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The map label for this gene is pheS

Identifier: 20808115

GI number: 20808115

Start: 1640965

End: 1641984

Strand: Reverse

Name: pheS

Synonym: TTE1689

Alternate gene names: 20808115

Gene position: 1641984-1640965 (Counterclockwise)

Preceding gene: 20808116

Following gene: 20808114

Centisome position: 61.05

GC content: 40.78

Gene sequence:

>1020_bases
ATGGAGGAGTTACTAAAAGAGCTTTCTAAAAGAGCAGAAGAAGAGATTCTTAAGGCAAAAAGCCTTCAAGAAATTGAAAG
TTTAAGGGTTAAATATTTGGGGAAAAAGGGCGAGCTTACGCAAATTTTGAGAGGGATGGGAAGTTTAAGCCCTGAAGAAA
GGCCAGTGATAGGGCAGTTAGCCAATGATGTGAGAGAAAAAATAGAGAATATGATTTTGGAGAGAAGAGAAAAAATTGCC
AAAGAAGAAAAGGAAAGAAAGATAAAAGAAGAGTACATAGATATTACCATGCCAGGCAAGCCTTACAAATACGGGCATAA
GCATCCTATTACTCTTGTGATGGATGAAATTAAAAGAATTTTTCTGGGCCTAGGTTTTTCTATTGCAGAAGGGCCAGAAG
TAGAGCTTGCTTACTACAATTTTGAAGCTTTGAACACTCCGGAAGACCATCCTGCTCGCGACTTGCAGGATACTTTTTAC
ATAACTTCTGATATACTTTTGAGGACGCAAACTTCTCCAGTTCAAGTGAGGACTATGGAAAAGACCAAACCACCTATAAG
AGTTATTTCGCCCGGCAGAGTCTACAGGTCTGATGACATAGATGCTACGCATTCTCCTGTATTCCATCAGATGGAGGGTT
TAGTGGTAGATGAGGGCATCACAATGGGGGATTTGAAAGGGGTTTTAAACGTATTTGCTAAAAAGTTTTTCGGGGAACAG
ACAAAGACAAAATTTAGGCCCCACTTTTTCCCCTTCACAGAGCCCAGTGCAGAAATGGATGTAAGCTGTTTTGCTTGTGG
CGGTAAGGGATGCCGTGTGTGCGGCTACACCGGCTGGATTGAGATTTTAGGTGCAGGCATGGTCCATCCTAATGTCTTGA
GGATGTCAGGAATTGACCCTGAGAAGTATACCGGTTTTGCCTTTGGGTTGGGAATAGACAGGATAGCGATGTTAAAATAT
GGGATAGAAGATTTGAGATTGTTATTTGAAAACGACATGAGATTTATAGAACAATTTTAA

Upstream 100 bases:

>100_bases
CCTCAAATGGGGTGCTAAGATAGGTGGTACCGCGGAATTCTTCGTCCTATGACGGAGGATTTTTTATTTTATAATCACAA
GAAAAGGGGTTGAAAAAGGG

Downstream 100 bases:

>100_bases
GGGGTGAGCTTATGTTAGTGTCTCTTTCTTGGTTGAAAGAATTTGTAGATATAGATGAAGACGCTAAGACAATAGCCGAA
GGGTTGACCATGTCTGGTTC

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEELLKELSKRAEEEILKAKSLQEIESLRVKYLGKKGELTQILRGMGSLSPEERPVIGQLANDVREKIENMILERREKIA
KEEKERKIKEEYIDITMPGKPYKYGHKHPITLVMDEIKRIFLGLGFSIAEGPEVELAYYNFEALNTPEDHPARDLQDTFY
ITSDILLRTQTSPVQVRTMEKTKPPIRVISPGRVYRSDDIDATHSPVFHQMEGLVVDEGITMGDLKGVLNVFAKKFFGEQ
TKTKFRPHFFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYTGFAFGLGIDRIAMLKY
GIEDLRLLFENDMRFIEQF

Sequences:

>Translated_339_residues
MEELLKELSKRAEEEILKAKSLQEIESLRVKYLGKKGELTQILRGMGSLSPEERPVIGQLANDVREKIENMILERREKIA
KEEKERKIKEEYIDITMPGKPYKYGHKHPITLVMDEIKRIFLGLGFSIAEGPEVELAYYNFEALNTPEDHPARDLQDTFY
ITSDILLRTQTSPVQVRTMEKTKPPIRVISPGRVYRSDDIDATHSPVFHQMEGLVVDEGITMGDLKGVLNVFAKKFFGEQ
TKTKFRPHFFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYTGFAFGLGIDRIAMLKY
GIEDLRLLFENDMRFIEQF
>Mature_339_residues
MEELLKELSKRAEEEILKAKSLQEIESLRVKYLGKKGELTQILRGMGSLSPEERPVIGQLANDVREKIENMILERREKIA
KEEKERKIKEEYIDITMPGKPYKYGHKHPITLVMDEIKRIFLGLGFSIAEGPEVELAYYNFEALNTPEDHPARDLQDTFY
ITSDILLRTQTSPVQVRTMEKTKPPIRVISPGRVYRSDDIDATHSPVFHQMEGLVVDEGITMGDLKGVLNVFAKKFFGEQ
TKTKFRPHFFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDPEKYTGFAFGLGIDRIAMLKY
GIEDLRLLFENDMRFIEQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=287, Percent_Identity=32.7526132404181, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI5729820, Length=289, Percent_Identity=28.3737024221453, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1788007, Length=335, Percent_Identity=48.6567164179104, Blast_Score=343, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI17508957, Length=269, Percent_Identity=31.5985130111524, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32563657, Length=269, Percent_Identity=31.5985130111524, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32566635, Length=257, Percent_Identity=32.6848249027237, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6321087, Length=295, Percent_Identity=31.5254237288136, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325304, Length=328, Percent_Identity=28.0487804878049, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI18858079, Length=288, Percent_Identity=31.9444444444444, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17137424, Length=290, Percent_Identity=28.6206896551724, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_THETN (Q8R9C6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623286.1
- ProteinModelPortal:   Q8R9C6
- SMR:   Q8R9C6
- GeneID:   996400
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1689
- NMPDR:   fig|273068.3.peg.1670
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- ProtClustDB:   PRK00488
- BioCyc:   TTEN273068:TTE1689-MONOMER
- BRENDA:   6.1.1.20
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 38737; Mature: 38737

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELLKELSKRAEEEILKAKSLQEIESLRVKYLGKKGELTQILRGMGSLSPEERPVIGQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHH
ANDVREKIENMILERREKIAKEEKERKIKEEYIDITMPGKPYKYGHKHPITLVMDEIKRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHH
FLGLGFSIAEGPEVELAYYNFEALNTPEDHPARDLQDTFYITSDILLRTQTSPVQVRTME
HHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHEEEHHEEEEECCCCEEEEEEC
KTKPPIRVISPGRVYRSDDIDATHSPVFHQMEGLVVDEGITMGDLKGVLNVFAKKFFGEQ
CCCCCEEEECCCCEEECCCCCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCH
TKTKFRPHFFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDP
HHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCC
EKYTGFAFGLGIDRIAMLKYGIEDLRLLFENDMRFIEQF
HHHCCEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEELLKELSKRAEEEILKAKSLQEIESLRVKYLGKKGELTQILRGMGSLSPEERPVIGQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHH
ANDVREKIENMILERREKIAKEEKERKIKEEYIDITMPGKPYKYGHKHPITLVMDEIKRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHH
FLGLGFSIAEGPEVELAYYNFEALNTPEDHPARDLQDTFYITSDILLRTQTSPVQVRTME
HHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHEEEHHEEEEECCCCEEEEEEC
KTKPPIRVISPGRVYRSDDIDATHSPVFHQMEGLVVDEGITMGDLKGVLNVFAKKFFGEQ
CCCCCEEEECCCCEEECCCCCCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCH
TKTKFRPHFFPFTEPSAEMDVSCFACGGKGCRVCGYTGWIEILGAGMVHPNVLRMSGIDP
HHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCCEEEECCCCC
EKYTGFAFGLGIDRIAMLKYGIEDLRLLFENDMRFIEQF
HHHCCEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336