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The map label for this gene is fabG [C]

Identifier: 209547820

GI number: 209547820

Start: 212986

End: 213687

Strand: Reverse

Name: fabG [C]

Synonym: Rleg2_0211

Alternate gene names: 209547820

Gene position: 213687-212986 (Counterclockwise)

Preceding gene: 209547821

Following gene: 209547819

Centisome position: 4.71

GC content: 66.81

Gene sequence:

>702_bases
ATGTCCGACTTTCCCTATGCCAGCGCCCTCATCGTCGGCGCGGGTTCCGGTATCAGCGCATCGCTCGCCCGGCAATTGTC
GGCGCTCGGAGTCAAGGTCGGGCTTGCCGCCCGCAACATCGAAAAGCTCCAGGCCCTCTTGGAGGAAACAGGCGCCAGCG
CATTCAGCGCCGATGTTTCGCAGCCTGCCAGCGTCGCGGCGCTGTTCGAAGAGGCCGCCGCCACCATCGGCGGGCCAGAT
GTCGTGATCTTCAATGCCGGCGCCCGGGTGCGCGGCCCGCTTGCCGAACTCGACCCCGACGAGGTGGAAAAGGCGATCGC
GACCACCGCCTTCGGCGGCTTTCTGGTGGCGCAACAGGCGGCGCAGCACATGATACCGCGCGGCCGCGGCGCAATCTTCT
TCACCGGCGCTTCGGCAAGCGTGAAAGGCTTTGCGCAATCGGCCCCCTTCGCTATGGGCAAGTTCGCGCTGCGCGGTCTT
GCCCAGAGTGCCGCCCGCGAGCTCGGGCCGATGGGCATCCATGTCGCCCATTTCGTCATCGACGGCGGCGTGCGTTCCGA
AATCCGGCCGGACCGGGCGGAGAAACCCGACGGCACGCTGCTGCCGGATGCGATCGCCCAGACCTATATCGACGTGCTTC
GCCAGCACCGCAGTGCATGGTCGCTGGAGGTGGAAGTCCGGCCCTGGACGGAGAACTTCTGA

Upstream 100 bases:

>100_bases
GATCGATGCGGGAGGGCCGCACTGAAATTCCGGCCAGGGCGCTGGCACGAGCCATTGGCACTTCCTACCTCTTTCGGACG
ATCCACGCAGGAAGATACTC

Downstream 100 bases:

>100_bases
GCCGCCGGCGGCGCCGAAGAGGCCGCTTTCGCGGCGGTTACGAACAGACTATGTTTCGTCGAAAGAGCTGGTTGGGAGGA
ACCGATGCCGCGCCTGGACC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSDFPYASALIVGAGSGISASLARQLSALGVKVGLAARNIEKLQALLEETGASAFSADVSQPASVAALFEEAAATIGGPD
VVIFNAGARVRGPLAELDPDEVEKAIATTAFGGFLVAQQAAQHMIPRGRGAIFFTGASASVKGFAQSAPFAMGKFALRGL
AQSAARELGPMGIHVAHFVIDGGVRSEIRPDRAEKPDGTLLPDAIAQTYIDVLRQHRSAWSLEVEVRPWTENF

Sequences:

>Translated_233_residues
MSDFPYASALIVGAGSGISASLARQLSALGVKVGLAARNIEKLQALLEETGASAFSADVSQPASVAALFEEAAATIGGPD
VVIFNAGARVRGPLAELDPDEVEKAIATTAFGGFLVAQQAAQHMIPRGRGAIFFTGASASVKGFAQSAPFAMGKFALRGL
AQSAARELGPMGIHVAHFVIDGGVRSEIRPDRAEKPDGTLLPDAIAQTYIDVLRQHRSAWSLEVEVRPWTENF
>Mature_232_residues
SDFPYASALIVGAGSGISASLARQLSALGVKVGLAARNIEKLQALLEETGASAFSADVSQPASVAALFEEAAATIGGPDV
VIFNAGARVRGPLAELDPDEVEKAIATTAFGGFLVAQQAAQHMIPRGRGAIFFTGASASVKGFAQSAPFAMGKFALRGLA
QSAARELGPMGIHVAHFVIDGGVRSEIRPDRAEKPDGTLLPDAIAQTYIDVLRQHRSAWSLEVEVRPWTENF

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=185, Percent_Identity=34.0540540540541, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=175, Percent_Identity=29.1428571428571, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI2367365, Length=180, Percent_Identity=30.5555555555556, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790717, Length=173, Percent_Identity=28.9017341040462, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=193, Percent_Identity=25.9067357512953, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571387, Length=223, Percent_Identity=29.5964125560538, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI23397609, Length=169, Percent_Identity=30.1775147928994, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281364892, Length=172, Percent_Identity=30.2325581395349, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007238, Length=133, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007236, Length=133, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 24300; Mature: 24169

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFPYASALIVGAGSGISASLARQLSALGVKVGLAARNIEKLQALLEETGASAFSADVS
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
QPASVAALFEEAAATIGGPDVVIFNAGARVRGPLAELDPDEVEKAIATTAFGGFLVAQQA
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQHMIPRGRGAIFFTGASASVKGFAQSAPFAMGKFALRGLAQSAARELGPMGIHVAHFVI
HHHHCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEE
DGGVRSEIRPDRAEKPDGTLLPDAIAQTYIDVLRQHRSAWSLEVEVRPWTENF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
>Mature Secondary Structure 
SDFPYASALIVGAGSGISASLARQLSALGVKVGLAARNIEKLQALLEETGASAFSADVS
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
QPASVAALFEEAAATIGGPDVVIFNAGARVRGPLAELDPDEVEKAIATTAFGGFLVAQQA
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQHMIPRGRGAIFFTGASASVKGFAQSAPFAMGKFALRGLAQSAARELGPMGIHVAHFVI
HHHHCCCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEE
DGGVRSEIRPDRAEKPDGTLLPDAIAQTYIDVLRQHRSAWSLEVEVRPWTENF
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]