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The map label for this gene is yhcK [H]

Identifier: 20808701

GI number: 20808701

Start: 2218765

End: 2220426

Strand: Reverse

Name: yhcK [H]

Synonym: TTE2335

Alternate gene names: 20808701

Gene position: 2220426-2218765 (Counterclockwise)

Preceding gene: 20808702

Following gene: 20808700

Centisome position: 82.56

GC content: 37.42

Gene sequence:

>1662_bases
ATGGGAAAGTACAGAGAGTACCTTTTCAATACTGCTCTAATTGCCACAGGTGGGTTGGTTTTTGCATTTGCGCTTTATCA
CTATGGATTAGGGATAGATTTTAGACTTTTTTTGATACTGCTCTTATTTGCTATAATTTTAGACAATCTTGGCATAATGT
ACACAGATATTAAGCTGTCTTTAAGCCCAAGTGTTGGAATTGCAGCCTTTTTGATTTTTGGTACAGTGGGTGCGGCTACT
TTGATGGTGACATCTGTAATGTTTGATACCATCGTAATGAGAAGGAAGATAAAAAATGGCTTTTTAAATGGAGCGATGTT
TGCGCTGTCTTACCTTCCTGCAGGATGGTTGTATGAATTCATGGGGGGAAAAATAGGCGAAATTTCTATTGCACAGGTTA
AGTACATTTTAGTTTACGTGATTGTGAGCTTTTTGATAAACAATTTTATACTCTATTATGCTCTTAAGGTGCAGGGGAAA
ATATTGTTCAAAGAGTACTGGAATGAGAGTGTACTTTTAGAACTTGGCACATATGTGTTAATGGTGCCAGCAGCTATGTT
GCTTGCATATGTGTATTTTAAACACAGCTTAATGTTCTTTGTATTGTCCCTTACGCCCCTCGTATTTATAGCTTATGTAT
TCAGAATGGTTAGAGATTTAGTTAAGGCAAATAAAAGGCTGAATGCCATATACGAAATGGTAAAAATGATAAATTCAAAG
CTGGAGCTGGACCAGATATTAGATACTATCGTAGAAGTTATATCTCAAGTTGTAGCTGTTTCCGCAGCAGCTATATACCT
CACAGATTCTAACGGAATTGCTACTTTAGTCAAAGCTGTTGGCGGTAAAGGGAAAGAAGGGTTTAGAGAGAGCTATTTCA
AAGGAGAGGGCTTGATAGGCAAAGTAATATCTTCTAATAAGATAGTTGCCATAAAGAATTTAAAAGAAGATAGAAGCCTA
GATAGAGAAAAGATTTTTGCCAATTACGGAAGCTTGATTGCTGCACCGTTAAGAAGTTCTGGAGTACCTATAGGATGCCT
TTTGATATTGCATGTTGAAACGAATGCATTTGATGACGATTCAGTAAGAATTATAGAAATCATTGTAGATCAGGCTTCTG
TCGCAATAACAAACGCTAAAAAGTATTACGAAGTAACGAGAAAGTCTATAACTGATCCCCTTACAAAAACTTATAACAGG
CGCTACTTTAACGACGCTCTTATGGAAAATATAATGAGGGCAGATGAAAACAATGAGCCTGTAAGCCTTATAATGTTTGA
TTTGGACAATTTTAAGCAGATAAACGACACATACGGGCATTTGATTGGCGATGAGGTGTTAAAAGAAGTGGCAAGGCGCA
TAAAAAACAATGTGAGGAGCAATGACATTGTAGCGAGATTTGGCGGAGAAGAATTTGCTGTGATTTTGCCAAAGCTTACA
GCAGAGCAAGCCTATATGATTGCAGAAAGAATCAGGACAGAGGTTTCTTCCAAGCCTATAAAAACTGAAAAAGGAGACAT
ATACGTTACAATAACAGGTGGAGTTGCTGATTACCCGAGTAAAGCTGATTCTGCAGAAAAGCTTGTAAGCCATGCAGATA
GAGCTTTATACGCGGGAGGAAAAAGCAAGGGCAGAAATAAAATTGCCATATATGAAGTCTAG

Upstream 100 bases:

>100_bases
AATTTCCTGTGACAGATGTCGTAAACAATTGTAAGCGTAAGAAGGATTTTTAAAATAAATGTAGAATACTTATATAATTC
GGAAAAACGAGGGGATTAGT

Downstream 100 bases:

>100_bases
AGGCCAGGGAATTTTTTCTTGGCTTTTTTATTTTACCTTTGTGCAAAAGTTTCGCATTGAAGTGAAAACTGTGCTATAAT
AAACCTTAGAACTAATTTCG

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MGKYREYLFNTALIATGGLVFAFALYHYGLGIDFRLFLILLLFAIILDNLGIMYTDIKLSLSPSVGIAAFLIFGTVGAAT
LMVTSVMFDTIVMRRKIKNGFLNGAMFALSYLPAGWLYEFMGGKIGEISIAQVKYILVYVIVSFLINNFILYYALKVQGK
ILFKEYWNESVLLELGTYVLMVPAAMLLAYVYFKHSLMFFVLSLTPLVFIAYVFRMVRDLVKANKRLNAIYEMVKMINSK
LELDQILDTIVEVISQVVAVSAAAIYLTDSNGIATLVKAVGGKGKEGFRESYFKGEGLIGKVISSNKIVAIKNLKEDRSL
DREKIFANYGSLIAAPLRSSGVPIGCLLILHVETNAFDDDSVRIIEIIVDQASVAITNAKKYYEVTRKSITDPLTKTYNR
RYFNDALMENIMRADENNEPVSLIMFDLDNFKQINDTYGHLIGDEVLKEVARRIKNNVRSNDIVARFGGEEFAVILPKLT
AEQAYMIAERIRTEVSSKPIKTEKGDIYVTITGGVADYPSKADSAEKLVSHADRALYAGGKSKGRNKIAIYEV

Sequences:

>Translated_553_residues
MGKYREYLFNTALIATGGLVFAFALYHYGLGIDFRLFLILLLFAIILDNLGIMYTDIKLSLSPSVGIAAFLIFGTVGAAT
LMVTSVMFDTIVMRRKIKNGFLNGAMFALSYLPAGWLYEFMGGKIGEISIAQVKYILVYVIVSFLINNFILYYALKVQGK
ILFKEYWNESVLLELGTYVLMVPAAMLLAYVYFKHSLMFFVLSLTPLVFIAYVFRMVRDLVKANKRLNAIYEMVKMINSK
LELDQILDTIVEVISQVVAVSAAAIYLTDSNGIATLVKAVGGKGKEGFRESYFKGEGLIGKVISSNKIVAIKNLKEDRSL
DREKIFANYGSLIAAPLRSSGVPIGCLLILHVETNAFDDDSVRIIEIIVDQASVAITNAKKYYEVTRKSITDPLTKTYNR
RYFNDALMENIMRADENNEPVSLIMFDLDNFKQINDTYGHLIGDEVLKEVARRIKNNVRSNDIVARFGGEEFAVILPKLT
AEQAYMIAERIRTEVSSKPIKTEKGDIYVTITGGVADYPSKADSAEKLVSHADRALYAGGKSKGRNKIAIYEV
>Mature_552_residues
GKYREYLFNTALIATGGLVFAFALYHYGLGIDFRLFLILLLFAIILDNLGIMYTDIKLSLSPSVGIAAFLIFGTVGAATL
MVTSVMFDTIVMRRKIKNGFLNGAMFALSYLPAGWLYEFMGGKIGEISIAQVKYILVYVIVSFLINNFILYYALKVQGKI
LFKEYWNESVLLELGTYVLMVPAAMLLAYVYFKHSLMFFVLSLTPLVFIAYVFRMVRDLVKANKRLNAIYEMVKMINSKL
ELDQILDTIVEVISQVVAVSAAAIYLTDSNGIATLVKAVGGKGKEGFRESYFKGEGLIGKVISSNKIVAIKNLKEDRSLD
REKIFANYGSLIAAPLRSSGVPIGCLLILHVETNAFDDDSVRIIEIIVDQASVAITNAKKYYEVTRKSITDPLTKTYNRR
YFNDALMENIMRADENNEPVSLIMFDLDNFKQINDTYGHLIGDEVLKEVARRIKNNVRSNDIVARFGGEEFAVILPKLTA
EQAYMIAERIRTEVSSKPIKTEKGDIYVTITGGVADYPSKADSAEKLVSHADRALYAGGKSKGRNKIAIYEV

Specific function: Unknown

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI145693134, Length=173, Percent_Identity=37.5722543352601, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1787262, Length=164, Percent_Identity=37.8048780487805, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1787802, Length=193, Percent_Identity=34.1968911917098, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786584, Length=181, Percent_Identity=31.4917127071823, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082007, Length=163, Percent_Identity=37.4233128834356, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787816, Length=181, Percent_Identity=37.0165745856354, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788381, Length=178, Percent_Identity=32.0224719101124, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87081881, Length=174, Percent_Identity=36.2068965517241, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787541, Length=187, Percent_Identity=31.0160427807487, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788085, Length=170, Percent_Identity=32.3529411764706, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081974, Length=124, Percent_Identity=34.6774193548387, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787056, Length=173, Percent_Identity=34.1040462427746, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788956, Length=165, Percent_Identity=31.5151515151515, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081977, Length=167, Percent_Identity=31.1377245508982, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 61769; Mature: 61638

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKYREYLFNTALIATGGLVFAFALYHYGLGIDFRLFLILLLFAIILDNLGIMYTDIKLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEE
LSPSVGIAAFLIFGTVGAATLMVTSVMFDTIVMRRKIKNGFLNGAMFALSYLPAGWLYEF
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHH
MGGKIGEISIAQVKYILVYVIVSFLINNFILYYALKVQGKILFKEYWNESVLLELGTYVL
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHCCCHHHHHHHHHHH
MVPAAMLLAYVYFKHSLMFFVLSLTPLVFIAYVFRMVRDLVKANKRLNAIYEMVKMINSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LELDQILDTIVEVISQVVAVSAAAIYLTDSNGIATLVKAVGGKGKEGFRESYFKGEGLIG
CHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHCCCCCEE
KVISSNKIVAIKNLKEDRSLDREKIFANYGSLIAAPLRSSGVPIGCLLILHVETNAFDDD
HEECCCCEEEEECCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCC
SVRIIEIIVDQASVAITNAKKYYEVTRKSITDPLTKTYNRRYFNDALMENIMRADENNEP
CCEEEEEEHHCHHHEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VSLIMFDLDNFKQINDTYGHLIGDEVLKEVARRIKNNVRSNDIVARFGGEEFAVILPKLT
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCHH
AEQAYMIAERIRTEVSSKPIKTEKGDIYVTITGGVADYPSKADSAEKLVSHADRALYAGG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCC
KSKGRNKIAIYEV
CCCCCCCEEEEEC
>Mature Secondary Structure 
GKYREYLFNTALIATGGLVFAFALYHYGLGIDFRLFLILLLFAIILDNLGIMYTDIKLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEE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CCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]