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The map label for this gene is NrdA [H]

Identifier: 20808702

GI number: 20808702

Start: 2220613

End: 2222688

Strand: Reverse

Name: NrdA [H]

Synonym: TTE2336

Alternate gene names: 20808702

Gene position: 2222688-2220613 (Counterclockwise)

Preceding gene: 20808703

Following gene: 20808701

Centisome position: 82.64

GC content: 42.77

Gene sequence:

>2076_bases
ATGTTTAAAAGAGTTGCAAAAGCTATCGCTACAAATGAAAAAGAGGAAGAGATGTTTTATAAGGTGATGAGTGAATGGAA
ATTTATTCCTGGTGGTAGGATATTGGCTGGGGCGGGGACTGGCAGAGAGGTTACATATTTCAACTGCTTTGTAATACCCG
TGGAAGCAAATGACCCTAAGAAGGGGAATGACAGCCGTGCCGCTATAATGGATACAATAGCTAAAATGTTGGAGATTAAT
TCAAGGGGCGGCGGCGTTGGAATTAACTGGAGCACATTAAGGCCCAGAGGTGCGTATGTGAAAGGGGTAGGGGGAACTTC
ATCGGGAGCAGTTAGCTGGATGCTAGCAGCCAATGAAGTTGCTACACAAGTTGAGCAGGGTGGAAGTCGTAGGGCAGCTT
TGATGTTCATGCTCTGGGATTGGCATCCAGACATAGAAGAGTTTATAAAAGTAAAAAAAGACCTTACAAAGATGCAGCAG
GCTAACCTTTCTGTGGCTGTTTCTGACGCTTTTATGGAAGCAGTAGCACAGGACAAGATGTGGAAGCTTGAGTTTCCAGA
TACTTCACATCCCAATTACGATGCCGAGTGGAAAGGAGACCTCAATGAGTGGAAAGCTAAGGGTTACCCTACTGTAGTAT
ATAAAGAGATTCCTGCAAGAGAGCTCTGGAACAAAATTGTGACTGCTGCGTGGGAGTCTGCAGAACCGGGAGTAGTCTTT
TTAGAAAGGTATAATAAATTGAGCAATACTTACTACATCACGAAGATAATTTCTACAAATCCTTGCGGAGAATTAGGCCT
TGAACCTTACGGTGTTTGCAATTTAGGGGCTATAAACTTAGTTGCATTTGTAGAAAATGGGAAAATTAATTTTGAGGAAT
TAGAGGAAACTGTAAAGATCGCGGTGAGATTTTTAGATAATGTGCTTGATTTGGGAGCATATGTGCTTCCGCAAAACAAA
GAGATGGCGCAGAAGCTTCGCAGAGTGGGATTGGGCTTGATGGGGCTTGCGGATGCTTTAATTCTTATGAACTTAAGGTA
TGGAAGTGAGGAATCCCTGAAGGCGACAGAAGAGATTGTGAGGAGAATAAGAGATGCGGCTTATAGGGCTTCTGTAGAAT
TAGCTAAAGAAAAAGGGCCTTTTCCTGAGTTTGTGGCTGATAAGTATTTGAAAGGCCAGTTTATACAAAGATTGCCAAAG
GACATAAGGGATGAAATTGCTAAATACGGCATAAGAAATGCTACTATTCTCACACAAGCTCCTACTGGTACCACTTCCAT
TCTTGCAGGAGTGAGTTCGGGGATAGAGCCCAATTTTGCGAAGGAGTACGTAAGGAAAGACCGTACAGGTACTCATACAG
TAAAGCACTGGTTGGCGGATTATCCTGCTTTTGTAAGCGCTCATGAAGTTACTCCAGAAGAGCACGTAAAAATGCAGGCC
GTACTGCAGAAATACATTGATTCAAGCATTTCTAAGACTATAAATCTGCCAAGAACCGCCACGGTTGATGATATAGATAA
TATATATAGACTAGCTTATGAACTTGGATGTAAAGGGATAACGGTTTACAGAGACGGGTCAAGAGAAGGAGTGCTTGTGA
CAGATACTAAGCCTCAGGAGAAGACAAAGATAACTGAAAGGCCACCTGTGTTAAAGGGAATTACAAAGAGGATAGAAACT
CCTCTAGGAAGAGCGTATGTGACTATAAACTTTATAGACAACAAGCCCTTTGAAGTATTTGTAAATATTGGACGAGCAGG
CTCAGATGTGGCGGCCTTTACAGAAGCTATAGCAAGGCTAATTTCTCTTGCGCTAAGGGGAGGGGTAGCAGTAGAAGACA
TAATAGAGCAGTTAGTAGGAATAGGAGGAGCGACGACCATAGGCTTTGGAGAGAATAGGGTGCTCTCTGTTCCTGATGCT
ATAGGAAAAGCTCTGAGAAACGGATATGAACAGCAAGGAAATTCTGTTAAAGTGTCAGCTACAAATGTGGATATATGTCC
TGTATGCGGCATGGCTACTTTTGTGTACACAGAAGGATGTAAGACCTGCCTTAACTGCGGTTATTCCCAGTGTTAA

