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The map label for this gene is hemN [H]

Identifier: 209547615

GI number: 209547615

Start: 3481

End: 4686

Strand: Reverse

Name: hemN [H]

Synonym: Rleg2_0003

Alternate gene names: 209547615

Gene position: 4686-3481 (Counterclockwise)

Preceding gene: 209547616

Following gene: NA

Centisome position: 0.1

GC content: 64.18

Gene sequence:

>1206_bases
GTGGACAATTTCGACACGCCAGGCCGCCCCTCGCGCGATGCGGCGCTGCTGCCCGATACCGGCGAGCCCGGCTTCGGCGT
CTATGTGCATTGGCCCTTCTGCGCGGCGAAGTGTCCCTATTGCGATTTCAACAGTCATGTGCGCCATCAGCCGGTCGATC
AGGAACGCTTTGCATCAGCCTTCCTGAAGGAGATGGCGGCGGTCCGGGCATTGAGCGGGCCGAAGACGGTGACGAGCATC
TTCCTCGGCGGCGGCACGCCCTCGCTGATGAAACCGGAAACGGTCTCCGCCATTCTCGACGGCATTGCCCGGCACTGGCA
CGTGCCTGCCGGCATCGAGATCACCATGGAGGCCAATCCGTCCAGCGTCGAGGCCGAGCGCTTCCGCGGCTACCGGGCGG
CCGGCGTCAACCGCGTCTCGCTCGGCGTGCAGGCGCTTGATGATCGGGACCTGAAATTCCTCGGCCGGCTGCATGATGTC
GCCGACGCGCTGAAGGCGATCCGGCTGGCGCGCGACATTTTTCCGCGCATGTCTTTCGACCTCATCTATGCCCGGCCGGA
CCAGACGGTCGAGCAATGGGAAAGGGAGCTGAAGCAAGCGATCTCTTACGCGGTCGATCATCTTTCGCTCTATCAACTCA
CCATCGAGGAAGGCACGCCGTTTTATGGCCTGCACAAAGCAGGCAAGCTGATCGTGCCGGATGGCGAGCAATCGGCCGTG
CTCTACGAGGCGACGCAGGAAATCACCGCGCGCGAGGGCATGCCGGCCTACGAGGTTTCCAACCACGCCCGGCCGGGTGC
TGAAAGCCGGCATAACCTGACCTATTGGCGTTACGGCGATTATGCCGGTATCGGCCCTGGCGCGCACGGCCGGCTGACGC
GCGGCCCCGAGAAGATCGCGACGGCGACCGAGCGCAAGCCGGAGTCCTGGCTCGACATGGTCGAGCGCGACGGCCACGGC
ATTCTCGACGAGGAGCGGCTCGGCTATGAGGAACAATCCGACGAATTGCTGCTGATGGGGCTGCGGCTCCGGGAAGGCGT
CGATCTTGCCCGCTGGCAGCAGCTTTCCGGCCGCGACCTCGACCCGAAACGCGAAGAGTTTCTGCTCGAACACAAATTCA
TCGAGCGGATCGGCAATTCACGCCTGCGCTGCACGCCCTCAGGAATGCTGATCCTCGATTCCGTCGTCGCCGATCTCGCC
TGCTGA

Upstream 100 bases:

>100_bases
AAAACACGGCTGGAGCGTCGGCAAGCCGCAGGCGCTATCGCACCGGGCCCGCGCCTTCAAACTCTTTGTCGAAACCTGCC
TGGAGGCATAAGGTCACCAC

Downstream 100 bases:

>100_bases
CGCCCACGCAATGCATTGGTTCCAGCGCGGCCGACATCGCGGGCCGCGCTGAAAACGTAATCTCAGCTGTGGCTGGTGGC
ACCGGCCTTGAACAGGCTGC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDNFDTPGRPSRDAALLPDTGEPGFGVYVHWPFCAAKCPYCDFNSHVRHQPVDQERFASAFLKEMAAVRALSGPKTVTSI
FLGGGTPSLMKPETVSAILDGIARHWHVPAGIEITMEANPSSVEAERFRGYRAAGVNRVSLGVQALDDRDLKFLGRLHDV
ADALKAIRLARDIFPRMSFDLIYARPDQTVEQWERELKQAISYAVDHLSLYQLTIEEGTPFYGLHKAGKLIVPDGEQSAV
LYEATQEITAREGMPAYEVSNHARPGAESRHNLTYWRYGDYAGIGPGAHGRLTRGPEKIATATERKPESWLDMVERDGHG
ILDEERLGYEEQSDELLLMGLRLREGVDLARWQQLSGRDLDPKREEFLLEHKFIERIGNSRLRCTPSGMLILDSVVADLA
C

