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The map label for this gene is nanM2 [H]

Identifier: 209397986

GI number: 209397986

Start: 5466215

End: 5467321

Strand: Reverse

Name: nanM2 [H]

Synonym: ECH74115_5814

Alternate gene names: 209397986

Gene position: 5467321-5466215 (Counterclockwise)

Preceding gene: 209398737

Following gene: 209397227

Centisome position: 98.12

GC content: 44.35

Gene sequence:

>1107_bases
ATGAATAAAACAATAACGGCGCTTGCTATCCTAATGGCTTCATTTGCCGCAAACGCGTCTGTATTACCGGAAACTCCTGT
ACCATTTAAAAGTGGTACCGGAGCAATTGATAACGACACTGTCTACATTGGTTTAGGTAGCGCAGGTACGGCATGGTACA
AGCTGGAGACACAGGCCAAAGATAAAAAATGGACAGCGTTAGCTGCATTCCCTGGTGGACCAAGAGATCAAGCAACCTCG
GCATTTATTGATGGCAATCTGTATGTGTTTGGCGGCATTGGCAAAAACAGCGAGGGCTTGACTCAGGTATTTAATGACGT
ACACAAATACAACCCCAAAACCAATAGCTGGGTTAAATTGATATCGCACGCGCCGATGGGCATGGCGGGCCATGTGACTT
TTGTACACAACGGCAAGGCTTATGTTACTGGCGGTGTTAACCAGAATATCTTCAATGGCTATTTTGAAGATCTCAACGAA
GCTGGAAAAGATTCAACCGCTGTAGATAAAATCAATGCACACTATTTTGACAAAAAAGCAGAAGATTATTTCTTTAATAA
GTTTCTGTTGTCTTTTGATCCCTCTACACAGCAATGGAGTTACGCTGGCGAATCTCCCTGGTACGGGACGGCTGGTGCGG
CGGTTGTGAATAAAGGTGATAAAACCTGGCTTATTAATGGCGAAGCCAAACCCGGATTGCGAACGGATGCCGTATTTGAA
CTTGATTTCACCGGTAATAATTTAAAATGGAATAGGCTTGCTCCCGTCTCATCACCAGATGGCGTCGCTGGCGGTTTTGC
GGGGATAAGCAATGATTCTCTTATATTTGCCGGAGGGGCCGGATTCAAAGGTTCACGAGAAAATTACCAAAACGGTAAGA
ACTATGCGCATGAAGGCCTGAAAAAATCATATAGCACTGATATTCATCTTTGGCATAACGGGAAATGGGATAAATCGGGT
GAATTATCGCAAGGTCGGGCCTACGGAGTATCATTGCCCTGGAATAATAGTCTATTGATTATTGGCGGTGAAACTGCAGG
CGGCAAAGCGGTGACGGATTCAGTTTTGATCTCTGTGAAGGATAATAAAGTCACAGTACAAAACTAA

Upstream 100 bases:

>100_bases
CTGGACCGTCAGGGTGTTTACAACGGCAGAGATAATTTATCGGAAAACAGTTATCGCATTGGTGTGTCATTTAAACTGTA
GTAGACAGGAGACAGTCACA

Downstream 100 bases:

>100_bases
CGCTTCAGGGCCCCGGTAAAGGGGCCCTGCTATCAATTTGTCATTTCAATTACGCGAAATTTATATGAACGCAATAATAT
CGCCTGATTATTACTATGTT

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase 2; Neu5Ac mutarotase 2; Sialic acid epimerase 2 [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNKTITALAILMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLETQAKDKKWTALAAFPGGPRDQATS
AFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLISHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNE
AGKDSTAVDKINAHYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFE
LDFTGNNLKWNRLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSTDIHLWHNGKWDKSG
ELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN

Sequences:

>Translated_368_residues
MNKTITALAILMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLETQAKDKKWTALAAFPGGPRDQATS
AFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLISHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNE
AGKDSTAVDKINAHYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFE
LDFTGNNLKWNRLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSTDIHLWHNGKWDKSG
ELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN
>Mature_368_residues
MNKTITALAILMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLETQAKDKKWTALAAFPGGPRDQATS
AFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLISHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNE
AGKDSTAVDKINAHYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFE
LDFTGNNLKWNRLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSTDIHLWHNGKWDKSG
ELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVKDNKVTVQN

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats [H]

Homologues:

Organism=Escherichia coli, GI87082419, Length=368, Percent_Identity=98.3695652173913, Blast_Score=741, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936 [H]

Pfam domain/function: PF01344 Kelch_1 [H]

EC number: NA

Molecular weight: Translated: 39550; Mature: 39550

Theoretical pI: Translated: 7.91; Mature: 7.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTITALAILMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLETQAK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCC
DKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKL
CCCEEEEEECCCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHH
ISHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKINAHYFDKKA
HHCCCCCCEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCC
EDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFE
HHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEE
LDFTGNNLKWNRLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGL
EEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHH
KKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVK
HHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEECEEEEEEE
DNKVTVQN
CCEEEECC
>Mature Secondary Structure
MNKTITALAILMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLETQAK
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCC
DKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKL
CCCEEEEEECCCCCCCCCCEEEECCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHH
ISHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAVDKINAHYFDKKA
HHCCCCCCEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHCCHHCCCCCC
EDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFE
HHHEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEE
LDFTGNNLKWNRLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGL
EEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHH
KKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLISVK
HHCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCEEECEEEEEEE
DNKVTVQN
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]