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The map label for this gene is DacC2 [H]

Identifier: 20807763

GI number: 20807763

Start: 1304673

End: 1305806

Strand: Direct

Name: DacC2 [H]

Synonym: TTE1314

Alternate gene names: 20807763

Gene position: 1304673-1305806 (Clockwise)

Preceding gene: 20807762

Following gene: 20807764

Centisome position: 48.51

GC content: 38.18

Gene sequence:

>1134_bases
ATGTCAAAAAAGTTTTTAGCATTATTGATAAGCACATTTTTGCTGTTTAATACGGCATATGCGGATGTCATGAATTTAAA
AGCAAAATCTGCAATACTTATGGAAGCAGAAACTGGAGAGATTCTATATGAAAAAGATATTCACAAACCTTTGCCTCCTG
CTAGTGTGACGAAAGTAATGACTTTGCTCCTTGCGATTGAGGCGATAGATTCAGGGAAGATCAAAGTCACAGACAAAGTG
GTCACCAGCAAACACGCTTTTGACATGGGGGGTACTCAAATATACCTTGAGGTAGGAGAAGAAATGACTGTAGACGATTT
GATGAAAGCTATTGCGATGAACTCAGCAAATGACGCATCTGTAGCTTTGGCTGAATATATAGCCGGTACAGAGGAAAATT
TTGTGGAAATGATGAACAAAAGAGCAAAGGAACTGGGAGCCAAAAATACCACTTTTAAAAACGCTACAGGTCTTCCTGAA
GAAGGACATTTAACCACGGTGTATGATATAGCAATGATTTCCAGAGAACTTGTAAAACATCCGTCAATTTTTAAGTATTT
GACTAATAAAATTGACTCCTTGAGGAATGGGAAATTCAGCCTTATAAACACAAATAAACTGCTTTGGAGGTACAAAGGAG
TTGATGGAATAAAAACAGGTTCTACCTCTGAGGCTCTTTACTGCATGGCTGCAACCGCAAAAAGAGGAGATACCAGGTTG
ATTGCTGTGGTATTTGGAGCTCCCGATTCGGAGACTAGGTTCAACGAGACGGCTAAATTGCTGGATTACGGGTTTGCAAA
TTTCGAAACGGTGAAAGTAGCTTCAAAAGGGGAAGTACTAGGAAAGATAAAGGTTTTAAAAGGGAATAAGGAGATGGTAG
AGGGAATTTCATTAAAAGATGAATATGTAGTTGTGAAAAAAGGCGAAGGGAAAAATATTAAAAAAGAGGTGGAGCTTAAG
AATTTTCTCACTGCTCCTGTAAGTAAAAATAATCCGTTAGGAGTGCTCAAAATCCTGCAGGAAGGAAAACTGATAAAGAC
AGTTGACATATACCCTGCCACTGATGTGAAGAAGGCGAATTTCTTTGAGAATTTTAATAAGGTGATAAACTACTGGATTA
AGAAAGGGAGTTAA

Upstream 100 bases:

>100_bases
GAAAGAAGTTTACAATAAATTTCATCCAAGAGCTTGAAAAGGCATAAAATTCACCCTCCGGTACACAATATAAAATAGCA
ACGAAGGAGGGTGAATTTTT

Downstream 100 bases:

>100_bases
GGCGGGCGGGTTTTTATCCCGTCCATTTATTTTTTAGAAAATTATTCTAAAAAAGGAGGATTTTTTAAATTTGTATCGAA
TATAATAGAGGGAGGTTGAT

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein dacF; PBP [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSKKFLALLISTFLLFNTAYADVMNLKAKSAILMEAETGEILYEKDIHKPLPPASVTKVMTLLLAIEAIDSGKIKVTDKV
VTSKHAFDMGGTQIYLEVGEEMTVDDLMKAIAMNSANDASVALAEYIAGTEENFVEMMNKRAKELGAKNTTFKNATGLPE
EGHLTTVYDIAMISRELVKHPSIFKYLTNKIDSLRNGKFSLINTNKLLWRYKGVDGIKTGSTSEALYCMAATAKRGDTRL
IAVVFGAPDSETRFNETAKLLDYGFANFETVKVASKGEVLGKIKVLKGNKEMVEGISLKDEYVVVKKGEGKNIKKEVELK
NFLTAPVSKNNPLGVLKILQEGKLIKTVDIYPATDVKKANFFENFNKVINYWIKKGS

