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The map label for this gene is MurA3

Identifier: 20809028

GI number: 20809028

Start: 2579002

End: 2580255

Strand: Reverse

Name: MurA3

Synonym: TTE2684

Alternate gene names: 20809028

Gene position: 2580255-2579002 (Counterclockwise)

Preceding gene: 20809029

Following gene: 20809027

Centisome position: 95.94

GC content: 43.22

Gene sequence:

>1254_bases
ATGGAAAAGTTTGTTATAAGAGGAGGGAAGCCTCTTCGTGGCACTGTCCAGATAAGCGGTGCTAAAAATTCTGCTGTTGC
GGTTTTACCTGCGGCTCTACTGGCAGATAGTCCAAGTGTCATAGACAATCTGCCTGATATAAAGGACATAGAAACTTTGG
CAGAAATAATAAAAAGATTAGGGGGCAAGGTAGAAAAAGGCAAACACGAAATAAAAATAGACCCCACAGGGCTTAATTCT
TTCCATCCTCCCAGGGAATTGGCGAGCAGGATGAGGGCCTCATATTATCTCATAGGTGCGCTTTTGAGTAAGTTTAACGA
AGCCATAATACCGATGCCGGGAGGGTGTAACATAGGAGTAAGGCCAATTGACCAGCACATCAAGGGTTTTGAAGCATTAG
GGGCTGAGACTACTATAGAGCACGGTTTTATAAGGATTAAGGCAGAGAAATTAAGAGGAGCTCACATATATTTTGACGTT
GTAAGTGTGGGGGCAACAATAAATTTGATGCTGGCAGCTGTCAAAGCAGAAGGGGTTACTATTTTAGAAAACTGTGCGAA
AGAGCCTCATGTAGTTGATGTAGCAAACTTTTTAAATGCAATGGGAGCAAATATAAAAGGTGCTGGGACTGACACTATAA
AGATTACAGGAGTGGACAAACTAGAGGGCTGCCATTACACAATCATCCCTGACCAGATTGAGGCTGGAACCTATATGGTG
GCAGCGGCGGCAACGGGAGGAGACGTATATGTAAAAGGCGTAATTCCGACCCACTTAGAGTCGATAATTGCAAAGCTTGT
GGAAATGGGAGTAATTGTGGAAGAGTATGACGATGTCATAAGAGTTAGAAGAGAAGGGCCTTTAAAAAGGGTTGATATAA
AGACTTTGCCGTATCCAGGCTTCCCGACGGACATGCAGCAGCCTTTTGCGGTGCTTTTAGCCTTAGCTGATGGGATAAGT
GTCATTACAGAAAATATATATGAGAACAGGTTTAGATATTTAGAAGAATTAAAGAAAATGGGAATGAAAGTGAGAGTGGA
GGGAAGAAGCGCTATCATAGAAGGAGTGGGCAAACTGACAGGTGCACCAGTTTACGCGACAGATCTAAGAGGTGGAGCTG
CAATGGTGATAGCAGGACTTGCAGCAGAGGGCATTACAGAAGTTTTGGACATTTACCACATTGACAGGGGATACGAAGCA
ATGGAAGTAAAGCTTCAGGCTTTAGGAGCTGACATAATAAGAATAAGAGAATGA

Upstream 100 bases:

>100_bases
TATCACACAAACACTTGTAAAATATTATGAATTGTATTAAAGTATATAGTGTGGCAGTATCTGATTTTTAGATGATTTTT
TGGTTGAAAGGAAGATGTGT

Downstream 100 bases:

>100_bases
GAGTAAAAATTCGTGTATAATGAACTGCATAACATCTAATCCTATTAATGGGGTGATGTTATGCAGTATAATTTTAATAA
GTTAGTTGCTACTGCAATAA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 3; UDP-N-acetylglucosamine enolpyruvyl transferase 3; EPT 3

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MEKFVIRGGKPLRGTVQISGAKNSAVAVLPAALLADSPSVIDNLPDIKDIETLAEIIKRLGGKVEKGKHEIKIDPTGLNS
FHPPRELASRMRASYYLIGALLSKFNEAIIPMPGGCNIGVRPIDQHIKGFEALGAETTIEHGFIRIKAEKLRGAHIYFDV
VSVGATINLMLAAVKAEGVTILENCAKEPHVVDVANFLNAMGANIKGAGTDTIKITGVDKLEGCHYTIIPDQIEAGTYMV
AAAATGGDVYVKGVIPTHLESIIAKLVEMGVIVEEYDDVIRVRREGPLKRVDIKTLPYPGFPTDMQQPFAVLLALADGIS
VITENIYENRFRYLEELKKMGMKVRVEGRSAIIEGVGKLTGAPVYATDLRGGAAMVIAGLAAEGITEVLDIYHIDRGYEA
MEVKLQALGADIIRIRE

Sequences:

>Translated_417_residues
MEKFVIRGGKPLRGTVQISGAKNSAVAVLPAALLADSPSVIDNLPDIKDIETLAEIIKRLGGKVEKGKHEIKIDPTGLNS
FHPPRELASRMRASYYLIGALLSKFNEAIIPMPGGCNIGVRPIDQHIKGFEALGAETTIEHGFIRIKAEKLRGAHIYFDV
VSVGATINLMLAAVKAEGVTILENCAKEPHVVDVANFLNAMGANIKGAGTDTIKITGVDKLEGCHYTIIPDQIEAGTYMV
AAAATGGDVYVKGVIPTHLESIIAKLVEMGVIVEEYDDVIRVRREGPLKRVDIKTLPYPGFPTDMQQPFAVLLALADGIS
VITENIYENRFRYLEELKKMGMKVRVEGRSAIIEGVGKLTGAPVYATDLRGGAAMVIAGLAAEGITEVLDIYHIDRGYEA
MEVKLQALGADIIRIRE
>Mature_417_residues
MEKFVIRGGKPLRGTVQISGAKNSAVAVLPAALLADSPSVIDNLPDIKDIETLAEIIKRLGGKVEKGKHEIKIDPTGLNS
FHPPRELASRMRASYYLIGALLSKFNEAIIPMPGGCNIGVRPIDQHIKGFEALGAETTIEHGFIRIKAEKLRGAHIYFDV
VSVGATINLMLAAVKAEGVTILENCAKEPHVVDVANFLNAMGANIKGAGTDTIKITGVDKLEGCHYTIIPDQIEAGTYMV
AAAATGGDVYVKGVIPTHLESIIAKLVEMGVIVEEYDDVIRVRREGPLKRVDIKTLPYPGFPTDMQQPFAVLLALADGIS
VITENIYENRFRYLEELKKMGMKVRVEGRSAIIEGVGKLTGAPVYATDLRGGAAMVIAGLAAEGITEVLDIYHIDRGYEA
MEVKLQALGADIIRIRE

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=46.88995215311, Blast_Score=384, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA3_THETN (Q8R6V0)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624199.1
- ProteinModelPortal:   Q8R6V0
- SMR:   Q8R6V0
- GeneID:   997762
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2684
- NMPDR:   fig|273068.3.peg.2220
- HOGENOM:   HBG482701
- OMA:   MLAAVHA
- ProtClustDB:   PRK12830
- BioCyc:   TTEN273068:TTE2684-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45002; Mature: 45002

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFVIRGGKPLRGTVQISGAKNSAVAVLPAALLADSPSVIDNLPDIKDIETLAEIIKRL
CCCEEEECCCCCEEEEEECCCCCCCCEEHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHH
GGKVEKGKHEIKIDPTGLNSFHPPRELASRMRASYYLIGALLSKFNEAIIPMPGGCNIGV
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
RPIDQHIKGFEALGAETTIEHGFIRIKAEKLRGAHIYFDVVSVGATINLMLAAVKAEGVT
CCHHHHHHHHHHCCCCCEECCCEEEEEHHHCCCCEEEEEEHHHCCHHHHHHEEHHCCCCH
ILENCAKEPHVVDVANFLNAMGANIKGAGTDTIKITGVDKLEGCHYTIIPDQIEAGTYMV
HHHHCCCCCCEEHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEE
AAAATGGDVYVKGVIPTHLESIIAKLVEMGVIVEEYDDVIRVRREGPLKRVDIKTLPYPG
EEEECCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
FPTDMQQPFAVLLALADGISVITENIYENRFRYLEELKKMGMKVRVEGRSAIIEGVGKLT
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHC
GAPVYATDLRGGAAMVIAGLAAEGITEVLDIYHIDRGYEAMEVKLQALGADIIRIRE
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECC
>Mature Secondary Structure
MEKFVIRGGKPLRGTVQISGAKNSAVAVLPAALLADSPSVIDNLPDIKDIETLAEIIKRL
CCCEEEECCCCCEEEEEECCCCCCCCEEHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHH
GGKVEKGKHEIKIDPTGLNSFHPPRELASRMRASYYLIGALLSKFNEAIIPMPGGCNIGV
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCC
RPIDQHIKGFEALGAETTIEHGFIRIKAEKLRGAHIYFDVVSVGATINLMLAAVKAEGVT
CCHHHHHHHHHHCCCCCEECCCEEEEEHHHCCCCEEEEEEHHHCCHHHHHHEEHHCCCCH
ILENCAKEPHVVDVANFLNAMGANIKGAGTDTIKITGVDKLEGCHYTIIPDQIEAGTYMV
HHHHCCCCCCEEHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCEEEE
AAAATGGDVYVKGVIPTHLESIIAKLVEMGVIVEEYDDVIRVRREGPLKRVDIKTLPYPG
EEEECCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
FPTDMQQPFAVLLALADGISVITENIYENRFRYLEELKKMGMKVRVEGRSAIIEGVGKLT
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHC
GAPVYATDLRGGAAMVIAGLAAEGITEVLDIYHIDRGYEAMEVKLQALGADIIRIRE
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336