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The map label for this gene is yncB

Identifier: 209396787

GI number: 209396787

Start: 1949381

End: 1950418

Strand: Direct

Name: yncB

Synonym: ECH74115_2055

Alternate gene names: 209396787

Gene position: 1949381-1950418 (Clockwise)

Preceding gene: 209398504

Following gene: 209398301

Centisome position: 34.98

GC content: 52.5

Gene sequence:

>1038_bases
ATGGGGCAACAAAAGCAGCGTAATCGACGTTGGGTTCTGGCCTCGCGTCCACATGGCGCACCGGTTCCGGAGAATTTCCG
TCTTGAAGAAGATGATGTCGCCACACCGGGTGAAGGACAGGTGTTACTGCGCACAGTTTATTTGTCCCTGGACCCGTATA
TGCGTGGACGTATGAGCGATGAGCCATCTTATTCACCGCCGGTTGATATTGGCGGCGTGATGGTCGGCGGTACGGTGAGC
CGTGTCGTGGAGTCGAATCATCCTGATTATCAGTCTGGCGACTGGGTGCTGGGCTACAGTGGATGGCAAGACTATGACAT
ATCCAGTGGTGATGATCTGGTGAAACTTGGCGATCATCCGCAAAATCCATCGTGGTCGCTGGGTGTGCTAGGGATGCCAG
GCTTTACCGCTTATATGGGCCTACTGGATATCGGTCAGCCTAAAGAGGGCGAAACGTTGGTGGTAGCTGCGGCGACAGGA
CCAGTGGGGGCGACGGTGGGGCAAATCGGCAAACTTAAAGGTTGCAGAGTGGTGGGGGTAGCCGGTGGCGCGGAAAAATG
CCGCCATGCTACCGAGGTGTTAGGCTTCGATGTTTGTCTTGATCACCACGCGGATGATTTTGCCGAACAACTGGCGAAAG
CGTGCCCAAAAGGTATTGATATCTATTATGAAAACGTGGGCGGTAAGGTATTCGATGCGGTGCTACCGTTACTTAATACA
TCTGCGCGCATTCCCGTCTGCGGATTAGTGAGCAGCTATAACGCTACAGAGCTACCACCCGGTCCGGATCGTTTACCTCT
GTTGATGGCTACAGTGCTGAAAAAACGTATTCGCTTGCAAGGTTTTATTATCGCTCAGGATTATGGTCACCGCATCCATG
AGTTTCAGAGGGAGATGGGGCAATGGGTGAAAGAGGATAAAATCCACTACCGCGAAGAAATTACTGACGGTTTAGAGAAT
GCGCCACAGACGTTTATCGGCCTGCTGAAGGGTAAAAACTTCGGCAAAGTGGTGATCCGCGTGGCGGGTGATGATTAA

Upstream 100 bases:

>100_bases
TTATTGCGTGTTGCAGAGGGGGGGTGACGGCTGCAAACAAAACCAATCCTGCGAGCCTGCTACTATTGATGGATTCATGC
CAAAAGCACAGGAGAGCATT

Downstream 100 bases:

>100_bases
AGTTTCAACGGCGGCGTAAGCCGCCATAAAAATCCAGGCAAAAAGCTTATTTTCAGCTTTAATTAACTAACCACATCATT
GTTCTGCTGCTAATAACAAC

Product: oxidoreductase, zinc-binding dehydrogenase family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MGQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSDEPSYSPPVDIGGVMVGGTVS
RVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHPQNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATG
PVGATVGQIGKLKGCRVVGVAGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNT
SARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMGQWVKEDKIHYREEITDGLEN
APQTFIGLLKGKNFGKVVIRVAGDD

Sequences:

>Translated_345_residues
MGQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSDEPSYSPPVDIGGVMVGGTVS
RVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHPQNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATG
PVGATVGQIGKLKGCRVVGVAGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNT
SARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMGQWVKEDKIHYREEITDGLEN
APQTFIGLLKGKNFGKVVIRVAGDD
>Mature_344_residues
GQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSDEPSYSPPVDIGGVMVGGTVSR
VVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHPQNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGP
VGATVGQIGKLKGCRVVGVAGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNTS
ARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMGQWVKEDKIHYREEITDGLENA
PQTFIGLLKGKNFGKVVIRVAGDD

Specific function: Unknown

COG id: COG2130

COG function: function code R; Putative NADP-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADP-dependent oxidoreductase L4BD family

Homologues:

Organism=Homo sapiens, GI226246682, Length=350, Percent_Identity=38, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI226246680, Length=350, Percent_Identity=38, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI22748929, Length=350, Percent_Identity=38, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI226059159, Length=338, Percent_Identity=37.8698224852071, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI226059133, Length=338, Percent_Identity=37.8698224852071, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI226056130, Length=311, Percent_Identity=36.3344051446945, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI28557745, Length=341, Percent_Identity=28.1524926686217, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI194239674, Length=239, Percent_Identity=28.8702928870293, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI13236495, Length=239, Percent_Identity=28.8702928870293, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI226510941, Length=345, Percent_Identity=100, Blast_Score=708, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901710, Length=360, Percent_Identity=32.7777777777778, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI133901712, Length=360, Percent_Identity=32.7777777777778, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323504, Length=371, Percent_Identity=26.4150943396226, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YNCB_ECOLI (P76113)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   D64897
- RefSeq:   AP_002072.1
- RefSeq:   NP_415966.6
- ProteinModelPortal:   P76113
- SMR:   P76113
- DIP:   DIP-12748N
- STRING:   P76113
- EnsemblBacteria:   EBESCT00000004338
- EnsemblBacteria:   EBESCT00000016227
- GeneID:   946012
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5907
- KEGG:   eco:b1449
- EchoBASE:   EB3534
- EcoGene:   EG13772
- eggNOG:   COG2130
- GeneTree:   EBGT00050000008794
- HOGENOM:   HBG753318
- ProtClustDB:   CLSK2397741
- BioCyc:   EcoCyc:G6760-MONOMER
- Genevestigator:   P76113
- InterPro:   IPR013149
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37610; Mature: 37479

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSD
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHCCCCC
EPSYSPPVDIGGVMVGGTVSRVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHP
CCCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCC
QNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGPVGATVGQIGKLKGCRVVGV
CCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEE
AGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNT
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCC
SARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMG
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHH
QWVKEDKIHYREEITDGLENAPQTFIGLLKGKNFGKVVIRVAGDD
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEEECCC
>Mature Secondary Structure 
GQQKQRNRRWVLASRPHGAPVPENFRLEEDDVATPGEGQVLLRTVYLSLDPYMRGRMSD
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHCCCCC
EPSYSPPVDIGGVMVGGTVSRVVESNHPDYQSGDWVLGYSGWQDYDISSGDDLVKLGDHP
CCCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCCC
QNPSWSLGVLGMPGFTAYMGLLDIGQPKEGETLVVAAATGPVGATVGQIGKLKGCRVVGV
CCCCCEEEEECCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEE
AGGAEKCRHATEVLGFDVCLDHHADDFAEQLAKACPKGIDIYYENVGGKVFDAVLPLLNT
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCC
SARIPVCGLVSSYNATELPPGPDRLPLLMATVLKKRIRLQGFIIAQDYGHRIHEFQREMG
CCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHH
QWVKEDKIHYREEITDGLENAPQTFIGLLKGKNFGKVVIRVAGDD
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503