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The map label for this gene is GalE [H]

Identifier: 20808331

GI number: 20808331

Start: 1865039

End: 1866028

Strand: Reverse

Name: GalE [H]

Synonym: TTE1927

Alternate gene names: 20808331

Gene position: 1866028-1865039 (Counterclockwise)

Preceding gene: 20808332

Following gene: 20808330

Centisome position: 69.38

GC content: 40.2

Gene sequence:

>990_bases
ATGGCGATTCTGGTTTGTGGTGGAGCAGGTTATATTGGAAGTCATGCAGTTTATGCTTTATTAAAAAGGAATGAGGAAGT
AGTTGTGGTAGACAACCTCGCCACAGGGCACAGTGAATCTGTTTTAGGAGGAAAATTATACATAGGAGATTTAAGGGATG
AAGATTTTTTAGACAAAGTTTTTTCAGAAAATGATATTGAGGCTGTAATGCACTTTGCAGCTTCTTCACTTGTTGGAGAA
AGCGTTGAAAATCCCTTTAAGTACTATGAGAACAATGTATGCGGGACTTTATCTCTTCTAAAGGCTATGAAAAAACATGG
TGTCAAAAAAATTGTATTTTCTTCAACTGCAGCAGTGTACGGTGAACCTGAGAGAATTCCAATAGAGGAAGAGGACAGGA
CCGAACCTACGAATCCTTATGGGGAGACAAAGCTCGCTATTGAAAAGATGTTAAAATGGGCGGATGCCGCTTATGGGATT
AAGTACGTGGCGCTTCGTTATTTTAATGTCGCGGGAGCTCTTGAAACAGGTGAAATTGGAGAAGACCATTCTCCTGAGAC
ACACCTTATTCCCATTATACTCCAGGTAGCTTTGGGGAAAAGAGATAAAGTAATGATTTATGGAGATGACTACCCTACAA
AAGACGGCACACCTATAAGAGATTATATACATGTCATGGACTTAGTAGATGCACACATTTTGGCTTTGGAGAAGTTAAGA
AAAGAAAATAAAAGCGAAGTTTACAATCTAGGTAATGGGGAAGGCTTTACTGTAAAAGAAGTCATAGAGGTTGCGAGGAA
AGTGACAGGACATCCTATTCCAGCAGAAGTTACAGGAAGGCGCCCAGGAGACCCTGCAGTTTTAGTTGCATCTTCCGAAA
AAGCGATGAAAGATCTGGGGTGGAGGCCTAAATATGCTTCTTTAGAAGAGATAATTAAAAGTGCCTGGATGTGGCATAAA
AACCATCCAAATGGCTTTAAAAGGGATTGA

Upstream 100 bases:

>100_bases
ACACGCAATTACACGCAGAAAATAGGATATGCTCCAACAGTCTATGTCACAGGAGTAGGTGAGGGAGCAGGAGAAGTTGA
ATATTTGAGGAGGTAATGAA

Downstream 100 bases:

>100_bases
AGGAAGGGATGGAAATGGAAAATTTAATACCAGTAAGTTACAAGCTACTAAAAGGAATGAATGAGTCTGTCATATTAAAT
ATTATACGAAAAATGGGGCC

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MAILVCGGAGYIGSHAVYALLKRNEEVVVVDNLATGHSESVLGGKLYIGDLRDEDFLDKVFSENDIEAVMHFAASSLVGE
SVENPFKYYENNVCGTLSLLKAMKKHGVKKIVFSSTAAVYGEPERIPIEEEDRTEPTNPYGETKLAIEKMLKWADAAYGI
KYVALRYFNVAGALETGEIGEDHSPETHLIPIILQVALGKRDKVMIYGDDYPTKDGTPIRDYIHVMDLVDAHILALEKLR
KENKSEVYNLGNGEGFTVKEVIEVARKVTGHPIPAEVTGRRPGDPAVLVASSEKAMKDLGWRPKYASLEEIIKSAWMWHK
NHPNGFKRD

Sequences:

>Translated_329_residues
MAILVCGGAGYIGSHAVYALLKRNEEVVVVDNLATGHSESVLGGKLYIGDLRDEDFLDKVFSENDIEAVMHFAASSLVGE
SVENPFKYYENNVCGTLSLLKAMKKHGVKKIVFSSTAAVYGEPERIPIEEEDRTEPTNPYGETKLAIEKMLKWADAAYGI
KYVALRYFNVAGALETGEIGEDHSPETHLIPIILQVALGKRDKVMIYGDDYPTKDGTPIRDYIHVMDLVDAHILALEKLR
KENKSEVYNLGNGEGFTVKEVIEVARKVTGHPIPAEVTGRRPGDPAVLVASSEKAMKDLGWRPKYASLEEIIKSAWMWHK
NHPNGFKRD
>Mature_328_residues
AILVCGGAGYIGSHAVYALLKRNEEVVVVDNLATGHSESVLGGKLYIGDLRDEDFLDKVFSENDIEAVMHFAASSLVGES
VENPFKYYENNVCGTLSLLKAMKKHGVKKIVFSSTAAVYGEPERIPIEEEDRTEPTNPYGETKLAIEKMLKWADAAYGIK
YVALRYFNVAGALETGEIGEDHSPETHLIPIILQVALGKRDKVMIYGDDYPTKDGTPIRDYIHVMDLVDAHILALEKLRK
ENKSEVYNLGNGEGFTVKEVIEVARKVTGHPIPAEVTGRRPGDPAVLVASSEKAMKDLGWRPKYASLEEIIKSAWMWHKN
HPNGFKRD

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=344, Percent_Identity=41.5697674418605, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI56118217, Length=344, Percent_Identity=41.5697674418605, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI189083684, Length=344, Percent_Identity=41.5697674418605, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI7657641, Length=341, Percent_Identity=28.4457478005865, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI42516563, Length=325, Percent_Identity=28.9230769230769, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI193211614, Length=256, Percent_Identity=26.171875, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI8393516, Length=256, Percent_Identity=26.171875, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI116268111, Length=373, Percent_Identity=24.3967828418231, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786974, Length=337, Percent_Identity=41.839762611276, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1788353, Length=358, Percent_Identity=29.608938547486, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI48994969, Length=361, Percent_Identity=27.1468144044321, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790049, Length=290, Percent_Identity=30, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788365, Length=297, Percent_Identity=24.5791245791246, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788366, Length=355, Percent_Identity=23.943661971831, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=41.0404624277457, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=40.8045977011494, Blast_Score=250, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17539532, Length=323, Percent_Identity=27.2445820433437, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17568069, Length=303, Percent_Identity=29.3729372937294, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115532424, Length=344, Percent_Identity=25.2906976744186, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI133901790, Length=309, Percent_Identity=24.5954692556634, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI133901786, Length=309, Percent_Identity=24.5954692556634, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539422, Length=322, Percent_Identity=24.223602484472, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539424, Length=322, Percent_Identity=24.5341614906832, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133901788, Length=322, Percent_Identity=24.5341614906832, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=44.1860465116279, Blast_Score=265, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6321437, Length=341, Percent_Identity=26.6862170087977, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19923002, Length=346, Percent_Identity=41.0404624277457, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21356223, Length=327, Percent_Identity=27.82874617737, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36503; Mature: 36372

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVCGGAGYIGSHAVYALLKRNEEVVVVDNLATGHSESVLGGKLYIGDLRDEDFLDKV
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHH
FSENDIEAVMHFAASSLVGESVENPFKYYENNVCGTLSLLKAMKKHGVKKIVFSSTAAVY
HCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCCCCEEEHHCCHHHC
GEPERIPIEEEDRTEPTNPYGETKLAIEKMLKWADAAYGIKYVALRYFNVAGALETGEIG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EDHSPETHLIPIILQVALGKRDKVMIYGDDYPTKDGTPIRDYIHVMDLVDAHILALEKLR
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KENKSEVYNLGNGEGFTVKEVIEVARKVTGHPIPAEVTGRRPGDPAVLVASSEKAMKDLG
HCCHHHHEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCC
WRPKYASLEEIIKSAWMWHKNHPNGFKRD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AILVCGGAGYIGSHAVYALLKRNEEVVVVDNLATGHSESVLGGKLYIGDLRDEDFLDKV
EEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHH
FSENDIEAVMHFAASSLVGESVENPFKYYENNVCGTLSLLKAMKKHGVKKIVFSSTAAVY
HCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHCCCCEEEHHCCHHHC
GEPERIPIEEEDRTEPTNPYGETKLAIEKMLKWADAAYGIKYVALRYFNVAGALETGEIG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
EDHSPETHLIPIILQVALGKRDKVMIYGDDYPTKDGTPIRDYIHVMDLVDAHILALEKLR
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KENKSEVYNLGNGEGFTVKEVIEVARKVTGHPIPAEVTGRRPGDPAVLVASSEKAMKDLG
HCCHHHHEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCC
WRPKYASLEEIIKSAWMWHKNHPNGFKRD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]