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The map label for this gene is FtsK

Identifier: 20807825

GI number: 20807825

Start: 1360871

End: 1363000

Strand: Reverse

Name: FtsK

Synonym: TTE1378

Alternate gene names: 20807825

Gene position: 1363000-1360871 (Counterclockwise)

Preceding gene: 20807826

Following gene: 20807824

Centisome position: 50.68

GC content: 38.12

Gene sequence:

>2130_bases
ATGATAGATAAAAAGCAAAAGCCGGTGAAAGAAGAAATTGTGGGAATAATTTTTCTAGCCTTTACTCTTATTTCTTTTTT
AAGCCTCTATACTGACTCAACAGGAATAATTGGCAAACACATAGGAATTTTTTTAAAAGGCTTTTTCGGGACAGGTTCCT
ATGTAATCTCTGCCCTGCTTTTGGTATTTGCCTTGATGTTTTTATTTACAAACAAAAACTTTATAAAGCTTCATCGTTCG
ATGGCTCTTTTAGGGTTATTCCTCATGTTTATAAGTTTAAATCAACTGTACTATTTTCCTGTGCTGACTGATTTTAAGGA
CTATCTTTCTGTAGCATATATAAGTGGAATTAACAACACAGGCGGAGGAATAATCGGCAGCCTGATAGTGTATTTTCTTG
TTAAAATGGTAGGCATAATTGGAAGCTATATATTATTAATATCCTTTACTGCCATTTTTATAGTCCTCATAACAGATATT
TCTCTTGTCAGTTTGATAAAGAGCTCTTATGACAAGTTAAAAGACCGCAAGAAGGTTTCAGCAAAAAACAAACTTCAAGA
CAAAATGGCAGAAAAAAAGGCAGAAGAGGTAGAATCTACTGAAGAATTAGTTGAAGTCGAGAAGAAGGAAAGAATTGATG
TTCCAATTGAGATAGTAGAACAAGTTGAAGAGGAAAGAAAAGTTTACGAAAAAGCTTTTTTAGAAAAGGAAGAAGGGGAA
TACACGCCTCCCCCCATTACTCTTTTAAAGGAGGCAATTCCTTCTCCTAAAATAAAGAACGAGGTACTTTTAGAAAAAGC
TAAAAAGATAGAGGAGACCTTAAGAAACTTCGGCATAGAAGCTAAAGTAGTTCAGGTAACCAAAGGACCTGCTATCACCC
GCTTTGAACTTCAGCCCAGCGCAGGAGTTAAAGTAAGCCGAATTGTGAGTTTGACAGATGACTTGGCCTTAAGCCTAGCT
GCTCCTTCTGTAAGAATAGAAGCTCCTATACCTGGCAAGTCTGCAATTGGAATAGAAGTTCCAAATGAAAAGATAACTCC
TGTATATCTAAGAGAAGTAATTGACAGCAAAAAGTTCAGAAGCTTTAAATCAGAACTTGCCATCGGCTTAGGAAAGGATA
TTGCCGGCAATATCGTGATAGCCGACCTTGCCAAGATGCCCCATCTTTTAATTGCAGGAGCAACTGGCTCAGGTAAGAGT
GTTTGCATAAATTCTCTGATAGTGAGTCTTCTTTACAAAGCTTCTCCTAAACAAGTTAAAATGATACTAATTGACCCAAA
GGTAGTAGAACTTAATATCTATAATGGCATACCTCATCTTTTAACTCCTGTAGTTACAGACCCTAAAAAAGCAGCAGGGG
TTTTGAACTGGGCAGTGCAGGAGATGATAAGGAGGTACAGTCTTTTTGCAGACCACGGAGTGAGAGATATAGAGAGCTAC
AATGAAAAGTACAAAGAAGAAAGGCTATATAAAATAGTCATAATCATAGATGAGCTCTCAGACTTGATGATGGTATCTCC
TGCCGAGGTTGAAGAGTATATATTTAGACTCGCTCAAATGGCAAGAGCTGCTGGAATACACTTGGTCATTGCTACTCAGA
GGCCCTCTGTTGATGTCATAACAGGAGTAATAAAGGCAAACATTCCTTCTAGAATTTCCTTTGCTGTTTCATCACAGATT
GACTCGAGGACTATTCTAGACATGACAGGGGCCGAAAAACTGCTGGGGAAAGGAGATATGCTTTTTGACCCTATCGGAGC
TTCTAAACCTATAAGGGTACAGGGAGCTTTCATCTCGGAAGAGGAAGTAGAAGCAGTTGTGAACTTTTTGAAAGAAAACT
ATAGCTCTCATTATGAAGAAATAAAAGTTGAAGAAAAAACAAATGGGAAAAATCTCGATGAAGAAGAGGACGAACTCTTG
GAAGATGCAGTCTCTGTAATCTTGGAGACAGGTCAAGCTTCTATTTCCCTCCTCCAGAGAAAGTTAAGAATAGGATACGC
TAGAGCTGCAAGAATTATAGACCAGCTTGAGCAAAAAGGAATAATAAGCGGATACGACGGAGCAAAACCGAGGCAAATTA
TACTGCCCAGAGAAGAAATACAAAAGATTCTAGAAAGGAAGTCGGTATGA

Upstream 100 bases:

>100_bases
AGATGAGTTTTTACATGCTCATCTATTTTTTTGTTGCTATTTTGTATAATTAATACTAAAATTTTTATAGGGAGAGAAAT
TGCTAGTTAGGTGATAAGAG

Downstream 100 bases:

>100_bases
GAAACGTTGGAATTATCTCATTAGGGTGCCCGAAAAACAGCGTTGACTCAGAAAAAATGCTAGCTTTACTGAAAGAAAAG
GGGTACAATATAGTAAATGA

Product: DNA segregation ATPase FtsK/SpoIIIE and related proteins

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MIDKKQKPVKEEIVGIIFLAFTLISFLSLYTDSTGIIGKHIGIFLKGFFGTGSYVISALLLVFALMFLFTNKNFIKLHRS
MALLGLFLMFISLNQLYYFPVLTDFKDYLSVAYISGINNTGGGIIGSLIVYFLVKMVGIIGSYILLISFTAIFIVLITDI
SLVSLIKSSYDKLKDRKKVSAKNKLQDKMAEKKAEEVESTEELVEVEKKERIDVPIEIVEQVEEERKVYEKAFLEKEEGE
YTPPPITLLKEAIPSPKIKNEVLLEKAKKIEETLRNFGIEAKVVQVTKGPAITRFELQPSAGVKVSRIVSLTDDLALSLA
APSVRIEAPIPGKSAIGIEVPNEKITPVYLREVIDSKKFRSFKSELAIGLGKDIAGNIVIADLAKMPHLLIAGATGSGKS
VCINSLIVSLLYKASPKQVKMILIDPKVVELNIYNGIPHLLTPVVTDPKKAAGVLNWAVQEMIRRYSLFADHGVRDIESY
NEKYKEERLYKIVIIIDELSDLMMVSPAEVEEYIFRLAQMARAAGIHLVIATQRPSVDVITGVIKANIPSRISFAVSSQI
DSRTILDMTGAEKLLGKGDMLFDPIGASKPIRVQGAFISEEEVEAVVNFLKENYSSHYEEIKVEEKTNGKNLDEEEDELL
EDAVSVILETGQASISLLQRKLRIGYARAARIIDQLEQKGIISGYDGAKPRQIILPREEIQKILERKSV

Sequences:

>Translated_709_residues
MIDKKQKPVKEEIVGIIFLAFTLISFLSLYTDSTGIIGKHIGIFLKGFFGTGSYVISALLLVFALMFLFTNKNFIKLHRS
MALLGLFLMFISLNQLYYFPVLTDFKDYLSVAYISGINNTGGGIIGSLIVYFLVKMVGIIGSYILLISFTAIFIVLITDI
SLVSLIKSSYDKLKDRKKVSAKNKLQDKMAEKKAEEVESTEELVEVEKKERIDVPIEIVEQVEEERKVYEKAFLEKEEGE
YTPPPITLLKEAIPSPKIKNEVLLEKAKKIEETLRNFGIEAKVVQVTKGPAITRFELQPSAGVKVSRIVSLTDDLALSLA
APSVRIEAPIPGKSAIGIEVPNEKITPVYLREVIDSKKFRSFKSELAIGLGKDIAGNIVIADLAKMPHLLIAGATGSGKS
VCINSLIVSLLYKASPKQVKMILIDPKVVELNIYNGIPHLLTPVVTDPKKAAGVLNWAVQEMIRRYSLFADHGVRDIESY
NEKYKEERLYKIVIIIDELSDLMMVSPAEVEEYIFRLAQMARAAGIHLVIATQRPSVDVITGVIKANIPSRISFAVSSQI
DSRTILDMTGAEKLLGKGDMLFDPIGASKPIRVQGAFISEEEVEAVVNFLKENYSSHYEEIKVEEKTNGKNLDEEEDELL
EDAVSVILETGQASISLLQRKLRIGYARAARIIDQLEQKGIISGYDGAKPRQIILPREEIQKILERKSV
>Mature_709_residues
MIDKKQKPVKEEIVGIIFLAFTLISFLSLYTDSTGIIGKHIGIFLKGFFGTGSYVISALLLVFALMFLFTNKNFIKLHRS
MALLGLFLMFISLNQLYYFPVLTDFKDYLSVAYISGINNTGGGIIGSLIVYFLVKMVGIIGSYILLISFTAIFIVLITDI
SLVSLIKSSYDKLKDRKKVSAKNKLQDKMAEKKAEEVESTEELVEVEKKERIDVPIEIVEQVEEERKVYEKAFLEKEEGE
YTPPPITLLKEAIPSPKIKNEVLLEKAKKIEETLRNFGIEAKVVQVTKGPAITRFELQPSAGVKVSRIVSLTDDLALSLA
APSVRIEAPIPGKSAIGIEVPNEKITPVYLREVIDSKKFRSFKSELAIGLGKDIAGNIVIADLAKMPHLLIAGATGSGKS
VCINSLIVSLLYKASPKQVKMILIDPKVVELNIYNGIPHLLTPVVTDPKKAAGVLNWAVQEMIRRYSLFADHGVRDIESY
NEKYKEERLYKIVIIIDELSDLMMVSPAEVEEYIFRLAQMARAAGIHLVIATQRPSVDVITGVIKANIPSRISFAVSSQI
DSRTILDMTGAEKLLGKGDMLFDPIGASKPIRVQGAFISEEEVEAVVNFLKENYSSHYEEIKVEEKTNGKNLDEEEDELL
EDAVSVILETGQASISLLQRKLRIGYARAARIIDQLEQKGIISGYDGAKPRQIILPREEIQKILERKSV

Specific function: DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind

COG id: COG1674

COG function: function code D; DNA segregation ATPase FtsK/SpoIIIE and related proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Located at the septum. The large C-terminal part of the protein is cytoplasmic (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FtsK domain

Homologues:

Organism=Escherichia coli, GI1787117, Length=488, Percent_Identity=50.6147540983607, Blast_Score=443, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTSK_THETN (Q8R5S4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622996.1
- ProteinModelPortal:   Q8R5S4
- SMR:   Q8R5S4
- GeneID:   997855
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1378
- NMPDR:   fig|273068.3.peg.1343
- HOGENOM:   HBG662140
- OMA:   NIYNGIP
- ProtClustDB:   CLSK901202
- BioCyc:   TTEN273068:TTE1378-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR018541
- InterPro:   IPR002543
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00382
- SMART:   SM00843

Pfam domain/function: PF09397 Ftsk_gamma; PF01580 FtsK_SpoIIIE

EC number: NA

Molecular weight: Translated: 78917; Mature: 78917

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50901 FTSK

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe2377f8)-; HASH(0xe9fa914)-; HASH(0xe74d4b0)-; HASH(0xe65c998)-; HASH(0xde7d830)-;

