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The map label for this gene is NuoG [C]

Identifier: 20807375

GI number: 20807375

Start: 903441

End: 905186

Strand: Direct

Name: NuoG [C]

Synonym: TTE0894

Alternate gene names: 20807375

Gene position: 903441-905186 (Clockwise)

Preceding gene: 20807374

Following gene: 20807376

Centisome position: 33.59

GC content: 43.13

Gene sequence:

>1746_bases
ATGGACAAAGTTCGCGTTACAATAGATGGCATAACTGTAGAAGTGCCTTCCTACTATACGGTACTGGAAGCGGCAAAAGA
AGCCGGCATAGACATACCTACTCTTTGCTATTTGAAAGAGATAAATCAAATTGGGGCTTGTCGCATATGTCTAGTTGAGA
TAGAGGGAGTAAGGAATTTACAGACTTCCTGCACCTACCCCGTGTTTGATGGGATGAAAGTCTATACCAATACTCCAAAG
ATAAGGGAAGCTCGCAGGCTAAATCTTGAACTCATACTGTCAAATCATGATAGAAACTGCTTGACCTGCGTAAGAAGCAC
CAATTGTGAGCTTCAAGCCCTTGCTAAAAGACTTGGAGTAGAGGAAATAAGGTTTGAAGGGGAAAATATAAAATACCCTA
TAGATGATGCCTCCCCTGCAGTTGTGAGAGACCCTAATAAGTGTGTGCTCTGCAGAAGATGTGTTGCAGTGTGCTCAGAA
GTTCAGAATGTATTTGCTATTGGAATGGTAAACAGAGGATTTAAGACAATGGTAGCTCCATCTTTTGGAAGAAGCTTAAA
GGATTCACCCTGTATTAGCTGTGGCCAGTGCATAATGGTATGTCCTGTTGGAGCTATATACGAAAAAGACCATACAAAGA
GGGTTTATGAAGCTTTGGCAGATGACAAAAAATACGTTGTAGCTCAGACTGCTCCAGCTGTAAGGGTAGCATTAGGAGAA
GAGTTTGGAATGCCTGTTGGTACCATTGTCACAGGGAAGATGGCAGCAGCACTGAGGAGAATGGGATTTGATGCGGTATT
TGATACAAACTTTGCAGCAGACCTCACGATAATGGAAGAGGGTTCTGAGCTTTTAGAGAGAATAAAACATGGCGGAAAGC
TTCCTATGATAACCTCCTGCAGCCCTGGCTGGATAGCTTTCTGTGAGAAGTACTATCCGGAGTTTATAGACAATCTCTCC
ACCTGCAAATCTCCTCACATGATGATGGGGGCACTGGTAAAGAGCTACTACGCGGAGAAAAAAGGGCTTGACCCTAAAGA
TATATTCGTAGTGTCAATAATGCCATGTACAGCGAAGAAGCTTGAGATTGAAAGAGAAGAGATGATAAGAAATGGAATGA
AAGATGTGGATGCCGTGCTTACCACAAGAGAGCTTGCGAGAATGATAAAAGAGATGGGAATCGATTTTGTGAACTTAAAA
GATGAAGAATTTGATGAGCCTTTAGGCATGTCTACAGGAGCAGGTGCCATATTTGGGGCTACAGGCGGTGTCATGGAGGC
AGCATTAAGGACTGTCGCTGAAATTGTAGAGGGAAGAGATATAGGGAAGATAGATTTTGAAGAAGTGAGAGGTTTAGAAG
GTGTGAGAGAGGCTACAATAACAATTGACGGGATGGATATAAAGATTGCTATTGCCAATGGAACAGGAAATGCTAAGAAG
CTCCTTGACAAGGTAAAGGCAGGAGAAGTCGAGTATCACTTTATAGAAGTGATGGGATGCCCAGGTGGCTGTATAATGGG
TGGAGGACAGCCAATCCACAATCCTAACGAGATGGAAGAAGTCAAGAAATTAAGGGCAAAGGCAATTTACGAGATAGACA
AGAACCTGCCTATAAGAAAGTCCCACGAGAACCCGGCGATAAAGAGGCTTTACGAGGAATTCCTGGGTTATCCTTTGAGC
GAGAAATCCCACGAACTTCTGCACACCCACTATTCAAGAAAAGAGCTTTATCCTCTCGTGAAATAA

Upstream 100 bases:

>100_bases
TGTGATTGACCAAGAGAAGTGTATTAAGTGCGGAACATGTATTGATAAGTGTCCGTTTGGCGCAATATACAAAAAATAAA
AGAGGAAGGAGTGTAAAAGG

Downstream 100 bases:

>100_bases
AGGAAGGTCCCCAACGTTTGTTGGGGGCTTTGCCATTTTTTTATTCAAAAGTTAGTTATAGAAATATATATAATTTGTGA
TATAATAAAAAGGAATGATA

Product: NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Products: NA

Alternate protein names: CpI; Fe-only hydrogenase; [Fe] hydrogenase [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MDKVRVTIDGITVEVPSYYTVLEAAKEAGIDIPTLCYLKEINQIGACRICLVEIEGVRNLQTSCTYPVFDGMKVYTNTPK
IREARRLNLELILSNHDRNCLTCVRSTNCELQALAKRLGVEEIRFEGENIKYPIDDASPAVVRDPNKCVLCRRCVAVCSE
VQNVFAIGMVNRGFKTMVAPSFGRSLKDSPCISCGQCIMVCPVGAIYEKDHTKRVYEALADDKKYVVAQTAPAVRVALGE
EFGMPVGTIVTGKMAAALRRMGFDAVFDTNFAADLTIMEEGSELLERIKHGGKLPMITSCSPGWIAFCEKYYPEFIDNLS
TCKSPHMMMGALVKSYYAEKKGLDPKDIFVVSIMPCTAKKLEIEREEMIRNGMKDVDAVLTTRELARMIKEMGIDFVNLK
DEEFDEPLGMSTGAGAIFGATGGVMEAALRTVAEIVEGRDIGKIDFEEVRGLEGVREATITIDGMDIKIAIANGTGNAKK
LLDKVKAGEVEYHFIEVMGCPGGCIMGGGQPIHNPNEMEEVKKLRAKAIYEIDKNLPIRKSHENPAIKRLYEEFLGYPLS
EKSHELLHTHYSRKELYPLVK

Sequences:

>Translated_581_residues
MDKVRVTIDGITVEVPSYYTVLEAAKEAGIDIPTLCYLKEINQIGACRICLVEIEGVRNLQTSCTYPVFDGMKVYTNTPK
IREARRLNLELILSNHDRNCLTCVRSTNCELQALAKRLGVEEIRFEGENIKYPIDDASPAVVRDPNKCVLCRRCVAVCSE
VQNVFAIGMVNRGFKTMVAPSFGRSLKDSPCISCGQCIMVCPVGAIYEKDHTKRVYEALADDKKYVVAQTAPAVRVALGE
EFGMPVGTIVTGKMAAALRRMGFDAVFDTNFAADLTIMEEGSELLERIKHGGKLPMITSCSPGWIAFCEKYYPEFIDNLS
TCKSPHMMMGALVKSYYAEKKGLDPKDIFVVSIMPCTAKKLEIEREEMIRNGMKDVDAVLTTRELARMIKEMGIDFVNLK
DEEFDEPLGMSTGAGAIFGATGGVMEAALRTVAEIVEGRDIGKIDFEEVRGLEGVREATITIDGMDIKIAIANGTGNAKK
LLDKVKAGEVEYHFIEVMGCPGGCIMGGGQPIHNPNEMEEVKKLRAKAIYEIDKNLPIRKSHENPAIKRLYEEFLGYPLS
EKSHELLHTHYSRKELYPLVK
>Mature_581_residues
MDKVRVTIDGITVEVPSYYTVLEAAKEAGIDIPTLCYLKEINQIGACRICLVEIEGVRNLQTSCTYPVFDGMKVYTNTPK
IREARRLNLELILSNHDRNCLTCVRSTNCELQALAKRLGVEEIRFEGENIKYPIDDASPAVVRDPNKCVLCRRCVAVCSE
VQNVFAIGMVNRGFKTMVAPSFGRSLKDSPCISCGQCIMVCPVGAIYEKDHTKRVYEALADDKKYVVAQTAPAVRVALGE
EFGMPVGTIVTGKMAAALRRMGFDAVFDTNFAADLTIMEEGSELLERIKHGGKLPMITSCSPGWIAFCEKYYPEFIDNLS
TCKSPHMMMGALVKSYYAEKKGLDPKDIFVVSIMPCTAKKLEIEREEMIRNGMKDVDAVLTTRELARMIKEMGIDFVNLK
DEEFDEPLGMSTGAGAIFGATGGVMEAALRTVAEIVEGRDIGKIDFEEVRGLEGVREATITIDGMDIKIAIANGTGNAKK
LLDKVKAGEVEYHFIEVMGCPGGCIMGGGQPIHNPNEMEEVKKLRAKAIYEIDKNLPIRKSHENPAIKRLYEEFLGYPLS
EKSHELLHTHYSRKELYPLVK

Specific function: Ndh-1 Shuttles Electrons From NADH, Via Fmn And Iron- Sulfur (Fe-S) Centers, To Quinones In The Respiratory Chain. The Immediate Electron Acceptor For The Enzyme In This Species Is Believed To Be Ubiquinone. Couples The Redox Reaction To Proton Translocat

COG id: COG4624

COG function: function code R; Iron only hydrogenase large subunit, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI11968051, Length=413, Percent_Identity=30.2663438256659, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI6912524, Length=412, Percent_Identity=29.126213592233, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI134284357, Length=370, Percent_Identity=30, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI84452151, Length=370, Percent_Identity=30, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI14165461, Length=452, Percent_Identity=28.0973451327434, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI33519475, Length=219, Percent_Identity=32.8767123287671, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI145693161, Length=253, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71995015, Length=407, Percent_Identity=28.992628992629, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI32566231, Length=227, Percent_Identity=34.8017621145374, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17565758, Length=227, Percent_Identity=34.8017621145374, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193209088, Length=228, Percent_Identity=34.6491228070175, Blast_Score=115, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6324089, Length=383, Percent_Identity=23.2375979112272, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI116007470, Length=407, Percent_Identity=29.4840294840295, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI116007466, Length=407, Percent_Identity=29.4840294840295, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI116007464, Length=407, Percent_Identity=29.4840294840295, Blast_Score=175, Evalue=8e-44,
Organism=Drosophila melanogaster, GI116007468, Length=407, Percent_Identity=29.4840294840295, Blast_Score=175, Evalue=9e-44,
Organism=Drosophila melanogaster, GI116007462, Length=286, Percent_Identity=33.5664335664336, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24640559, Length=219, Percent_Identity=33.7899543378995, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640557, Length=219, Percent_Identity=33.7899543378995, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR009016
- InterPro:   IPR004108
- InterPro:   IPR003149
- InterPro:   IPR013352
- InterPro:   IPR001041 [H]

Pfam domain/function: PF02906 Fe_hyd_lg_C; PF02256 Fe_hyd_SSU [H]

EC number: =1.12.7.2 [H]

Molecular weight: Translated: 64467; Mature: 64467

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKVRVTIDGITVEVPSYYTVLEAAKEAGIDIPTLCYLKEINQIGACRICLVEIEGVRNL
CCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCC
QTSCTYPVFDGMKVYTNTPKIREARRLNLELILSNHDRNCLTCVRSTNCELQALAKRLGV
HHCCCCCCCCCEEEEECCCHHHHHHHCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHCH
EEIRFEGENIKYPIDDASPAVVRDPNKCVLCRRCVAVCSEVQNVFAIGMVNRGFKTMVAP
HHEEECCCCCEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC
SFGRSLKDSPCISCGQCIMVCPVGAIYEKDHTKRVYEALADDKKYVVAQTAPAVRVALGE
HHCCCCCCCCCCCCCCEEEECCCHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEECCH
EFGMPVGTIVTGKMAAALRRMGFDAVFDTNFAADLTIMEEGSELLERIKHGGKLPMITSC
HHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCCCEEECC
SPGWIAFCEKYYPEFIDNLSTCKSPHMMMGALVKSYYAEKKGLDPKDIFVVSIMPCTAKK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHH
LEIEREEMIRNGMKDVDAVLTTRELARMIKEMGIDFVNLKDEEFDEPLGMSTGAGAIFGA
HCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCCCCCCCCCEEECC
TGGVMEAALRTVAEIVEGRDIGKIDFEEVRGLEGVREATITIDGMDIKIAIANGTGNAKK
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEEECCEEEEEEECCCCHHHH
LLDKVKAGEVEYHFIEVMGCPGGCIMGGGQPIHNPNEMEEVKKLRAKAIYEIDKNLPIRK
HHHHHHCCCEEEEEEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
SHENPAIKRLYEEFLGYPLSEKSHELLHTHYSRKELYPLVK
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDKVRVTIDGITVEVPSYYTVLEAAKEAGIDIPTLCYLKEINQIGACRICLVEIEGVRNL
CCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCC
QTSCTYPVFDGMKVYTNTPKIREARRLNLELILSNHDRNCLTCVRSTNCELQALAKRLGV
HHCCCCCCCCCEEEEECCCHHHHHHHCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHCH
EEIRFEGENIKYPIDDASPAVVRDPNKCVLCRRCVAVCSEVQNVFAIGMVNRGFKTMVAP
HHEEECCCCCEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCC
SFGRSLKDSPCISCGQCIMVCPVGAIYEKDHTKRVYEALADDKKYVVAQTAPAVRVALGE
HHCCCCCCCCCCCCCCEEEECCCHHHHCCHHHHHHHHHHCCCCEEEEEECCCCEEEECCH
EFGMPVGTIVTGKMAAALRRMGFDAVFDTNFAADLTIMEEGSELLERIKHGGKLPMITSC
HHCCCHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCCCEEECC
SPGWIAFCEKYYPEFIDNLSTCKSPHMMMGALVKSYYAEKKGLDPKDIFVVSIMPCTAKK
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHH
LEIEREEMIRNGMKDVDAVLTTRELARMIKEMGIDFVNLKDEEFDEPLGMSTGAGAIFGA
HCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHCCCCCCCCCCCCEEECC
TGGVMEAALRTVAEIVEGRDIGKIDFEEVRGLEGVREATITIDGMDIKIAIANGTGNAKK
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEEEECCEEEEEEECCCCHHHH
LLDKVKAGEVEYHFIEVMGCPGGCIMGGGQPIHNPNEMEEVKKLRAKAIYEIDKNLPIRK
HHHHHHCCCEEEEEEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
SHENPAIKRLYEEFLGYPLSEKSHELLHTHYSRKELYPLVK
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1911757; 9836629; 10529166 [H]