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The map label for this gene is Sir2

Identifier: 20807999

GI number: 20807999

Start: 1529328

End: 1530056

Strand: Reverse

Name: Sir2

Synonym: TTE1570

Alternate gene names: 20807999

Gene position: 1530056-1529328 (Counterclockwise)

Preceding gene: 20808001

Following gene: 20807996

Centisome position: 56.89

GC content: 39.78

Gene sequence:

>729_bases
ATGGATTTTAAAATATTAAAAGAAAAACTACCTCAATCGAATTTGACAGTTGTGCTGACAGGAGCAGGGATATCTAAAGA
AAGTGGGATACCTACTTTTAGAGGAGAAGATGGGCTATGGAAAAAGTACAATCCAGAAGAACTTGCAACGCCATGGGCTT
TTCAAAGAAATCCAGCTCTTGTTTGGGAATGGTATGATTACAGAAGGAGGATAATTTCTAAAGCGAAACCTAATAAATGT
CATCTGCTCATTGCAGAGTTTGAGGAAAGGTTTAAAAATGTAAGAGTAATTACGCAAAATGTAGATGGCTTACATGAGGC
AGCAGGGTCTACAAATGTGATAGAACTTCATGGGAATATATGGAAAGTAAAATGCACAAAATGTGACTTCAGAGGCATAA
ATAGAGAAGTGCCTTTAAGCAAAATACCTCCTGAGTGCCCGAAATGCGGATCTATTGTAAGACCAGATGTGGTCTGGTTT
GGTGAACCTCTCCCATCTGATAAGCTTACAGAGGCTATGGAGCTGTCACAAAGAGCAGACCTTTTTATTGTGATTGGTAC
ATCTTTAATGGTGCAGCCTGCAGCTTCTCTTCCTTTTCTGGCCCTTGAAAGAGGAGCTTTTGTAGTAGAGGTAAGTCCTG
AAGAGACTCCACTTTCAAGGAAAGCACATCTTTTTTTCCAAATGGGAGCGGTTGAATTTGCCATGAAATTTGAAGAGAAG
GAGGGATAA

Upstream 100 bases:

>100_bases
ATATATTTTACCATAGTTTTGTTGCTTTTTTGAAAAAAGGAGTTTTGAAATTGAAGGAGAAATTTTTAAATGATAAAAAT
GTAGGGGGGAGGAAAAGAAA

Downstream 100 bases:

>100_bases
AAAATAAAAGGGCACACATTTATGTGCCACTGAACTTCTTGAGGTGATTGATAAGCTTTTTCTTTTCTTTTTCAGGAATT
TTGTCCCAATTATTTGATAC

Product: Sir2 family NAD-dependent protein deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MDFKILKEKLPQSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRIISKAKPNKC
HLLIAEFEERFKNVRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWF
GEPLPSDKLTEAMELSQRADLFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEK
EG

Sequences:

>Translated_242_residues
MDFKILKEKLPQSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRIISKAKPNKC
HLLIAEFEERFKNVRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWF
GEPLPSDKLTEAMELSQRADLFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEK
EG
>Mature_242_residues
MDFKILKEKLPQSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRIISKAKPNKC
HLLIAEFEERFKNVRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWF
GEPLPSDKLTEAMELSQRADLFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEK
EG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain

Homologues:

Organism=Homo sapiens, GI300795542, Length=219, Percent_Identity=43.37899543379, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI6912664, Length=237, Percent_Identity=40.5063291139241, Blast_Score=177, Evalue=5e-45,
Organism=Homo sapiens, GI13787215, Length=231, Percent_Identity=40.6926406926407, Blast_Score=174, Evalue=5e-44,
Organism=Homo sapiens, GI6912660, Length=199, Percent_Identity=36.6834170854271, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI63054862, Length=196, Percent_Identity=36.2244897959184, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI7657575, Length=201, Percent_Identity=32.3383084577114, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI13775602, Length=202, Percent_Identity=34.1584158415842, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI13775600, Length=202, Percent_Identity=34.1584158415842, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI300797705, Length=195, Percent_Identity=32.8205128205128, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI300797577, Length=239, Percent_Identity=31.7991631799163, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI6912662, Length=236, Percent_Identity=30.5084745762712, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI7706712, Length=195, Percent_Identity=31.7948717948718, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI215982798, Length=133, Percent_Identity=33.8345864661654, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI308199517, Length=211, Percent_Identity=42.654028436019, Blast_Score=152, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17541892, Length=195, Percent_Identity=35.3846153846154, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71990482, Length=214, Percent_Identity=32.7102803738318, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=242, Percent_Identity=31.404958677686, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71990487, Length=216, Percent_Identity=32.4074074074074, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=214, Percent_Identity=26.1682242990654, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324599, Length=279, Percent_Identity=29.7491039426523, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325242, Length=213, Percent_Identity=32.3943661971831, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320397, Length=240, Percent_Identity=26.25, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137536, Length=224, Percent_Identity=33.0357142857143, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571445, Length=216, Percent_Identity=32.4074074074074, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24648389, Length=198, Percent_Identity=35.8585858585859, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645650, Length=236, Percent_Identity=30.0847457627119, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28571443, Length=139, Percent_Identity=32.3741007194245, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571441, Length=139, Percent_Identity=32.3741007194245, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24650933, Length=199, Percent_Identity=27.1356783919598, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NPD1_THETN (Q8R9N6)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623170.1
- ProteinModelPortal:   Q8R9N6
- SMR:   Q8R9N6
- GeneID:   995865
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1570
- NMPDR:   fig|273068.3.peg.1517
- HOGENOM:   HBG641281
- OMA:   FVHEARL
- BioCyc:   TTEN273068:TTE1570-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01121
- InterPro:   IPR003000
- PANTHER:   PTHR11085

Pfam domain/function: PF02146 SIR2

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27403; Mature: 27403

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50305 SIRTUIN

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKILKEKLPQSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPAL
CCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCE
VWEWYDYRRRIISKAKPNKCHLLIAEFEERFKNVRVITQNVDGLHEAAGSTNVIELHGNI
EEHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCEEEEEECCCHHHHHCCCCCEEEECCCE
WKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWFGEPLPSDKLTEAMELSQRAD
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCC
LFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEK
EEEEECCCEEECCCCCCCEEEEECCEEEEEECCCCCCCCCCEEEEEEECHHHEEEHHHCC
EG
CC
>Mature Secondary Structure
MDFKILKEKLPQSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPAL
CCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCE
VWEWYDYRRRIISKAKPNKCHLLIAEFEERFKNVRVITQNVDGLHEAAGSTNVIELHGNI
EEHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCEEEEEECCCHHHHHCCCCCEEEECCCE
WKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWFGEPLPSDKLTEAMELSQRAD
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCC
LFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEK
EEEEECCCEEECCCCCCCEEEEECCEEEEEECCCCCCCCCCEEEEEEECHHHEEEHHHCC
EG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336