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The map label for this gene is NhaC [H]

Identifier: 20808543

GI number: 20808543

Start: 2078242

End: 2079630

Strand: Direct

Name: NhaC [H]

Synonym: TTE2156

Alternate gene names: 20808543

Gene position: 2078242-2079630 (Clockwise)

Preceding gene: 20808542

Following gene: 20808544

Centisome position: 77.27

GC content: 35.57

Gene sequence:

>1389_bases
ATGCAGAACAAATTTGGATTTTCCCTTTCAATTTTTCTGTTCACATTAATTCTCACCATGACAATGGTTCTATTTTTCCA
TAAACCACCTTATATTCCTCTTTTTATAAGCTATATGTTTACATTTTTTGCTTTATTAAAATACTTCTCCGCCAAGGAAC
TACTAAACATGTCCCTAAAAGGTGTAAAAAGAGGGATAAACGTGATGATAATACTGCTTCTTATAGGAGCACTAGTCGCA
CTCTGGAAGCAAAATGGAACACTTCCAGCCCTTATATACTACTTTTCCCGCTTTTTAAAGCCACATGGATTCCTTTTGAC
CTCTTTTGTCATCACCTCAACAATATCCATGATTCTGGGAACCGCTGTGGGAACAGCCAGCACCATTGGAATAGTAATAA
TTGGACTTGCTCATGCCTTTGGATACCCTCTCCCTGTAGTGGCTGGTGCTGTAATTTCGGGTTCTTTCATAGGAGACAGA
ACATCCCCTTTGGCAGGAAATGTAGCTCTTCTTTCCGATATGGGAGAAATACAGCAGTACAATGTATTAAAATCTCTGTT
TAAAACGGCAATTCCTGTATTTACAATTACAGCTTTTTTGTACTACCTCTTTGACTATCATTTAAATTTTTCTGCCAAAT
ATGACATTAGCAATCTCTTCACAATAATAGTACAGAGCTATCGATTAAGTGCAATATTATTCATCGCACCGCTCACAATA
ATAATATTGGCCCTTTTTAGAATCCCTACAAAGACAAATCTTGCAATTGCTGTATCAATTTCCTTCTTAAGTTCAATAAT
TTTGGGGTACTCTCCTCTTGACTCATTAAAAGTAATTCTTATAGGAAATACCTTTTATTCTCCCGAATTTAAGTCCATTT
TTAGCGGTGGCGGAATGGTTTCAATCCTCCCAATGATAGGAGTAGTAACCTTTGCTACTGCTTTGGCAGGAATATTAGAA
GATGCAGGAATAATAAAAAGTGTATTTCAAAGCATAGATAAAATTAAAAATTTCAAACTTGCCTATTTAATCACTATGCT
TTTAAGTACTCTCATGGCAGTAATAACCTGCAACCAAGCTTTATCCGTAATTTTGCCCTCGCGAATAATGATAAACGTAT
ATGAAAGATTAGAAATTGCAAGAGAAGAAATGGTAAGAGCCATAGCAGATTCTGGAATGATACTGGCGGGAATAATACCC
TGGAATTTGGCAGCCATGCTACCTGCTGCAGTATTAGGAGTAAAAGTAACTGAATATTTGCCCTATGCATACCTAAACCT
TTTATTTCCCCTCTTATCAATAGCTTTTGTTTTTGCAAAAGACGCAAATGAGTTGATAAAATTTTATCAAAAATTTGTTG
AAAAGGGGAGAAATTTATTGCAAAATTAA

Upstream 100 bases:

>100_bases
GTTTAGAGGCTCTACTGTAATAAAATTGATTAAAAAAGCTAAAAATATCGAGATACACGTAATTCCTTACACAAAATAAA
AGCTCAAGGGGTAATGAAAA

Downstream 100 bases:

>100_bases
ATATGTAAAGTTTAAAAACAGGGGGGAATAAAAGGCTATGGTAGATGTAATAGAACTAGCTGCTCATTTAATGGCTTTAT
CAGCTCGAACAGCTCCTAAA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQNKFGFSLSIFLFTLILTMTMVLFFHKPPYIPLFISYMFTFFALLKYFSAKELLNMSLKGVKRGINVMIILLLIGALVA
LWKQNGTLPALIYYFSRFLKPHGFLLTSFVITSTISMILGTAVGTASTIGIVIIGLAHAFGYPLPVVAGAVISGSFIGDR
TSPLAGNVALLSDMGEIQQYNVLKSLFKTAIPVFTITAFLYYLFDYHLNFSAKYDISNLFTIIVQSYRLSAILFIAPLTI
IILALFRIPTKTNLAIAVSISFLSSIILGYSPLDSLKVILIGNTFYSPEFKSIFSGGGMVSILPMIGVVTFATALAGILE
DAGIIKSVFQSIDKIKNFKLAYLITMLLSTLMAVITCNQALSVILPSRIMINVYERLEIAREEMVRAIADSGMILAGIIP
WNLAAMLPAAVLGVKVTEYLPYAYLNLLFPLLSIAFVFAKDANELIKFYQKFVEKGRNLLQN

Sequences:

>Translated_462_residues
MQNKFGFSLSIFLFTLILTMTMVLFFHKPPYIPLFISYMFTFFALLKYFSAKELLNMSLKGVKRGINVMIILLLIGALVA
LWKQNGTLPALIYYFSRFLKPHGFLLTSFVITSTISMILGTAVGTASTIGIVIIGLAHAFGYPLPVVAGAVISGSFIGDR
TSPLAGNVALLSDMGEIQQYNVLKSLFKTAIPVFTITAFLYYLFDYHLNFSAKYDISNLFTIIVQSYRLSAILFIAPLTI
IILALFRIPTKTNLAIAVSISFLSSIILGYSPLDSLKVILIGNTFYSPEFKSIFSGGGMVSILPMIGVVTFATALAGILE
DAGIIKSVFQSIDKIKNFKLAYLITMLLSTLMAVITCNQALSVILPSRIMINVYERLEIAREEMVRAIADSGMILAGIIP
WNLAAMLPAAVLGVKVTEYLPYAYLNLLFPLLSIAFVFAKDANELIKFYQKFVEKGRNLLQN
>Mature_462_residues
MQNKFGFSLSIFLFTLILTMTMVLFFHKPPYIPLFISYMFTFFALLKYFSAKELLNMSLKGVKRGINVMIILLLIGALVA
LWKQNGTLPALIYYFSRFLKPHGFLLTSFVITSTISMILGTAVGTASTIGIVIIGLAHAFGYPLPVVAGAVISGSFIGDR
TSPLAGNVALLSDMGEIQQYNVLKSLFKTAIPVFTITAFLYYLFDYHLNFSAKYDISNLFTIIVQSYRLSAILFIAPLTI
IILALFRIPTKTNLAIAVSISFLSSIILGYSPLDSLKVILIGNTFYSPEFKSIFSGGGMVSILPMIGVVTFATALAGILE
DAGIIKSVFQSIDKIKNFKLAYLITMLLSTLMAVITCNQALSVILPSRIMINVYERLEIAREEMVRAIADSGMILAGIIP
WNLAAMLPAAVLGVKVTEYLPYAYLNLLFPLLSIAFVFAKDANELIKFYQKFVEKGRNLLQN

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50980; Mature: 50980

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNKFGFSLSIFLFTLILTMTMVLFFHKPPYIPLFISYMFTFFALLKYFSAKELLNMSLK
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVKRGINVMIILLLIGALVALWKQNGTLPALIYYFSRFLKPHGFLLTSFVITSTISMILG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TAVGTASTIGIVIIGLAHAFGYPLPVVAGAVISGSFIGDRTSPLAGNVALLSDMGEIQQY
HHHCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
NVLKSLFKTAIPVFTITAFLYYLFDYHLNFSAKYDISNLFTIIVQSYRLSAILFIAPLTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IILALFRIPTKTNLAIAVSISFLSSIILGYSPLDSLKVILIGNTFYSPEFKSIFSGGGMV
HHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHCCCCHH
SILPMIGVVTFATALAGILEDAGIIKSVFQSIDKIKNFKLAYLITMLLSTLMAVITCNQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LSVILPSRIMINVYERLEIAREEMVRAIADSGMILAGIIPWNLAAMLPAAVLGVKVTEYL
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
PYAYLNLLFPLLSIAFVFAKDANELIKFYQKFVEKGRNLLQN
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]