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The map label for this gene is edd [H]

Identifier: 209547969

GI number: 209547969

Start: 365317

End: 367140

Strand: Reverse

Name: edd [H]

Synonym: Rleg2_0361

Alternate gene names: 209547969

Gene position: 367140-365317 (Counterclockwise)

Preceding gene: 209547970

Following gene: 209547962

Centisome position: 8.09

GC content: 66.28

Gene sequence:

>1824_bases
ATGTCCGCTCACGCACGCATTTCTGCGATCACCGATCGCATTGTCGAACGCTCGAAGCCAACCCGCGAGCGGTATCTGGA
GCGCCTGCGCGCCGCCGCTTCCAAGGGCGTCCAGCGCTCGGTGCTCGGCTGCGCCAACCTCGCCCACGGCTTTGCGGTCT
GTTCCCCCGCCGATAAGGATGCGCTCGCCGGCGACCACATCCCTAATCTCGGCATCATCACCGCCTATAACGACATGCTC
TCGGCCCACCAGCCGTTCGAGACCTATCCGGCGATCATCCGCGAGGCGGCCGCAGAGGCAGGCGGCGTGGCGCAGGTGGC
GGGCGGCGTGCCGGCAATGTGCGACGGCGTCACCCAGGGCCAGCCGGGCATGGAGCTATCGCTGTTCTCGCGCGACCTGA
TCGCCATGTCGGCGGGCGTCGGCCTGTCGCACAACATGTTCGATGCCGCCCTCTTCCTCGGCGTCTGCGACAAGATCGTG
CCGGGCCTCGTCATCGCCGCGCTCTCCTTCGGGCACCTGCCGTCGATCTTCGTTCCGGCCGGTCCGATGACGACAGGCCT
GCCGAACGACGAGAAGTCGCGCGTGCGCCAGCTCTTTGCCGAGGGCAAGGTCGGTCGCGCCGAGCTCCTGGAGGCCGAGT
CCAAGTCCTATCACGGTCCCGGCACCTGCACCTTCTACGGCACCGCCAATTCCAACCAGATGCTGATGGAGATCATGGGC
TTCCACCTGCCCGGTTCCTCCTTCATCAATCCCGGCACGCCGCTGCGCGAAGCGCTGACGCGCGAAGCCGCCAAGCGGGC
GCTGGCGATCACCGCGCTCGGCAATGAATTCACCCCGGCCGGCGAGATGATCGACGAGCGCTCGGTCGTCAACGGCGTCG
TCGGTCTGCATGCCACCGGCGGCTCGACCAATCATACGCTGCACCTCGTTGCCATGGCGCGCGCAGCCGGCATCCAGCTC
ACCTGGCAGGACATTGCCGAGCTTTCGGAAGTGGTGCCGCTGCTTGCCCGCGTTTATCCGAACGGGCTTGCCGACGTAAA
CCATTTCCAGGCGGCCGGCGGCATGGGCTTCCTGATCAAGGAACTCCTGAAGCATGGCCTGGTGCATGACGACGTACGCA
CCGTCTTCGGCCGGGGTCTTCAAGCCTATACGGTCGATGCCCGGCTCGGCGAAAACGGTACCGTCCGGCGCGAGCCGTCG
CCGGAGAAGAGCGTCGATCCCAAGGTTCTCTCCAGCATCGAAACGCCGTTCCAGGCGAATGGCGGGCTGAAGATGCTGCG
CGGCAATCTCGGCAAGGCGGTGATCAAGATCTCCGCCGTCAAGCCGGAGCGTCACATCATCGAGGCGCCGGCGATCATCT
TCCACAGCCAGCAGGAGCTGCAGGACGCCTTCAAGGAAGGCAAGCTCAACCGCGATTTCATCGCCGTCGTGCGCTTCCAG
GGCCCAAAGGCGAACGGCATGCCGGAGCTGCACAAGCTGACGCCGCCGCTCGGCGTGCTACAGGACCGCGGTTTCCGCGT
GGCGCTTTTGACCGACGGACGCATGTCGGGGGCCTCCGGCAAGGTGCCGGCCGCGATCCATGTGACGCCTGAGGCGGTCG
ACGGCGGCCCGATTGCCCGCATCCGCGAGGGCGACATCATCCGCCTGGACGCGATCAAGGGCACGCTCGAACTGCTCGTC
GATGCGGCCGATATGGCCGAGCGCGAGCCGGTGACCGTCGATCTCTCCGACAATGAATTCGGCATGGGCCGCGAACTCTT
TGCACCCTTCCGCCGCGCCGTCGGCGCTTCGGATCAGGGCGCCAGCGTGCTCTTCCACCACTGA

