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The map label for this gene is Ffh [H]

Identifier: 20807909

GI number: 20807909

Start: 1433884

End: 1435227

Strand: Reverse

Name: Ffh [H]

Synonym: TTE1462

Alternate gene names: 20807909

Gene position: 1435227-1433884 (Counterclockwise)

Preceding gene: 20807910

Following gene: 20807908

Centisome position: 53.37

GC content: 42.49

Gene sequence:

>1344_bases
TTGATGGCTTTTGAAAGCCTTTCTGAAAGGCTGCAGGGAGTTTTTAAAAAGCTAAGGGGTAAGGGGAAACTGACGGAAAA
AGACATAAAAGAGGCGATGAGGGAAGTAAAAGTTGCCCTTTTGGAAGCTGATGTAAATTTCAAGGTAGTCAAGGACTTCA
TAAATTCTGTCACTGAAAAGGCTCTGGGGCAGGAAGTAATGGAGAGCCTTACTCCTGCCCAGCAGGTGATAAAGATTGTG
CATGAAGAGCTCATAAAGCTTATGGGCTCTGTAGAGAGCCGATTGAATCTGGGCAGTAAAGTGCCTGCTGTTATAATGAT
GGTGGGTTTACAAGGCTCCGGAAAAACTACTGCCTGCGGCAAACTGGCTAACCTTTTAAAAAAACAGGGCAAGAATCCGT
TGCTGGTGGCCTGCGATACCGTAAGGCCAGCGGCTATCAAACAGCTGCAGGTTTTGGGAGCAAACATAAATGTACCCGTT
TTTACCATGGGAGATAAGGTGGACACTGCTGACATAGCAAAAGCCTCCATCGACTATGCCAAGTCCCATAATGTGGATGT
GGTTATAATTGATACAGCAGGAAGACTTCACATTGATGATGAATTGATGGAGGAGCTTGTGAGGATTAAGGAAGCAGTCC
ATCCCGATGAGATACTGCTTGTGGCTGATGCCATGACAGGACAAGATGCAGTAAATGTGGCTTCTTCCTTTAATGAAAGG
CTTGATATAACTGGTGTTATACTGACAAAGCTTGATGGGGATACAAGAGGTGGAGCTGCTCTTTCCATTAAAGCTGTGAC
TCAAAAACCTATAAAATACGTGGGGATTGGAGAAAAGCTTGGAGATATAGAGCCTTTTTACCCTGATAGAATGGCTTCCC
GCATTTTAGGGATGGGTGATGTCTTAACCCTTATAGAAAAAGCTCAAGCTGCAATAGATGAGAAAAAGGCCCTTGAGATG
GGGCAAAAAATACTGTCAAAGCAGTTTACTCTTGAGGACTTTTTAGAGCAGTTGAGAAGTCTTAAAAATATGGGGCCACT
TGATCAGCTGCTTGCCATGATTCCCGGTGTAAACAAGAGTGTTTTGAAAAATGTAGAAGTTTCTGAGAAGGATTTAAAGC
GAATTGAAGCTATAATACTTTCTATGACAAAAGAAGAGAGACAAAATCCTTCCATTATAAATGGAAGTAGAAAGAGAAGA
ATAGCAAGGGGCAGCGGCACTACAATCCAGGAGGTGAACAACCTCTTGAAGCAGTTTGAAGAAACCAAAAAGATGATGAA
GAGATTTGCTGATATAGACAAAGACCTTAAAAGAGGTAAACTGAGGTTGCCTTTCTTGCAGTAG

Upstream 100 bases:

>100_bases
ATAAAATTAATAAAGGAAAGGGAAAAGGACGAAGAGATTCTAAAAATTATTGAGGATATGGCTCGAGAGTTGGAAGAGTT
AAATCCTTAGGAGGTATTTT

Downstream 100 bases:

>100_bases
GTGAAGGCGGGCGACTTTTAAAGGAGGTGAGAAAGTGGCAGTTAGAATAAGGCTTAAAAGGTTCGGAGCTAAAAAGAGGC
CTTTCTACAGAATAGTAGTT

Product: Signal recognition particle GTPase

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MMAFESLSERLQGVFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKALGQEVMESLTPAQQVIKIV
HEELIKLMGSVESRLNLGSKVPAVIMMVGLQGSGKTTACGKLANLLKKQGKNPLLVACDTVRPAAIKQLQVLGANINVPV
FTMGDKVDTADIAKASIDYAKSHNVDVVIIDTAGRLHIDDELMEELVRIKEAVHPDEILLVADAMTGQDAVNVASSFNER
LDITGVILTKLDGDTRGGAALSIKAVTQKPIKYVGIGEKLGDIEPFYPDRMASRILGMGDVLTLIEKAQAAIDEKKALEM
GQKILSKQFTLEDFLEQLRSLKNMGPLDQLLAMIPGVNKSVLKNVEVSEKDLKRIEAIILSMTKEERQNPSIINGSRKRR
IARGSGTTIQEVNNLLKQFEETKKMMKRFADIDKDLKRGKLRLPFLQ

Sequences:

>Translated_447_residues
MMAFESLSERLQGVFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKALGQEVMESLTPAQQVIKIV
HEELIKLMGSVESRLNLGSKVPAVIMMVGLQGSGKTTACGKLANLLKKQGKNPLLVACDTVRPAAIKQLQVLGANINVPV
FTMGDKVDTADIAKASIDYAKSHNVDVVIIDTAGRLHIDDELMEELVRIKEAVHPDEILLVADAMTGQDAVNVASSFNER
LDITGVILTKLDGDTRGGAALSIKAVTQKPIKYVGIGEKLGDIEPFYPDRMASRILGMGDVLTLIEKAQAAIDEKKALEM
GQKILSKQFTLEDFLEQLRSLKNMGPLDQLLAMIPGVNKSVLKNVEVSEKDLKRIEAIILSMTKEERQNPSIINGSRKRR
IARGSGTTIQEVNNLLKQFEETKKMMKRFADIDKDLKRGKLRLPFLQ
>Mature_447_residues
MMAFESLSERLQGVFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEKALGQEVMESLTPAQQVIKIV
HEELIKLMGSVESRLNLGSKVPAVIMMVGLQGSGKTTACGKLANLLKKQGKNPLLVACDTVRPAAIKQLQVLGANINVPV
FTMGDKVDTADIAKASIDYAKSHNVDVVIIDTAGRLHIDDELMEELVRIKEAVHPDEILLVADAMTGQDAVNVASSFNER
LDITGVILTKLDGDTRGGAALSIKAVTQKPIKYVGIGEKLGDIEPFYPDRMASRILGMGDVLTLIEKAQAAIDEKKALEM
GQKILSKQFTLEDFLEQLRSLKNMGPLDQLLAMIPGVNKSVLKNVEVSEKDLKRIEAIILSMTKEERQNPSIINGSRKRR
IARGSGTTIQEVNNLLKQFEETKKMMKRFADIDKDLKRGKLRLPFLQ

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=34.1463414634146, Blast_Score=255, Evalue=8e-68,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=34.9614395886889, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI23308697, Length=304, Percent_Identity=28.9473684210526, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=28.9473684210526, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI89061728, Length=154, Percent_Identity=39.6103896103896, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1788963, Length=425, Percent_Identity=50.3529411764706, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=39.3939393939394, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17539958, Length=447, Percent_Identity=31.9910514541387, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI193206261, Length=294, Percent_Identity=30.952380952381, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=410, Percent_Identity=36.0975609756098, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=29.8076923076923, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17647949, Length=449, Percent_Identity=32.293986636971, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24641198, Length=308, Percent_Identity=28.5714285714286, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49296; Mature: 49296

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAFESLSERLQGVFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEK
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ALGQEVMESLTPAQQVIKIVHEELIKLMGSVESRLNLGSKVPAVIMMVGLQGSGKTTACG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCHHHH
KLANLLKKQGKNPLLVACDTVRPAAIKQLQVLGANINVPVFTMGDKVDTADIAKASIDYA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
KSHNVDVVIIDTAGRLHIDDELMEELVRIKEAVHPDEILLVADAMTGQDAVNVASSFNER
HCCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCC
LDITGVILTKLDGDTRGGAALSIKAVTQKPIKYVGIGEKLGDIEPFYPDRMASRILGMGD
CCEEEEEEEEECCCCCCCCEEEEEHHHHCCCCEEECCCHHCCCCCCCHHHHHHHHHCCHH
VLTLIEKAQAAIDEKKALEMGQKILSKQFTLEDFLEQLRSLKNMGPLDQLLAMIPGVNKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHH
VLKNVEVSEKDLKRIEAIILSMTKEERQNPSIINGSRKRRIARGSGTTIQEVNNLLKQFE
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
ETKKMMKRFADIDKDLKRGKLRLPFLQ
HHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MMAFESLSERLQGVFKKLRGKGKLTEKDIKEAMREVKVALLEADVNFKVVKDFINSVTEK
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ALGQEVMESLTPAQQVIKIVHEELIKLMGSVESRLNLGSKVPAVIMMVGLQGSGKTTACG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECCCCCCCHHHH
KLANLLKKQGKNPLLVACDTVRPAAIKQLQVLGANINVPVFTMGDKVDTADIAKASIDYA
HHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHH
KSHNVDVVIIDTAGRLHIDDELMEELVRIKEAVHPDEILLVADAMTGQDAVNVASSFNER
HCCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCC
LDITGVILTKLDGDTRGGAALSIKAVTQKPIKYVGIGEKLGDIEPFYPDRMASRILGMGD
CCEEEEEEEEECCCCCCCCEEEEEHHHHCCCCEEECCCHHCCCCCCCHHHHHHHHHCCHH
VLTLIEKAQAAIDEKKALEMGQKILSKQFTLEDFLEQLRSLKNMGPLDQLLAMIPGVNKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCHH
VLKNVEVSEKDLKRIEAIILSMTKEERQNPSIINGSRKRRIARGSGTTIQEVNNLLKQFE
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHH
ETKKMMKRFADIDKDLKRGKLRLPFLQ
HHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]