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The map label for this gene is HisA

Identifier: 20808524

GI number: 20808524

Start: 2050890

End: 2051612

Strand: Reverse

Name: HisA

Synonym: TTE2134

Alternate gene names: 20808524

Gene position: 2051612-2050890 (Counterclockwise)

Preceding gene: 20808525

Following gene: 20808523

Centisome position: 76.28

GC content: 34.58

Gene sequence:

>723_bases
ATGCTTGTAATACCTGCAATTGACATATTGGATGGGAAATGTGTAAGACTCACAAAAGGGAATTTTGATTCAAAAGAAGT
ATATTATGACAATCCTGCAGATATGGCTAAGATGTGGCAAGAGTGTGGTGCAAAGAGAATTCATGTAGTGGATCTGGATG
GGGCAAGGCAAGGACATTTAGTAAATAGAAAAGTTATTGAGAAAATTGTAAATAGCTGTAGTGTTGATATTGAAGTAGGT
GGAGGAATAAGGAATAAAGAGGCTTTAGATTATCTTTTTTCAATTGGAGTATCGTACATTATTTTAGGTTCTGCTGCAAT
ATATGATAAAGACCTTCTTCTTTATTCTGTCTCACATTATGGAGAAAAGACTATAGTGGGAATTGATTCAAAAAAAAGAG
AAGTTGCTGTAAGTGGATGGCTTGAAAGGACTAAAATAAAGGATACTGAGTTGGCTGAGAAGATAAAAGAGATAGGGATA
AAGACAATAATTTTTACTGATATTTCAAAAGATGGCACACTTCATGGGCCAAATTTTGAAGCTTTAAAGGATATGCTAAA
GGTAGGAGTAGAAATAATAGCTTCAGGAGGCATATCTTCAATTGAAGATTTAAAAAGGCTTAAAGATATGGGAGTTACTG
GTGCTATTATTGGGAAGGCCTTGTACACTGGTATGATAGACTTAAAAGCTGCATTGCTGGAATTAGAAAGAGAGGGAATT
TAA

Upstream 100 bases:

>100_bases
CTGTCATTATTAAAGACAATGTTTTTTCCTGTCAGTTTCATCCAGAAAAAAGCGGAGAGACAGGGCTTAAAATTTTAAAA
AATTTTGGAGAGATGATAAA

Downstream 100 bases:

>100_bases
ATGCTTGCAAAGAGAATAATACCATGTCTGGATGTTAAAGATGGAAGAGTAGTAAAAGGAATAAATTTTGTAAATTTAAA
GGATGCTGGAGACCCTGTTG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MLVIPAIDILDGKCVRLTKGNFDSKEVYYDNPADMAKMWQECGAKRIHVVDLDGARQGHLVNRKVIEKIVNSCSVDIEVG
GGIRNKEALDYLFSIGVSYIILGSAAIYDKDLLLYSVSHYGEKTIVGIDSKKREVAVSGWLERTKIKDTELAEKIKEIGI
KTIIFTDISKDGTLHGPNFEALKDMLKVGVEIIASGGISSIEDLKRLKDMGVTGAIIGKALYTGMIDLKAALLELEREGI

Sequences:

>Translated_240_residues
MLVIPAIDILDGKCVRLTKGNFDSKEVYYDNPADMAKMWQECGAKRIHVVDLDGARQGHLVNRKVIEKIVNSCSVDIEVG
GGIRNKEALDYLFSIGVSYIILGSAAIYDKDLLLYSVSHYGEKTIVGIDSKKREVAVSGWLERTKIKDTELAEKIKEIGI
KTIIFTDISKDGTLHGPNFEALKDMLKVGVEIIASGGISSIEDLKRLKDMGVTGAIIGKALYTGMIDLKAALLELEREGI
>Mature_240_residues
MLVIPAIDILDGKCVRLTKGNFDSKEVYYDNPADMAKMWQECGAKRIHVVDLDGARQGHLVNRKVIEKIVNSCSVDIEVG
GGIRNKEALDYLFSIGVSYIILGSAAIYDKDLLLYSVSHYGEKTIVGIDSKKREVAVSGWLERTKIKDTELAEKIKEIGI
KTIIFTDISKDGTLHGPNFEALKDMLKVGVEIIASGGISSIEDLKRLKDMGVTGAIIGKALYTGMIDLKAALLELEREGI

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=33.0543933054393, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1788336, Length=251, Percent_Identity=25.8964143426295, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_THETN (Q8R884)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623695.1
- ProteinModelPortal:   Q8R884
- SMR:   Q8R884
- GeneID:   997445
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2134
- NMPDR:   fig|273068.3.peg.2238
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   TTEN273068:TTE2134-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26330; Mature: 26330

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIPAIDILDGKCVRLTKGNFDSKEVYYDNPADMAKMWQECGAKRIHVVDLDGARQGHL
CEEECCEEECCCCEEEEECCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCCH
VNRKVIEKIVNSCSVDIEVGGGIRNKEALDYLFSIGVSYIILGSAAIYDKDLLLYSVSHY
HHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCHHHEEEHHHC
GEKTIVGIDSKKREVAVSGWLERTKIKDTELAEKIKEIGIKTIIFTDISKDGTLHGPNFE
CCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
ALKDMLKVGVEIIASGGISSIEDLKRLKDMGVTGAIIGKALYTGMIDLKAALLELEREGI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLVIPAIDILDGKCVRLTKGNFDSKEVYYDNPADMAKMWQECGAKRIHVVDLDGARQGHL
CEEECCEEECCCCEEEEECCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCCH
VNRKVIEKIVNSCSVDIEVGGGIRNKEALDYLFSIGVSYIILGSAAIYDKDLLLYSVSHY
HHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCHHHEEEHHHC
GEKTIVGIDSKKREVAVSGWLERTKIKDTELAEKIKEIGIKTIIFTDISKDGTLHGPNFE
CCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHH
ALKDMLKVGVEIIASGGISSIEDLKRLKDMGVTGAIIGKALYTGMIDLKAALLELEREGI
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336