Sequences:

>Translated_401_residues
MDNFDTPGRPSRDAALLPDTGEPGFGVYVHWPFCAAKCPYCDFNSHVRHQPVDQERFASAFLKEMAAVRALSGPKTVTSI
FLGGGTPSLMKPETVSAILDGIARHWHVPAGIEITMEANPSSVEAERFRGYRAAGVNRVSLGVQALDDRDLKFLGRLHDV
ADALKAIRLARDIFPRMSFDLIYARPDQTVEQWERELKQAISYAVDHLSLYQLTIEEGTPFYGLHKAGKLIVPDGEQSAV
LYEATQEITAREGMPAYEVSNHARPGAESRHNLTYWRYGDYAGIGPGAHGRLTRGPEKIATATERKPESWLDMVERDGHG
ILDEERLGYEEQSDELLLMGLRLREGVDLARWQQLSGRDLDPKREEFLLEHKFIERIGNSRLRCTPSGMLILDSVVADLA
C
>Mature_401_residues
MDNFDTPGRPSRDAALLPDTGEPGFGVYVHWPFCAAKCPYCDFNSHVRHQPVDQERFASAFLKEMAAVRALSGPKTVTSI
FLGGGTPSLMKPETVSAILDGIARHWHVPAGIEITMEANPSSVEAERFRGYRAAGVNRVSLGVQALDDRDLKFLGRLHDV
ADALKAIRLARDIFPRMSFDLIYARPDQTVEQWERELKQAISYAVDHLSLYQLTIEEGTPFYGLHKAGKLIVPDGEQSAV
LYEATQEITAREGMPAYEVSNHARPGAESRHNLTYWRYGDYAGIGPGAHGRLTRGPEKIATATERKPESWLDMVERDGHG
ILDEERLGYEEQSDELLLMGLRLREGVDLARWQQLSGRDLDPKREEFLLEHKFIERIGNSRLRCTPSGMLILDSVVADLA
C

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=376, Percent_Identity=39.6276595744681, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1789325, Length=291, Percent_Identity=40.5498281786942, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87082341, Length=248, Percent_Identity=27.0161290322581, Blast_Score=101, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44844; Mature: 44844

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNFDTPGRPSRDAALLPDTGEPGFGVYVHWPFCAAKCPYCDFNSHVRHQPVDQERFASA
CCCCCCCCCCCCCCEECCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FLKEMAAVRALSGPKTVTSIFLGGGTPSLMKPETVSAILDGIARHWHVPAGIEITMEANP
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCC
SSVEAERFRGYRAAGVNRVSLGVQALDDRDLKFLGRLHDVADALKAIRLARDIFPRMSFD
CCCCHHHHCCHHHCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LIYARPDQTVEQWERELKQAISYAVDHLSLYQLTIEEGTPFYGLHKAGKLIVPDGEQSAV
EEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEHHCCCEEEECCCCCCEE
LYEATQEITAREGMPAYEVSNHARPGAESRHNLTYWRYGDYAGIGPGAHGRLTRGPEKIA
EHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
TATERKPESWLDMVERDGHGILDEERLGYEEQSDELLLMGLRLREGVDLARWQQLSGRDL
HHHCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCEEEEEHHHHCCCCHHHHHHHCCCCC
DPKREEFLLEHKFIERIGNSRLRCTPSGMLILDSVVADLAC
CHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDNFDTPGRPSRDAALLPDTGEPGFGVYVHWPFCAAKCPYCDFNSHVRHQPVDQERFASA
CCCCCCCCCCCCCCEECCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHH
FLKEMAAVRALSGPKTVTSIFLGGGTPSLMKPETVSAILDGIARHWHVPAGIEITMEANP
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCC
SSVEAERFRGYRAAGVNRVSLGVQALDDRDLKFLGRLHDVADALKAIRLARDIFPRMSFD
CCCCHHHHCCHHHCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LIYARPDQTVEQWERELKQAISYAVDHLSLYQLTIEEGTPFYGLHKAGKLIVPDGEQSAV
EEEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEEEHHCCCEEEECCCCCCEE
LYEATQEITAREGMPAYEVSNHARPGAESRHNLTYWRYGDYAGIGPGAHGRLTRGPEKIA
EHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHH
TATERKPESWLDMVERDGHGILDEERLGYEEQSDELLLMGLRLREGVDLARWQQLSGRDL
HHHCCCCHHHHHHHHCCCCCCCCHHHCCCCCCCCCEEEEEHHHHCCCCHHHHHHHCCCCC
DPKREEFLLEHKFIERIGNSRLRCTPSGMLILDSVVADLAC
CHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]