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The map label for this gene is ThrB

Identifier: 20808963

GI number: 20808963

Start: 2510898

End: 2511836

Strand: Reverse

Name: ThrB

Synonym: TTE2618

Alternate gene names: 20808963

Gene position: 2511836-2510898 (Counterclockwise)

Preceding gene: 20808964

Following gene: 20808962

Centisome position: 93.4

GC content: 39.72

Gene sequence:

>939_bases
ATGGATAGTGACATGTCAGGCGGAATGGTAAAAGTGATGGTGCCGGCATCTACGGCTAATTTGGGCCCGGGTTTTGATGT
GCTGGGTGTGGCTTTGAACCTTTATACAGAGATTTCGATGGAGTTCATAAAAGATGGTCTGGAGATTTTTGTAGAAGGGG
AAGGGGTAGAAGATATAGAAAATGACCAAAATAATCTGATCTATAAATCGGCAGAAGTGATTTTTAAAAAAATAGGGGTT
TTTAATAAAGGGTTGAGGATAAAAATAAAAAATGAAATTCCACTGGGAAGGGGATTAGGGAGCAGTGCAGCAGCCATTGT
AGGCGGGCTACTAGCTGCAAACGAATTGACAGGAAGAGTATTGAAAAGAGAAGAAATACTCAATTTGGCGGCTTTAATAG
AAGGACATGCGGACAATGTCACAGCCGCTTTAAATGGAGGGTTGAATGTATCTATTTTTGATAAAAATAAAGTTTATTAT
GCAAGAAAAGCCTTGGAGGATGACATAGATTTTTTAGCCTTTGTACCTCAGGAAATGGTAAGGACAGAAATTGCAAGAAA
AGTCTTGCCTGAAAAAGTGGACTTTAATGATGCTGTATTTAACACGGGAAGGACGGCTTTTTTAGTGAGCGTATTGATTG
AGAAAAAGTATGAACTTTTAAAAATTGCCACCCAAGACATGCTTCACCAAAAGTATAGAGCTAAGCTCGTTCCTTTCATG
GAGGAATGCTTTGAAAAAGCATTGTTGGCAGGTGCTTATGCTGCTTTTTTAAGCGGTGCAGGTCCGACCATTATGGCCAT
CTCTTCCCCGGAAAACTCTGAGAGGGTTTTAAAGGAAGTTGGAAAAGTATATGAAGAAAGAGGGCTGTCATACAGGGCCT
ACAGGTTAAAATGTGAAAACAATGGAGCACAAGTTTTAAAAACGCCTTCATTCGTTTGA

Upstream 100 bases:

>100_bases
CTTACGGGGAATGGTTTAAAAGACCCTGATACTGCTGTTAAACTAGGGGGAGAGGTAAAGAGAATACAGCCAAATCTAAA
GGAATTGGAGGAAGTTTTGT

Downstream 100 bases:

>100_bases
GGCGCTTATTTTTATATAGTGTGCTATAATAAACTGAGAAGAATTTTGTTGAGAAATGGAGGTTTTGAAGGAATGAGAAA
ATTTTCTATTAGAATTTTTA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDSDMSGGMVKVMVPASTANLGPGFDVLGVALNLYTEISMEFIKDGLEIFVEGEGVEDIENDQNNLIYKSAEVIFKKIGV
FNKGLRIKIKNEIPLGRGLGSSAAAIVGGLLAANELTGRVLKREEILNLAALIEGHADNVTAALNGGLNVSIFDKNKVYY
ARKALEDDIDFLAFVPQEMVRTEIARKVLPEKVDFNDAVFNTGRTAFLVSVLIEKKYELLKIATQDMLHQKYRAKLVPFM
EECFEKALLAGAYAAFLSGAGPTIMAISSPENSERVLKEVGKVYEERGLSYRAYRLKCENNGAQVLKTPSFV

Sequences:

>Translated_312_residues
MDSDMSGGMVKVMVPASTANLGPGFDVLGVALNLYTEISMEFIKDGLEIFVEGEGVEDIENDQNNLIYKSAEVIFKKIGV
FNKGLRIKIKNEIPLGRGLGSSAAAIVGGLLAANELTGRVLKREEILNLAALIEGHADNVTAALNGGLNVSIFDKNKVYY
ARKALEDDIDFLAFVPQEMVRTEIARKVLPEKVDFNDAVFNTGRTAFLVSVLIEKKYELLKIATQDMLHQKYRAKLVPFM
EECFEKALLAGAYAAFLSGAGPTIMAISSPENSERVLKEVGKVYEERGLSYRAYRLKCENNGAQVLKTPSFV
>Mature_312_residues
MDSDMSGGMVKVMVPASTANLGPGFDVLGVALNLYTEISMEFIKDGLEIFVEGEGVEDIENDQNNLIYKSAEVIFKKIGV
FNKGLRIKIKNEIPLGRGLGSSAAAIVGGLLAANELTGRVLKREEILNLAALIEGHADNVTAALNGGLNVSIFDKNKVYY
ARKALEDDIDFLAFVPQEMVRTEIARKVLPEKVDFNDAVFNTGRTAFLVSVLIEKKYELLKIATQDMLHQKYRAKLVPFM
EECFEKALLAGAYAAFLSGAGPTIMAISSPENSERVLKEVGKVYEERGLSYRAYRLKCENNGAQVLKTPSFV

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=316, Percent_Identity=28.4810126582279, Blast_Score=120, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321814, Length=350, Percent_Identity=30.8571428571429, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_THETN (Q8R711)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624134.1
- ProteinModelPortal:   Q8R711
- SMR:   Q8R711
- GeneID:   997260
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2618
- NMPDR:   fig|273068.3.peg.2126
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- ProtClustDB:   PRK01212
- BioCyc:   TTEN273068:TTE2618-MONOMER
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 34212; Mature: 34212

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00627 GHMP_KINASES_ATP; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSDMSGGMVKVMVPASTANLGPGFDVLGVALNLYTEISMEFIKDGLEIFVEGEGVEDIE
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHC
NDQNNLIYKSAEVIFKKIGVFNKGLRIKIKNEIPLGRGLGSSAAAIVGGLLAANELTGRV
CCCCCEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LKREEILNLAALIEGHADNVTAALNGGLNVSIFDKNKVYYARKALEDDIDFLAFVPQEMV
HHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHCHHHHHHHHHHHH
RTEIARKVLPEKVDFNDAVFNTGRTAFLVSVLIEKKYELLKIATQDMLHQKYRAKLVPFM
HHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EECFEKALLAGAYAAFLSGAGPTIMAISSPENSERVLKEVGKVYEERGLSYRAYRLKCEN
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEECC
NGAQVLKTPSFV
CCCEEECCCCCC
>Mature Secondary Structure
MDSDMSGGMVKVMVPASTANLGPGFDVLGVALNLYTEISMEFIKDGLEIFVEGEGVEDIE
CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHC
NDQNNLIYKSAEVIFKKIGVFNKGLRIKIKNEIPLGRGLGSSAAAIVGGLLAANELTGRV
CCCCCEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LKREEILNLAALIEGHADNVTAALNGGLNVSIFDKNKVYYARKALEDDIDFLAFVPQEMV
HHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHCHHHHHHHHHHHH
RTEIARKVLPEKVDFNDAVFNTGRTAFLVSVLIEKKYELLKIATQDMLHQKYRAKLVPFM
HHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EECFEKALLAGAYAAFLSGAGPTIMAISSPENSERVLKEVGKVYEERGLSYRAYRLKCEN
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEECC
NGAQVLKTPSFV
CCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336