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The map label for this gene is lytS [H]

Identifier: 20807352

GI number: 20807352

Start: 879340

End: 881079

Strand: Reverse

Name: lytS [H]

Synonym: TTE0871

Alternate gene names: 20807352

Gene position: 881079-879340 (Counterclockwise)

Preceding gene: 20807364

Following gene: 20807351

Centisome position: 32.76

GC content: 38.33

Gene sequence:

>1740_bases
ATGTATGACCTTTTAATCATTCTGGCGGAAAGATTTAGCATAATTGCACTTTTAGCCTTTCTCCTCTCAAAAGCCGAATT
TTTCAAAAAAATGGTATACAATACTGCTCTCACCAAAAAAGACCTGCTCATCACCATGCTTATATTTGGCCTGATTGGAA
TAGCAGGAACTTACCTAGGAGTCCCCATAAATGACGCAATAGCAAATTCAAGAGTAGTGGGCCCTATGGTGGCAGGGCTT
ATAGGCGGACCTCTTGTAGGCCTGGGCGCAGGCCTTATAGCAGGTGTACATCGCTTCTTCCTAGGAGGCTTCACAGCCAT
CTCCTGTGGAATATCCACCATTATTGAAGGTTTTGCAGGTGGCCTCATACGAAAATACTACAAAGGTGAATATATACCCT
GGGAATACGCATTTATGGCAGGATTTATAGGCGAAGGAGTGCAGATGCTGATAATTTTGGCGACAGCTAAACCTTTTCAT
CAGGCCGTTGAACTTGTAAAAATCATAGGAATCCCTATGATGGTAGTAAATGCTACAGGAATAGGCATTTTTATGATAAT
GATAAAATCCATATTCGACGAAAAAGAACAGATTGCTGCAATGCAGGCAAAAATAGCTTTAGATATCGCCTCCAAAACTC
TTCCTTATTTGAGAAAAGGCTTAAATGAAGAATCCGCTCAAAAGACAGCAGAAATAATCTTAGAGTGCACAAATGTCTCC
GCAGTAGCAATCACTGACAAAAAGAGAATACTGGCCCATGTCGGAATAGCTTCTGACCACCACAAACCAGGGATGTCCAT
ACTAACAAATGCCACAAAAGAAGCAATACAAAAAGGAGAAATAAGGATTGCAAAGTCTAAAGAAGAAATAGGCTGTCCTT
ATGAAAACTGTGAACTTCACTCTGCTGTAATTGTACCACTTTTTAAATATGACAAACTAGTAGGTACTCTAAAACTTTAC
AAAGGAGGAAAAAAATCGCGCGGCAATGTAATAACCAATACAGAGATAGAACTGGCGAAGGGGCTGGGACATTTGATATC
ATATCAGCTAGAAATTGCAGATGCAGAGTACCAGAAAAAATTGGCAACCGAGGCAAAATTAAATGCCCTTCAGTCCCAAA
TAAACCCTCATTTTCTGTTTAACTCTTTAAATACTGTTATTTCCTTCATACGCACAAATCCAGAAAGGGCAAGAGAACTT
TTAATAAATTTGAGTGAATATTTCAGGCACAATCTGAGAAATGTAGGAAAATATATAACCATTGAAGAAGAATTAAACAA
TATAAACGCGTATCTGTATATTGAAAAAGCTCGTTTTGGCGACAAACTGAATGTAGAGCAAGATGTAGATATAAGTGTGC
TTTCCTGTTACATGCCCTCATTTATACTGCAGCCTATTGTAGAAAATGCTGTAAAGCATGGAATTTTACCAAAAGGCGAA
AGAGGGACGGTAAAAATAAAAATAAAAGATGAAGGAGATTATATAAGCTTCTATGTGGAAGATGATGGGGTAGGAATGAC
TGAAGAAGAACTGCAAAATCTCTTTAAGAAGGGAGTAGGAAAAGGAGCAGGAATAGGTCTTTACAATGTCAACGAAAGGC
TCACTGTGGCTTTTTGCAAGGAATGTGCCTTGTCAATTGAAAGTAAATTAGGTGAAGGCACAAAAGTATCCTTCAAAATT
CCTAAAATTTACCTGCAGAGGAATGATATTTATGAAGAAGCTGAGAGCGTTAATTATTGA