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKKQKPVKEEIVGIIFLAFTLISFLSLYTDSTGIIGKHIGIFLKGFFGTGSYVISALL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LVFALMFLFTNKNFIKLHRSMALLGLFLMFISLNQLYYFPVLTDFKDYLSVAYISGINNT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCCCCC
GGGIIGSLIVYFLVKMVGIIGSYILLISFTAIFIVLITDISLVSLIKSSYDKLKDRKKVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKNKLQDKMAEKKAEEVESTEELVEVEKKERIDVPIEIVEQVEEERKVYEKAFLEKEEGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YTPPPITLLKEAIPSPKIKNEVLLEKAKKIEETLRNFGIEAKVVQVTKGPAITRFELQPS
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCC
AGVKVSRIVSLTDDLALSLAAPSVRIEAPIPGKSAIGIEVPNEKITPVYLREVIDSKKFR
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
SFKSELAIGLGKDIAGNIVIADLAKMPHLLIAGATGSGKSVCINSLIVSLLYKASPKQVK
HHHHHHHHHCCCCCCCCEEEEHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEE
MILIDPKVVELNIYNGIPHLLTPVVTDPKKAAGVLNWAVQEMIRRYSLFADHGVRDIESY
EEEECCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
NEKYKEERLYKIVIIIDELSDLMMVSPAEVEEYIFRLAQMARAAGIHLVIATQRPSVDVI
HHHHHHHHHEEEEEEEECHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHH
TGVIKANIPSRISFAVSSQIDSRTILDMTGAEKLLGKGDMLFDPIGASKPIRVQGAFISE
HHHHHCCCCCHHHHHHHCCCCCCEEEECCCHHHHHCCCCCEECCCCCCCCEEEEECCCCH
EEVEAVVNFLKENYSSHYEEIKVEEKTNGKNLDEEEDELLEDAVSVILETGQASISLLQR
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
KLRIGYARAARIIDQLEQKGIISGYDGAKPRQIILPREEIQKILERKSV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHCCH
>Mature Secondary Structure
MIDKKQKPVKEEIVGIIFLAFTLISFLSLYTDSTGIIGKHIGIFLKGFFGTGSYVISALL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
LVFALMFLFTNKNFIKLHRSMALLGLFLMFISLNQLYYFPVLTDFKDYLSVAYISGINNT
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHCCCCC
GGGIIGSLIVYFLVKMVGIIGSYILLISFTAIFIVLITDISLVSLIKSSYDKLKDRKKVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKNKLQDKMAEKKAEEVESTEELVEVEKKERIDVPIEIVEQVEEERKVYEKAFLEKEEGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YTPPPITLLKEAIPSPKIKNEVLLEKAKKIEETLRNFGIEAKVVQVTKGPAITRFELQPS
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCC
AGVKVSRIVSLTDDLALSLAAPSVRIEAPIPGKSAIGIEVPNEKITPVYLREVIDSKKFR
CCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHH
SFKSELAIGLGKDIAGNIVIADLAKMPHLLIAGATGSGKSVCINSLIVSLLYKASPKQVK
HHHHHHHHHCCCCCCCCEEEEHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEE
MILIDPKVVELNIYNGIPHLLTPVVTDPKKAAGVLNWAVQEMIRRYSLFADHGVRDIESY
EEEECCEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
NEKYKEERLYKIVIIIDELSDLMMVSPAEVEEYIFRLAQMARAAGIHLVIATQRPSVDVI
HHHHHHHHHEEEEEEEECHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHH
TGVIKANIPSRISFAVSSQIDSRTILDMTGAEKLLGKGDMLFDPIGASKPIRVQGAFISE
HHHHHCCCCCHHHHHHHCCCCCCEEEECCCHHHHHCCCCCEECCCCCCCCEEEEECCCCH
EEVEAVVNFLKENYSSHYEEIKVEEKTNGKNLDEEEDELLEDAVSVILETGQASISLLQR
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
KLRIGYARAARIIDQLEQKGIISGYDGAKPRQIILPREEIQKILERKSV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336