Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 209547971

GI number: 209547971

Start: 367927

End: 369402

Strand: Reverse

Name: zwf [H]

Synonym: Rleg2_0363

Alternate gene names: 209547971

Gene position: 369402-367927 (Counterclockwise)

Preceding gene: 209547972

Following gene: 209547970

Centisome position: 8.14

GC content: 62.53

Gene sequence:

>1476_bases
ATGAGCAGCCAGATTATTCCCGTTGAGCCTTTTGATTACGTCGTCTTCGGCGGCAGCGGCGACCTTGCCGAACGCAAGCT
TCTGCCCGCGCTCTACCATCGCCAGATCGAGGGCCAGTTCTCCGAACCGACCCGGGTGATCGGCGCTTCGCGCAGCCCGC
TTTCCCATGAGGAATACCGCAAATTCGCCAAGGATGCGTTGAACGAGCACCTGAAGAAGGGCGAATATGACGAAGCCGAG
GTGGAGAAGTTCTGCGCCCGTCTCTACTACGTCTCGGTCGACGCCCGCACCGACACCGGCTGGGACCAGCTGAAGAAGTT
GCTCGACGAGGGCAAGGAGCGCGTGCGCGCCTTCTACCTCGCCGTCGCGCCCGGCATCTTCGGCGATATTTCGCAGAAGA
TCCACGACCACAAGCTGATCACCAAGTCGACCCGCATCGTCGTCGAGAAGCCAATCGGCCGCGACCTCGCCTCGGCACTG
CAGCTCAACGATACGATCGGCCGCGCCTTCAAGGAAGAACAGATCTTCCGCATCGATCACTATCTCGGCAAGGAGACGGT
GCAGAACCTGATGGCACTGCGCTTCGCCAACGCGCTCTATGAGCCGCTGTGGAACGCCAACTACATCGATCACGTGCAGA
TCACCGTGGCTGAAGCGGTCGGCCTCGAAGGCCGCGCCGGCTATTACGATACGGCCGGCGCGCTTCGCGACATGGTGCAG
AACCATATCCTGCAGCTGCTCTGCCTGACGGCGATGGAAGTGCCCTCGTCGATGGATTCGGAAGCCGTTCGCGACGAGAA
GCTGAAAGTGCTGCGCGCGCTGAAGCCGCTCAATGCCTCCAATGTCGAGCAGGCAACGGTCCGCGGCCAGTATCGCGCCG
GCGCCTCGGGCAGCGGCCCCGTCAAGGGCTATCTCGAAGAGCTCGAAGGCGGCGTCTCGAATACCGAGACCTTCGTCGCC
ATCAAGGCGGAGATCAACAACTGGCGCTGGGCGGGCGTTCCCTTCTATATCCGCACCGGCAAGCGGCTGACCGGACGCAT
GTCCGAGATCGTCATCACCTTCAAGCCGATCCCGCATGCGATCTTCGACCAGGCAGCCGGGCGCATCGTCGCCAACCAGC
TGATCATAAGGCTGCAGCCGGATGAGGGCGTCAAGCAGTCGCTGATGATCAAGGATCCGGGCCCGGGCGGCATGCGCCTG
CGCAACGTCTCGCTCGACATGAGCTTCGCCCAGGCCTTCAACGTCCGCAATCCCGACGCCTACGAGCGCCTGCTGATGGA
CGTGATCCGCTCCAACCAGACGCTGTTCATGCGCCGCGACGAAGTTGAAGCCGCATGGAAATGGGTGGATCCGATCCTGA
AGGGTTGGGAAACCACCGGTCAGCAGGTGCAGGGCTATACCGCCGGCACCTGGGGCCCGAGCCAGGCCATTGCGCTGATC
GAGCGCGACGGCCGCACCTGGCATGACGATATCTAG

Upstream 100 bases:

>100_bases
CTAAAACCGGTGCCTGACAGATTCATTGCACTGCACACTGGCTTTTTTAAATCGATTAGATTAAAAGGGCCGCCAACCAG
CCTGATTGAGAGACAAGCTC

Downstream 100 bases:

>100_bases
GACGAAACCGATGGCATCGACCCTGCATTCCTTCGCCAGCCCCGCAGATCTCGCCGGCAGCCTTGCCGAGAAGGTTGCCG
ATACGCTTTCGGCGGCGATC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSSQIIPVEPFDYVVFGGSGDLAERKLLPALYHRQIEGQFSEPTRVIGASRSPLSHEEYRKFAKDALNEHLKKGEYDEAE
VEKFCARLYYVSVDARTDTGWDQLKKLLDEGKERVRAFYLAVAPGIFGDISQKIHDHKLITKSTRIVVEKPIGRDLASAL
QLNDTIGRAFKEEQIFRIDHYLGKETVQNLMALRFANALYEPLWNANYIDHVQITVAEAVGLEGRAGYYDTAGALRDMVQ
NHILQLLCLTAMEVPSSMDSEAVRDEKLKVLRALKPLNASNVEQATVRGQYRAGASGSGPVKGYLEELEGGVSNTETFVA
IKAEINNWRWAGVPFYIRTGKRLTGRMSEIVITFKPIPHAIFDQAAGRIVANQLIIRLQPDEGVKQSLMIKDPGPGGMRL
RNVSLDMSFAQAFNVRNPDAYERLLMDVIRSNQTLFMRRDEVEAAWKWVDPILKGWETTGQQVQGYTAGTWGPSQAIALI
ERDGRTWHDDI

Sequences:

>Translated_491_residues
MSSQIIPVEPFDYVVFGGSGDLAERKLLPALYHRQIEGQFSEPTRVIGASRSPLSHEEYRKFAKDALNEHLKKGEYDEAE
VEKFCARLYYVSVDARTDTGWDQLKKLLDEGKERVRAFYLAVAPGIFGDISQKIHDHKLITKSTRIVVEKPIGRDLASAL
QLNDTIGRAFKEEQIFRIDHYLGKETVQNLMALRFANALYEPLWNANYIDHVQITVAEAVGLEGRAGYYDTAGALRDMVQ
NHILQLLCLTAMEVPSSMDSEAVRDEKLKVLRALKPLNASNVEQATVRGQYRAGASGSGPVKGYLEELEGGVSNTETFVA
IKAEINNWRWAGVPFYIRTGKRLTGRMSEIVITFKPIPHAIFDQAAGRIVANQLIIRLQPDEGVKQSLMIKDPGPGGMRL
RNVSLDMSFAQAFNVRNPDAYERLLMDVIRSNQTLFMRRDEVEAAWKWVDPILKGWETTGQQVQGYTAGTWGPSQAIALI
ERDGRTWHDDI
>Mature_490_residues
SSQIIPVEPFDYVVFGGSGDLAERKLLPALYHRQIEGQFSEPTRVIGASRSPLSHEEYRKFAKDALNEHLKKGEYDEAEV
EKFCARLYYVSVDARTDTGWDQLKKLLDEGKERVRAFYLAVAPGIFGDISQKIHDHKLITKSTRIVVEKPIGRDLASALQ
LNDTIGRAFKEEQIFRIDHYLGKETVQNLMALRFANALYEPLWNANYIDHVQITVAEAVGLEGRAGYYDTAGALRDMVQN
HILQLLCLTAMEVPSSMDSEAVRDEKLKVLRALKPLNASNVEQATVRGQYRAGASGSGPVKGYLEELEGGVSNTETFVAI
KAEINNWRWAGVPFYIRTGKRLTGRMSEIVITFKPIPHAIFDQAAGRIVANQLIIRLQPDEGVKQSLMIKDPGPGGMRLR
NVSLDMSFAQAFNVRNPDAYERLLMDVIRSNQTLFMRRDEVEAAWKWVDPILKGWETTGQQVQGYTAGTWGPSQAIALIE
RDGRTWHDDI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=484, Percent_Identity=39.8760330578512, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI108773793, Length=484, Percent_Identity=39.8760330578512, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI52145310, Length=366, Percent_Identity=32.5136612021858, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1788158, Length=482, Percent_Identity=48.5477178423236, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=36.7556468172485, Blast_Score=321, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6324088, Length=475, Percent_Identity=38.5263157894737, Blast_Score=306, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24643350, Length=475, Percent_Identity=37.2631578947368, Blast_Score=301, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24643352, Length=475, Percent_Identity=37.2631578947368, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI221513548, Length=502, Percent_Identity=30.8764940239044, Blast_Score=215, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55257; Mature: 55125

