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The map label for this gene is pyrE [H]

Identifier: 209547745

GI number: 209547745

Start: 126073

End: 126762

Strand: Direct

Name: pyrE [H]

Synonym: Rleg2_0134

Alternate gene names: 209547745

Gene position: 126073-126762 (Clockwise)

Preceding gene: 209547744

Following gene: 209547746

Centisome position: 2.78

GC content: 62.03

Gene sequence:

>690_bases
ATGATCCAGACGACATTTCCCGACCGCGCCGTCATGGCCGAACTGGTGGCCAAGATGCTCTGGGAGATCAAGGCGGTGCA
TTTCAATGCCGCCCAGCCTTATAAACTTGCCTCCGGCATGGCGAGCCCGGTCTATATCGATTGCCGCAAGCTGCTTTCCT
TCCCGCGCATCCGCTCGACAGTGATGGATTTCGCCGCCAGCACCCTGTTGCGCGATGCCGGCTTCGAGCAGTTCGATTGC
ATCGCCGGCGGTGAGACCGCCGGCATCCCCTTCGCCGCGCTGCTTGCCGATCGCCTCGGCCTGCCGATGATCTATGTCCG
CAAGCAGCCGAAGGGCCATGGCCGCAATGCCCAGATCGAAGGCAATATGCCGGAAGGGTCGCGCGTGCTGGTCATCGAGG
ACCTGACGACGGCCGGAACCAGCATGTTCAAGTTCATCGATGCCGTGCGCGCTGCCGGCGGCATCGTCGATCACGGCATC
GCGCTGTTCTTCTACGACATCTTCGGCCAGCAGCGCTTTACCGACGGCAAGGTGAGACTGCATCACATCGCCACCTGGCG
CAATATGCTGGCGGTCGCCAAGGCGCAGAAGCTGTTCGACGACAAGACGCTTGAGGAGGTCGAGGCTTTCCTCGATGCGC
CGCTCGCCTGGTCGGGACTCAATGGCGGCGTCAGTGAGCTTTCGCTCTAA

Upstream 100 bases:

>100_bases
CTCGATATCGGCCGTCTGTTGCTGGAATAGCCGCGCCTGCGTCTGGAAACGATGGGCTCTTGCTGCTATTGCCGGAGACA
CAAAGCTGAAGGAGAGCCGC

Downstream 100 bases:

>100_bases
TCGGTTGACAAAAGCTCGCTTAATCGGTTGATGAACATATCAGTGCTGTTGGGAGAAATTCGATGATTTTGTGCTGCGGC
GAAGCCTTGATCGACATGCT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MIQTTFPDRAVMAELVAKMLWEIKAVHFNAAQPYKLASGMASPVYIDCRKLLSFPRIRSTVMDFAASTLLRDAGFEQFDC
IAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIEGNMPEGSRVLVIEDLTTAGTSMFKFIDAVRAAGGIVDHGI
ALFFYDIFGQQRFTDGKVRLHHIATWRNMLAVAKAQKLFDDKTLEEVEAFLDAPLAWSGLNGGVSELSL

Sequences:

>Translated_229_residues
MIQTTFPDRAVMAELVAKMLWEIKAVHFNAAQPYKLASGMASPVYIDCRKLLSFPRIRSTVMDFAASTLLRDAGFEQFDC
IAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIEGNMPEGSRVLVIEDLTTAGTSMFKFIDAVRAAGGIVDHGI
ALFFYDIFGQQRFTDGKVRLHHIATWRNMLAVAKAQKLFDDKTLEEVEAFLDAPLAWSGLNGGVSELSL
>Mature_229_residues
MIQTTFPDRAVMAELVAKMLWEIKAVHFNAAQPYKLASGMASPVYIDCRKLLSFPRIRSTVMDFAASTLLRDAGFEQFDC
IAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIEGNMPEGSRVLVIEDLTTAGTSMFKFIDAVRAAGGIVDHGI
ALFFYDIFGQQRFTDGKVRLHHIATWRNMLAVAKAQKLFDDKTLEEVEAFLDAPLAWSGLNGGVSELSL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=203, Percent_Identity=31.0344827586207, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17508631, Length=132, Percent_Identity=34.8484848484849, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17554964, Length=159, Percent_Identity=25.1572327044025, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17933654, Length=200, Percent_Identity=26, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25154; Mature: 25154

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTTFPDRAVMAELVAKMLWEIKAVHFNAAQPYKLASGMASPVYIDCRKLLSFPRIRST
CCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHH
VMDFAASTLLRDAGFEQFDCIAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIE
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEE
GNMPEGSRVLVIEDLTTAGTSMFKFIDAVRAAGGIVDHGIALFFYDIFGQQRFTDGKVRL
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEE
HHIATWRNMLAVAKAQKLFDDKTLEEVEAFLDAPLAWSGLNGGVSELSL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCEECCCCCCHHHCCC
>Mature Secondary Structure
MIQTTFPDRAVMAELVAKMLWEIKAVHFNAAQPYKLASGMASPVYIDCRKLLSFPRIRST
CCCCCCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHH
VMDFAASTLLRDAGFEQFDCIAGGETAGIPFAALLADRLGLPMIYVRKQPKGHGRNAQIE
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEE
GNMPEGSRVLVIEDLTTAGTSMFKFIDAVRAAGGIVDHGIALFFYDIFGQQRFTDGKVRL
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEE
HHIATWRNMLAVAKAQKLFDDKTLEEVEAFLDAPLAWSGLNGGVSELSL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCEECCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA