Click here to switch to the map view.

The map label for this gene is AhpC2 [C]

Identifier: 20808569

GI number: 20808569

Start: 2098109

End: 2098774

Strand: Direct

Name: AhpC2 [C]

Synonym: TTE2186

Alternate gene names: 20808569

Gene position: 2098109-2098774 (Clockwise)

Preceding gene: 20808568

Following gene: 20808596

Centisome position: 78.01

GC content: 39.04

Gene sequence:

>666_bases
ATGGAAACAGAAGCAATAGAAAATATACCAAGAGTCTGTCTCCCTCAGATAGGAGCTCCGGCTCCCGACTTTAAAGCCAA
CAGCACGTTTGGTCCTATTAAACTTTCCGATTACCGCGGAAAATGGGTAGTGCTTTTTTCTCACCCGGGGGATTTTACAC
CTGTATGTACTACAGAATTCATAGCCTTCACACAGGTTTATACTAGTTTTGTAGAAAGAAACGTACAGTTAATAGGCTTA
AGCGTGGACAGCAATCCTTCTCATCTTGCTTGGGTTGAAAATATATATAAAACCACAGGTGTAGAAATTCCCTTCCCTAT
AATTGAAGACAAAGACATGAGAATTGCAAAACTATACGGAATGATATCTCCTGCAGAAACTTCTACAAGCGCTGTCAGAG
CAGTATTTATAATAGATGATAAGCAAATACTCCGCCTCATCCTCTACTATCCGCTAGAAATAGGAAGAAATATACAGGAA
ATAATACGAATAATAGATGCTCTCCAAACAGTGGATAAATACAAAGTTTTGGCTCCTGCTAATTGGTATCCTGGAATGCC
TGTAATTGTACCTCCTCCAAAAACTTATCCCGAACTTAAACAAAGGCTTAAAAACGTCGAAGGGTACACTTGCACAGACT
GGTACTTGTGCTATAAAAAAGTTTAA

Upstream 100 bases:

>100_bases
TTCTACTTATCATAGCCTATAAAGCGCTGTTTTAGCAATAACATATCTTTTGATTTGCGAATATAATGTAGTAGTCAAGT
AAAAGCTAAGAGGTGATTAT

Downstream 100 bases:

>100_bases
GCCGGAAATCCGGCTTAAACTTTTTTACTTGTTCTGGAAGTCATACACCATAGTTCCTGTGTACAAAAGTCTTGACCCAA
AAGAAAATTTAGGCAAACTT

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
METEAIENIPRVCLPQIGAPAPDFKANSTFGPIKLSDYRGKWVVLFSHPGDFTPVCTTEFIAFTQVYTSFVERNVQLIGL
SVDSNPSHLAWVENIYKTTGVEIPFPIIEDKDMRIAKLYGMISPAETSTSAVRAVFIIDDKQILRLILYYPLEIGRNIQE
IIRIIDALQTVDKYKVLAPANWYPGMPVIVPPPKTYPELKQRLKNVEGYTCTDWYLCYKKV

Sequences:

>Translated_221_residues
METEAIENIPRVCLPQIGAPAPDFKANSTFGPIKLSDYRGKWVVLFSHPGDFTPVCTTEFIAFTQVYTSFVERNVQLIGL
SVDSNPSHLAWVENIYKTTGVEIPFPIIEDKDMRIAKLYGMISPAETSTSAVRAVFIIDDKQILRLILYYPLEIGRNIQE
IIRIIDALQTVDKYKVLAPANWYPGMPVIVPPPKTYPELKQRLKNVEGYTCTDWYLCYKKV
>Mature_221_residues
METEAIENIPRVCLPQIGAPAPDFKANSTFGPIKLSDYRGKWVVLFSHPGDFTPVCTTEFIAFTQVYTSFVERNVQLIGL
SVDSNPSHLAWVENIYKTTGVEIPFPIIEDKDMRIAKLYGMISPAETSTSAVRAVFIIDDKQILRLILYYPLEIGRNIQE
IIRIIDALQTVDKYKVLAPANWYPGMPVIVPPPKTYPELKQRLKNVEGYTCTDWYLCYKKV

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI4758638, Length=191, Percent_Identity=41.8848167539267, Blast_Score=147, Evalue=6e-36,
Organism=Homo sapiens, GI4505591, Length=182, Percent_Identity=43.956043956044, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI32455266, Length=182, Percent_Identity=43.956043956044, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI32455264, Length=182, Percent_Identity=43.956043956044, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI32189392, Length=181, Percent_Identity=41.4364640883978, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI5453549, Length=183, Percent_Identity=39.8907103825137, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI5802974, Length=195, Percent_Identity=34.8717948717949, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI32483377, Length=189, Percent_Identity=35.4497354497354, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI33188454, Length=83, Percent_Identity=51.8072289156626, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1786822, Length=166, Percent_Identity=28.9156626506024, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204376, Length=187, Percent_Identity=40.6417112299465, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI32565831, Length=187, Percent_Identity=40.6417112299465, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25153706, Length=191, Percent_Identity=36.6492146596859, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17554494, Length=182, Percent_Identity=34.0659340659341, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319407, Length=196, Percent_Identity=45.4081632653061, Blast_Score=168, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6323613, Length=183, Percent_Identity=36.6120218579235, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320661, Length=197, Percent_Identity=34.010152284264, Blast_Score=112, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17157991, Length=190, Percent_Identity=42.6315789473684, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24641739, Length=190, Percent_Identity=42.6315789473684, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24652436, Length=196, Percent_Identity=41.3265306122449, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24652434, Length=196, Percent_Identity=41.3265306122449, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17975518, Length=196, Percent_Identity=41.3265306122449, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24581278, Length=197, Percent_Identity=38.5786802030457, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24656348, Length=183, Percent_Identity=39.8907103825137, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17864676, Length=183, Percent_Identity=39.8907103825137, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17738015, Length=183, Percent_Identity=38.2513661202186, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357347, Length=179, Percent_Identity=33.5195530726257, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): TDXH2_THETN (Q8R844)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623740.1
- ProteinModelPortal:   Q8R844
- SMR:   Q8R844
- GeneID:   997506
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2186
- NMPDR:   fig|273068.3.peg.2326
- HOGENOM:   HBG493509
- OMA:   DFEARST
- ProtClustDB:   PRK13189
- BioCyc:   TTEN273068:TTE2186-MONOMER
- BRENDA:   1.11.1.15
- HAMAP:   MF_00401
- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA; SSF52833 Thiordxn-like_fd

EC number: =1.11.1.15

Molecular weight: Translated: 25136; Mature: 25136

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS51352 THIOREDOXIN_2

Important sites: ACT_SITE 56-56

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METEAIENIPRVCLPQIGAPAPDFKANSTFGPIKLSDYRGKWVVLFSHPGDFTPVCTTEF
CCCHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHH
IAFTQVYTSFVERNVQLIGLSVDSNPSHLAWVENIYKTTGVEIPFPIIEDKDMRIAKLYG
HHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHH
MISPAETSTSAVRAVFIIDDKQILRLILYYPLEIGRNIQEIIRIIDALQTVDKYKVLAPA
CCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECC
NWYPGMPVIVPPPKTYPELKQRLKNVEGYTCTDWYLCYKKV
CCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEHEEEEEECC
>Mature Secondary Structure
METEAIENIPRVCLPQIGAPAPDFKANSTFGPIKLSDYRGKWVVLFSHPGDFTPVCTTEF
CCCHHHHHCCHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHH
IAFTQVYTSFVERNVQLIGLSVDSNPSHLAWVENIYKTTGVEIPFPIIEDKDMRIAKLYG
HHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHH
MISPAETSTSAVRAVFIIDDKQILRLILYYPLEIGRNIQEIIRIIDALQTVDKYKVLAPA
CCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECC
NWYPGMPVIVPPPKTYPELKQRLKNVEGYTCTDWYLCYKKV
CCCCCCCEEECCCCCCHHHHHHHHCCCCCEEEHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336