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The map label for this gene is fabF [H]

Identifier: 209395848

GI number: 209395848

Start: 4449420

End: 4450649

Strand: Direct

Name: fabF [H]

Synonym: ECH74115_4814

Alternate gene names: 209395848

Gene position: 4449420-4450649 (Clockwise)

Preceding gene: 209397871

Following gene: 209396708

Centisome position: 79.85

GC content: 55.04

Gene sequence:

>1230_bases
ATGACACGTCGCGTAGTGATTACAGGAATGGGCGGCGTGACTGCCTTTGGTGAAAACTGGCAGGACGTTTCTGCACGCTT
ACTGGCATATGAAAATGCGGTGCGCAAAATGCCGGAGTGGCAGGTCTACGATGGGCTGCACACCCTGCTTGGCGCGCCTG
TTGATGATTTCACGCTACCGGAGCACTACACCCGCAAGCGTATCCGTGCGATGGGCCGCGTGTCGCAAATGTCGACCCGT
GCCAGCGAGCTGGCGTTAGAGCAGGCAGGGTTGATTGGCGATCCGATATTAACCAGCGGCGAAACGGGCATTGCGTACGG
TTCATCGACCGGCAGTACCGGCCCGGTAAGCGAGTTCGCCACCATGCTGACGGAAAAGCACACCAATAACATCACTGGCA
CCACCTATGTGCAGATGATGCCGCACACCACCGCCGTTAATACTGGCCTCTTTTTCGGCCTGCGCGGGCGGGTGATCCCA
ACCTCCAGCGCCTGTACTTCCGGCAGCCAGGCAATCGGTTATGCGTGGGAAGCCATTCGCCACGGTTATCAAACGGTGAT
GGTTGCTGGTGGTGCCGAAGAGTTATGTCCTTCAGAAGCAGCGGTATTTGATACGCTTTTCGCCACCAGCCAGCACAATG
ATGCGCCGAAAACCACACCTTCACCGTTCGATGAAAACCGCGACGGGCTGGTGATTGGTGAAGGCGCAGGTACGCTCATT
CTCGAAGAACTGGAGCACGCCAAAGCGCGCGGCGCGACCATTTACGGTGAAATCGTCGGCTTTGCGACTAACTGCGACGC
GGCACATATTACCCAGCCGCAGCGCGAAACCATGCAGTATTGTATGGAGCAATCGCTGAAAATCGCCGGGTTAAGCGCAC
AAGATATCGGCTATATTTCAGCGCATGGTACGGCGACCGATCGCGGTGATATGGCAGAAAGTCTGGCGACAGCAACCATT
TACGGTGATAATGTGCCGCTCTCCTCGCTGAAAAGTTATTTTGGTCATACGCTTGGTGCCTGTGGCGCGCTCGAAGCCTG
GATGAGTCTGCAAATGATGCGCGAAGGTTGGTTTGCGCCTACGCTAAACCTGAATAAACCAGACCCGAATTGTGGCGCGC
TGGATTACATCATGCATGAAGCCCGCAAGGTTGATTGTGAGTTTTTGCAGAGTAACAACTTTGCCTTTGGCGGCATTAAT
ACATCCATCATCATTAAACGTTGGCCCTGA

Upstream 100 bases:

>100_bases
TGGGCCAGGCGGAAGAAGTTGCCGGGCTTGCCAGCTATTTAATGTCTGATATTGCGGGTTACGTCACCCGCCAGGTTATT
TCCATCAACGGAGGGATGTT

Downstream 100 bases:

>100_bases
TATGTATCGGATAGTTCTGGGGAAAGTTTCGACCTTAAGCGCAGCTCCACTGCCACCGGGTTTACGCGAGCAAGCACCGC
AAGGTCCACGACGCGAACGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDGLHTLLGAPVDDFTLPEHYTRKRIRAMGRVSQMSTR
ASELALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFATMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIP
TSSACTSGSQAIGYAWEAIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLI
LEELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYISAHGTATDRGDMAESLATATI
YGDNVPLSSLKSYFGHTLGACGALEAWMSLQMMREGWFAPTLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGIN
TSIIIKRWP

Sequences:

>Translated_409_residues
MTRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDGLHTLLGAPVDDFTLPEHYTRKRIRAMGRVSQMSTR
ASELALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFATMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIP
TSSACTSGSQAIGYAWEAIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLI
LEELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYISAHGTATDRGDMAESLATATI
YGDNVPLSSLKSYFGHTLGACGALEAWMSLQMMREGWFAPTLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGIN
TSIIIKRWP
>Mature_408_residues
TRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDGLHTLLGAPVDDFTLPEHYTRKRIRAMGRVSQMSTRA
SELALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFATMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIPT
SSACTSGSQAIGYAWEAIRHGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLIL
EELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYISAHGTATDRGDMAESLATATIY
GDNVPLSSLKSYFGHTLGACGALEAWMSLQMMREGWFAPTLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGINT
SIIIKRWP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=34.0476190476191, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI223972627, Length=163, Percent_Identity=36.8098159509202, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI41872631, Length=293, Percent_Identity=26.2798634812287, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1787337, Length=424, Percent_Identity=37.2641509433962, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788663, Length=410, Percent_Identity=33.1707317073171, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=29.951690821256, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=34.8484848484849, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=26.4788732394366, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17550940, Length=259, Percent_Identity=25.0965250965251, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=452, Percent_Identity=30.9734513274336, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=33.806146572104, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19920632, Length=272, Percent_Identity=28.3088235294118, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221330659, Length=272, Percent_Identity=28.3088235294118, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24581345, Length=270, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44148; Mature: 44017

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDGLHTLLGAPVDDFTLP
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
EHYTRKRIRAMGRVSQMSTRASELALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
TMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIPTSSACTSGSQAIGYAWEAIR
HHHHHHCCCCCCCEEEEEECCCCHHHCCCEEEECCCCEECCCCCCCCCCCHHHHHHHHHH
HGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLI
CCCEEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
LEELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYIS
HHHHHHHHHCCCEEEEEEEEEECCCCHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCEEE
AHGTATDRGDMAESLATATIYGDNVPLSSLKSYFGHTLGACGALEAWMSLQMMREGWFAP
ECCCCCCCHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGINTSIIIKRWP
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCEEECCCCEEEEEEECC
>Mature Secondary Structure 
TRRVVITGMGGVTAFGENWQDVSARLLAYENAVRKMPEWQVYDGLHTLLGAPVDDFTLP
CCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCC
EHYTRKRIRAMGRVSQMSTRASELALEQAGLIGDPILTSGETGIAYGSSTGSTGPVSEFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
TMLTEKHTNNITGTTYVQMMPHTTAVNTGLFFGLRGRVIPTSSACTSGSQAIGYAWEAIR
HHHHHHCCCCCCCEEEEEECCCCHHHCCCEEEECCCCEECCCCCCCCCCCHHHHHHHHHH
HGYQTVMVAGGAEELCPSEAAVFDTLFATSQHNDAPKTTPSPFDENRDGLVIGEGAGTLI
CCCEEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
LEELEHAKARGATIYGEIVGFATNCDAAHITQPQRETMQYCMEQSLKIAGLSAQDIGYIS
HHHHHHHHHCCCEEEEEEEEEECCCCHHHCCCCHHHHHHHHHHCCCEEECCCCCCCCEEE
AHGTATDRGDMAESLATATIYGDNVPLSSLKSYFGHTLGACGALEAWMSLQMMREGWFAP
ECCCCCCCHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLNLNKPDPNCGALDYIMHEARKVDCEFLQSNNFAFGGINTSIIIKRWP
CCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]