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The map label for this gene is cyaA

Identifier: 209396473

GI number: 209396473

Start: 4887926

End: 4890472

Strand: Direct

Name: cyaA

Synonym: ECH74115_5244

Alternate gene names: 209396473

Gene position: 4887926-4890472 (Clockwise)

Preceding gene: 209399680

Following gene: 209400519

Centisome position: 87.72

GC content: 51.98

Gene sequence:

>2547_bases
TTGTACCTCTATATTGAGACTCTGAAACAGAGACTGGATGCCATAAATCAATTGCGTGTGGATCGCGCGCTTGCTGCTAT
GGGGCCTGCATTCCAACAGGTCTACAGTCTACTGCCGACATTGTTGCACTATCACCATCCGCTAATGCCGGGTTACCTTG
ATGGTAACGTTCCCAAAGGCATTTGCCTTTACACGCCTGATGAAACTCAACGCCACTACCTGAACGAGCTTGAACTGTAT
CGTGGAATGTCAGTACAGGACCCGCCGAAAGGTGAGCTTCCAATTACTGGTGTATACACCATGGGCAGCACCTCGTCCGT
AGGGCAAAGTTGTTCCTCTGACCTGGATATCTGGGTCTGTCATCAATCCTGGCTCGATAGCGAAGAGCGCCAGTTGCTAC
AACGTAAATGCAGCCTGCTGGAAAGCTGGGCCGCCTCGCTGGGTGTGGAAGTTAGCTTCTTCCTGATTGATGAAAACCGT
TTTCGCCACAACGAGAGTGGCAGTCTGGGGGGCGAAGATTGTGGCTCCACCCAGCATATACTGCTGCTTGATGAATTTTA
TCGTACCGCCGTGCGTCTCGCCGGTAAGCGTATTCTGTGGAATATGGTGCCGTGCGACGAAGAAGAGCATTACGATGACT
ACGTAATGACGCTCTACGCACAAGGCGTGCTGACGCCAAATGAATGGCTGGATCTCGGCGGCTTAAGCTCGCTTTCCGCT
GAAGAATACTTCGGTGCCAGCCTTTGGCAACTCTACAAGAGTATCGATTCTCCATACAAAGCGGTGCTGAAGACACTGCT
GCTGGAAGCCTATTCCTGGGAATACCCGAACCCACGCCTGCTGGCGAAAGATATCAAACAGCGTTTGCACGACGGCGAGA
TTGTATCGTTTGGCCTCGATCCTTACTGCATGATGCTGGAGCGTGTTACTGAATACCTGACGGCGATTGAAGATTTCACC
CGTCTGGATTTAGTACGTCGCTGCTTCTATTTAAAAGTGTGCGAAAAGCTCAGCCGTGAACGCGCCTGCGTAGGCTGGCG
TCGCGCAGTGTTGAGCCAGTTAGTGAGCGAGTGGGGGTGGGACGAAGCTCGTCTGGCAATGCTCGATAACCGCGCTAACT
GGAAGATTGATCAGGTGCGTGAGGCGCACAACGAGTTGCTCGACGCGATGATGCAGAGCTACCGTAATCTGATCCGCTTT
GCGCGTCGCAATAACCTTAGCGTCTCCGCCAGTCCGCAGGATATCGGCGTGCTGACGCGTAAGCTGTATGCCGCGTTTGA
AGCATTACCAGGTAAAGTGACGCTGGTAAACCCGCAGATTTCACCCGATCTCTCGGAACCGAATCTGACCTTTATTTATG
TGCCGCCGGGCCGGGCTAACCGTTCAGGTTGGTATCTGTATAACCGCGCGCCAAATATTGAGTCGATCATCAGCCATCAG
CCGCTGGAATATAACCGTTACCTGAATAAACTGGTGGCGTGGGCATGGTTTAACGGCCTGCTGACCTCGCGCACCCGCTT
GTATATTAAAGGTAACGGCATTGTCGATTTGCCTAAGTTGCAGGAGATGGTCGCCGACGTGTCGCACCATTTCCCGTTGC
GCTTACCTGCACCGACACCGAAGGCGCTCTACAGCCCGTGTGAGATCCGCCATCTGGCGATTATCGTTAACCTGGAATAT
GACCCGACAGCTGCGTTCCGCAATCAGGTGGTGCATTTTGATTTCCGTAAGCTGGATGTTTTCAGCTTTGGCGAGAATCA
AAATTGCCTGGTAGGTAGCGTTGACCTGCTGTATCGCAACTCGTGGAATGAAGTGCGTACGCTGCACTTCAACGGCGAGC
AATCGATGATCGAAGCCCTGAAAACTATTCTCGGCAAAATGCATCAGGACGCCGCACCGCCAGATAGCGTGGAAGTCTTC
TGTTATAGCCAGCATCTGCGCGGCTTAATTCGTACTCGCGTGCAGCAACTGGTTTCTGAGTGTATTGAATTGCGTCTTTC
CAGCACCCGCCAGGAAACCGGGCGTTTCAAGGCGCTGCGCGTTTCTGGTCAAACCTGGGGCTTGTTCTTCGAACGCCTGA
ATGTATCGGTACAGAAACTGGAGAACGCCATCGAGTTTTATGGCGCTATTTCGCATAACAAACTGCACGGCCTGTCAGTG
CAGGTTGAAACCAATCACGTCAAATTACCGGCGGTGGTGGACGGCTTTGCCAGCGAAGGGATCATCCAGTTCTTTTTCGA
AGAAACGCAAGATGAGAATGGCTTTAATATCTACATTCTCGACGAAAGCAATCGGGTTGAGGTGTATCACCACTGCGAAG
GCAGCAAAGAGGAGCTGGTACGTGACGTCAGTCGCTTCTACTCGTCATCGCATGACCGTTTTACCTACGGCTCAAGCTTC
ATCAACTTCAACCTGCCGCAGTTCTATCAGATTGTGAAGGTTGATGGTCGTGAACAGGTGATTCCGTTCCGCACAAAATC
TATCGGTAACATGCCGCCTGCCAATCAGGATCACGATACGCCGCTATTACAGCAGTATTTTTCGTGA

Upstream 100 bases:

>100_bases
AACGGTTACCTTTGACATACGAAATATCCCGAATGCCGCGTGTTACCGTTGATGTTGGCGGAATCACAGTCATGACGGGT
AGCAAATCAGGCGATACGTC

Downstream 100 bases:

>100_bases
TGAACGTGCCGGAAAGCGAGGCTTATCCGGCATGCAATCTTAGCGGAAACTGACTGTTTCACCCGCCTGCTGCGTCGCCG
CCTGTTCCAGCAAATCCCGG

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase; Adenylyl cyclase

Number of amino acids: Translated: 848; Mature: 848

Protein sequence:

>848_residues
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPKGICLYTPDETQRHYLNELELY
RGMSVQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDSEERQLLQRKCSLLESWAASLGVEVSFFLIDENR
FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDFT
RLDLVRRCFYLKVCEKLSRERACVGWRRAVLSQLVSEWGWDEARLAMLDNRANWKIDQVREAHNELLDAMMQSYRNLIRF
ARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRSGWYLYNRAPNIESIISHQ
PLEYNRYLNKLVAWAWFNGLLTSRTRLYIKGNGIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNLEY
DPTAAFRNQVVHFDFRKLDVFSFGENQNCLVGSVDLLYRNSWNEVRTLHFNGEQSMIEALKTILGKMHQDAAPPDSVEVF
CYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGLSV
QVETNHVKLPAVVDGFASEGIIQFFFEETQDENGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGSSF
INFNLPQFYQIVKVDGREQVIPFRTKSIGNMPPANQDHDTPLLQQYFS

Sequences:

>Translated_848_residues
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPKGICLYTPDETQRHYLNELELY
RGMSVQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDSEERQLLQRKCSLLESWAASLGVEVSFFLIDENR
FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDFT
RLDLVRRCFYLKVCEKLSRERACVGWRRAVLSQLVSEWGWDEARLAMLDNRANWKIDQVREAHNELLDAMMQSYRNLIRF
ARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRSGWYLYNRAPNIESIISHQ
PLEYNRYLNKLVAWAWFNGLLTSRTRLYIKGNGIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNLEY
DPTAAFRNQVVHFDFRKLDVFSFGENQNCLVGSVDLLYRNSWNEVRTLHFNGEQSMIEALKTILGKMHQDAAPPDSVEVF
CYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGLSV
QVETNHVKLPAVVDGFASEGIIQFFFEETQDENGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGSSF
INFNLPQFYQIVKVDGREQVIPFRTKSIGNMPPANQDHDTPLLQQYFS
>Mature_848_residues
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPKGICLYTPDETQRHYLNELELY
RGMSVQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVCHQSWLDSEERQLLQRKCSLLESWAASLGVEVSFFLIDENR
FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLDPYCMMLERVTEYLTAIEDFT
RLDLVRRCFYLKVCEKLSRERACVGWRRAVLSQLVSEWGWDEARLAMLDNRANWKIDQVREAHNELLDAMMQSYRNLIRF
ARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRSGWYLYNRAPNIESIISHQ
PLEYNRYLNKLVAWAWFNGLLTSRTRLYIKGNGIVDLPKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNLEY
DPTAAFRNQVVHFDFRKLDVFSFGENQNCLVGSVDLLYRNSWNEVRTLHFNGEQSMIEALKTILGKMHQDAAPPDSVEVF
CYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGLSV
QVETNHVKLPAVVDGFASEGIIQFFFEETQDENGFNIYILDESNRVEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGSSF
INFNLPQFYQIVKVDGREQVIPFRTKSIGNMPPANQDHDTPLLQQYFS

Specific function: Unknown

COG id: COG3072

COG function: function code F; Adenylate cyclase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylyl cyclase class-1 family

Homologues:

Organism=Escherichia coli, GI1790238, Length=848, Percent_Identity=99.8820754716981, Blast_Score=1763, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYAA_ECO57 (Q8XAP1)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B86067
- PIR:   H91220
- RefSeq:   NP_290434.1
- RefSeq:   NP_312763.1
- EnsemblBacteria:   EBESCT00000027031
- EnsemblBacteria:   EBESCT00000057861
- GeneID:   915191
- GeneID:   960357
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5322
- KEGG:   ecs:ECs4736
- GeneTree:   EBGT00050000010325
- HOGENOM:   HBG678054
- OMA:   LWQLYKG
- ProtClustDB:   PRK09450
- BioCyc:   ECOL83334:ECS4736-MONOMER
- GO:   GO:0005737
- InterPro:   IPR000274
- PIRSF:   PIRSF001444

Pfam domain/function: PF01295 Adenylate_cycl

EC number: =4.6.1.1

Molecular weight: Translated: 97560; Mature: 97560

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS01092 ADENYLATE_CYCLASE_1_1; PS01093 ADENYLATE_CYCLASE_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPKG
CEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ICLYTPDETQRHYLNELELYRGMSVQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVC
EEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEEE
HQSWLDSEERQLLQRKCSLLESWAASLGVEVSFFLIDENRFRHNESGSLGGEDCGSTQHI
CHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
LLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA
EEHHHHHHHHHHHHCHHHEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCH
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCC
PYCMMLERVTEYLTAIEDFTRLDLVRRCFYLKVCEKLSRERACVGWRRAVLSQLVSEWGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEARLAMLDNRANWKIDQVREAHNELLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTR
CHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
KLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRSGWYLYNRAPNIESIISHQ
HHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHCCC
PLEYNRYLNKLVAWAWFNGLLTSRTRLYIKGNGIVDLPKLQEMVADVSHHFPLRLPAPTP
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHHHHHCCCEECCCCCC
KALYSPCEIRHLAIIVNLEYDPTAAFRNQVVHFDFRKLDVFSFGENQNCLVGSVDLLYRN
HHHCCCCCEEEEEEEEEECCCCCHHHHCCEEEEEEEEEEEEECCCCCCEEEECCHHEEEC
SWNEVRTLHFNGEQSMIEALKTILGKMHQDAAPPDSVEVFCYSQHLRGLIRTRVQQLVSE
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
CIELRLSSTRQETGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGLSV
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECEEE
QVETNHVKLPAVVDGFASEGIIQFFFEETQDENGFNIYILDESNRVEVYHHCEGSKEELV
EEECCCEECCHHHCCHHCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCHHHHH
RDVSRFYSSSHDRFTYGSSFINFNLPQFYQIVKVDGREQVIPFRTKSIGNMPPANQDHDT
HHHHHHHCCCCCCEEECCCEEECCCHHHHHEEEECCCCCCCCCHHHCCCCCCCCCCCCCC
PLLQQYFS
HHHHHHCC
>Mature Secondary Structure
MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPKG
CEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
ICLYTPDETQRHYLNELELYRGMSVQDPPKGELPITGVYTMGSTSSVGQSCSSDLDIWVC
EEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHCCCCCEEEEE
HQSWLDSEERQLLQRKCSLLESWAASLGVEVSFFLIDENRFRHNESGSLGGEDCGSTQHI
CHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEE
LLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMTLYAQGVLTPNEWLDLGGLSSLSA
EEHHHHHHHHHHHHCHHHEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHCCCCCCCCCH
EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPNPRLLAKDIKQRLHDGEIVSFGLD
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEECCC
PYCMMLERVTEYLTAIEDFTRLDLVRRCFYLKVCEKLSRERACVGWRRAVLSQLVSEWGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEARLAMLDNRANWKIDQVREAHNELLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTR
CHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHH
KLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRSGWYLYNRAPNIESIISHQ
HHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCHHHHHCCC
PLEYNRYLNKLVAWAWFNGLLTSRTRLYIKGNGIVDLPKLQEMVADVSHHFPLRLPAPTP
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECHHHHHHHHHHHHCCCEECCCCCC
KALYSPCEIRHLAIIVNLEYDPTAAFRNQVVHFDFRKLDVFSFGENQNCLVGSVDLLYRN
HHHCCCCCEEEEEEEEEECCCCCHHHHCCEEEEEEEEEEEEECCCCCCEEEECCHHEEEC
SWNEVRTLHFNGEQSMIEALKTILGKMHQDAAPPDSVEVFCYSQHLRGLIRTRVQQLVSE
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
CIELRLSSTRQETGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGLSV
HHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECEEE
QVETNHVKLPAVVDGFASEGIIQFFFEETQDENGFNIYILDESNRVEVYHHCEGSKEELV
EEECCCEECCHHHCCHHCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEECCCCHHHHH
RDVSRFYSSSHDRFTYGSSFINFNLPQFYQIVKVDGREQVIPFRTKSIGNMPPANQDHDT
HHHHHHHCCCCCCEEECCCEEECCCHHHHHEEEECCCCCCCCCHHHCCCCCCCCCCCCCC
PLLQQYFS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796