Upstream 100 bases:

>100_bases
AATGCTTCCAGCGTGGAACGAACAGAGGGAGAAGGTTTTTCTGGACAGGTATGCCTTAAAAGACAGAGAGGGCAAACCCG
TTGAAAAAAAGCCTGAAGAG

Downstream 100 bases:

>100_bases
CAATTGGGTCCCCTTGTCAAGAGGGGACCTAAATTTTTTTACACATGTTACACAGTTCGACATATTGCGATGGGTATTTG
TGGTACAATTTCCTGTGACA

Product: ribonucleotide reductase alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 691; Mature: 691

Protein sequence:

>691_residues
MFKRVAKAIATNEKEEEMFYKVMSEWKFIPGGRILAGAGTGREVTYFNCFVIPVEANDPKKGNDSRAAIMDTIAKMLEIN
SRGGGVGINWSTLRPRGAYVKGVGGTSSGAVSWMLAANEVATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQ
ANLSVAVSDAFMEAVAQDKMWKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKIVTAAWESAEPGVVF
LERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAFVENGKINFEELEETVKIAVRFLDNVLDLGAYVLPQNK
EMAQKLRRVGLGLMGLADALILMNLRYGSEESLKATEEIVRRIRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRLPK
DIRDEIAKYGIRNATILTQAPTGTTSILAGVSSGIEPNFAKEYVRKDRTGTHTVKHWLADYPAFVSAHEVTPEEHVKMQA
VLQKYIDSSISKTINLPRTATVDDIDNIYRLAYELGCKGITVYRDGSREGVLVTDTKPQEKTKITERPPVLKGITKRIET
PLGRAYVTINFIDNKPFEVFVNIGRAGSDVAAFTEAIARLISLALRGGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDA
IGKALRNGYEQQGNSVKVSATNVDICPVCGMATFVYTEGCKTCLNCGYSQC

Sequences:

>Translated_691_residues
MFKRVAKAIATNEKEEEMFYKVMSEWKFIPGGRILAGAGTGREVTYFNCFVIPVEANDPKKGNDSRAAIMDTIAKMLEIN
SRGGGVGINWSTLRPRGAYVKGVGGTSSGAVSWMLAANEVATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQ
ANLSVAVSDAFMEAVAQDKMWKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKIVTAAWESAEPGVVF
LERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAFVENGKINFEELEETVKIAVRFLDNVLDLGAYVLPQNK
EMAQKLRRVGLGLMGLADALILMNLRYGSEESLKATEEIVRRIRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRLPK
DIRDEIAKYGIRNATILTQAPTGTTSILAGVSSGIEPNFAKEYVRKDRTGTHTVKHWLADYPAFVSAHEVTPEEHVKMQA
VLQKYIDSSISKTINLPRTATVDDIDNIYRLAYELGCKGITVYRDGSREGVLVTDTKPQEKTKITERPPVLKGITKRIET
PLGRAYVTINFIDNKPFEVFVNIGRAGSDVAAFTEAIARLISLALRGGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDA
IGKALRNGYEQQGNSVKVSATNVDICPVCGMATFVYTEGCKTCLNCGYSQC
>Mature_691_residues
MFKRVAKAIATNEKEEEMFYKVMSEWKFIPGGRILAGAGTGREVTYFNCFVIPVEANDPKKGNDSRAAIMDTIAKMLEIN
SRGGGVGINWSTLRPRGAYVKGVGGTSSGAVSWMLAANEVATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQ
ANLSVAVSDAFMEAVAQDKMWKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKIVTAAWESAEPGVVF
LERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAFVENGKINFEELEETVKIAVRFLDNVLDLGAYVLPQNK
EMAQKLRRVGLGLMGLADALILMNLRYGSEESLKATEEIVRRIRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRLPK
DIRDEIAKYGIRNATILTQAPTGTTSILAGVSSGIEPNFAKEYVRKDRTGTHTVKHWLADYPAFVSAHEVTPEEHVKMQA
VLQKYIDSSISKTINLPRTATVDDIDNIYRLAYELGCKGITVYRDGSREGVLVTDTKPQEKTKITERPPVLKGITKRIET
PLGRAYVTINFIDNKPFEVFVNIGRAGSDVAAFTEAIARLISLALRGGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDA
IGKALRNGYEQQGNSVKVSATNVDICPVCGMATFVYTEGCKTCLNCGYSQC

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=561, Percent_Identity=28.1639928698752, Blast_Score=205, Evalue=9e-53,
Organism=Escherichia coli, GI1789030, Length=570, Percent_Identity=24.2105263157895, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI2367133, Length=569, Percent_Identity=24.4288224956063, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17555242, Length=527, Percent_Identity=29.0322580645161, Blast_Score=197, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322123, Length=480, Percent_Identity=30.8333333333333, Blast_Score=198, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320914, Length=484, Percent_Identity=30.3719008264463, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17352481, Length=486, Percent_Identity=28.8065843621399, Blast_Score=192, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 76383; Mature: 76383

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKRVAKAIATNEKEEEMFYKVMSEWKFIPGGRILAGAGTGREVTYFNCFVIPVEANDPK
CHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEEEECCCCC
KGNDSRAAIMDTIAKMLEINSRGGGVGINWSTLRPRGAYVKGVGGTSSGAVSWMLAANEV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHH
ATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQANLSVAVSDAFMEAVAQDKM
HHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCE
WKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKIVTAAWESAEPGVVF
EEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEE
LERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAFVENGKINFEELEETVKI
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
AVRFLDNVLDLGAYVLPQNKEMAQKLRRVGLGLMGLADALILMNLRYGSEESLKATEEIV
HHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RRIRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRLPKDIRDEIAKYGIRNATILTQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PTGTTSILAGVSSGIEPNFAKEYVRKDRTGTHTVKHWLADYPAFVSAHEVTPEEHVKMQA
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHH
VLQKYIDSSISKTINLPRTATVDDIDNIYRLAYELGCKGITVYRDGSREGVLVTDTKPQE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCH
KTKITERPPVLKGITKRIETPLGRAYVTINFIDNKPFEVFVNIGRAGSDVAAFTEAIARL
HCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHH
ISLALRGGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDAIGKALRNGYEQQGNSVKVSA
HHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCEEECCHHHHHHHHCCHHHCCCEEEEEE
TNVDICPVCGMATFVYTEGCKTCLNCGYSQC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKRVAKAIATNEKEEEMFYKVMSEWKFIPGGRILAGAGTGREVTYFNCFVIPVEANDPK
CHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEEEECCCCC
KGNDSRAAIMDTIAKMLEINSRGGGVGINWSTLRPRGAYVKGVGGTSSGAVSWMLAANEV
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHH
ATQVEQGGSRRAALMFMLWDWHPDIEEFIKVKKDLTKMQQANLSVAVSDAFMEAVAQDKM
HHHHHCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCE
WKLEFPDTSHPNYDAEWKGDLNEWKAKGYPTVVYKEIPARELWNKIVTAAWESAEPGVVF
EEEECCCCCCCCCCCCCCCCHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEE
LERYNKLSNTYYITKIISTNPCGELGLEPYGVCNLGAINLVAFVENGKINFEELEETVKI
HHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHH
AVRFLDNVLDLGAYVLPQNKEMAQKLRRVGLGLMGLADALILMNLRYGSEESLKATEEIV
HHHHHHHHHHCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RRIRDAAYRASVELAKEKGPFPEFVADKYLKGQFIQRLPKDIRDEIAKYGIRNATILTQA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PTGTTSILAGVSSGIEPNFAKEYVRKDRTGTHTVKHWLADYPAFVSAHEVTPEEHVKMQA
CCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHH
VLQKYIDSSISKTINLPRTATVDDIDNIYRLAYELGCKGITVYRDGSREGVLVTDTKPQE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCH
KTKITERPPVLKGITKRIETPLGRAYVTINFIDNKPFEVFVNIGRAGSDVAAFTEAIARL
HCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHH
ISLALRGGVAVEDIIEQLVGIGGATTIGFGENRVLSVPDAIGKALRNGYEQQGNSVKVSA
HHHHHHCCCCHHHHHHHHHCCCCCEEECCCCCCEEECCHHHHHHHHCCHHHCCCEEEEEE
TNVDICPVCGMATFVYTEGCKTCLNCGYSQC
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]