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The map label for this gene is Dxs

Identifier: 20807747

GI number: 20807747

Start: 1288350

End: 1290218

Strand: Direct

Name: Dxs

Synonym: TTE1298

Alternate gene names: 20807747

Gene position: 1288350-1290218 (Clockwise)

Preceding gene: 20807746

Following gene: 20807748

Centisome position: 47.9

GC content: 39.06

Gene sequence:

>1869_bases
ATGCTTGAACAGATTAATAGCCCTTACGATTTAAAAAAACTTGACATAAAAGACCTTCCAAGACTTTCTGAAGAGATAAG
GCAGTTTATAGTTGAAAAAGTTTCAAAGACTGGAGGACACTTAGCTTCGAACCTAGGGATTGTCGAACTCACTCTTGCAC
TTCACTACGTTTTTAATTCTCCTGTTGACAAAATAATTTGGGATGTCGGTCATCAGTGTTATGTACATAAAATGATTACA
GGGAGAAGGGACAAATTTGATACTTTAAGGCAGTTTAATGGGCTTTCTGGTTATACTAAGAGGACAGAGAGCATTCACGA
TATATTTGGAGCAGGCCACAGCAGCACCTCACTGTCGGCAGCATTGGGAATTGCAACTGCTAGGGATTTAAAGGGAGAAA
AATATCATGTTATAGCAGTGATTGGTGACGGGGCCTTGACAGGCGGCATGGCTCTGGAAGCTTTGAACAACATTGGAAGG
TCTCGGAAGGATGTCATTGTAATTTTAAATCATAATGAGATGTCTATTTCTGAAAATGTAGGAAGCCTTTCTCTTTATTT
GAGCAAATTAAGAACTGACCCCACTTACAATAAGGTGAAGCAGGAGATTGACAATCTGTTAAATATCATACCTCCAATAG
GCAAAAGCCTTCACAAGTATATTGAAAAAATCAAAGATTCTATAAAGCAATTGGTAGTTCCAGGGATGTTTTTTGAAGAG
CTGGGTTTTACTTATTTAGGACCTATTGACGGTCATAATGTGGAAGAACTCATTGAAGTTTTAGAAAGGTCTAAAAAAAT
GAAGGGGCCTTTGCTTATACATGTTGTTACAAAAAAAGGGAAAGGATATATGTTTGCGGAAAAAAGGCCAGATAAATTCC
ACTCTGCAGCTCCTTTTGACATAGAAACAGGTAAATTTGTAGGAGAAGGAAAAGACAGCTATTCTGACGTTTTTGGCAAA
ACCCTTGCTGAAATGGCGCTAAAAGACGAGAAGATTGTTGCGATAACAGCAGCCATGCCAGAAGGCACTGGGCTTATTCA
TTTTGCAAAGTTAATACCGGATAGATTCTTCGACGTGGGAATAGCCGAACAACACGCTACTACTTTTGCTGCAGGGCTTG
CTGTTGAAGGATACAAGCCTTATTTTGCTGTATATTCCACTTTTTTGCAAAGAGCTTACGACCAGGTGATTCACGATGTG
TGTATACAAAAACTTCCAGTAGTTTTTGCTGTTGACAGAGCAGGGATTGTCGGGGAAGACGGAGAAACCCATCAAGGGGT
GTTTGATATATCTTTCTTAAGGGCAATTCCAAATATCGCTATAATGTCACCAAAAGATGCCAATGAATTGGTTGAAATGG
TAAAGTTATCGAGAAATTTAGATTTTCCTGTAGCCATAAGGTATCCAAGAGGTAAAGCGGGTGAGTATGATATTTCAAGA
AAGCCAAGTTTTCCATTGGGCAAAGGAGAAGTGCTTCTTGAAGGAGAAAAAATAGCCGTATTTGCTCTGGGCAGAATGGT
GTCAAAATCAATTGATGCGGCGGAAATTTTAAAAGGCCATGGTATCAATCCTTTTGTCGTAAATTTGAGATTTGTTAAGC
CTCTTGATGAAGAACTCATTTTAGAAATTTCTAATAAAGTAGACCTCGTCGTGACTGTGGAGGACAACGTTATAGCGGGA
GGAGTAGGCAGCGCTATATTGGAGCTTTTGAACGATAAGAAAGTCTATAGGCCTGTGCTACGCTTAGGATTTCCTGATAA
ATTCATAGAACATGGAGATGTAGAAAGCTTGTTTAAAAAGTACGGTTTAGATTCTCAGTCAATAGCCGATACTATTTTAC
AAAGGTACAAGGAAATGAGGGGATCATGA

Upstream 100 bases:

>100_bases
GACAGGAGTCGTGCTGGCGTGGCTGGAAAAAAATTTAGGCATAAACATATTACCTGACTATAAAAATAATAGAAGGAAAA
AAAGAAAGTGAGGGTTTTGT

Downstream 100 bases:

>100_bases
AGGAGAGAATAGATGTACTTCTCGTAAAAAGGGGCTTTTTCTCTTCAAGAGAAAAGGCAAAAGCAGCTATAATGGCAGGA
GAAGTGTACGTAGACGGCAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MLEQINSPYDLKKLDIKDLPRLSEEIRQFIVEKVSKTGGHLASNLGIVELTLALHYVFNSPVDKIIWDVGHQCYVHKMIT
GRRDKFDTLRQFNGLSGYTKRTESIHDIFGAGHSSTSLSAALGIATARDLKGEKYHVIAVIGDGALTGGMALEALNNIGR
SRKDVIVILNHNEMSISENVGSLSLYLSKLRTDPTYNKVKQEIDNLLNIIPPIGKSLHKYIEKIKDSIKQLVVPGMFFEE
LGFTYLGPIDGHNVEELIEVLERSKKMKGPLLIHVVTKKGKGYMFAEKRPDKFHSAAPFDIETGKFVGEGKDSYSDVFGK
TLAEMALKDEKIVAITAAMPEGTGLIHFAKLIPDRFFDVGIAEQHATTFAAGLAVEGYKPYFAVYSTFLQRAYDQVIHDV
CIQKLPVVFAVDRAGIVGEDGETHQGVFDISFLRAIPNIAIMSPKDANELVEMVKLSRNLDFPVAIRYPRGKAGEYDISR
KPSFPLGKGEVLLEGEKIAVFALGRMVSKSIDAAEILKGHGINPFVVNLRFVKPLDEELILEISNKVDLVVTVEDNVIAG
GVGSAILELLNDKKVYRPVLRLGFPDKFIEHGDVESLFKKYGLDSQSIADTILQRYKEMRGS

Sequences:

>Translated_622_residues
MLEQINSPYDLKKLDIKDLPRLSEEIRQFIVEKVSKTGGHLASNLGIVELTLALHYVFNSPVDKIIWDVGHQCYVHKMIT
GRRDKFDTLRQFNGLSGYTKRTESIHDIFGAGHSSTSLSAALGIATARDLKGEKYHVIAVIGDGALTGGMALEALNNIGR
SRKDVIVILNHNEMSISENVGSLSLYLSKLRTDPTYNKVKQEIDNLLNIIPPIGKSLHKYIEKIKDSIKQLVVPGMFFEE
LGFTYLGPIDGHNVEELIEVLERSKKMKGPLLIHVVTKKGKGYMFAEKRPDKFHSAAPFDIETGKFVGEGKDSYSDVFGK
TLAEMALKDEKIVAITAAMPEGTGLIHFAKLIPDRFFDVGIAEQHATTFAAGLAVEGYKPYFAVYSTFLQRAYDQVIHDV
CIQKLPVVFAVDRAGIVGEDGETHQGVFDISFLRAIPNIAIMSPKDANELVEMVKLSRNLDFPVAIRYPRGKAGEYDISR
KPSFPLGKGEVLLEGEKIAVFALGRMVSKSIDAAEILKGHGINPFVVNLRFVKPLDEELILEISNKVDLVVTVEDNVIAG
GVGSAILELLNDKKVYRPVLRLGFPDKFIEHGDVESLFKKYGLDSQSIADTILQRYKEMRGS
>Mature_622_residues
MLEQINSPYDLKKLDIKDLPRLSEEIRQFIVEKVSKTGGHLASNLGIVELTLALHYVFNSPVDKIIWDVGHQCYVHKMIT
GRRDKFDTLRQFNGLSGYTKRTESIHDIFGAGHSSTSLSAALGIATARDLKGEKYHVIAVIGDGALTGGMALEALNNIGR
SRKDVIVILNHNEMSISENVGSLSLYLSKLRTDPTYNKVKQEIDNLLNIIPPIGKSLHKYIEKIKDSIKQLVVPGMFFEE
LGFTYLGPIDGHNVEELIEVLERSKKMKGPLLIHVVTKKGKGYMFAEKRPDKFHSAAPFDIETGKFVGEGKDSYSDVFGK
TLAEMALKDEKIVAITAAMPEGTGLIHFAKLIPDRFFDVGIAEQHATTFAAGLAVEGYKPYFAVYSTFLQRAYDQVIHDV
CIQKLPVVFAVDRAGIVGEDGETHQGVFDISFLRAIPNIAIMSPKDANELVEMVKLSRNLDFPVAIRYPRGKAGEYDISR
KPSFPLGKGEVLLEGEKIAVFALGRMVSKSIDAAEILKGHGINPFVVNLRFVKPLDEELILEISNKVDLVVTVEDNVIAG
GVGSAILELLNDKKVYRPVLRLGFPDKFIEHGDVESLFKKYGLDSQSIADTILQRYKEMRGS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=539, Percent_Identity=23.747680890538, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4507521, Length=539, Percent_Identity=23.747680890538, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI225637463, Length=517, Percent_Identity=23.0174081237911, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI225637459, Length=509, Percent_Identity=23.1827111984283, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI225637461, Length=517, Percent_Identity=23.0174081237911, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI133778974, Length=418, Percent_Identity=23.6842105263158, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI156564403, Length=302, Percent_Identity=24.1721854304636, Blast_Score=70, Evalue=8e-12,
Organism=Escherichia coli, GI1786622, Length=614, Percent_Identity=49.185667752443, Blast_Score=605, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17539652, Length=404, Percent_Identity=26.7326732673267, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319698, Length=305, Percent_Identity=27.2131147540984, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551847, Length=617, Percent_Identity=25.2836304700162, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550715, Length=617, Percent_Identity=25.2836304700162, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24645119, Length=574, Percent_Identity=25.4355400696864, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666278, Length=633, Percent_Identity=24.0126382306477, Blast_Score=100, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_THETN (Q8RAC5)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622918.1
- ProteinModelPortal:   Q8RAC5
- SMR:   Q8RAC5
- GeneID:   997659
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1298
- NMPDR:   fig|273068.3.peg.1189
- HOGENOM:   HBG571647
- OMA:   RESILRY
- ProtClustDB:   PRK05444
- BioCyc:   TTEN273068:TTE1298-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68976; Mature: 68976

