVESMDLGFTLQARCLERIARGEAG
CCCCEEEEEECCCCEEEEEECCEEECCCCCCCCCCCHHHHCCCEEHHHHHHHHHHCCCCC
PEACVVPVPGDIDAMVANAYLDLAR
CCEEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9440516; 10360571 [H]