Sequences:

>Translated_377_residues
MSKKFLALLISTFLLFNTAYADVMNLKAKSAILMEAETGEILYEKDIHKPLPPASVTKVMTLLLAIEAIDSGKIKVTDKV
VTSKHAFDMGGTQIYLEVGEEMTVDDLMKAIAMNSANDASVALAEYIAGTEENFVEMMNKRAKELGAKNTTFKNATGLPE
EGHLTTVYDIAMISRELVKHPSIFKYLTNKIDSLRNGKFSLINTNKLLWRYKGVDGIKTGSTSEALYCMAATAKRGDTRL
IAVVFGAPDSETRFNETAKLLDYGFANFETVKVASKGEVLGKIKVLKGNKEMVEGISLKDEYVVVKKGEGKNIKKEVELK
NFLTAPVSKNNPLGVLKILQEGKLIKTVDIYPATDVKKANFFENFNKVINYWIKKGS
>Mature_376_residues
SKKFLALLISTFLLFNTAYADVMNLKAKSAILMEAETGEILYEKDIHKPLPPASVTKVMTLLLAIEAIDSGKIKVTDKVV
TSKHAFDMGGTQIYLEVGEEMTVDDLMKAIAMNSANDASVALAEYIAGTEENFVEMMNKRAKELGAKNTTFKNATGLPEE
GHLTTVYDIAMISRELVKHPSIFKYLTNKIDSLRNGKFSLINTNKLLWRYKGVDGIKTGSTSEALYCMAATAKRGDTRLI
AVVFGAPDSETRFNETAKLLDYGFANFETVKVASKGEVLGKIKVLKGNKEMVEGISLKDEYVVVKKGEGKNIKKEVELKN
FLTAPVSKNNPLGVLKILQEGKLIKTVDIYPATDVKKANFFENFNKVINYWIKKGS

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=363, Percent_Identity=35.8126721763085, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI87082022, Length=354, Percent_Identity=33.6158192090396, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1786851, Length=391, Percent_Identity=32.7365728900256, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI87082054, Length=239, Percent_Identity=26.3598326359833, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 41681; Mature: 41550

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKFLALLISTFLLFNTAYADVMNLKAKSAILMEAETGEILYEKDIHKPLPPASVTKVM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHH
TLLLAIEAIDSGKIKVTDKVVTSKHAFDMGGTQIYLEVGEEMTVDDLMKAIAMNSANDAS
HHHHHHHHCCCCCEEEEHHHHHCCHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCHH
VALAEYIAGTEENFVEMMNKRAKELGAKNTTFKNATGLPEEGHLTTVYDIAMISRELVKH
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHC
PSIFKYLTNKIDSLRNGKFSLINTNKLLWRYKGVDGIKTGSTSEALYCMAATAKRGDTRL
CHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCEE
IAVVFGAPDSETRFNETAKLLDYGFANFETVKVASKGEVLGKIKVLKGNKEMVEGISLKD
EEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEECCHHHHHCCCCCC
EYVVVKKGEGKNIKKEVELKNFLTAPVSKNNPLGVLKILQEGKLIKTVDIYPATDVKKAN
CEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHH
FFENFNKVINYWIKKGS
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKKFLALLISTFLLFNTAYADVMNLKAKSAILMEAETGEILYEKDIHKPLPPASVTKVM
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHHHH
TLLLAIEAIDSGKIKVTDKVVTSKHAFDMGGTQIYLEVGEEMTVDDLMKAIAMNSANDAS
HHHHHHHHCCCCCEEEEHHHHHCCHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCHH
VALAEYIAGTEENFVEMMNKRAKELGAKNTTFKNATGLPEEGHLTTVYDIAMISRELVKH
HHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHC
PSIFKYLTNKIDSLRNGKFSLINTNKLLWRYKGVDGIKTGSTSEALYCMAATAKRGDTRL
CHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCEE
IAVVFGAPDSETRFNETAKLLDYGFANFETVKVASKGEVLGKIKVLKGNKEMVEGISLKD
EEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEECCHHHHHCCCCCC
EYVVVKKGEGKNIKKEVELKNFLTAPVSKNNPLGVLKILQEGKLIKTVDIYPATDVKKAN
CEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCHHH
FFENFNKVINYWIKKGS
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1629150; 8969508; 9384377 [H]