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQIIPVEPFDYVVFGGSGDLAERKLLPALYHRQIEGQFSEPTRVIGASRSPLSHEEYR
CCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHH
KFAKDALNEHLKKGEYDEAEVEKFCARLYYVSVDARTDTGWDQLKKLLDEGKERVRAFYL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AVAPGIFGDISQKIHDHKLITKSTRIVVEKPIGRDLASALQLNDTIGRAFKEEQIFRIDH
HHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGKETVQNLMALRFANALYEPLWNANYIDHVQITVAEAVGLEGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCHHHHHHHHHHH
NHILQLLCLTAMEVPSSMDSEAVRDEKLKVLRALKPLNASNVEQATVRGQYRAGASGSGP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCC
VKGYLEELEGGVSNTETFVAIKAEINNWRWAGVPFYIRTGKRLTGRMSEIVITFKPIPHA
HHHHHHHHCCCCCCCCEEEEEEEECCCEEECCCCEEEECCCHHHCCCEEEEEEECCCCHH
IFDQAAGRIVANQLIIRLQPDEGVKQSLMIKDPGPGGMRLRNVSLDMSFAQAFNVRNPDA
HHHHHHHHEEEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEEECHHHHHHHCCCCCHH
YERLLMDVIRSNQTLFMRRDEVEAAWKWVDPILKGWETTGQQVQGYTAGTWGPSQAIALI
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHEEEEE
ERDGRTWHDDI
ECCCCCCCCCC
>Mature Secondary Structure 
SSQIIPVEPFDYVVFGGSGDLAERKLLPALYHRQIEGQFSEPTRVIGASRSPLSHEEYR
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCHHHHH
KFAKDALNEHLKKGEYDEAEVEKFCARLYYVSVDARTDTGWDQLKKLLDEGKERVRAFYL
HHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
AVAPGIFGDISQKIHDHKLITKSTRIVVEKPIGRDLASALQLNDTIGRAFKEEQIFRIDH
HHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLGKETVQNLMALRFANALYEPLWNANYIDHVQITVAEAVGLEGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCCCHHHHHHHHHHH
NHILQLLCLTAMEVPSSMDSEAVRDEKLKVLRALKPLNASNVEQATVRGQYRAGASGSGP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCC
VKGYLEELEGGVSNTETFVAIKAEINNWRWAGVPFYIRTGKRLTGRMSEIVITFKPIPHA
HHHHHHHHCCCCCCCCEEEEEEEECCCEEECCCCEEEECCCHHHCCCEEEEEEECCCCHH
IFDQAAGRIVANQLIIRLQPDEGVKQSLMIKDPGPGGMRLRNVSLDMSFAQAFNVRNPDA
HHHHHHHHEEEEEEEEEECCCCCCCCEEEEECCCCCCCEEEEEEECHHHHHHHCCCCCHH
YERLLMDVIRSNQTLFMRRDEVEAAWKWVDPILKGWETTGQQVQGYTAGTWGPSQAIALI
HHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHEEEEE
ERDGRTWHDDI
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]