Upstream 100 bases:

>100_bases
ATTGCAGTAGAGTAAAAATTTTTGTACAATAGATGTGACAAGGTACAAATTATTACTACGACAAAAATACAAAAATTCCT
TTATTTTGGAGTGAATACCT

Downstream 100 bases:

>100_bases
GGACGAACAACCTGCCAGAGAAGAACTAAAATATCTATTGCAGGAATATGAAGATATAGAGGTAGTTGGAGAAGCAGACA
ATGGAATAACTGGATTACAT

Product: regulator of cell autolysis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MYDLLIILAERFSIIALLAFLLSKAEFFKKMVYNTALTKKDLLITMLIFGLIGIAGTYLGVPINDAIANSRVVGPMVAGL
IGGPLVGLGAGLIAGVHRFFLGGFTAISCGISTIIEGFAGGLIRKYYKGEYIPWEYAFMAGFIGEGVQMLIILATAKPFH
QAVELVKIIGIPMMVVNATGIGIFMIMIKSIFDEKEQIAAMQAKIALDIASKTLPYLRKGLNEESAQKTAEIILECTNVS
AVAITDKKRILAHVGIASDHHKPGMSILTNATKEAIQKGEIRIAKSKEEIGCPYENCELHSAVIVPLFKYDKLVGTLKLY
KGGKKSRGNVITNTEIELAKGLGHLISYQLEIADAEYQKKLATEAKLNALQSQINPHFLFNSLNTVISFIRTNPERAREL
LINLSEYFRHNLRNVGKYITIEEELNNINAYLYIEKARFGDKLNVEQDVDISVLSCYMPSFILQPIVENAVKHGILPKGE
RGTVKIKIKDEGDYISFYVEDDGVGMTEEELQNLFKKGVGKGAGIGLYNVNERLTVAFCKECALSIESKLGEGTKVSFKI
PKIYLQRNDIYEEAESVNY

Sequences:

>Translated_579_residues
MYDLLIILAERFSIIALLAFLLSKAEFFKKMVYNTALTKKDLLITMLIFGLIGIAGTYLGVPINDAIANSRVVGPMVAGL
IGGPLVGLGAGLIAGVHRFFLGGFTAISCGISTIIEGFAGGLIRKYYKGEYIPWEYAFMAGFIGEGVQMLIILATAKPFH
QAVELVKIIGIPMMVVNATGIGIFMIMIKSIFDEKEQIAAMQAKIALDIASKTLPYLRKGLNEESAQKTAEIILECTNVS
AVAITDKKRILAHVGIASDHHKPGMSILTNATKEAIQKGEIRIAKSKEEIGCPYENCELHSAVIVPLFKYDKLVGTLKLY
KGGKKSRGNVITNTEIELAKGLGHLISYQLEIADAEYQKKLATEAKLNALQSQINPHFLFNSLNTVISFIRTNPERAREL
LINLSEYFRHNLRNVGKYITIEEELNNINAYLYIEKARFGDKLNVEQDVDISVLSCYMPSFILQPIVENAVKHGILPKGE
RGTVKIKIKDEGDYISFYVEDDGVGMTEEELQNLFKKGVGKGAGIGLYNVNERLTVAFCKECALSIESKLGEGTKVSFKI
PKIYLQRNDIYEEAESVNY
>Mature_579_residues
MYDLLIILAERFSIIALLAFLLSKAEFFKKMVYNTALTKKDLLITMLIFGLIGIAGTYLGVPINDAIANSRVVGPMVAGL
IGGPLVGLGAGLIAGVHRFFLGGFTAISCGISTIIEGFAGGLIRKYYKGEYIPWEYAFMAGFIGEGVQMLIILATAKPFH
QAVELVKIIGIPMMVVNATGIGIFMIMIKSIFDEKEQIAAMQAKIALDIASKTLPYLRKGLNEESAQKTAEIILECTNVS
AVAITDKKRILAHVGIASDHHKPGMSILTNATKEAIQKGEIRIAKSKEEIGCPYENCELHSAVIVPLFKYDKLVGTLKLY
KGGKKSRGNVITNTEIELAKGLGHLISYQLEIADAEYQKKLATEAKLNALQSQINPHFLFNSLNTVISFIRTNPERAREL
LINLSEYFRHNLRNVGKYITIEEELNNINAYLYIEKARFGDKLNVEQDVDISVLSCYMPSFILQPIVENAVKHGILPKGE
RGTVKIKIKDEGDYISFYVEDDGVGMTEEELQNLFKKGVGKGAGIGLYNVNERLTVAFCKECALSIESKLGEGTKVSFKI
PKIYLQRNDIYEEAESVNY

