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The map label for this gene is Lpd2 [H]

Identifier: 20808100

GI number: 20808100

Start: 1621163

End: 1622518

Strand: Reverse

Name: Lpd2 [H]

Synonym: TTE1674

Alternate gene names: 20808100

Gene position: 1622518-1621163 (Counterclockwise)

Preceding gene: 20808101

Following gene: 20808099

Centisome position: 60.33

GC content: 39.75

Gene sequence:

>1356_bases
ATGAATTACGATGTGATAGTCGTAGGAGGAGGACCTGGAGGTTATACTGCAGCCATTAGATTAAGTGAATTGGGTAAAAA
AGTAGCTTTGATAGAAGAAGATTCTCTGGGAGGTACATGCCTTAATAGAGGGTGTATTCCTACAAAGGTTTATGCTCACG
CTGCAGAACTTGTAACCCGCATAAAAGAAGCAAAAGACTTTGGAATAACTGCAGAGTACACTTTAGATATTGCCAAGCTT
CGCCAGAAAAAAGAGCGGGTAGTAAAGAGATTAGTAGGTGGGGTAGGTTATTTGATGAACTTACACCACATTGATGTCAT
AAATGGAAAGGGAACGTTTATTGATAAAAATACTGTTGAAGTAAATGGAGCAAAGTACACTGCAGAGAATTTTATAATTG
CTACTGGTTCAAAGGTATTTCTGCCCCCTATAGAGGGAATTGACTTAGAAGGCGTCATGACAAGCGATAAAGCTTTGGAA
TTAGAAAAAATTCCTGAAAAAATAGTGATAATTGGAGCAGGAATTATTGGACTTGAATTTGCAAATATTTATGCTTCTTT
GGGGAGCAAAGTAATTATGATAGAGATGCTTCCTCAGCTTTTACCAATGCTTGATAGAGATGTAGTTGGAGTGATGGAAA
AAGCATTGAAAAAGCAAAAGATAGAGCTTCATCTAAATAGTAAAGTAGAAAAAATAGAAAGAGGTCTGAGAGTAATTTAT
ACAGAAAACGGTAATCAAGAGAGTGTCGAATGTGATGCTGTTTTGGTTGCGGTAGGAAGAGTGCCTAATGTAAACGGGGT
CGATGCTTTAAACCTCGAGATGAACGGAAGAGGAATAAAAGTGGATTCCCATATGAGGACAAGCATAGAAAATATATACG
CTATTGGAGATGTTACAGGAGGCATACAACTGGCACATGTGGCTTCTTATCAGGGAATTGTAGCTGCTCACAACATAGCA
GGGGAAGAAAAAGAAGCGGATCTGACGGCGGTACCTAACTGCCTTTATACAAATCCAGAGGTTGCTTGGGTTGGTCTTAA
TGAATCACAGGCAAGAGAAAAGTATGGAGAAGTGAAAATAGGCACTTTCCCGTATACGGCTTTGGGAAGGGCTATGACTA
TGGGAGAAAGCGATGGGTTTGTGAAAATAATCGCAGAAGGAAAATATGGAAGAGTAGTCGGTATGGAGATAATAGGGGCT
GGTGCTACAGAGATAATACATGAAGGGGTATTGGCCATAAAAGAGGAGTTTACGCTGGAGGAATTGGCAGATAGCATACA
TGCTCATCCTACACTTTCTGAGAGTATAAAAGAGGCTGCAGAGGATGCTTTAGGGATGCCAATAAACAAAGGTTAA

Upstream 100 bases:

>100_bases
GGTAATATAAGCCATGAGATGCTCTTGTTGTGATGAGAAAATTAAAGAAAAACTAAGATATTAAGAGAAAATAAAAGATA
ATAGAGGGAGGAGTATAATC

Downstream 100 bases:

