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The map label for this gene is Gcn3

Identifier: 20808019

GI number: 20808019

Start: 1546744

End: 1547781

Strand: Reverse

Name: Gcn3

Synonym: TTE1590

Alternate gene names: 20808019

Gene position: 1547781-1546744 (Counterclockwise)

Preceding gene: 20808020

Following gene: 20808018

Centisome position: 57.55

GC content: 41.81

Gene sequence:

>1038_bases
ATGAAGGAGATTAAGACAATGGAATTTAGAGATGGCGTGCTTTATCTGATAGACCAGAGGAAACTTCCCTTAAGTTATGA
ATTTTTTGAATGCAGAACTTATCAGGATGTAGACTTTGCTATAAAAGACATGGTAGTAAGGGGTGCTCCGGCGATAGGAG
CAGCTGCAGCTTATGGCGTGGTACTCGCAGCTCAGCAGTTTATGAAAGAAGAGAAGGAAAATTTTTTAAAAAACATGGAA
AATGCTCTAAATGTGCTTTCAAAGTCCAGGCCTACAGCTGTGAACCTCACCTGGGCTATTGGCAGGATGAGGGGTGTTTT
AGAAAAGGTAAAGGATTTGAGTGTTTCAGATATATACGAGGCGTTAAAAGAAGAAGCCAATAAGATTTACTTTGAGGATT
TAGAGACAAATAAAAAGATGGCTAAGATTGGAAATGAAGTGATAAAGCCAAACGCAGTCATACTGACTCACTGCAACACA
GGAGCTTTGGCCACAGTTGGCTATGGCACAGCTTTAGGGGTCATAAGAGAAGCCCATTACAGCGGAAAGAATATTTTTGT
ATACGCTGATGAGACAAGGCCCAGGCTTCAGGGGGCGAAATTGACAGCTTGGGAACTTGTCCAAGAGGGAATACCGGCTA
AATTAATTGCTGACAGTGTAGCTGCTACTCTCATAAGAGATGGAAAGATTGACATCATACTCGTGGGGGCAGACAGAATA
GCCCTAAACGGAGATACTGCTAATAAAATCGGTACCTTCATGCTCTCTGTTGTGGCAAAAGTGTACAATGTTCCTTTTTA
TGTGGTGGCACCTACCAGCACCATCGATTTTAACATAGAGACTGGAGCCGAAATAGTCATAGAAGAAAGAAGTCCTGAAG
AGGTAACACATATAAATGGTGTGAGAATTGCACCTGAAGGCATAGATGTGTACAACCCCGCTTTTGATGTTACGCCCCAT
GAAAATATCACTGGTATAATCACAGAAAAGGGCATAATAAGGCCGCCTTTTAGAGAGAACATATTGAAATTGAGGTGA

Upstream 100 bases:

>100_bases
TCATAAGCGGTTTTTATAAGTTAGAGCAGTATGAAGAGGCTTTTTCTCCAAAAAATACTTTTAAGGCAGTTTTTGACTTA
AGAGGTTAGGAGGAGTTGGA

Downstream 100 bases:

>100_bases
GGGTTAGGACATGACGTTAAGCGATAAGGAAATAATTGTGAAAGATTTGACATTTCGCTACAAAGAGCAAAAGGACAGAA
ATGCTATAGAGGGGATTAAC

Product: translation initiation factor eIF-2B alpha subunit

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKEIKTMEFRDGVLYLIDQRKLPLSYEFFECRTYQDVDFAIKDMVVRGAPAIGAAAAYGVVLAAQQFMKEEKENFLKNME
NALNVLSKSRPTAVNLTWAIGRMRGVLEKVKDLSVSDIYEALKEEANKIYFEDLETNKKMAKIGNEVIKPNAVILTHCNT
GALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGAKLTAWELVQEGIPAKLIADSVAATLIRDGKIDIILVGADRI
ALNGDTANKIGTFMLSVVAKVYNVPFYVVAPTSTIDFNIETGAEIVIEERSPEEVTHINGVRIAPEGIDVYNPAFDVTPH
ENITGIITEKGIIRPPFRENILKLR

Sequences:

>Translated_345_residues
MKEIKTMEFRDGVLYLIDQRKLPLSYEFFECRTYQDVDFAIKDMVVRGAPAIGAAAAYGVVLAAQQFMKEEKENFLKNME
NALNVLSKSRPTAVNLTWAIGRMRGVLEKVKDLSVSDIYEALKEEANKIYFEDLETNKKMAKIGNEVIKPNAVILTHCNT
GALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGAKLTAWELVQEGIPAKLIADSVAATLIRDGKIDIILVGADRI
ALNGDTANKIGTFMLSVVAKVYNVPFYVVAPTSTIDFNIETGAEIVIEERSPEEVTHINGVRIAPEGIDVYNPAFDVTPH
ENITGIITEKGIIRPPFRENILKLR
>Mature_345_residues
MKEIKTMEFRDGVLYLIDQRKLPLSYEFFECRTYQDVDFAIKDMVVRGAPAIGAAAAYGVVLAAQQFMKEEKENFLKNME
NALNVLSKSRPTAVNLTWAIGRMRGVLEKVKDLSVSDIYEALKEEANKIYFEDLETNKKMAKIGNEVIKPNAVILTHCNT
GALATVGYGTALGVIREAHYSGKNIFVYADETRPRLQGAKLTAWELVQEGIPAKLIADSVAATLIRDGKIDIILVGADRI
ALNGDTANKIGTFMLSVVAKVYNVPFYVVAPTSTIDFNIETGAEIVIEERSPEEVTHINGVRIAPEGIDVYNPAFDVTPH
ENITGIITEKGIIRPPFRENILKLR

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=354, Percent_Identity=41.5254237288136, Blast_Score=252, Evalue=3e-67,
Organism=Homo sapiens, GI23943880, Length=334, Percent_Identity=37.4251497005988, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4503503, Length=204, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI78000156, Length=166, Percent_Identity=28.3132530120482, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI78000158, Length=166, Percent_Identity=28.3132530120482, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI187607323, Length=166, Percent_Identity=28.3132530120482, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=352, Percent_Identity=38.6363636363636, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17557123, Length=287, Percent_Identity=28.9198606271777, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=379, Percent_Identity=39.0501319261214, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6322878, Length=280, Percent_Identity=27.1428571428571, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357667, Length=359, Percent_Identity=40.9470752089136, Blast_Score=257, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24651647, Length=359, Percent_Identity=40.9470752089136, Blast_Score=257, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_THETN (Q8R9L7)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623190.1
- HSSP:   Q9X013
- ProteinModelPortal:   Q8R9L7
- SMR:   Q8R9L7
- GeneID:   996067
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1590
- NMPDR:   fig|273068.3.peg.1538
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK901319
- BioCyc:   TTEN273068:TTE1590-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38240; Mature: 38240

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: ACT_SITE 238-238 BINDING 90-90 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEIKTMEFRDGVLYLIDQRKLPLSYEFFECRTYQDVDFAIKDMVVRGAPAIGAAAAYGV
CCCCCCEEECCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHH
VLAAQQFMKEEKENFLKNMENALNVLSKSRPTAVNLTWAIGRMRGVLEKVKDLSVSDIYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHH
ALKEEANKIYFEDLETNKKMAKIGNEVIKPNAVILTHCNTGALATVGYGTALGVIREAHY
HHHHHHCEEEEEHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHC
SGKNIFVYADETRPRLQGAKLTAWELVQEGIPAKLIADSVAATLIRDGKIDIILVGADRI
CCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCEE
ALNGDTANKIGTFMLSVVAKVYNVPFYVVAPTSTIDFNIETGAEIVIEERSPEEVTHING
EECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEECCCCCHHHHCCC
VRIAPEGIDVYNPAFDVTPHENITGIITEKGIIRPPFRENILKLR
EEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHEECC
>Mature Secondary Structure
MKEIKTMEFRDGVLYLIDQRKLPLSYEFFECRTYQDVDFAIKDMVVRGAPAIGAAAAYGV
CCCCCCEEECCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHH
VLAAQQFMKEEKENFLKNMENALNVLSKSRPTAVNLTWAIGRMRGVLEKVKDLSVSDIYE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHH
ALKEEANKIYFEDLETNKKMAKIGNEVIKPNAVILTHCNTGALATVGYGTALGVIREAHY
HHHHHHCEEEEEHHHCCHHHHHHHHHHCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHC
SGKNIFVYADETRPRLQGAKLTAWELVQEGIPAKLIADSVAATLIRDGKIDIILVGADRI
CCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCEE
ALNGDTANKIGTFMLSVVAKVYNVPFYVVAPTSTIDFNIETGAEIVIEERSPEEVTHING
EECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEEECCCCCHHHHCCC
VRIAPEGIDVYNPAFDVTPHENITGIITEKGIIRPPFRENILKLR
EEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336