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The map label for this gene is coaX

Identifier: 20808745

GI number: 20808745

Start: 2270372

End: 2271139

Strand: Reverse

Name: coaX

Synonym: TTE2381

Alternate gene names: 20808745

Gene position: 2271139-2270372 (Counterclockwise)

Preceding gene: 20808746

Following gene: 20808743

Centisome position: 84.45

GC content: 42.84

Gene sequence:

>768_bases
TTGCTTTTAGCTTTTGACGTGGGCAACACCAACATAGTCATGGGCGTATTTAAAGGGAAAAAGCTCCTTCACTCCTTCAG
GATTTCGACAGACAAAAATAAAACTTACGATGAATACGGGATGCTGGTAAACCAGCTTATCGGTTACAACGGGATAAGTC
TTACGGAAATTGATGATGTGATAATTTCTTCAGTAGTTCCACCCCTTATGAATACTCTGCAGGTCATGTCTTTGAAGTAC
TTCAGGACAAAGCCTATAGTAGTAGGTCCGGGAATAAAGACGGGGATAAACATAAAATACGACAACCCAAAAGAGGTTGG
AGCAGACAGGATAGTTAACGCTGTGGCGGCGTACGAGCTCTACGGTGGACCTGTAATAGTCATAGACTTTGGAACTGCTA
CCACCTTTTGCGCGATATCAGAAAAAGGGGAGTATTTAGGAGGAATAATTGCTCCCGGGCTTATGATTTCTGCAGATGCG
CTTTTCCAAAGGACTGCAAAGCTTCCGAAGATAGACCTTACAAAACCTCCCACAGTTATAAACAGAAACACTGTCGCCAG
CATGCAATCAGGTATAATCTACGGGCATGTGGGAATGGTGGACTACATAGTCACGAGGATGAAGGGAGAATTTGCACCTT
CTGCCTATGTAGTGGCAACAGGGGGCTTTGCAAATATGATTGCAGAGGAATCGAAGACAATAGATACAGTCAATGAAATG
CTCACATTAGAGGGATTGAGGATTATATATGAGAGGAATAAAGAATAA

Upstream 100 bases:

>100_bases
TCTCCTTGTAACTGCTGTAGTAAAGTCAGTTAAAAAAGCGTACAATAGATAAAAAGCAGGCTTTTTGCCTGCTTAATTTT
AATTAAAGAAGGTGATAAAT

Downstream 100 bases:

>100_bases
TTCCTCTCATTTTATTTTTCTAATTTTTGCAATTGTGTAAAGGAGTAGGGGGAAGAACACCTCAAACCAGAATCCCTCAA
AGGGGAAACACCTCTGAAAA

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MLLAFDVGNTNIVMGVFKGKKLLHSFRISTDKNKTYDEYGMLVNQLIGYNGISLTEIDDVIISSVVPPLMNTLQVMSLKY
FRTKPIVVGPGIKTGINIKYDNPKEVGADRIVNAVAAYELYGGPVIVIDFGTATTFCAISEKGEYLGGIIAPGLMISADA
LFQRTAKLPKIDLTKPPTVINRNTVASMQSGIIYGHVGMVDYIVTRMKGEFAPSAYVVATGGFANMIAEESKTIDTVNEM
LTLEGLRIIYERNKE

Sequences:

>Translated_255_residues
MLLAFDVGNTNIVMGVFKGKKLLHSFRISTDKNKTYDEYGMLVNQLIGYNGISLTEIDDVIISSVVPPLMNTLQVMSLKY
FRTKPIVVGPGIKTGINIKYDNPKEVGADRIVNAVAAYELYGGPVIVIDFGTATTFCAISEKGEYLGGIIAPGLMISADA
LFQRTAKLPKIDLTKPPTVINRNTVASMQSGIIYGHVGMVDYIVTRMKGEFAPSAYVVATGGFANMIAEESKTIDTVNEM
LTLEGLRIIYERNKE
>Mature_255_residues
MLLAFDVGNTNIVMGVFKGKKLLHSFRISTDKNKTYDEYGMLVNQLIGYNGISLTEIDDVIISSVVPPLMNTLQVMSLKY
FRTKPIVVGPGIKTGINIKYDNPKEVGADRIVNAVAAYELYGGPVIVIDFGTATTFCAISEKGEYLGGIIAPGLMISADA
LFQRTAKLPKIDLTKPPTVINRNTVASMQSGIIYGHVGMVDYIVTRMKGEFAPSAYVVATGGFANMIAEESKTIDTVNEM
LTLEGLRIIYERNKE

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_THETN (Q8R7M2)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623916.1
- ProteinModelPortal:   Q8R7M2
- SMR:   Q8R7M2
- GeneID:   997353
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2381
- NMPDR:   fig|273068.3.peg.2557
- HOGENOM:   HBG634537
- OMA:   PAIVVDF
- ProtClustDB:   PRK13318
- BioCyc:   TTEN273068:TTE2381-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 27817; Mature: 27817

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: ACT_SITE 109-109 BINDING 100-100 BINDING 132-132 BINDING 184-184

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAFDVGNTNIVMGVFKGKKLLHSFRISTDKNKTYDEYGMLVNQLIGYNGISLTEIDDV
CEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
IISSVVPPLMNTLQVMSLKYFRTKPIVVGPGIKTGINIKYDNPKEVGADRIVNAVAAYEL
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHC
YGGPVIVIDFGTATTFCAISEKGEYLGGIIAPGLMISADALFQRTAKLPKIDLTKPPTVI
CCCCEEEEECCCCEEEEEECCCCCHHCHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCEE
NRNTVASMQSGIIYGHVGMVDYIVTRMKGEFAPSAYVVATGGFANMIAEESKTIDTVNEM
CCCHHHHHHCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
LTLEGLRIIYERNKE
HHHHHEEEEEECCCC
>Mature Secondary Structure
MLLAFDVGNTNIVMGVFKGKKLLHSFRISTDKNKTYDEYGMLVNQLIGYNGISLTEIDDV
CEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
IISSVVPPLMNTLQVMSLKYFRTKPIVVGPGIKTGINIKYDNPKEVGADRIVNAVAAYEL
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHC
YGGPVIVIDFGTATTFCAISEKGEYLGGIIAPGLMISADALFQRTAKLPKIDLTKPPTVI
CCCCEEEEECCCCEEEEEECCCCCHHCHHHCCCHHHHHHHHHHHHHCCCEEECCCCCCEE
NRNTVASMQSGIIYGHVGMVDYIVTRMKGEFAPSAYVVATGGFANMIAEESKTIDTVNEM
CCCHHHHHHCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHH
LTLEGLRIIYERNKE
HHHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336