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The map label for this gene is grdE [H]

Identifier: 20808288

GI number: 20808288

Start: 1823234

End: 1824520

Strand: Reverse

Name: grdE [H]

Synonym: TTE1879

Alternate gene names: 20808288

Gene position: 1824520-1823234 (Counterclockwise)

Preceding gene: 20808289

Following gene: 20808287

Centisome position: 67.84

GC content: 38.54

Gene sequence:

>1287_bases
ATGAGGCTGGAAATAGGGAATATTTATATAAAAGATGTGGTGTTTTCTGATGTAACAAAAGTAAAAGATGGAGTGCTTTA
CTTAAATAAAGAAGAAATAATTAAAGCTTTAAAGCAAGACAGCAGACTAGAAAGAGTAGATATAGAAATTGCAAAGCCGG
GAGAAGAAGTGAGAATAATACCAGTAAAGGACGTAATTGAACCGCGTGTCAAAGTTAGAGGAAAAGGAGGAATATTTCCA
GGATTTATAAGCAAAGTAGAGACAGTAGGAGAGGGTAGAACTCATGTCTTAAAAGGGACAGCTGTGGTGACAACCGGTAG
GATTGTGGGATTCCAGGAAGGCATAATTGACATGTCAGGGGAAGGTGCAAAATATACTCCTTTTTCGAAGCTTATAAATA
TCGTAGTGGTGTGTGAACCCGTAGAAGGGCTTCCAAAACATGAACATGAGGAAGTTGTAAGAATAGCTGGTTTAAAAGCA
GCAGCTTTGATAGGGGAAGCTGGAAGAGATGTAGAACCTGATGAGATAAAGGAATATGAAACTTTGCCACTCCTTGAAAG
TGTGAAAAAGTATCCCGATTTGCCTAGAGTAGGATATATTTACATGTTACAGAGCCAGGGGTTGCTTCACGATACTTATG
TGTATGGAGTTGATGCTAAGAAAATTGTTCCAACTTTCATTTATCCTACAGAAGTGATGGACGGGGCTATAGTCAGCGGC
AATTGCGTTTCAGCCTGCGATAAAAATACCACCTATGTTCACATGAATAATCCCATCATAGAAGATTTATATGAAAAGCA
TGGCAAAGAAATAAATTTTGTGGGAATAATCATAACAAATGAAAATGTCACACTAGCGGACAAAGAAAGGTCTTCTGATT
ATACAGCCAAATTGGCAGAATACCTTGGGCTTGAGGGAGTCATTATTTCAGAAGAAGGTTTCGGGAATCCAGACACAGAC
TTGATAATGAATTGTCGTAAGCTGGAAGAGAAAGGAATAAAAACGGTTCTTGTTACAGATGAATTTGCAGGAAGAGACGG
TTTGTCTCAGTCTTTAGCAGATGCAGACCCGAGAGCAAATGCTGTTGTAAGTACAGGAAATGCAAATGAGATAATAAGGC
TCCCAAAAATGAAAAAGATTATAGGGCATATAGAAGCAGCAAATGTAATAGCGGGTGGTTTTGAGGGAAGCGTTAAAGAA
GATGGCAGCATAGAGGTAGAATTACAGGCTATTACTGGTTCTACTTCTGAAGTGGGATTTAATAATCTGACTGCAAGAGA
ATATTAA

Upstream 100 bases:

>100_bases
CTTTACAAAAATGGCGAAAAAGTGGATGAAATATCAAAAGATGTGACAATAGAGAAGATTGAGGAGATGATAAAAAGGCA
TATTTAGAGGAGGTGATTTT

Downstream 100 bases:

>100_bases
AGGGAGGTAGAAAGAATGTTAGAAGGTAAGAAAGTGATAATAGTAGGCGATAGGGATGGAATACCAGGTCCTGCCATTGA
AGAGTGTATAAAGACAACTG

Product: grdE proprotein

Products: NA

Alternate protein names: Selenoprotein PB alpha/beta [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRLEIGNIYIKDVVFSDVTKVKDGVLYLNKEEIIKALKQDSRLERVDIEIAKPGEEVRIIPVKDVIEPRVKVRGKGGIFP
GFISKVETVGEGRTHVLKGTAVVTTGRIVGFQEGIIDMSGEGAKYTPFSKLINIVVVCEPVEGLPKHEHEEVVRIAGLKA
AALIGEAGRDVEPDEIKEYETLPLLESVKKYPDLPRVGYIYMLQSQGLLHDTYVYGVDAKKIVPTFIYPTEVMDGAIVSG
NCVSACDKNTTYVHMNNPIIEDLYEKHGKEINFVGIIITNENVTLADKERSSDYTAKLAEYLGLEGVIISEEGFGNPDTD
LIMNCRKLEEKGIKTVLVTDEFAGRDGLSQSLADADPRANAVVSTGNANEIIRLPKMKKIIGHIEAANVIAGGFEGSVKE
DGSIEVELQAITGSTSEVGFNNLTAREY

Sequences:

>Translated_428_residues
MRLEIGNIYIKDVVFSDVTKVKDGVLYLNKEEIIKALKQDSRLERVDIEIAKPGEEVRIIPVKDVIEPRVKVRGKGGIFP
GFISKVETVGEGRTHVLKGTAVVTTGRIVGFQEGIIDMSGEGAKYTPFSKLINIVVVCEPVEGLPKHEHEEVVRIAGLKA
AALIGEAGRDVEPDEIKEYETLPLLESVKKYPDLPRVGYIYMLQSQGLLHDTYVYGVDAKKIVPTFIYPTEVMDGAIVSG
NCVSACDKNTTYVHMNNPIIEDLYEKHGKEINFVGIIITNENVTLADKERSSDYTAKLAEYLGLEGVIISEEGFGNPDTD
LIMNCRKLEEKGIKTVLVTDEFAGRDGLSQSLADADPRANAVVSTGNANEIIRLPKMKKIIGHIEAANVIAGGFEGSVKE
DGSIEVELQAITGSTSEVGFNNLTAREY
>Mature_428_residues
MRLEIGNIYIKDVVFSDVTKVKDGVLYLNKEEIIKALKQDSRLERVDIEIAKPGEEVRIIPVKDVIEPRVKVRGKGGIFP
GFISKVETVGEGRTHVLKGTAVVTTGRIVGFQEGIIDMSGEGAKYTPFSKLINIVVVCEPVEGLPKHEHEEVVRIAGLKA
AALIGEAGRDVEPDEIKEYETLPLLESVKKYPDLPRVGYIYMLQSQGLLHDTYVYGVDAKKIVPTFIYPTEVMDGAIVSG
NCVSACDKNTTYVHMNNPIIEDLYEKHGKEINFVGIIITNENVTLADKERSSDYTAKLAEYLGLEGVIISEEGFGNPDTD
LIMNCRKLEEKGIKTVLVTDEFAGRDGLSQSLADADPRANAVVSTGNANEIIRLPKMKKIIGHIEAANVIAGGFEGSVKE
DGSIEVELQAITGSTSEVGFNNLTAREY

Specific function: In the first step of glycine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB- activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated seleno

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016585
- InterPro:   IPR015417 [H]

Pfam domain/function: PF09338 Gly_reductase [H]

EC number: =1.21.4.2 [H]

Molecular weight: Translated: 46854; Mature: 46854

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEIGNIYIKDVVFSDVTKVKDGVLYLNKEEIIKALKQDSRLERVDIEIAKPGEEVRII
CEEEECCEEEEHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCEEEEEEEEECCCCCEEEE
PVKDVIEPRVKVRGKGGIFPGFISKVETVGEGRTHVLKGTAVVTTGRIVGFQEGIIDMSG
EHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECEEEEEECEEEEECCCCEEECC
EGAKYTPFSKLINIVVVCEPVEGLPKHEHEEVVRIAGLKAAALIGEAGRDVEPDEIKEYE
CCCCCCCHHHHEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHH
TLPLLESVKKYPDLPRVGYIYMLQSQGLLHDTYVYGVDAKKIVPTFIYPTEVMDGAIVSG
HHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEECCHHHHCEEEEEHHHHCCCEEECC
NCVSACDKNTTYVHMNNPIIEDLYEKHGKEINFVGIIITNENVTLADKERSSDYTAKLAE
CCHHHCCCCCEEEEECCCHHHHHHHHCCCEEEEEEEEEECCCEEEECCCCCCHHHHHHHH
YLGLEGVIISEEGFGNPDTDLIMNCRKLEEKGIKTVLVTDEFAGRDGLSQSLADADPRAN
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCCCCCCC
AVVSTGNANEIIRLPKMKKIIGHIEAANVIAGGFEGSVKEDGSIEVELQAITGSTSEVGF
EEEECCCCCCEEECCHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEEEEECCCCCCCC
NNLTAREY
CCCCCCCC
>Mature Secondary Structure
MRLEIGNIYIKDVVFSDVTKVKDGVLYLNKEEIIKALKQDSRLERVDIEIAKPGEEVRII
CEEEECCEEEEHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCEEEEEEEEECCCCCEEEE
PVKDVIEPRVKVRGKGGIFPGFISKVETVGEGRTHVLKGTAVVTTGRIVGFQEGIIDMSG
EHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECEEEEEECEEEEECCCCEEECC
EGAKYTPFSKLINIVVVCEPVEGLPKHEHEEVVRIAGLKAAALIGEAGRDVEPDEIKEYE
CCCCCCCHHHHEEEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHH
TLPLLESVKKYPDLPRVGYIYMLQSQGLLHDTYVYGVDAKKIVPTFIYPTEVMDGAIVSG
HHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEECCHHHHCEEEEEHHHHCCCEEECC
NCVSACDKNTTYVHMNNPIIEDLYEKHGKEINFVGIIITNENVTLADKERSSDYTAKLAE
CCHHHCCCCCEEEEECCCHHHHHHHHCCCEEEEEEEEEECCCEEEECCCCCCHHHHHHHH
YLGLEGVIISEEGFGNPDTDLIMNCRKLEEKGIKTVLVTDEFAGRDGLSQSLADADPRAN
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCCCCCCC
AVVSTGNANEIIRLPKMKKIIGHIEAANVIAGGFEGSVKEDGSIEVELQAITGSTSEVGF
EEEECCCCCCEEECCHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEEEEECCCCCCCC
NNLTAREY
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10091582; 8529639 [H]