BacMap

Definition	Escherichia coli O157:H7 str. EC4115, complete genome.
Accession	NC_011353
Length	5,572,075

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The map label for this gene is fabG [H]

Identifier: 209397871

GI number: 209397871

Start: 4448692

End: 4449423

Strand: Direct

Name: fabG [H]

Synonym: ECH74115_4813

Alternate gene names: 209397871

Gene position: 4448692-4449423 (Clockwise)

Preceding gene: 209397892

Following gene: 209395848

Centisome position: 79.84

GC content: 56.56

Gene sequence:

>732_bases
ATGAGTCGTTCAGTTCTGGTTACTGGTGCCAGCAAAGGCATTGGTCGCGCCATCGCCTGCCAACTGGCGGCAGACGGCTT
TAACATTGGCGTTCACTATCACCGTGACGCCACAGGCGCTCAGGAAACGCTGAATGCCATTGTCGCCAATGGGGGTAACG
GGCGTTTGCTCAGTTTCGACGTCGCAAACCGCGAACAGTGTCGGGAAGTGCTGGAGCACGAAATCGCGCAACACGGTGCC
TGGTACGGCGTGGTCAGTAACGCCGGGATCGCCCGCGATGCCGCTTTTCCGGCTTTAAGCGATGACGACTGGGATGCGGT
GATCCACACCAACCTCGACAGTTTCTACAACGTCATTCAGCCGTGCATTATGCCGATGATCGGCGCACGCCAGGGTGGGC
GCATCATCACGCTATCCTCGGTTTCCGGCGTAATGGGCAATCGCGGCCAGGTGAATTACAGCGCTGCCAAAGCCGGAATT
ATCGGCGCAACAAAAGCGCTGGCTATCGAACTCGCGAAGCGCAAAATCACCGTCAACTGCATCGCGCCGGGGCTTATTGA
TACCGGGATGATCGAAATGGAAGAGAGCGCCCTGAAAGAGGCAATGTCGATGATCCCCATGAAACGCATGGGCCAGGCGG
AAGAAGTTGCCGGGCTTGCCAGCTATTTAATGTCTGATATTGCGGGTTACGTCACCCGCCAGGTTATTTCCATCAACGGA
GGGATGTTATGA

Upstream 100 bases:

>100_bases
TTGAGTGCAGCATCAACGACGGCGAGGCGACGGGCCGCATTAACACCTTCCAGCCGACCGCGGAAGAACTTACCACCCTG
TTTCAACAAGGAGCGTCCTG

Downstream 100 bases:

>100_bases
CACGTCGCGTAGTGATTACAGGAATGGGCGGCGTGACTGCCTTTGGTGAAAACTGGCAGGACGTTTCTGCACGCTTACTG
GCATATGAAAATGCGGTGCG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSRSVLVTGASKGIGRAIACQLAADGFNIGVHYHRDATGAQETLNAIVANGGNGRLLSFDVANREQCREVLEHEIAQHGA
WYGVVSNAGIARDAAFPALSDDDWDAVIHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGI
IGATKALAIELAKRKITVNCIAPGLIDTGMIEMEESALKEAMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISING
GML

Sequences:

>Translated_243_residues
MSRSVLVTGASKGIGRAIACQLAADGFNIGVHYHRDATGAQETLNAIVANGGNGRLLSFDVANREQCREVLEHEIAQHGA
WYGVVSNAGIARDAAFPALSDDDWDAVIHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGI
IGATKALAIELAKRKITVNCIAPGLIDTGMIEMEESALKEAMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISING
GML
>Mature_242_residues
SRSVLVTGASKGIGRAIACQLAADGFNIGVHYHRDATGAQETLNAIVANGGNGRLLSFDVANREQCREVLEHEIAQHGAW
YGVVSNAGIARDAAFPALSDDDWDAVIHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGII
GATKALAIELAKRKITVNCIAPGLIDTGMIEMEESALKEAMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISINGG
ML

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=247, Percent_Identity=36.0323886639676, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=34.8360655737705, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI32483357, Length=248, Percent_Identity=31.4516129032258, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4504505, Length=189, Percent_Identity=37.037037037037, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI126723750, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI66933014, Length=191, Percent_Identity=30.8900523560209, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI19923817, Length=245, Percent_Identity=27.3469387755102, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=28.8617886178862, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7705925, Length=243, Percent_Identity=27.5720164609054, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI59889578, Length=190, Percent_Identity=29.4736842105263, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI31542939, Length=206, Percent_Identity=28.6407766990291, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4503301, Length=147, Percent_Identity=29.9319727891156, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=238, Percent_Identity=42.0168067226891, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=34.4262295081967, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=36.2139917695473, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=34.4, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=29.7959183673469, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=27.8688524590164, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI2367365, Length=239, Percent_Identity=30.5439330543933, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=30.3643724696356, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=27.8688524590164, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=28, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=26.9387755102041, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=28.3524904214559, Blast_Score=70, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=242, Percent_Identity=36.7768595041322, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17555706, Length=243, Percent_Identity=35.3909465020576, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560676, Length=244, Percent_Identity=30.7377049180328, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=31.6205533596838, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=29.5019157088123, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=31.7460317460317, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=27.5303643724696, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=30.5019305019305, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=27.5193798449612, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=26.2096774193548, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=255, Percent_Identity=28.2352941176471, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=255, Percent_Identity=28.6274509803922, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=27.4900398406374, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=23.6947791164659, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=260, Percent_Identity=27.6923076923077, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=256, Percent_Identity=26.5625, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=25.5208333333333, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=192, Percent_Identity=25.5208333333333, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=256, Percent_Identity=25.78125, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=251, Percent_Identity=27.0916334661355, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=189, Percent_Identity=32.2751322751323, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324126, Length=186, Percent_Identity=31.7204301075269, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322227, Length=226, Percent_Identity=25.2212389380531, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=234, Percent_Identity=27.3504273504274, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=35.9504132231405, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=34.1463414634146, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=31.2757201646091, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=29.9595141700405, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI23397609, Length=247, Percent_Identity=28.7449392712551, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=26.4227642276423, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859837, Length=192, Percent_Identity=34.375, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24640492, Length=208, Percent_Identity=28.3653846153846, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=27.1653543307087, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR011285
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25670; Mature: 25539

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVLVTGASKGIGRAIACQLAADGFNIGVHYHRDATGAQETLNAIVANGGNGRLLSFD
CCCCEEEECCCCCCCHHEEEEEECCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEE
VANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSDDDWDAVIHTNLDSFYNVIQ
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCEEEECCHHHHHHHHH
PCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGIIGATKALAIELAKRKITVNC
HHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHEEEEEE
IAPGLIDTGMIEMEESALKEAMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISING
ECCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GML
CCC
>Mature Secondary Structure 
SRSVLVTGASKGIGRAIACQLAADGFNIGVHYHRDATGAQETLNAIVANGGNGRLLSFD
CCCEEEECCCCCCCHHEEEEEECCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEE
VANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSDDDWDAVIHTNLDSFYNVIQ
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCCCEEEECCHHHHHHHHH
PCIMPMIGARQGGRIITLSSVSGVMGNRGQVNYSAAKAGIIGATKALAIELAKRKITVNC
HHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHEEEEEE
IAPGLIDTGMIEMEESALKEAMSMIPMKRMGQAEEVAGLASYLMSDIAGYVTRQVISING
ECCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GML
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]