>100_bases
AATAGGGGGAATTGTTTTGAGGAGAGGAGAAGTATTAAAATTAGGTGTGGTTCCTTATCTTGAAGGGAAAGAGATACAGC
TTAAGGCTTTTGAAAAAGTT

Product: dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzyme

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; S complex, 50 kDa subunit [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNYDVIVVGGGPGGYTAAIRLSELGKKVALIEEDSLGGTCLNRGCIPTKVYAHAAELVTRIKEAKDFGITAEYTLDIAKL
RQKKERVVKRLVGGVGYLMNLHHIDVINGKGTFIDKNTVEVNGAKYTAENFIIATGSKVFLPPIEGIDLEGVMTSDKALE
LEKIPEKIVIIGAGIIGLEFANIYASLGSKVIMIEMLPQLLPMLDRDVVGVMEKALKKQKIELHLNSKVEKIERGLRVIY
TENGNQESVECDAVLVAVGRVPNVNGVDALNLEMNGRGIKVDSHMRTSIENIYAIGDVTGGIQLAHVASYQGIVAAHNIA
GEEKEADLTAVPNCLYTNPEVAWVGLNESQAREKYGEVKIGTFPYTALGRAMTMGESDGFVKIIAEGKYGRVVGMEIIGA
GATEIIHEGVLAIKEEFTLEELADSIHAHPTLSESIKEAAEDALGMPINKG

Sequences:

>Translated_451_residues
MNYDVIVVGGGPGGYTAAIRLSELGKKVALIEEDSLGGTCLNRGCIPTKVYAHAAELVTRIKEAKDFGITAEYTLDIAKL
RQKKERVVKRLVGGVGYLMNLHHIDVINGKGTFIDKNTVEVNGAKYTAENFIIATGSKVFLPPIEGIDLEGVMTSDKALE
LEKIPEKIVIIGAGIIGLEFANIYASLGSKVIMIEMLPQLLPMLDRDVVGVMEKALKKQKIELHLNSKVEKIERGLRVIY
TENGNQESVECDAVLVAVGRVPNVNGVDALNLEMNGRGIKVDSHMRTSIENIYAIGDVTGGIQLAHVASYQGIVAAHNIA
GEEKEADLTAVPNCLYTNPEVAWVGLNESQAREKYGEVKIGTFPYTALGRAMTMGESDGFVKIIAEGKYGRVVGMEIIGA
GATEIIHEGVLAIKEEFTLEELADSIHAHPTLSESIKEAAEDALGMPINKG
>Mature_451_residues
MNYDVIVVGGGPGGYTAAIRLSELGKKVALIEEDSLGGTCLNRGCIPTKVYAHAAELVTRIKEAKDFGITAEYTLDIAKL
RQKKERVVKRLVGGVGYLMNLHHIDVINGKGTFIDKNTVEVNGAKYTAENFIIATGSKVFLPPIEGIDLEGVMTSDKALE
LEKIPEKIVIIGAGIIGLEFANIYASLGSKVIMIEMLPQLLPMLDRDVVGVMEKALKKQKIELHLNSKVEKIERGLRVIY
TENGNQESVECDAVLVAVGRVPNVNGVDALNLEMNGRGIKVDSHMRTSIENIYAIGDVTGGIQLAHVASYQGIVAAHNIA
GEEKEADLTAVPNCLYTNPEVAWVGLNESQAREKYGEVKIGTFPYTALGRAMTMGESDGFVKIIAEGKYGRVVGMEIIGA
GATEIIHEGVLAIKEEFTLEELADSIHAHPTLSESIKEAAEDALGMPINKG

Specific function: Catalyzes the oxidation of dihydrolipoamide to lipoamide [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=470, Percent_Identity=38.5106382978723, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI50301238, Length=457, Percent_Identity=31.9474835886214, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI33519430, Length=451, Percent_Identity=29.0465631929047, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI33519428, Length=451, Percent_Identity=29.0465631929047, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI33519426, Length=451, Percent_Identity=29.0465631929047, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI148277065, Length=451, Percent_Identity=29.0465631929047, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI148277071, Length=451, Percent_Identity=29.0465631929047, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=30.2521008403361, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI291045266, Length=453, Percent_Identity=26.9315673289183, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291045268, Length=445, Percent_Identity=25.6179775280899, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1786307, Length=450, Percent_Identity=40.8888888888889, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI87081717, Length=449, Percent_Identity=32.0712694877506, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=32.0276497695853, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI87082354, Length=460, Percent_Identity=29.3478260869565, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789065, Length=262, Percent_Identity=25.9541984732824, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=38.0434782608696, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71983419, Length=433, Percent_Identity=30.9468822170901, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71983429, Length=433, Percent_Identity=30.9468822170901, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=27.9661016949153, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71982272, Length=485, Percent_Identity=28.659793814433, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321091, Length=464, Percent_Identity=38.3620689655172, Blast_Score=276, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6325166, Length=459, Percent_Identity=30.718954248366, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=28.3898305084746, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=39.1120507399577, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=29.957805907173, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=29.957805907173, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=29.957805907173, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI17737741, Length=468, Percent_Identity=27.7777777777778, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48580; Mature: 48580

