Click here to switch to the map view.

The map label for this gene is ArgH [H]

Identifier: 20808848

GI number: 20808848

Start: 2381784

End: 2383103

Strand: Reverse

Name: ArgH [H]

Synonym: TTE2493

Alternate gene names: 20808848

Gene position: 2383103-2381784 (Counterclockwise)

Preceding gene: 20808849

Following gene: 20808847

Centisome position: 88.61

GC content: 35.68

Gene sequence:

>1320_bases
ATGAAGCTGTGGGGAGGTAGGTTTAAAAAGGACTTGGACAAACTGATGGAGGATTTCAATTCCTCCATTTCTTTTGATAT
AAGGCTTTTAAAGTATGATATAATGGGCTCTATTGCCCATGCAAAGGGTCTTTACAAGGCTGGCGTTTTAACAGAAGAGG
AGCTTAATTTGATAGAAAAAGGGCTTAAAGAAATACTTGAGGAATCCGAGTTAAAAGAAATACCTCAGGATGAAGATGTT
CATTCCTATGTAGAAAGGCTTCTTGTAGAGAAAATAGGCGATGTAGGGCGTAAACTTCACACAGGAAGAAGCAGAAACGA
CCAAGTTGCGACGGATGAAAGGCTTTATTTAAGAGATGAGATAGACAAAATAAAAGAGGATTTAATAAAGCTTATAGATA
CTCTAAAAGAAATGGCTGAAACTTATAAAGAAACAATTATGCCGGGATATACGCATTTACAGAGGGCACAGCCTGTGACT
TTTGGACATTATCTTCTTGCCTATGTTGAAATGTTTAAAAGAGATTTGTCAAGGCTTGATGATATGATGAAAAGAGTCAA
TGTAATGCCTTTGGGTTCTGGTGCTCTTGCAGGTACTACCTTTAATATCGACAGATATTATGTCGCTTCTCTTTTAGGGT
TCGATGATATAACCTTAAACAGTATGGACGGGGTTAGTGATAGAGATTTTGTGATAGAATTTTTAAGCTTTGCTTCTATA
ACAATGATGCATTTGAGCAGATTCTGTGAGGAATTAATTTTGTGGTCTACAAAGGAATTTGACTTTATTGAAATGGACGA
TAGATTTTCAACAGGAAGCAGTATGATGCCGCAAAAGAAAAATCCTGATGCAGCAGAATTAATAAGGGGCAAAACCGGCA
GGGTTTACGGCGATTTGATTACAATACTTACCGTGATGAAAGGACTCCCTCTTGCATATAACAAAGACATGCAGGAGGAT
AAAGAGGCCTTGTTTGACGGAATAGACACTTTAAAAATGTCTTTGAAAGTATTTACAGAAATGATAAAGACAATTAAAGT
AAAAACAGACAACATGGAAAAAGCTGCAAAATATGGTTATATGAATGCTACAGATTTTGCAGACTATCTTGTACAAAAAG
GTATTCCTTTTAGGACCGCCCATGAAATTGCAGGCAAAGTTGTCTTATATGCGATAGAACGAAACTTACCAATTGAAGAG
TTATCACTTGAAGAACTTAAAAAATTCAGCGATGTAATAGAAAAAGATGTATATGAGGCGATAGATATAAAAAATATTTT
AAAAAAGAGAAAGACAATAGGTTCACCGAGGATATTCTAA

Upstream 100 bases:

>100_bases
GATGAAGTTTACAACCAAAAAGACGCAGAAGGATTTATAAACCTCTTTGGGCTTTCTTTAAAAATTAGGGCTTTGATGGA
AATGGGAAGGAAGGATATGG

Downstream 100 bases:

>100_bases
TCTTATCAAGATATATGAGCTCCTGTCTTTGAGAATAAAAAGCAGGAGCTTAAATTTTGCTCTGTCAAATAAACTTAATC
CTTTTTGATTAAAGTTTAAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKLWGGRFKKDLDKLMEDFNSSISFDIRLLKYDIMGSIAHAKGLYKAGVLTEEELNLIEKGLKEILEESELKEIPQDEDV
HSYVERLLVEKIGDVGRKLHTGRSRNDQVATDERLYLRDEIDKIKEDLIKLIDTLKEMAETYKETIMPGYTHLQRAQPVT
FGHYLLAYVEMFKRDLSRLDDMMKRVNVMPLGSGALAGTTFNIDRYYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLITILTVMKGLPLAYNKDMQED
KEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGYMNATDFADYLVQKGIPFRTAHEIAGKVVLYAIERNLPIEE
LSLEELKKFSDVIEKDVYEAIDIKNILKKRKTIGSPRIF