Upstream 100 bases:

>100_bases
TCGAGATCTACTGGGCTCCCTGATCGACCGTCAATCCGGATTGAATATCAGGCCAGAGCCGCCGAAACAGATTAGACAAC
GAACAAGGCAGGGATCTTCC

Downstream 100 bases:

>100_bases
GCGTCGCTGCCGGGCACAAACAAAAACCCGCGGGCGCACGAAGCACCCGCGGGTTTTCTGTATCAGTCTTGCGCTCGCTC
AGGCGCGGATATCGAGAACG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MSAHARISAITDRIVERSKPTRERYLERLRAAASKGVQRSVLGCANLAHGFAVCSPADKDALAGDHIPNLGIITAYNDML
SAHQPFETYPAIIREAAAEAGGVAQVAGGVPAMCDGVTQGQPGMELSLFSRDLIAMSAGVGLSHNMFDAALFLGVCDKIV
PGLVIAALSFGHLPSIFVPAGPMTTGLPNDEKSRVRQLFAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
FHLPGSSFINPGTPLREALTREAAKRALAITALGNEFTPAGEMIDERSVVNGVVGLHATGGSTNHTLHLVAMARAAGIQL
TWQDIAELSEVVPLLARVYPNGLADVNHFQAAGGMGFLIKELLKHGLVHDDVRTVFGRGLQAYTVDARLGENGTVRREPS
PEKSVDPKVLSSIETPFQANGGLKMLRGNLGKAVIKISAVKPERHIIEAPAIIFHSQQELQDAFKEGKLNRDFIAVVRFQ
GPKANGMPELHKLTPPLGVLQDRGFRVALLTDGRMSGASGKVPAAIHVTPEAVDGGPIARIREGDIIRLDAIKGTLELLV
DAADMAEREPVTVDLSDNEFGMGRELFAPFRRAVGASDQGASVLFHH

Sequences:

>Translated_607_residues
MSAHARISAITDRIVERSKPTRERYLERLRAAASKGVQRSVLGCANLAHGFAVCSPADKDALAGDHIPNLGIITAYNDML
SAHQPFETYPAIIREAAAEAGGVAQVAGGVPAMCDGVTQGQPGMELSLFSRDLIAMSAGVGLSHNMFDAALFLGVCDKIV
PGLVIAALSFGHLPSIFVPAGPMTTGLPNDEKSRVRQLFAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
FHLPGSSFINPGTPLREALTREAAKRALAITALGNEFTPAGEMIDERSVVNGVVGLHATGGSTNHTLHLVAMARAAGIQL
TWQDIAELSEVVPLLARVYPNGLADVNHFQAAGGMGFLIKELLKHGLVHDDVRTVFGRGLQAYTVDARLGENGTVRREPS
PEKSVDPKVLSSIETPFQANGGLKMLRGNLGKAVIKISAVKPERHIIEAPAIIFHSQQELQDAFKEGKLNRDFIAVVRFQ
GPKANGMPELHKLTPPLGVLQDRGFRVALLTDGRMSGASGKVPAAIHVTPEAVDGGPIARIREGDIIRLDAIKGTLELLV
DAADMAEREPVTVDLSDNEFGMGRELFAPFRRAVGASDQGASVLFHH
>Mature_606_residues
SAHARISAITDRIVERSKPTRERYLERLRAAASKGVQRSVLGCANLAHGFAVCSPADKDALAGDHIPNLGIITAYNDMLS
AHQPFETYPAIIREAAAEAGGVAQVAGGVPAMCDGVTQGQPGMELSLFSRDLIAMSAGVGLSHNMFDAALFLGVCDKIVP
GLVIAALSFGHLPSIFVPAGPMTTGLPNDEKSRVRQLFAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMGF
HLPGSSFINPGTPLREALTREAAKRALAITALGNEFTPAGEMIDERSVVNGVVGLHATGGSTNHTLHLVAMARAAGIQLT
WQDIAELSEVVPLLARVYPNGLADVNHFQAAGGMGFLIKELLKHGLVHDDVRTVFGRGLQAYTVDARLGENGTVRREPSP
EKSVDPKVLSSIETPFQANGGLKMLRGNLGKAVIKISAVKPERHIIEAPAIIFHSQQELQDAFKEGKLNRDFIAVVRFQG
PKANGMPELHKLTPPLGVLQDRGFRVALLTDGRMSGASGKVPAAIHVTPEAVDGGPIARIREGDIIRLDAIKGTLELLVD
AADMAEREPVTVDLSDNEFGMGRELFAPFRRAVGASDQGASVLFHH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=595, Percent_Identity=63.3613445378151, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=544, Percent_Identity=29.2279411764706, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI2367371, Length=465, Percent_Identity=31.1827956989247, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1786464, Length=475, Percent_Identity=29.2631578947368, Blast_Score=139, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322476, Length=499, Percent_Identity=30.060120240481, Blast_Score=180, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64622; Mature: 64491

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAHARISAITDRIVERSKPTRERYLERLRAAASKGVQRSVLGCANLAHGFAVCSPADKD
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEECCCCCCC
ALAGDHIPNLGIITAYNDMLSAHQPFETYPAIIREAAAEAGGVAQVAGGVPAMCDGVTQG
CCCCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
QPGMELSLFSRDLIAMSAGVGLSHNMFDAALFLGVCDKIVPGLVIAALSFGHLPSIFVPA
CCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
GPMTTGLPNDEKSRVRQLFAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
FHLPGSSFINPGTPLREALTREAAKRALAITALGNEFTPAGEMIDERSVVNGVVGLHATG
CCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECC
GSTNHTLHLVAMARAAGIQLTWQDIAELSEVVPLLARVYPNGLADVNHFQAAGGMGFLIK
CCCCCEEEEEEEHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHH
ELLKHGLVHDDVRTVFGRGLQAYTVDARLGENGTVRREPSPEKSVDPKVLSSIETPFQAN
HHHHHCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
GGLKMLRGNLGKAVIKISAVKPERHIIEAPAIIFHSQQELQDAFKEGKLNRDFIAVVRFQ
CCHHHHHCCCCCEEEEEEEECCHHHHHHCCHHEECCHHHHHHHHHHCCCCCCEEEEEEEC
GPKANGMPELHKLTPPLGVLQDRGFRVALLTDGRMSGASGKVPAAIHVTPEAVDGGPIAR
CCCCCCCCHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEE
IREGDIIRLDAIKGTLELLVDAADMAEREPVTVDLSDNEFGMGRELFAPFRRAVGASDQG
ECCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
ASVLFHH
CEEEECC
>Mature Secondary Structure 
SAHARISAITDRIVERSKPTRERYLERLRAAASKGVQRSVLGCANLAHGFAVCSPADKD
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEECCCCCCC
ALAGDHIPNLGIITAYNDMLSAHQPFETYPAIIREAAAEAGGVAQVAGGVPAMCDGVTQG
CCCCCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
QPGMELSLFSRDLIAMSAGVGLSHNMFDAALFLGVCDKIVPGLVIAALSFGHLPSIFVPA
CCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
GPMTTGLPNDEKSRVRQLFAEGKVGRAELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
FHLPGSSFINPGTPLREALTREAAKRALAITALGNEFTPAGEMIDERSVVNGVVGLHATG
CCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEECC
GSTNHTLHLVAMARAAGIQLTWQDIAELSEVVPLLARVYPNGLADVNHFQAAGGMGFLIK
CCCCCEEEEEEEHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHH
ELLKHGLVHDDVRTVFGRGLQAYTVDARLGENGTVRREPSPEKSVDPKVLSSIETPFQAN
HHHHHCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCC
GGLKMLRGNLGKAVIKISAVKPERHIIEAPAIIFHSQQELQDAFKEGKLNRDFIAVVRFQ
CCHHHHHCCCCCEEEEEEEECCHHHHHHCCHHEECCHHHHHHHHHHCCCCCCEEEEEEEC
GPKANGMPELHKLTPPLGVLQDRGFRVALLTDGRMSGASGKVPAAIHVTPEAVDGGPIAR
CCCCCCCCHHHHCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEE
IREGDIIRLDAIKGTLELLVDAADMAEREPVTVDLSDNEFGMGRELFAPFRRAVGASDQG
ECCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCC
ASVLFHH
CEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]