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The map label for this gene is GalK

Identifier: 20808332

GI number: 20808332

Start: 1866033

End: 1867205

Strand: Reverse

Name: GalK

Synonym: TTE1928

Alternate gene names: 20808332

Gene position: 1867205-1866033 (Counterclockwise)

Preceding gene: 20808333

Following gene: 20808331

Centisome position: 69.43

GC content: 37.34

Gene sequence:

>1173_bases
ATGGAAATAGCAGTGGTAGAAGCTTTAGAAAAATTTTATGGCAAGAGTGACAGAGAAATAAGGCTTTTTTACTCGCCAGG
AAGAGTGAATCTAATTGGAGAGCACACGGATTATAACGGAGGCTATGTATTTCCATGTGCTCTTGATTTTGGAACTTATG
CTGCTATAAGAAAAAGAGATGACAAAAAAGTATTTATGGCTTCATTAAATTTTGATTTAAAGGTAGAGGTGGATTTGGAC
TCGATTTTCTACGATAAAGAGCATGACTGGGCAAATTATCCTAAAGGGGTTTTAAAGATATTGCAGGAGGAAGGGTATGA
ATTTTCTGGGTTTGAAATTGTATTTGGGGGTAATATCCCGGTTGGTGCAGGCCTTTCCTCGTCAGCTTCAATAGAAATGG
TTACAGCTGTTGCAGTCAATGAAGTTTTCAATTTAAACATTGACAGGATAAATCTTGTAAAGCTTTGTCAGAGGGCAGAA
AATACGTTTGTGGGGGTAAACTGCGGTATAATGGACCAATTTGCCGTTGGAATGGGTAAAAAAGGCCATGCAATCCTCTT
GAAAAGTGATACTTTGGAATACTCGTATGTGCCCTTAAATCTTGAAGGCTACAAAATTTTGATTACAAATACAAATAAAA
AAAGAGGACTTTTAGACTCAAAATACAATGAAAGAAGAAGTGAATGTGAGAAAGCTCTTACTTATCTCAAGAAAGCTTTG
CCTGTAAAAAATTTATCTGAAGTTACAGTTGAACGGTTTGAAGAGTATAAAGATTTGATACCTGATGAGGTCTTGAGAAA
AAGGGCAAGGCATGTCATAACAGAGAATAAAAGAGTTTTAGATGCAGTAAAAGCCTTAAATGATAATGATATAGTCAAAT
TTGGTAAATTGATGATAGAGTCGCATAATTCGTTAAGAAATGACTTTGAAGTTACAGGGAAAGAACTGGACACACTGGTA
GAAGAAGCGCTAAAATTAAAGGGAGTAGTGGGCTCTCGAATGACTGGAGCAGGATTTGGAGGGTGCACAGTAAGCATTGT
AAAAGAAGACGCAGTGGAAGAATTCATAGAGGTAGTGACACGCAATTACACGCAGAAAATAGGATATGCTCCAACAGTCT
ATGTCACAGGAGTAGGTGAGGGAGCAGGAGAAGTTGAATATTTGAGGAGGTAA

Upstream 100 bases:

>100_bases
GATGCAGGAGTTTTTAAGAGAGACGAAAAAGGCAAAAAAGCCTTTGAAAAATTTATGGAAACAGCAGGATTTAAAAAATT
ATCATGAAAGGAGACGAAAG

Downstream 100 bases:

>100_bases
TGAAATGGCGATTCTGGTTTGTGGTGGAGCAGGTTATATTGGAAGTCATGCAGTTTATGCTTTATTAAAAAGGAATGAGG
AAGTAGTTGTGGTAGACAAC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MEIAVVEALEKFYGKSDREIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRDDKKVFMASLNFDLKVEVDLD
SIFYDKEHDWANYPKGVLKILQEEGYEFSGFEIVFGGNIPVGAGLSSSASIEMVTAVAVNEVFNLNIDRINLVKLCQRAE
NTFVGVNCGIMDQFAVGMGKKGHAILLKSDTLEYSYVPLNLEGYKILITNTNKKRGLLDSKYNERRSECEKALTYLKKAL
PVKNLSEVTVERFEEYKDLIPDEVLRKRARHVITENKRVLDAVKALNDNDIVKFGKLMIESHNSLRNDFEVTGKELDTLV
EEALKLKGVVGSRMTGAGFGGCTVSIVKEDAVEEFIEVVTRNYTQKIGYAPTVYVTGVGEGAGEVEYLRR

Sequences:

>Translated_390_residues
MEIAVVEALEKFYGKSDREIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRDDKKVFMASLNFDLKVEVDLD
SIFYDKEHDWANYPKGVLKILQEEGYEFSGFEIVFGGNIPVGAGLSSSASIEMVTAVAVNEVFNLNIDRINLVKLCQRAE
NTFVGVNCGIMDQFAVGMGKKGHAILLKSDTLEYSYVPLNLEGYKILITNTNKKRGLLDSKYNERRSECEKALTYLKKAL
PVKNLSEVTVERFEEYKDLIPDEVLRKRARHVITENKRVLDAVKALNDNDIVKFGKLMIESHNSLRNDFEVTGKELDTLV
EEALKLKGVVGSRMTGAGFGGCTVSIVKEDAVEEFIEVVTRNYTQKIGYAPTVYVTGVGEGAGEVEYLRR
>Mature_390_residues
MEIAVVEALEKFYGKSDREIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRDDKKVFMASLNFDLKVEVDLD
SIFYDKEHDWANYPKGVLKILQEEGYEFSGFEIVFGGNIPVGAGLSSSASIEMVTAVAVNEVFNLNIDRINLVKLCQRAE
NTFVGVNCGIMDQFAVGMGKKGHAILLKSDTLEYSYVPLNLEGYKILITNTNKKRGLLDSKYNERRSECEKALTYLKKAL
PVKNLSEVTVERFEEYKDLIPDEVLRKRARHVITENKRVLDAVKALNDNDIVKFGKLMIESHNSLRNDFEVTGKELDTLV
EEALKLKGVVGSRMTGAGFGGCTVSIVKEDAVEEFIEVVTRNYTQKIGYAPTVYVTGVGEGAGEVEYLRR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily

Homologues:

Organism=Homo sapiens, GI4503895, Length=368, Percent_Identity=40.7608695652174, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4503897, Length=436, Percent_Identity=28.6697247706422, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI48527957, Length=436, Percent_Identity=28.6697247706422, Blast_Score=129, Evalue=6e-30,
Organism=Escherichia coli, GI1786972, Length=366, Percent_Identity=41.8032786885246, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71989053, Length=431, Percent_Identity=29.0023201856148, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320212, Length=457, Percent_Identity=26.9146608315098, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319494, Length=182, Percent_Identity=35.1648351648352, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24661292, Length=452, Percent_Identity=26.7699115044248, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355577, Length=452, Percent_Identity=26.7699115044248, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24661285, Length=452, Percent_Identity=26.7699115044248, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GAL1_THETN (Q8R8R7)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623503.1
- ProteinModelPortal:   Q8R8R7
- SMR:   Q8R8R7
- GeneID:   997123
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1928
- NMPDR:   fig|273068.3.peg.1790
- HOGENOM:   HBG725121
- OMA:   EYVGAPT
- ProtClustDB:   PRK05322
- BioCyc:   TTEN273068:TTE1928-MONOMER
- BRENDA:   2.7.1.6
- GO:   GO:0005737
- HAMAP:   MF_00246
- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000530
- PRINTS:   PR00473
- PRINTS:   PR00959
- TIGRFAMs:   TIGR00131

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.6

Molecular weight: Translated: 43750; Mature: 43750

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00106 GALACTOKINASE; PS00627 GHMP_KINASES_ATP; PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIAVVEALEKFYGKSDREIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRD
CCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHCCC
DKKVFMASLNFDLKVEVDLDSIFYDKEHDWANYPKGVLKILQEEGYEFSGFEIVFGGNIP
CCEEEEEECCCEEEEEEEHHHEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCC
VGAGLSSSASIEMVTAVAVNEVFNLNIDRINLVKLCQRAENTFVGVNCGIMDQFAVGMGK
CCCCCCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCC
KGHAILLKSDTLEYSYVPLNLEGYKILITNTNKKRGLLDSKYNERRSECEKALTYLKKAL
CCCEEEEECCCCEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
PVKNLSEVTVERFEEYKDLIPDEVLRKRARHVITENKRVLDAVKALNDNDIVKFGKLMIE
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
SHNSLRNDFEVTGKELDTLVEEALKLKGVVGSRMTGAGFGGCTVSIVKEDAVEEFIEVVT
CCHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
RNYTQKIGYAPTVYVTGVGEGAGEVEYLRR
HHHHHHCCCCCEEEEEECCCCCCCHHHHCC
>Mature Secondary Structure
MEIAVVEALEKFYGKSDREIRLFYSPGRVNLIGEHTDYNGGYVFPCALDFGTYAAIRKRD
CCCHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCEEEEEEECCCHHHHHHCCC
DKKVFMASLNFDLKVEVDLDSIFYDKEHDWANYPKGVLKILQEEGYEFSGFEIVFGGNIP
CCEEEEEECCCEEEEEEEHHHEEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCC
VGAGLSSSASIEMVTAVAVNEVFNLNIDRINLVKLCQRAENTFVGVNCGIMDQFAVGMGK
CCCCCCCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCC
KGHAILLKSDTLEYSYVPLNLEGYKILITNTNKKRGLLDSKYNERRSECEKALTYLKKAL
CCCEEEEECCCCEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
PVKNLSEVTVERFEEYKDLIPDEVLRKRARHVITENKRVLDAVKALNDNDIVKFGKLMIE
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHH
SHNSLRNDFEVTGKELDTLVEEALKLKGVVGSRMTGAGFGGCTVSIVKEDAVEEFIEVVT
CCHHHCCHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH
RNYTQKIGYAPTVYVTGVGEGAGEVEYLRR
HHHHHHCCCCCEEEEEECCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336