Sequences:

>Translated_439_residues
MKLWGGRFKKDLDKLMEDFNSSISFDIRLLKYDIMGSIAHAKGLYKAGVLTEEELNLIEKGLKEILEESELKEIPQDEDV
HSYVERLLVEKIGDVGRKLHTGRSRNDQVATDERLYLRDEIDKIKEDLIKLIDTLKEMAETYKETIMPGYTHLQRAQPVT
FGHYLLAYVEMFKRDLSRLDDMMKRVNVMPLGSGALAGTTFNIDRYYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLITILTVMKGLPLAYNKDMQED
KEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGYMNATDFADYLVQKGIPFRTAHEIAGKVVLYAIERNLPIEE
LSLEELKKFSDVIEKDVYEAIDIKNILKKRKTIGSPRIF
>Mature_439_residues
MKLWGGRFKKDLDKLMEDFNSSISFDIRLLKYDIMGSIAHAKGLYKAGVLTEEELNLIEKGLKEILEESELKEIPQDEDV
HSYVERLLVEKIGDVGRKLHTGRSRNDQVATDERLYLRDEIDKIKEDLIKLIDTLKEMAETYKETIMPGYTHLQRAQPVT
FGHYLLAYVEMFKRDLSRLDDMMKRVNVMPLGSGALAGTTFNIDRYYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLITILTVMKGLPLAYNKDMQED
KEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGYMNATDFADYLVQKGIPFRTAHEIAGKVVLYAIERNLPIEE
LSLEELKKFSDVIEKDVYEAIDIKNILKKRKTIGSPRIF

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=436, Percent_Identity=48.1651376146789, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI68303542, Length=436, Percent_Identity=48.1651376146789, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI68303547, Length=436, Percent_Identity=45.8715596330275, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI68303549, Length=436, Percent_Identity=45.6422018348624, Blast_Score=383, Evalue=1e-106,
Organism=Escherichia coli, GI1790398, Length=445, Percent_Identity=52.5842696629213, Blast_Score=478, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6321806, Length=440, Percent_Identity=45.9090909090909, Blast_Score=393, Evalue=1e-110,
Organism=Drosophila melanogaster, GI221473854, Length=437, Percent_Identity=46.4530892448513, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI78706858, Length=437, Percent_Identity=46.4530892448513, Blast_Score=393, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50497; Mature: 50497

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFKKDLDKLMEDFNSSISFDIRLLKYDIMGSIAHAKGLYKAGVLTEEELNLIEK
CCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GLKEILEESELKEIPQDEDVHSYVERLLVEKIGDVGRKLHTGRSRNDQVATDERLYLRDE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
IDKIKEDLIKLIDTLKEMAETYKETIMPGYTHLQRAQPVTFGHYLLAYVEMFKRDLSRLD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DMMKRVNVMPLGSGALAGTTFNIDRYYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
HHHHHCCCCCCCCCCCCCCEECCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHH
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLI
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHH
TILTVMKGLPLAYNKDMQEDKEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGY
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
MNATDFADYLVQKGIPFRTAHEIAGKVVLYAIERNLPIEELSLEELKKFSDVIEKDVYEA
CCHHHHHHHHHHCCCCCHHHHHHHHHEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHH
IDIKNILKKRKTIGSPRIF
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLWGGRFKKDLDKLMEDFNSSISFDIRLLKYDIMGSIAHAKGLYKAGVLTEEELNLIEK
CCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GLKEILEESELKEIPQDEDVHSYVERLLVEKIGDVGRKLHTGRSRNDQVATDERLYLRDE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
IDKIKEDLIKLIDTLKEMAETYKETIMPGYTHLQRAQPVTFGHYLLAYVEMFKRDLSRLD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
DMMKRVNVMPLGSGALAGTTFNIDRYYVASLLGFDDITLNSMDGVSDRDFVIEFLSFASI
HHHHHCCCCCCCCCCCCCCEECCHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHH
TMMHLSRFCEELILWSTKEFDFIEMDDRFSTGSSMMPQKKNPDAAELIRGKTGRVYGDLI
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHH
TILTVMKGLPLAYNKDMQEDKEALFDGIDTLKMSLKVFTEMIKTIKVKTDNMEKAAKYGY
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
MNATDFADYLVQKGIPFRTAHEIAGKVVLYAIERNLPIEELSLEELKKFSDVIEKDVYEA
CCHHHHHHHHHHCCCCCHHHHHHHHHEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHH
IDIKNILKKRKTIGSPRIF
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA