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The map label for this gene is cdsA

Identifier: 209399460

GI number: 209399460

Start: 199002

End: 199859

Strand: Direct

Name: cdsA

Synonym: ECH74115_0185

Alternate gene names: 209399460

Gene position: 199002-199859 (Clockwise)

Preceding gene: 209396854

Following gene: 209399122

Centisome position: 3.57

GC content: 50.82

Gene sequence:

>858_bases
TTGCTGAAGTATCGCCTGATATCTGCTTTTGTGTTAATACCCGTCGTCATCGCGGCGTTGTTTCTGTTGCCGCCGGTGGG
GTTCGCCATTGTAACGCTGGTGGTCTGCATGCTGGCAGCGTGGGAATGGGGACAGCTTAGCGGTTTTACCACTCGTTCGC
AGCGAGTATGGTTGGCGGTGTTATGCGGGTTATTGTTGGCGCTGATGCTTTTTCTGTTGCCGGAATATCACCGAAATATT
CATCAACCGCTGGTTGAAATCTCACTTTGGGCTTCGCTGGGTTGGTGGATTGTCGCGCTATTGCTGGTGCTGTTTTACCC
AGGTTCCGCAGCAATCTGGCGTAACTCTAAAACATTGCGCCTTATTTTTGGCGTGCTAACCATTGTTCCCTTCTTCTGGG
GCATGCTGGCGTTACGGGCCTGGCACTATGACGAGAATCATTACAGTGGCGCAATATGGCTGCTCTATGTCATGATCCTG
GTATGGGGCGCTGACTCCGGCGCATATATGTTTGGCAAATTGTTTGGTAAACATAAGCTGGCACCGAAGGTTTCTCCGGG
TAAAACCTGGCAAGGCTTTATCGGTGGACTCGCTACTGCAGCGGTAATCTCATGGGGTTATGGCATGTGGGCGAATCTCG
ACGTCGCTCCCGTCACCTTACTCATTTGCTCTATTGTCGCAGCGTTAGCCTCAGTGCTCGGCGATCTGACCGAGAGTATG
TTTAAGCGTGAAGCAGGAATTAAGGACAGCGGTCATTTAATTCCAGGACACGGTGGTATTTTAGATCGTATTGATAGCCT
GACGGCTGCGGTACCGGTCTTTGCTTGCTTGTTGTTACTGGTATTCAGGACGCTTTAA

Upstream 100 bases:

>100_bases
TGAACAAGACTTTGAAGGGGCGTTAAATGCCTTTGCTAATCGAGAGCGTCGTTTCGGCGGCACCGAGCCCGGTGATGAAA
CAGCCTGATGGGGGTCGCTT

Downstream 100 bases:

>100_bases
CGGAAGGTAATATGCTGAGTTTTCTCTGGGATTTGGCTTCGTTCATCGTTGCACTGGGTGTACTTATCACCGTGCATGAA
TTTGGTCATTTCTGGGTTGC

Product: CDP-diglyceride synthase

Products: NA

Alternate protein names: CDP-DAG synthase; CDP-DG synthase; CDP-diacylglycerol synthase; CDS; CDP-diglyceride pyrophosphorylase; CDP-diglyceride synthase; CTP:phosphatidate cytidylyltransferase

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLKYRLISAFVLIPVVIAALFLLPPVGFAIVTLVVCMLAAWEWGQLSGFTTRSQRVWLAVLCGLLLALMLFLLPEYHRNI
HQPLVEISLWASLGWWIVALLLVLFYPGSAAIWRNSKTLRLIFGVLTIVPFFWGMLALRAWHYDENHYSGAIWLLYVMIL
VWGADSGAYMFGKLFGKHKLAPKVSPGKTWQGFIGGLATAAVISWGYGMWANLDVAPVTLLICSIVAALASVLGDLTESM
FKREAGIKDSGHLIPGHGGILDRIDSLTAAVPVFACLLLLVFRTL

Sequences:

>Translated_285_residues
MLKYRLISAFVLIPVVIAALFLLPPVGFAIVTLVVCMLAAWEWGQLSGFTTRSQRVWLAVLCGLLLALMLFLLPEYHRNI
HQPLVEISLWASLGWWIVALLLVLFYPGSAAIWRNSKTLRLIFGVLTIVPFFWGMLALRAWHYDENHYSGAIWLLYVMIL
VWGADSGAYMFGKLFGKHKLAPKVSPGKTWQGFIGGLATAAVISWGYGMWANLDVAPVTLLICSIVAALASVLGDLTESM
FKREAGIKDSGHLIPGHGGILDRIDSLTAAVPVFACLLLLVFRTL
>Mature_285_residues
MLKYRLISAFVLIPVVIAALFLLPPVGFAIVTLVVCMLAAWEWGQLSGFTTRSQRVWLAVLCGLLLALMLFLLPEYHRNI
HQPLVEISLWASLGWWIVALLLVLFYPGSAAIWRNSKTLRLIFGVLTIVPFFWGMLALRAWHYDENHYSGAIWLLYVMIL
VWGADSGAYMFGKLFGKHKLAPKVSPGKTWQGFIGGLATAAVISWGYGMWANLDVAPVTLLICSIVAALASVLGDLTESM
FKREAGIKDSGHLIPGHGGILDRIDSLTAAVPVFACLLLLVFRTL

Specific function: Phospholipid biosynthesis. [C]

COG id: COG0575

COG function: function code I; CDP-diglyceride synthetase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDS family

Homologues:

Organism=Escherichia coli, GI87081696, Length=285, Percent_Identity=100, Blast_Score=562, Evalue=1e-162,
Organism=Escherichia coli, GI1787677, Length=117, Percent_Identity=44.4444444444444, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CDSA_ECO57 (P0ABG2)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A85502
- PIR:   A99651
- RefSeq:   NP_285869.2
- RefSeq:   NP_308204.2
- ProteinModelPortal:   P0ABG2
- EnsemblBacteria:   EBESCT00000027468
- EnsemblBacteria:   EBESCT00000058720
- GeneID:   913883
- GeneID:   956900
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0186
- KEGG:   ecs:ECs0177
- GeneTree:   EBGT00050000008770
- HOGENOM:   HBG732679
- OMA:   FFAYFYF
- ProtClustDB:   PRK11624
- BioCyc:   ECOL83334:ECS0177-MONOMER
- InterPro:   IPR000374

Pfam domain/function: PF01148 CTP_transf_1

EC number: =2.7.7.41

Molecular weight: Translated: 31454; Mature: 31454

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS01315 CDS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x24e76460)-; HASH(0x240678f0)-; HASH(0x24e38a08)-; HASH(0x245093cc)-; HASH(0x24f5c950)-; HASH(0x249e97e0)-; HASH(0x23aeb414)-; HASH(0x246067e0)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure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HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796