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The map label for this gene is MntA2

Identifier: 20808692

GI number: 20808692

Start: 2207270

End: 2208535

Strand: Reverse

Name: MntA2

Synonym: TTE2326

Alternate gene names: 20808692

Gene position: 2208535-2207270 (Counterclockwise)

Preceding gene: 20808693

Following gene: 20808691

Centisome position: 82.12

GC content: 39.34

Gene sequence:

>1266_bases
TTGGAGACGAGGGAAATTGCGTCTCAAAGAAGAAAAAATTTGTATTTGGGAATAGAGTTAAAAAAATTTCTAAAATATTT
AGGACCCGCTTTTATTGTGAGCGTTGCCTATGTTGACCCGGGGAATTTTGCGACAAACATAAGCGGAGGTTCTCTTTTTG
ATTATCACTTGATATGGGTCATACTCTGGAGCAATGTCATAGCCATATTTCTGCAGATACAGTCGGCAAAGCTCGGTATT
GCCACAGGATACAATTTGCCAGAGATGTGCAGCATAATATTTCCGAGGAAGTGGAATTGGTTTTTGTGGATAACGGCAGA
ATTAGCTGCTATGGCTACAGACCTTGCAGAATTTTTAGGGGGGACTATGGGACTTTACTTGCTTTTTCACATTCCCATGA
CGTATGCTGCTTTCTTGACAGGAGTGGTGACATTTGCAATAGTGTACATGGAAAAATATGGGCAGAAAGTGGTGGAGGGT
ATTATTTTTGGTTTAGTGGCAGTCATAAGTCTTGCTTACGCCTTTGAGCTTTTTATTGCAAGGCCTGATTGGAGCAAAGT
TTTATACCATACTTTCATTCCTTCTATTCCCAATAAAGACGCTATGCTGATTGCCGTAGGTATATTGGGTGCTACTGTAA
TGCCTCATGTTATATATTTGCACTCTCAATTAGTGCAGTACAGAAACAAGGATGGCAGTCTACAGGCTAAGAAAGAGCAT
TTAAAAATGGAGAAAATAGATATACTTGTTGCTATGAACACAGCGTTTATAATAAATGCAGCAATGCTTATAGTGTCAGC
GGCAGTTTTTTACAAAAACGGTATTGTCATTGAATCCATAGAAGAAGCTCATAAAACGCTGGAACCGCTGTTAGGGGTCT
TCTCAAGCTGGGCTTTTGGAATTGCTCTTTTGGCGTCAGGTTTTTCTTCCTCTGCAGTAGGGACTATGGCAGGACAGACG
ATAATGAAAGGATTTGTAGGTCTTAATATTCCGCTTAATGTAAGAAGGCTTGTCACAATGGTTCCAGCTATTACAATAAT
TGCTCTGGGAATTGATCCGTTGAAAAGTTTGATAGTGAGTCAGGTGGTATTAAGTTTTGAACTGCCTATGGCTATCATCC
CTCTCCTTCTTATTACCTCTAATAAAAAATTTATGAAGGAATTTGCTGATACGCCTTTGGAGAGGATTATGGGAGTGTTA
GTGGCCTCTTTTGTGATGATATTGAACGGGTTACTTCTTTATTTAACTTTAAAGGGAGAAGTTTAA

Upstream 100 bases:

>100_bases
ACTGGCTAGGCCTTTTTTATTTTTTTGCACAAGGACAAATAAAAGCACATATTGTTAGTAAAGTGAGCTGGTGTGTTTTT
TAAGATGAGGGGGGATTTTG

Downstream 100 bases:

>100_bases
GTGGTATAATTTAAACAAGCAAAGCATTTTTGAAAGATGGTGGAGAGATGAAGAAGTCGACCACAAAATTTGTATGCAGA
GAATGCGGATTTGAGAGCAG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
METREIASQRRKNLYLGIELKKFLKYLGPAFIVSVAYVDPGNFATNISGGSLFDYHLIWVILWSNVIAIFLQIQSAKLGI
ATGYNLPEMCSIIFPRKWNWFLWITAELAAMATDLAEFLGGTMGLYLLFHIPMTYAAFLTGVVTFAIVYMEKYGQKVVEG
IIFGLVAVISLAYAFELFIARPDWSKVLYHTFIPSIPNKDAMLIAVGILGATVMPHVIYLHSQLVQYRNKDGSLQAKKEH
LKMEKIDILVAMNTAFIINAAMLIVSAAVFYKNGIVIESIEEAHKTLEPLLGVFSSWAFGIALLASGFSSSAVGTMAGQT
IMKGFVGLNIPLNVRRLVTMVPAITIIALGIDPLKSLIVSQVVLSFELPMAIIPLLLITSNKKFMKEFADTPLERIMGVL
VASFVMILNGLLLYLTLKGEV

Sequences:

>Translated_421_residues
METREIASQRRKNLYLGIELKKFLKYLGPAFIVSVAYVDPGNFATNISGGSLFDYHLIWVILWSNVIAIFLQIQSAKLGI
ATGYNLPEMCSIIFPRKWNWFLWITAELAAMATDLAEFLGGTMGLYLLFHIPMTYAAFLTGVVTFAIVYMEKYGQKVVEG
IIFGLVAVISLAYAFELFIARPDWSKVLYHTFIPSIPNKDAMLIAVGILGATVMPHVIYLHSQLVQYRNKDGSLQAKKEH
LKMEKIDILVAMNTAFIINAAMLIVSAAVFYKNGIVIESIEEAHKTLEPLLGVFSSWAFGIALLASGFSSSAVGTMAGQT
IMKGFVGLNIPLNVRRLVTMVPAITIIALGIDPLKSLIVSQVVLSFELPMAIIPLLLITSNKKFMKEFADTPLERIMGVL
VASFVMILNGLLLYLTLKGEV
>Mature_421_residues
METREIASQRRKNLYLGIELKKFLKYLGPAFIVSVAYVDPGNFATNISGGSLFDYHLIWVILWSNVIAIFLQIQSAKLGI
ATGYNLPEMCSIIFPRKWNWFLWITAELAAMATDLAEFLGGTMGLYLLFHIPMTYAAFLTGVVTFAIVYMEKYGQKVVEG
IIFGLVAVISLAYAFELFIARPDWSKVLYHTFIPSIPNKDAMLIAVGILGATVMPHVIYLHSQLVQYRNKDGSLQAKKEH
LKMEKIDILVAMNTAFIINAAMLIVSAAVFYKNGIVIESIEEAHKTLEPLLGVFSSWAFGIALLASGFSSSAVGTMAGQT
IMKGFVGLNIPLNVRRLVTMVPAITIIALGIDPLKSLIVSQVVLSFELPMAIIPLLLITSNKKFMKEFADTPLERIMGVL
VASFVMILNGLLLYLTLKGEV

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=426, Percent_Identity=32.1596244131455, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI295293178, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI295293167, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI295293171, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI295293169, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI295293175, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI295293173, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI10835169, Length=433, Percent_Identity=30.4849884526559, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=43, Blast_Score=332, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17569473, Length=377, Percent_Identity=32.6259946949602, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71999499, Length=454, Percent_Identity=28.1938325991189, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI193210616, Length=446, Percent_Identity=27.3542600896861, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71993856, Length=233, Percent_Identity=30.0429184549356, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323062, Length=400, Percent_Identity=35.5, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324450, Length=446, Percent_Identity=32.0627802690583, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321841, Length=409, Percent_Identity=34.718826405868, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24648607, Length=439, Percent_Identity=30.751708428246, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281362176, Length=439, Percent_Identity=30.751708428246, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24648609, Length=439, Percent_Identity=30.751708428246, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI45553443, Length=420, Percent_Identity=31.1904761904762, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_THETN (Q8R7S2)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623863.1
- GeneID:   995534
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2326
- NMPDR:   fig|273068.3.peg.2503
- HOGENOM:   HBG312498
- OMA:   DERSNIG
- ProtClustDB:   PRK00701
- BioCyc:   TTEN273068:TTE2326-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447
- TIGRFAMs:   TIGR01197

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 46518; Mature: 46518

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfac6710)-; HASH(0x1055105c)-; HASH(0xeb7b4ec)-; HASH(0x1016b164)-; HASH(0xcfc4d64)-; HASH(0x104cccc8)-; HASH(0x10279ee0)-; HASH(0xed22598)-; HASH(0xc9f22c0)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METREIASQRRKNLYLGIELKKFLKYLGPAFIVSVAYVDPGNFATNISGGSLFDYHLIWV
CCCHHHHHHHHCCEEEEEEHHHHHHHHCHHHEEEEEEECCCCCEECCCCCCHHHHHHHHH
ILWSNVIAIFLQIQSAKLGIATGYNLPEMCSIIFPRKWNWFLWITAELAAMATDLAEFLG
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
GTMGLYLLFHIPMTYAAFLTGVVTFAIVYMEKYGQKVVEGIIFGLVAVISLAYAFELFIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
RPDWSKVLYHTFIPSIPNKDAMLIAVGILGATVMPHVIYLHSQLVQYRNKDGSLQAKKEH
CCCHHHHHHHHHCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LKMEKIDILVAMNTAFIINAAMLIVSAAVFYKNGIVIESIEEAHKTLEPLLGVFSSWAFG
HHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IALLASGFSSSAVGTMAGQTIMKGFVGLNIPLNVRRLVTMVPAITIIALGIDPLKSLIVS
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QVVLSFELPMAIIPLLLITSNKKFMKEFADTPLERIMGVLVASFVMILNGLLLYLTLKGE
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCC
V
H
>Mature Secondary Structure
METREIASQRRKNLYLGIELKKFLKYLGPAFIVSVAYVDPGNFATNISGGSLFDYHLIWV
CCCHHHHHHHHCCEEEEEEHHHHHHHHCHHHEEEEEEECCCCCEECCCCCCHHHHHHHHH
ILWSNVIAIFLQIQSAKLGIATGYNLPEMCSIIFPRKWNWFLWITAELAAMATDLAEFLG
HHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHH
GTMGLYLLFHIPMTYAAFLTGVVTFAIVYMEKYGQKVVEGIIFGLVAVISLAYAFELFIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
RPDWSKVLYHTFIPSIPNKDAMLIAVGILGATVMPHVIYLHSQLVQYRNKDGSLQAKKEH
CCCHHHHHHHHHCCCCCCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LKMEKIDILVAMNTAFIINAAMLIVSAAVFYKNGIVIESIEEAHKTLEPLLGVFSSWAFG
HHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHH
IALLASGFSSSAVGTMAGQTIMKGFVGLNIPLNVRRLVTMVPAITIIALGIDPLKSLIVS
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QVVLSFELPMAIIPLLLITSNKKFMKEFADTPLERIMGVLVASFVMILNGLLLYLTLKGE
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEEECCC
V
H

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336