Click here to switch to the map view.

The map label for this gene is TrxB [H]

Identifier: 20808290

GI number: 20808290

Start: 1824865

End: 1825791

Strand: Reverse

Name: TrxB [H]

Synonym: TTE1881

Alternate gene names: 20808290

Gene position: 1825791-1824865 (Counterclockwise)

Preceding gene: 20808291

Following gene: 20808289

Centisome position: 67.89

GC content: 39.81

Gene sequence:

>927_bases
GTGTCTACTTTATATGATTGTCTCATAATTGGTGGAGGGCCTGCTGGACTATCTGCAGCGATTTACGCTTCAAGAGGAAA
ATTGAATACTGTAGTTTTTGAAAGAAGTAAGATTGGAGGTCAAGCTGCTATAACGGATGATATAGAAAATTATCCCGGTT
CTGTGGAAGAGGCGACAGGACCTAAAATTGTAAAGAGGATGAGAGAACAGGCAGAATCTTTTGGAACTTGTTTTGTCATG
GAAGAAGTCAAAAAAGTAGAATTGAGCGAAAAGATAAAAAAGGTTATAACTACAAAAGGCTGTTATGAAGGGAAGACGGT
TATAATTGCTACAGGAGCGGAACATATGAAATTAAATGTGCCAGGAGAAGAAGAATTTATAGGCAAAGGAGTTTCTTATT
GCGCAACCTGTGATGCAGATTTCTTTACTGATTTGGATGTGGTAGTGGTAGGGGGAGGGGACTCTGCTGTTCAGGAGGCG
TTATACCTCACTAAATTTGCTAAAAACGTTACAATTATCCACAGAAGAGATAAGTTAAGAGCAAACAAATGCTTGCAAGA
TAAGGCTTTTAAAAATCCCAAAATAAAATTTCTGTGGGACAGCGTAGTGGAAAGGATAGAAGGGGATGGGATAGTAGAGA
AAGTTATAGTGAGAAACGTCAAAACAGGAGAGTTGAAGGAAGTAAAAACGGATGGGGTGTTTATTTTCATCGGGATGAAG
CCCAGTACAGAAATTTTCAAGGGATTAATTGAGATGGATGAAAGGGGATATATTCTGACAGATGAAAATATGAGGACAAA
TATTGAAGGAGTGTTTGCCGCAGGGGATTGCAGGGCAAAACTGTTAAGACAAATAGTGACAGCAGCGGCAGATGGGGCGA
TAGCAGCAGTAGCTGCTGAGAGGTATATTGAAGAATTGGAGTGTTGA

Upstream 100 bases:

>100_bases
TTATATAGACGATGAAAAGGTTTTAAATGACTTTGCCTACCTTGATAAAGAATTGATAAAAGAAGCTATAGAAACTTTTA
GAGAATAGCGAGGTGAAATT

Downstream 100 bases:

>100_bases
AAGGAGGTGAGAATTGGTGATTGAAGTGAATAAAGACAATTTTGATGAAGTAGTAAAAAAGGAAGAAAAGTTGGTCTTGA
TTGACTTTTGGGGACCAAAG

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSTLYDCLIIGGGPAGLSAAIYASRGKLNTVVFERSKIGGQAAITDDIENYPGSVEEATGPKIVKRMREQAESFGTCFVM
EEVKKVELSEKIKKVITTKGCYEGKTVIIATGAEHMKLNVPGEEEFIGKGVSYCATCDADFFTDLDVVVVGGGDSAVQEA
LYLTKFAKNVTIIHRRDKLRANKCLQDKAFKNPKIKFLWDSVVERIEGDGIVEKVIVRNVKTGELKEVKTDGVFIFIGMK
PSTEIFKGLIEMDERGYILTDENMRTNIEGVFAAGDCRAKLLRQIVTAAADGAIAAVAAERYIEELEC

Sequences:

>Translated_308_residues
MSTLYDCLIIGGGPAGLSAAIYASRGKLNTVVFERSKIGGQAAITDDIENYPGSVEEATGPKIVKRMREQAESFGTCFVM
EEVKKVELSEKIKKVITTKGCYEGKTVIIATGAEHMKLNVPGEEEFIGKGVSYCATCDADFFTDLDVVVVGGGDSAVQEA
LYLTKFAKNVTIIHRRDKLRANKCLQDKAFKNPKIKFLWDSVVERIEGDGIVEKVIVRNVKTGELKEVKTDGVFIFIGMK
PSTEIFKGLIEMDERGYILTDENMRTNIEGVFAAGDCRAKLLRQIVTAAADGAIAAVAAERYIEELEC
>Mature_307_residues
STLYDCLIIGGGPAGLSAAIYASRGKLNTVVFERSKIGGQAAITDDIENYPGSVEEATGPKIVKRMREQAESFGTCFVME
EVKKVELSEKIKKVITTKGCYEGKTVIIATGAEHMKLNVPGEEEFIGKGVSYCATCDADFFTDLDVVVVGGGDSAVQEAL
YLTKFAKNVTIIHRRDKLRANKCLQDKAFKNPKIKFLWDSVVERIEGDGIVEKVIVRNVKTGELKEVKTDGVFIFIGMKP
STEIFKGLIEMDERGYILTDENMRTNIEGVFAAGDCRAKLLRQIVTAAADGAIAAVAAERYIEELEC

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=293, Percent_Identity=26.2798634812287, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI65787454, Length=293, Percent_Identity=26.2798634812287, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI21389617, Length=293, Percent_Identity=26.2798634812287, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787114, Length=310, Percent_Identity=40.3225806451613, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI87081763, Length=307, Percent_Identity=32.5732899022801, Blast_Score=154, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320560, Length=312, Percent_Identity=39.1025641025641, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321898, Length=316, Percent_Identity=38.2911392405063, Blast_Score=215, Evalue=9e-57,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 33688; Mature: 33557

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLYDCLIIGGGPAGLSAAIYASRGKLNTVVFERSKIGGQAAITDDIENYPGSVEEATG
CCCEEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCCCCCEEECCCHHHCCCCCCCCCC
PKIVKRMREQAESFGTCFVMEEVKKVELSEKIKKVITTKGCYEGKTVIIATGAEHMKLNV
HHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEC
PGEEEFIGKGVSYCATCDADFFTDLDVVVVGGGDSAVQEALYLTKFAKNVTIIHRRDKLR
CCCHHHHHCCCCCEEECCCCHHCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECHHHH
ANKCLQDKAFKNPKIKFLWDSVVERIEGDGIVEKVIVRNVKTGELKEVKTDGVFIFIGMK
HHHHHHHHHCCCCCEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEECCCEEEEEECC
PSTEIFKGLIEMDERGYILTDENMRTNIEGVFAAGDCRAKLLRQIVTAAADGAIAAVAAE
CCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHH
RYIEELEC
HHHHHHCC
>Mature Secondary Structure 
STLYDCLIIGGGPAGLSAAIYASRGKLNTVVFERSKIGGQAAITDDIENYPGSVEEATG
CCEEEEEEECCCCCCCCEEEEECCCCEEEEEEECCCCCCCEEECCCHHHCCCCCCCCCC
PKIVKRMREQAESFGTCFVMEEVKKVELSEKIKKVITTKGCYEGKTVIIATGAEHMKLNV
HHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEC
PGEEEFIGKGVSYCATCDADFFTDLDVVVVGGGDSAVQEALYLTKFAKNVTIIHRRDKLR
CCCHHHHHCCCCCEEECCCCHHCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEECHHHH
ANKCLQDKAFKNPKIKFLWDSVVERIEGDGIVEKVIVRNVKTGELKEVKTDGVFIFIGMK
HHHHHHHHHCCCCCEEEHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEECCCEEEEEECC
PSTEIFKGLIEMDERGYILTDENMRTNIEGVFAAGDCRAKLLRQIVTAAADGAIAAVAAE
CCHHHHHHHHHHCCCCEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHH
RYIEELEC
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8223622; 2537814 [H]