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The map label for this gene is PotE5 [H]

Identifier: 20808890

GI number: 20808890

Start: 2428057

End: 2429484

Strand: Reverse

Name: PotE5 [H]

Synonym: TTE2536

Alternate gene names: 20808890

Gene position: 2429484-2428057 (Counterclockwise)

Preceding gene: 20808891

Following gene: 20808889

Centisome position: 90.33

GC content: 37.39

Gene sequence:

>1428_bases
ATGGTGTTATTAATGACAGAACTTCAAAAACGAATAAGCTTTATTGGTTTAGTTGCTCTTGGAGCAGCGGGCGTTATAGG
AACAAGCTGGATATATACAAACAGTAAGTTTTTTGCAGCATACGGAGCAGGAGGGGAAATTTTTGGATTTGTTGTAGCGA
CAGTGATTGCTAGTTTAATTGCTTTGGCTTATGCCGAATTGTCTACTGTTTTCCCCAGAGCTGGAGGAGAAGTTGTTTAC
ACGTATGTCGCATTTGGTAAGACAACCTCTTTTATAGCAGGATGGGCGTTAGTAGGCGCTTATTTAGCTTCTCTGGCATT
TTATGTGACGGCATCAAGTTTGTTATTGGCATGGATTTTTCCTCAACTTGAACAAGGCCCATATTATGTTATTGCGGGGA
CTAAAATACATTTACCTGAACTTATAGTAGGTATTGCTATTACATTGTTAGTGTTTTTAGTAAATTATTATGGAGCTCAT
TTAGCATCAGGGATTCAAATTGTAATGTTTGGAACAATGATTGTACTAGGGTTACTGTTAGTAATTGTAGGATTTACTCA
CGGTCAAGCATCAAACTTTTGGCCTGCCTGGAGTAAAGATATGAATCCATTCCTTTCGACAATGAGATTTGTTTTACCCG
CTATGACATATTTAACAGGGTTTGAGTTAGTTGCTGTACTAGCAGAAGAAGCAAATATGCCCGTAAGGAAAATTGGCATT
AGTGTTATCTTATCAGTTGTTTTAGCGGGATTGTTTTATACGATAGTGTTGCTATCTTCTGCGTGGGTTATTCCGTGGCA
AGAGACTGCTAAATTAAAATTAGGAACAATAGATGCTTTTAAAGTAGCTGGTTTTCCTGCATTAGGATGGGCGGCATATT
TTATTTCTGTCCTAGGATTAGTTACAAGTTTTGTAGGTTTATTTGCAGCAACGCCTAGATTAATCTTGTCTTTGTCACGT
GCAGGAGTTCTTCCCCAGACCTTCACTAAAACACATCCTAAATATGGAACACCTGTAAATGCTCTTTACTTAACTCTTGG
ATTTGCACTTGGTTTAGGATGGCTGGGAAAAGGAGCTATGGTATGGTTTTTAGATATGGGAGGATTTGCTATTGCAATTG
CGTGGGTATTGGCTACTCTTAGTTTGATTAAAATAAGAAAAAAATATCCTAATCTTAGAGGTGCTTATAGGACTTCGGCT
ACTCTCTTACCTTTAATTGGAGGTATAGTAGCAATTATAATTGCAATAGCTACTTTGATTCCAGGAACGCCTTTGTCATT
AGCTTGGCCATATGAATATATTGTTTTAGGTGTGTGGGCTATAGTGGGAGTTATACTATATGCTAAAGCTCCAAAAGGTA
ATGAGGAAGAAGCATTGAAAAATTTGTTAGGTGAGTATTATGAAGCTATAAAAAAGGCTAGTGATTAA

Upstream 100 bases:

>100_bases
TAGATTTTTGTACAGTTTGGGTAACCAGGTGAGTATGTAAAGAGAGAAAACTAAAGTAAGATTTTAGAAATTAAAAAATA
ATAAAAAAGAGAAAGAAAGG

Downstream 100 bases:

>100_bases
TTATGGATAAAATTGGGGTTTTCAAAGATACTCCTGCTCCTTTACCTAAAAAGGAATGGAAAAAGTGTCAAGTATGTTTT
ATCCCATTGTAGGTGCGATA

Product: amino acid transporters

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MVLLMTELQKRISFIGLVALGAAGVIGTSWIYTNSKFFAAYGAGGEIFGFVVATVIASLIALAYAELSTVFPRAGGEVVY
TYVAFGKTTSFIAGWALVGAYLASLAFYVTASSLLLAWIFPQLEQGPYYVIAGTKIHLPELIVGIAITLLVFLVNYYGAH
LASGIQIVMFGTMIVLGLLLVIVGFTHGQASNFWPAWSKDMNPFLSTMRFVLPAMTYLTGFELVAVLAEEANMPVRKIGI
SVILSVVLAGLFYTIVLLSSAWVIPWQETAKLKLGTIDAFKVAGFPALGWAAYFISVLGLVTSFVGLFAATPRLILSLSR
AGVLPQTFTKTHPKYGTPVNALYLTLGFALGLGWLGKGAMVWFLDMGGFAIAIAWVLATLSLIKIRKKYPNLRGAYRTSA
TLLPLIGGIVAIIIAIATLIPGTPLSLAWPYEYIVLGVWAIVGVILYAKAPKGNEEEALKNLLGEYYEAIKKASD

Sequences:

>Translated_475_residues
MVLLMTELQKRISFIGLVALGAAGVIGTSWIYTNSKFFAAYGAGGEIFGFVVATVIASLIALAYAELSTVFPRAGGEVVY
TYVAFGKTTSFIAGWALVGAYLASLAFYVTASSLLLAWIFPQLEQGPYYVIAGTKIHLPELIVGIAITLLVFLVNYYGAH
LASGIQIVMFGTMIVLGLLLVIVGFTHGQASNFWPAWSKDMNPFLSTMRFVLPAMTYLTGFELVAVLAEEANMPVRKIGI
SVILSVVLAGLFYTIVLLSSAWVIPWQETAKLKLGTIDAFKVAGFPALGWAAYFISVLGLVTSFVGLFAATPRLILSLSR
AGVLPQTFTKTHPKYGTPVNALYLTLGFALGLGWLGKGAMVWFLDMGGFAIAIAWVLATLSLIKIRKKYPNLRGAYRTSA
TLLPLIGGIVAIIIAIATLIPGTPLSLAWPYEYIVLGVWAIVGVILYAKAPKGNEEEALKNLLGEYYEAIKKASD
>Mature_475_residues
MVLLMTELQKRISFIGLVALGAAGVIGTSWIYTNSKFFAAYGAGGEIFGFVVATVIASLIALAYAELSTVFPRAGGEVVY
TYVAFGKTTSFIAGWALVGAYLASLAFYVTASSLLLAWIFPQLEQGPYYVIAGTKIHLPELIVGIAITLLVFLVNYYGAH
LASGIQIVMFGTMIVLGLLLVIVGFTHGQASNFWPAWSKDMNPFLSTMRFVLPAMTYLTGFELVAVLAEEANMPVRKIGI
SVILSVVLAGLFYTIVLLSSAWVIPWQETAKLKLGTIDAFKVAGFPALGWAAYFISVLGLVTSFVGLFAATPRLILSLSR
AGVLPQTFTKTHPKYGTPVNALYLTLGFALGLGWLGKGAMVWFLDMGGFAIAIAWVLATLSLIKIRKKYPNLRGAYRTSA
TLLPLIGGIVAIIIAIATLIPGTPLSLAWPYEYIVLGVWAIVGVILYAKAPKGNEEEALKNLLGEYYEAIKKASD

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=347, Percent_Identity=26.5129682997118, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI114326544, Length=415, Percent_Identity=23.3734939759036, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI114326550, Length=415, Percent_Identity=23.3734939759036, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788480, Length=414, Percent_Identity=24.1545893719807, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=433, Percent_Identity=26.0969976905312, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667468, Length=363, Percent_Identity=28.3746556473829, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221512776, Length=365, Percent_Identity=25.7534246575342, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24666159, Length=365, Percent_Identity=25.7534246575342, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI281366235, Length=370, Percent_Identity=23.5135135135135, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI116007820, Length=370, Percent_Identity=23.5135135135135, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24668806, Length=402, Percent_Identity=20.8955223880597, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21356285, Length=402, Percent_Identity=20.8955223880597, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24668802, Length=402, Percent_Identity=20.8955223880597, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51030; Mature: 51030

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLMTELQKRISFIGLVALGAAGVIGTSWIYTNSKFFAAYGAGGEIFGFVVATVIASLI
CEEEHHHHHHHHHHHHHHHHHHCHHHHCCEEEECCEEEEEECCCCHHHHHHHHHHHHHHH
ALAYAELSTVFPRAGGEVVYTYVAFGKTTSFIAGWALVGAYLASLAFYVTASSLLLAWIF
HHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQLEQGPYYVIAGTKIHLPELIVGIAITLLVFLVNYYGAHLASGIQIVMFGTMIVLGLLL
HHHCCCCEEEEECCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VIVGFTHGQASNFWPAWSKDMNPFLSTMRFVLPAMTYLTGFELVAVLAEEANMPVRKIGI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SVILSVVLAGLFYTIVLLSSAWVIPWQETAKLKLGTIDAFKVAGFPALGWAAYFISVLGL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHH
VTSFVGLFAATPRLILSLSRAGVLPQTFTKTHPKYGTPVNALYLTLGFALGLGWLGKGAM
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
VWFLDMGGFAIAIAWVLATLSLIKIRKKYPNLRGAYRTSATLLPLIGGIVAIIIAIATLI
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PGTPLSLAWPYEYIVLGVWAIVGVILYAKAPKGNEEEALKNLLGEYYEAIKKASD
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLLMTELQKRISFIGLVALGAAGVIGTSWIYTNSKFFAAYGAGGEIFGFVVATVIASLI
CEEEHHHHHHHHHHHHHHHHHHCHHHHCCEEEECCEEEEEECCCCHHHHHHHHHHHHHHH
ALAYAELSTVFPRAGGEVVYTYVAFGKTTSFIAGWALVGAYLASLAFYVTASSLLLAWIF
HHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQLEQGPYYVIAGTKIHLPELIVGIAITLLVFLVNYYGAHLASGIQIVMFGTMIVLGLLL
HHHCCCCEEEEECCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VIVGFTHGQASNFWPAWSKDMNPFLSTMRFVLPAMTYLTGFELVAVLAEEANMPVRKIGI
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SVILSVVLAGLFYTIVLLSSAWVIPWQETAKLKLGTIDAFKVAGFPALGWAAYFISVLGL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHH
VTSFVGLFAATPRLILSLSRAGVLPQTFTKTHPKYGTPVNALYLTLGFALGLGWLGKGAM
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCE
VWFLDMGGFAIAIAWVLATLSLIKIRKKYPNLRGAYRTSATLLPLIGGIVAIIIAIATLI
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
PGTPLSLAWPYEYIVLGVWAIVGVILYAKAPKGNEEEALKNLLGEYYEAIKKASD
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]