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQINSPYDLKKLDIKDLPRLSEEIRQFIVEKVSKTGGHLASNLGIVELTLALHYVFNS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCC
PVDKIIWDVGHQCYVHKMITGRRDKFDTLRQFNGLSGYTKRTESIHDIFGAGHSSTSLSA
CHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHH
ALGIATARDLKGEKYHVIAVIGDGALTGGMALEALNNIGRSRKDVIVILNHNEMSISENV
HHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEHHCCC
GSLSLYLSKLRTDPTYNKVKQEIDNLLNIIPPIGKSLHKYIEKIKDSIKQLVVPGMFFEE
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
LGFTYLGPIDGHNVEELIEVLERSKKMKGPLLIHVVTKKGKGYMFAEKRPDKFHSAAPFD
CCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCHHCCCCCCC
IETGKFVGEGKDSYSDVFGKTLAEMALKDEKIVAITAAMPEGTGLIHFAKLIPDRFFDVG
CCCCCEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCHHHHCCC
IAEQHATTFAAGLAVEGYKPYFAVYSTFLQRAYDQVIHDVCIQKLPVVFAVDRAGIVGED
CCHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
GETHQGVFDISFLRAIPNIAIMSPKDANELVEMVKLSRNLDFPVAIRYPRGKAGEYDISR
CCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
KPSFPLGKGEVLLEGEKIAVFALGRMVSKSIDAAEILKGHGINPFVVNLRFVKPLDEELI
CCCCCCCCCCEEEECCEEEEHHHHHHHHHCCCHHHHHHCCCCCEEEEEEEEECCCCHHHH
LEISNKVDLVVTVEDNVIAGGVGSAILELLNDKKVYRPVLRLGFPDKFIEHGDVESLFKK
HHCCCCEEEEEEECCCEEECCHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCHHHHHHH
YGLDSQSIADTILQRYKEMRGS
HCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLEQINSPYDLKKLDIKDLPRLSEEIRQFIVEKVSKTGGHLASNLGIVELTLALHYVFNS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHCC
PVDKIIWDVGHQCYVHKMITGRRDKFDTLRQFNGLSGYTKRTESIHDIFGAGHSSTSLSA
CHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCHHHH
ALGIATARDLKGEKYHVIAVIGDGALTGGMALEALNNIGRSRKDVIVILNHNEMSISENV
HHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEHHCCC
GSLSLYLSKLRTDPTYNKVKQEIDNLLNIIPPIGKSLHKYIEKIKDSIKQLVVPGMFFEE
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
LGFTYLGPIDGHNVEELIEVLERSKKMKGPLLIHVVTKKGKGYMFAEKRPDKFHSAAPFD
CCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCHHCCCCCCC
IETGKFVGEGKDSYSDVFGKTLAEMALKDEKIVAITAAMPEGTGLIHFAKLIPDRFFDVG
CCCCCEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCHHHHCCC
IAEQHATTFAAGLAVEGYKPYFAVYSTFLQRAYDQVIHDVCIQKLPVVFAVDRAGIVGED
CCHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
GETHQGVFDISFLRAIPNIAIMSPKDANELVEMVKLSRNLDFPVAIRYPRGKAGEYDISR
CCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCC
KPSFPLGKGEVLLEGEKIAVFALGRMVSKSIDAAEILKGHGINPFVVNLRFVKPLDEELI
CCCCCCCCCCEEEECCEEEEHHHHHHHHHCCCHHHHHHCCCCCEEEEEEEEECCCCHHHH
LEISNKVDLVVTVEDNVIAGGVGSAILELLNDKKVYRPVLRLGFPDKFIEHGDVESLFKK
HHCCCCEEEEEEECCCEEECCHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCHHHHHHH
YGLDSQSIADTILQRYKEMRGS
HCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336