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYDVIVVGGGPGGYTAAIRLSELGKKVALIEEDSLGGTCLNRGCIPTKVYAHAAELVTR
CCEEEEEEECCCCCEEEEEEHHHCCCEEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHH
IKEAKDFGITAEYTLDIAKLRQKKERVVKRLVGGVGYLMNLHHIDVINGKGTFIDKNTVE
HHHHHHCCCEEHEEHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCCCEEECCEEE
VNGAKYTAENFIIATGSKVFLPPIEGIDLEGVMTSDKALELEKIPEKIVIIGAGIIGLEF
ECCCEEEECEEEEEECCEEEECCCCCCCCCCEECCCCCEEHHHCCCEEEEEECCHHHHHH
ANIYASLGSKVIMIEMLPQLLPMLDRDVVGVMEKALKKQKIELHLNSKVEKIERGLRVIY
HHHHHHHCCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHCEEEEEECHHHHHHHCCEEEEE
TENGNQESVECDAVLVAVGRVPNVNGVDALNLEMNGRGIKVDSHMRTSIENIYAIGDVTG
ECCCCCCCEECCEEEEEECCCCCCCCCEEEEEEECCCEEEECHHHHHHHHHEEEEECCCC
GIQLAHVASYQGIVAAHNIAGEEKEADLTAVPNCLYTNPEVAWVGLNESQAREKYGEVKI
CEEEEEECCCCCEEEEECCCCCCCCCCHHHCCCEEECCCCEEEEECCHHHHHHHHCCEEE
GTFPYTALGRAMTMGESDGFVKIIAEGKYGRVVGMEIIGAGATEIIHEGVLAIKEEFTLE
CCCCHHHHHHEEECCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCHH
ELADSIHAHPTLSESIKEAAEDALGMPINKG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNYDVIVVGGGPGGYTAAIRLSELGKKVALIEEDSLGGTCLNRGCIPTKVYAHAAELVTR
CCEEEEEEECCCCCEEEEEEHHHCCCEEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHH
IKEAKDFGITAEYTLDIAKLRQKKERVVKRLVGGVGYLMNLHHIDVINGKGTFIDKNTVE
HHHHHHCCCEEHEEHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCCCEEECCEEE
VNGAKYTAENFIIATGSKVFLPPIEGIDLEGVMTSDKALELEKIPEKIVIIGAGIIGLEF
ECCCEEEECEEEEEECCEEEECCCCCCCCCCEECCCCCEEHHHCCCEEEEEECCHHHHHH
ANIYASLGSKVIMIEMLPQLLPMLDRDVVGVMEKALKKQKIELHLNSKVEKIERGLRVIY
HHHHHHHCCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHCEEEEEECHHHHHHHCCEEEEE
TENGNQESVECDAVLVAVGRVPNVNGVDALNLEMNGRGIKVDSHMRTSIENIYAIGDVTG
ECCCCCCCEECCEEEEEECCCCCCCCCEEEEEEECCCEEEECHHHHHHHHHEEEEECCCC
GIQLAHVASYQGIVAAHNIAGEEKEADLTAVPNCLYTNPEVAWVGLNESQAREKYGEVKI
CEEEEEECCCCCEEEEECCCCCCCCCCHHHCCCEEECCCCEEEEECCHHHHHHHHCCEEE
GTFPYTALGRAMTMGESDGFVKIIAEGKYGRVVGMEIIGAGATEIIHEGVLAIKEEFTLE
CCCCHHHHHHEEECCCCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCHH
ELADSIHAHPTLSESIKEAAEDALGMPINKG
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1697575; 8969500; 9384377; 1936936 [H]