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The map label for this gene is murC

Identifier: 20808924

GI number: 20808924

Start: 2464856

End: 2466238

Strand: Direct

Name: murC

Synonym: TTE2575

Alternate gene names: 20808924

Gene position: 2464856-2466238 (Clockwise)

Preceding gene: 20808880

Following gene: 20808928

Centisome position: 91.65

GC content: 38.25

Gene sequence:

>1383_bases
ATGGAAATAGATCTTGAAAAATTTAAAAGAATTCATTTTATTGGAATTGGCGGTATAAGCATGAGCGGGTTAGCTCATAT
ACTGCTGGAGGAAGGACATACAATAACAGGCTCAGACATAAAAAACTCTCATTTGATTGAAAGGCTCGAAAAAGAAGGGG
CAAAAATAAATATCCCTCATATGGCAGAAAGCGTGATAGGCGCTGACCTTGTGGTATATACAGCAGCGATACATGATGAC
AATGTGGAATACCAAAAAGCAAAAGAACTGGGAATTCCCATAATAGACAGGGCTACACTTCTAGGCCTTATAATGAAAAA
ATACAAATTTGGTGTTGCTGTTGCAGGAAGCCATGGAAAAACCACCACAACCTCTCTTATTTCAGTAATACTTGACAGAG
CAGGCTATGACCCAACGGTCTTGGTTGGAGGAGAAATAGATGCAATAGGCGGAAATGTGAGGGTGGGAAAAAGTGAATAC
TTCGTCACAGAAGCCTGTGAATACACGGACAGCTTCCTCAAATTTTATCCCTACATAGCTGTAATACTAAACGTAGACTC
AGACCATCTGGACTACTTTAAAAATATTGACAACATAAAGCAGTCCTTCAGACAATTTGCAAGCCTTGTTCCTTCAGATG
GCTTTGTAGTAGCCTGCAAAGACGATGCAAATACAATGCATGTGATAAAAGGCTTGGAGAAAAACATCGTAACATACGGC
ATTAACGAAAAAAGCGATTGGCAGGCAAAAGATATAACTTACGATGAAAAAGGCTGCGCAAGTTTTAATGTTTATTACAG
AGGAAAATTTATAGGGCATTTTAAGCTCTCCATTCCTGGCAAGCACAATATATACAATGCTCTCGCTTCTCTTGCTGTAA
CTTACCTTCTAGGAGTTGACACAGAAAAGGCTAAAGAATATATAAAAGAATTTAAAGGCACCCACAGAAGATTTGAAGTC
AAAGGAGTAGTAGAAGGGGTTACAGTTGTAGATGATTACGCTCATCACCCTGCAGAAATACATGCAACTTTAGAGGCTGC
GAAAAATTATCCTCACAAAAGGATAATAGCCATATTCCAGCCCCACACCTATTCAAGGACAAAAGCTTTGCTTTCCGACT
TTGCCGAATCTTTTGATGCTGCTGACAAAATAATAATAACTGACATATATGCCGCAAGAGAAAAAGACACAGGAATTGTA
TCTTCAAAAGACTTAGTAGATTTGATCTTCAAAAGAGGAAAGGACGTCCTTTATATAAAGGATTTTGACTCCATTGTAGA
ATATCTAAAAGAAAACACAGAAGAAGGTGACTTAGTCCTCACAATAGGAGCTGGCAACATATACGAGGTAGGAGAAAAAT
TTCTAGAAGAGAACAAAAAATAA

Upstream 100 bases:

>100_bases
TGGTATAATTTTTTTATAAAACAGTGACAACAAAAAGGCGTCTAGCATATTCTAACCATATGATGGCAATAATATGAAGT
AGAAACGAGAGGTGCATTTT

Downstream 100 bases:

>100_bases
AGGAGAAGATTTACTCCTTCAGGTAAGTCTTCTCCTTTCTCCTCTGTCATATAATACAACCCCTTTGGATACACCTCTAT
CTGGAAACACAAGATTTTCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MEIDLEKFKRIHFIGIGGISMSGLAHILLEEGHTITGSDIKNSHLIERLEKEGAKINIPHMAESVIGADLVVYTAAIHDD
NVEYQKAKELGIPIIDRATLLGLIMKKYKFGVAVAGSHGKTTTTSLISVILDRAGYDPTVLVGGEIDAIGGNVRVGKSEY
FVTEACEYTDSFLKFYPYIAVILNVDSDHLDYFKNIDNIKQSFRQFASLVPSDGFVVACKDDANTMHVIKGLEKNIVTYG
INEKSDWQAKDITYDEKGCASFNVYYRGKFIGHFKLSIPGKHNIYNALASLAVTYLLGVDTEKAKEYIKEFKGTHRRFEV
KGVVEGVTVVDDYAHHPAEIHATLEAAKNYPHKRIIAIFQPHTYSRTKALLSDFAESFDAADKIIITDIYAAREKDTGIV
SSKDLVDLIFKRGKDVLYIKDFDSIVEYLKENTEEGDLVLTIGAGNIYEVGEKFLEENKK

Sequences:

>Translated_460_residues
MEIDLEKFKRIHFIGIGGISMSGLAHILLEEGHTITGSDIKNSHLIERLEKEGAKINIPHMAESVIGADLVVYTAAIHDD
NVEYQKAKELGIPIIDRATLLGLIMKKYKFGVAVAGSHGKTTTTSLISVILDRAGYDPTVLVGGEIDAIGGNVRVGKSEY
FVTEACEYTDSFLKFYPYIAVILNVDSDHLDYFKNIDNIKQSFRQFASLVPSDGFVVACKDDANTMHVIKGLEKNIVTYG
INEKSDWQAKDITYDEKGCASFNVYYRGKFIGHFKLSIPGKHNIYNALASLAVTYLLGVDTEKAKEYIKEFKGTHRRFEV
KGVVEGVTVVDDYAHHPAEIHATLEAAKNYPHKRIIAIFQPHTYSRTKALLSDFAESFDAADKIIITDIYAAREKDTGIV
SSKDLVDLIFKRGKDVLYIKDFDSIVEYLKENTEEGDLVLTIGAGNIYEVGEKFLEENKK
>Mature_460_residues
MEIDLEKFKRIHFIGIGGISMSGLAHILLEEGHTITGSDIKNSHLIERLEKEGAKINIPHMAESVIGADLVVYTAAIHDD
NVEYQKAKELGIPIIDRATLLGLIMKKYKFGVAVAGSHGKTTTTSLISVILDRAGYDPTVLVGGEIDAIGGNVRVGKSEY
FVTEACEYTDSFLKFYPYIAVILNVDSDHLDYFKNIDNIKQSFRQFASLVPSDGFVVACKDDANTMHVIKGLEKNIVTYG
INEKSDWQAKDITYDEKGCASFNVYYRGKFIGHFKLSIPGKHNIYNALASLAVTYLLGVDTEKAKEYIKEFKGTHRRFEV
KGVVEGVTVVDDYAHHPAEIHATLEAAKNYPHKRIIAIFQPHTYSRTKALLSDFAESFDAADKIIITDIYAAREKDTGIV
SSKDLVDLIFKRGKDVLYIKDFDSIVEYLKENTEEGDLVLTIGAGNIYEVGEKFLEENKK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=35.8369098712446, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1790680, Length=466, Percent_Identity=28.9699570815451, Blast_Score=191, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_THETN (Q8R749)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624095.1
- ProteinModelPortal:   Q8R749
- SMR:   Q8R749
- GeneID:   995966
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2575
- NMPDR:   fig|273068.3.peg.2056
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   TTEN273068:TTE2575-MONOMER
- BRENDA:   6.3.2.8
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51283; Mature: 51283

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIDLEKFKRIHFIGIGGISMSGLAHILLEEGHTITGSDIKNSHLIERLEKEGAKINIPH
CCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCEEECCH
MAESVIGADLVVYTAAIHDDNVEYQKAKELGIPIIDRATLLGLIMKKYKFGVAVAGSHGK
HHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCCC
TTTTSLISVILDRAGYDPTVLVGGEIDAIGGNVRVGKSEYFVTEACEYTDSFLKFYPYIA
HHHHHHHHHHHHHCCCCCEEEECCEEEECCCEEEECCCCEEHHHHHHHHHHHHHHHCEEE
VILNVDSDHLDYFKNIDNIKQSFRQFASLVPSDGFVVACKDDANTMHVIKGLEKNIVTYG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCEEEEC
INEKSDWQAKDITYDEKGCASFNVYYRGKFIGHFKLSIPGKHNIYNALASLAVTYLLGVD
CCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
TEKAKEYIKEFKGTHRRFEVKGVVEGVTVVDDYAHHPAEIHATLEAAKNYPHKRIIAIFQ
HHHHHHHHHHHCCCCCEEEEEHHHCCEEEEHHHCCCCHHHHHHHHHHHCCCCEEEEEEEC
PHTYSRTKALLSDFAESFDAADKIIITDIYAAREKDTGIVSSKDLVDLIFKRGKDVLYIK
CCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEE
DFDSIVEYLKENTEEGDLVLTIGAGNIYEVGEKFLEENKK
CHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIDLEKFKRIHFIGIGGISMSGLAHILLEEGHTITGSDIKNSHLIERLEKEGAKINIPH
CCCCHHHHCEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHCCCEEECCH
MAESVIGADLVVYTAAIHDDNVEYQKAKELGIPIIDRATLLGLIMKKYKFGVAVAGSHGK
HHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCCC
TTTTSLISVILDRAGYDPTVLVGGEIDAIGGNVRVGKSEYFVTEACEYTDSFLKFYPYIA
HHHHHHHHHHHHHCCCCCEEEECCEEEECCCEEEECCCCEEHHHHHHHHHHHHHHHCEEE
VILNVDSDHLDYFKNIDNIKQSFRQFASLVPSDGFVVACKDDANTMHVIKGLEKNIVTYG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCEEEEC
INEKSDWQAKDITYDEKGCASFNVYYRGKFIGHFKLSIPGKHNIYNALASLAVTYLLGVD
CCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCC
TEKAKEYIKEFKGTHRRFEVKGVVEGVTVVDDYAHHPAEIHATLEAAKNYPHKRIIAIFQ
HHHHHHHHHHHCCCCCEEEEEHHHCCEEEEHHHCCCCHHHHHHHHHHHCCCCEEEEEEEC
PHTYSRTKALLSDFAESFDAADKIIITDIYAAREKDTGIVSSKDLVDLIFKRGKDVLYIK
CCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEEE
DFDSIVEYLKENTEEGDLVLTIGAGNIYEVGEKFLEENKK
CHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336