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The map label for this gene is Prc3 [C]

Identifier: 20808962

GI number: 20808962

Start: 2509464

End: 2510825

Strand: Reverse

Name: Prc3 [C]

Synonym: TTE2617

Alternate gene names: 20808962

Gene position: 2510825-2509464 (Counterclockwise)

Preceding gene: 20808963

Following gene: 20808961

Centisome position: 93.36

GC content: 38.4

Gene sequence:

>1362_bases
ATGAGAAAATTTTCTATTAGAATTTTTACACTTCTGCTGGTATTCTTCTTGGCATTTACATCCTACACTTATGCCGAAGT
ATCTACGCAAGACCAGGACTTGTACAACGAATTAGCAGATATTGGAGCTATAATGAAATACATCACTGATAACTACATTG
ACAATGTCACATATGAGCAACTAAAAGAGGCCGCCTTAAAGGGGATTTTTAGTAGCCTTGACGAATACAGTACATACTTT
ACAAAAGAAGAATTTTCTCAATTTGAAAGGGGCACTTCTGGAACTTTTAGCGGCACAGGGATGGTGCTTATTGAAAAAGA
TGGGAAAATTGTTGTAGATTCAGTGATTGAAGATTCTCCTGCTGCAAAGGCTGGTGTGAAGAGCGGTTACATCATAAAAA
CAGTTGACGGCAAAAGCGTGGAAGGCATGAAATTGACAGATGTAGTAAACATGATACTGGGAGACCCCGGCACAAAGGTG
AAAATCACTTTTGACGTAGGAGGTACTCTTAAAGAAATCGAACTTGTAAGACAGGTCATTCACATAAACCCTGTCTCTTA
CAAACTCCTTGAAGAGGGAATCGGGTACATAAAAATAACAGAATTTAATGAAAATACTACAGCCAATTTGACAAAAGCCT
TACTTTTTATGGATAAAAACAACGTTAAAAAGCTTATTCTCGATTTAAGAAACAATCCTGGAGGGCTTCTCACTGAAGTG
GTGAGTGCTGCAAACTTTTTTGTGCCACAGGGCATTGTTGTCACAATAGAAAGAAGAAATGGAGAAAAAGAGGATTATTA
CTCATACCTGACTAAGCCTAAATATAAACTAGCTGTTCTTGTCAATAAAGGCACTGCCTCTGCTGCGGAAATACTGGCGG
GAGCAATACAGGACACAAAAGTAGGATTTTTGGTGGGAGAAAATACGTACGGCAAGGGAACTGTTCAATCTGTAGTGCCT
TTGGAGGATGGAAGCGGCTTTAAACTTACAATTGCCCGCTACAAACTTCCATCAGGAAGGTATATTGGAAAAGAAGGTTT
AACTCCTGATGTCTATGTGAAAAATGTGCAGTACACTGCTGATATAAAATTTGGCGGAGAATTGAAGATTGGATCAAGGG
GAAATGAAGTTAAAATATTGCAAAAATATCTCAATTTGCTCAAATTTAATGCCGGACCGGAAGATGGCATATTTGGACCT
AAAACAGCCAATGCTGTAAAAGAACTTCAGAAAAAAGCAGGGCTTTCCCCAACAGGTGTATTTGACAAGAACACGTACAA
TGCCCTTTTAAAAATGATAGACAGCTTAAATAACAAAGATGCTGTCCTTGAAAAAGCTTTGGAGCTTTTGAGAAACATGT
AG

Upstream 100 bases:

>100_bases
AGTTTTAAAAACGCCTTCATTCGTTTGAGGCGCTTATTTTTATATAGTGTGCTATAATAAACTGAGAAGAATTTTGTTGA
GAAATGGAGGTTTTGAAGGA

Downstream 100 bases:

>100_bases
GAGTGATGCGCATTTGAAAATACTGCTTGCACCGGATTCTTTCAAAGGAAGTTTATCTTCAAAAGAAGTATGCCATGCTA
TGGAAAATGGCATAAAAAGA

Product: periplasmic protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRKFSIRIFTLLLVFFLAFTSYTYAEVSTQDQDLYNELADIGAIMKYITDNYIDNVTYEQLKEAALKGIFSSLDEYSTYF
TKEEFSQFERGTSGTFSGTGMVLIEKDGKIVVDSVIEDSPAAKAGVKSGYIIKTVDGKSVEGMKLTDVVNMILGDPGTKV
KITFDVGGTLKEIELVRQVIHINPVSYKLLEEGIGYIKITEFNENTTANLTKALLFMDKNNVKKLILDLRNNPGGLLTEV
VSAANFFVPQGIVVTIERRNGEKEDYYSYLTKPKYKLAVLVNKGTASAAEILAGAIQDTKVGFLVGENTYGKGTVQSVVP
LEDGSGFKLTIARYKLPSGRYIGKEGLTPDVYVKNVQYTADIKFGGELKIGSRGNEVKILQKYLNLLKFNAGPEDGIFGP
KTANAVKELQKKAGLSPTGVFDKNTYNALLKMIDSLNNKDAVLEKALELLRNM

Sequences:

>Translated_453_residues
MRKFSIRIFTLLLVFFLAFTSYTYAEVSTQDQDLYNELADIGAIMKYITDNYIDNVTYEQLKEAALKGIFSSLDEYSTYF
TKEEFSQFERGTSGTFSGTGMVLIEKDGKIVVDSVIEDSPAAKAGVKSGYIIKTVDGKSVEGMKLTDVVNMILGDPGTKV
KITFDVGGTLKEIELVRQVIHINPVSYKLLEEGIGYIKITEFNENTTANLTKALLFMDKNNVKKLILDLRNNPGGLLTEV
VSAANFFVPQGIVVTIERRNGEKEDYYSYLTKPKYKLAVLVNKGTASAAEILAGAIQDTKVGFLVGENTYGKGTVQSVVP
LEDGSGFKLTIARYKLPSGRYIGKEGLTPDVYVKNVQYTADIKFGGELKIGSRGNEVKILQKYLNLLKFNAGPEDGIFGP
KTANAVKELQKKAGLSPTGVFDKNTYNALLKMIDSLNNKDAVLEKALELLRNM
>Mature_453_residues
MRKFSIRIFTLLLVFFLAFTSYTYAEVSTQDQDLYNELADIGAIMKYITDNYIDNVTYEQLKEAALKGIFSSLDEYSTYF
TKEEFSQFERGTSGTFSGTGMVLIEKDGKIVVDSVIEDSPAAKAGVKSGYIIKTVDGKSVEGMKLTDVVNMILGDPGTKV
KITFDVGGTLKEIELVRQVIHINPVSYKLLEEGIGYIKITEFNENTTANLTKALLFMDKNNVKKLILDLRNNPGGLLTEV
VSAANFFVPQGIVVTIERRNGEKEDYYSYLTKPKYKLAVLVNKGTASAAEILAGAIQDTKVGFLVGENTYGKGTVQSVVP
LEDGSGFKLTIARYKLPSGRYIGKEGLTPDVYVKNVQYTADIKFGGELKIGSRGNEVKILQKYLNLLKFNAGPEDGIFGP
KTANAVKELQKKAGLSPTGVFDKNTYNALLKMIDSLNNKDAVLEKALELLRNM

Specific function: Involved In The Cleavage Of A C-Terminal Peptide Of 11 Residues From The Precursor Form Of Penicillin-Binding Protein 3 (Pbp3). May Be Involved In Protection Of The Bacterium From Thermal And Osmotic Stresses. [C]

COG id: COG0793

COG function: function code M; Periplasmic protease

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Escherichia coli, GI1788134, Length=316, Percent_Identity=31.6455696202532, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR005151
- InterPro:   IPR004447
- InterPro:   IPR002477 [H]

Pfam domain/function: PF00595 PDZ; PF03572 Peptidase_S41; PF01471 PG_binding_1 [H]

EC number: 3.4.21.102 [C]

Molecular weight: Translated: 49954; Mature: 49954

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS50176 ARM_REPEAT ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFSIRIFTLLLVFFLAFTSYTYAEVSTQDQDLYNELADIGAIMKYITDNYIDNVTYEQ
CCEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LKEAALKGIFSSLDEYSTYFTKEEFSQFERGTSGTFSGTGMVLIEKDGKIVVDSVIEDSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEHHHCCCC
AAKAGVKSGYIIKTVDGKSVEGMKLTDVVNMILGDPGTKVKITFDVGGTLKEIELVRQVI
CHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
HINPVSYKLLEEGIGYIKITEFNENTTANLTKALLFMDKNNVKKLILDLRNNPGGLLTEV
HCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHEEECCCCHHHHHHHHCCCCCHHHHHH
VSAANFFVPQGIVVTIERRNGEKEDYYSYLTKPKYKLAVLVNKGTASAAEILAGAIQDTK
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCE
VGFLVGENTYGKGTVQSVVPLEDGSGFKLTIARYKLPSGRYIGKEGLTPDVYVKNVQYTA
EEEEEECCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCEECCCCCCCCEEEEEEEEEE
DIKFGGELKIGSRGNEVKILQKYLNLLKFNAGPEDGIFGPKTANAVKELQKKAGLSPTGV
EEEECCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
FDKNTYNALLKMIDSLNNKDAVLEKALELLRNM
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKFSIRIFTLLLVFFLAFTSYTYAEVSTQDQDLYNELADIGAIMKYITDNYIDNVTYEQ
CCEEHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LKEAALKGIFSSLDEYSTYFTKEEFSQFERGTSGTFSGTGMVLIEKDGKIVVDSVIEDSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEHHHCCCC
AAKAGVKSGYIIKTVDGKSVEGMKLTDVVNMILGDPGTKVKITFDVGGTLKEIELVRQVI
CHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHH
HINPVSYKLLEEGIGYIKITEFNENTTANLTKALLFMDKNNVKKLILDLRNNPGGLLTEV
HCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHHEEECCCCHHHHHHHHCCCCCHHHHHH
VSAANFFVPQGIVVTIERRNGEKEDYYSYLTKPKYKLAVLVNKGTASAAEILAGAIQDTK
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHCCCE
VGFLVGENTYGKGTVQSVVPLEDGSGFKLTIARYKLPSGRYIGKEGLTPDVYVKNVQYTA
EEEEEECCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCEECCCCCCCCEEEEEEEEEE
DIKFGGELKIGSRGNEVKILQKYLNLLKFNAGPEDGIFGPKTANAVKELQKKAGLSPTGV
EEEECCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
FDKNTYNALLKMIDSLNNKDAVLEKALELLRNM
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Cleavage of the C-terminal peptide from the precursor form of penicillin-binding protein 3 [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA