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The map label for this gene is nanC

Identifier: 209398737

GI number: 209398737

Start: 5467341

End: 5467889

Strand: Reverse

Name: nanC

Synonym: ECH74115_5815

Alternate gene names: 209398737

Gene position: 5467889-5467341 (Counterclockwise)

Preceding gene: 209400769

Following gene: 209397986

Centisome position: 98.13

GC content: 41.89

Gene sequence:

>549_bases
ATGGAAAGTAATACCTGGAATACCATTCATGATAATAAAAAGGAAAATGCCGCACTCAATGATGTTCAGGTTGAAGTTAA
TTACGCGATTAAACTTGATGATCAATGGACGGTGCGCCCGGGAATGTTAACGCATTTTAGCAGCAACGGCACACGCTACG
GACCCTACGTAAAACTGTCCTGGGACGCGACAAAAGATCTTAATTTTGGCATTCGCTATCGTTACGACTGGAAAGCTTAC
CGACAACAAGACTTATCCGGTGATATGTCTCGTGATAACGTTCATCGTTGGGATGGATATGTCACTTACCATATTAATAG
TGATTTCACCTTCGCATGGCAAACGACGCTATACAGCAAACAGAACGATTATCGCTATGCAAACCATAAGAAATGGGCGA
CGGAAAATGCATTTGTTCTACAATACCATATGACGCCCGATATTACGCCATACATAGAATATGACTACCTGGACCGTCAG
GGTGTTTACAACGGCAGAGATAATTTATCGGAAAACAGTTATCGCATTGGTGTGTCATTTAAACTGTAG

Upstream 100 bases:

>100_bases
TGCGACACTGGACGTACGTGGTGGATATCGTAGTGGAAGCCACGCCTATGAGACTCGACTCAAAGTCAGTGAGGGATGGC
AAAATGGATGGTGGGCAAGC

Downstream 100 bases:

>100_bases
TAGACAGGAGACAGTCACAATGAATAAAACAATAACGGCGCTTGCTATCCTAATGGCTTCATTTGCCGCAAACGCGTCTG
TATTACCGGAAACTCCTGTA

Product: oligogalacturonate-specific porin protein

Products: NA

Alternate protein names: Porin nanC

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MESNTWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDATKDLNFGIRYRYDWKAY
RQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQ
GVYNGRDNLSENSYRIGVSFKL

Sequences:

>Translated_182_residues
MESNTWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDATKDLNFGIRYRYDWKAY
RQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQ
GVYNGRDNLSENSYRIGVSFKL
>Mature_182_residues
MESNTWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDATKDLNFGIRYRYDWKAY
RQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQ
GVYNGRDNLSENSYRIGVSFKL

Specific function: Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac or sialic acid) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oligogalacturonate-specific porin kdgM (TC 1.B.35) family. NanC subfamily

Homologues:

Organism=Escherichia coli, GI87082420, Length=182, Percent_Identity=100, Blast_Score=380, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NANC_ECO57 (P69857)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- RefSeq:   NP_290927.1
- RefSeq:   NP_313297.2
- ProteinModelPortal:   P69857
- SMR:   P69857
- EnsemblBacteria:   EBESCT00000026327
- EnsemblBacteria:   EBESCT00000055708
- GeneID:   913696
- GeneID:   959742
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5907
- KEGG:   ecs:ECs5270
- GeneTree:   EBGT00050000008772
- HOGENOM:   HBG416127
- OMA:   SSDMSRD
- ProtClustDB:   CLSK880894
- BioCyc:   ECOL83334:ECS5270-MONOMER
- InterPro:   IPR009331
- InterPro:   IPR001702
- Gene3D:   G3DSA:2.40.160.10

Pfam domain/function: PF06178 KdgM

EC number: NA

Molecular weight: Translated: 21750; Mature: 21750

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNTWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLS
CCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCEEECCCEEEEECCCCCEECCEEEEE
WDATKDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSK
ECCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCEECCCEEEEEECCCEEEEEEEEEECC
QNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSF
CCCCEECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
KL
EC
>Mature Secondary Structure
MESNTWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLS
CCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCEEECCCEEEEECCCCCEECCEEEEE
WDATKDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSK
ECCCCCCCCCEEEEECHHHHHHCCCCCCCCCCCCEECCCEEEEEECCCEEEEEEEEEECC
QNDYRYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSF
CCCCEECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEE
KL
EC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796