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=578, Percent_Identity=36.5051903114187, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788446, Length=577, Percent_Identity=35.3552859618718, Blast_Score=331, Evalue=7e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63919; Mature: 63919

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLLIILAERFSIIALLAFLLSKAEFFKKMVYNTALTKKDLLITMLIFGLIGIAGTYLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
VPINDAIANSRVVGPMVAGLIGGPLVGLGAGLIAGVHRFFLGGFTAISCGISTIIEGFAG
CCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIRKYYKGEYIPWEYAFMAGFIGEGVQMLIILATAKPFHQAVELVKIIGIPMMVVNATG
HHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC
IGIFMIMIKSIFDEKEQIAAMQAKIALDIASKTLPYLRKGLNEESAQKTAEIILECTNVS
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCE
AVAITDKKRILAHVGIASDHHKPGMSILTNATKEAIQKGEIRIAKSKEEIGCPYENCELH
EEEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHCCCCCCCCCCC
SAVIVPLFKYDKLVGTLKLYKGGKKSRGNVITNTEIELAKGLGHLISYQLEIADAEYQKK
HHHEEHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHEEEEECCHHHHHH
LATEAKLNALQSQINPHFLFNSLNTVISFIRTNPERARELLINLSEYFRHNLRNVGKYIT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
IEEELNNINAYLYIEKARFGDKLNVEQDVDISVLSCYMPSFILQPIVENAVKHGILPKGE
EHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RGTVKIKIKDEGDYISFYVEDDGVGMTEEELQNLFKKGVGKGAGIGLYNVNERLTVAFCK
CCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
ECALSIESKLGEGTKVSFKIPKIYLQRNDIYEEAESVNY
HHHHHHHHHCCCCCEEEEECCEEEEECCHHHHHHHHCCC
>Mature Secondary Structure
MYDLLIILAERFSIIALLAFLLSKAEFFKKMVYNTALTKKDLLITMLIFGLIGIAGTYLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
VPINDAIANSRVVGPMVAGLIGGPLVGLGAGLIAGVHRFFLGGFTAISCGISTIIEGFAG
CCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIRKYYKGEYIPWEYAFMAGFIGEGVQMLIILATAKPFHQAVELVKIIGIPMMVVNATG
HHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCC
IGIFMIMIKSIFDEKEQIAAMQAKIALDIASKTLPYLRKGLNEESAQKTAEIILECTNVS
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCE
AVAITDKKRILAHVGIASDHHKPGMSILTNATKEAIQKGEIRIAKSKEEIGCPYENCELH
EEEEECHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHCCCCCCCCCCC
SAVIVPLFKYDKLVGTLKLYKGGKKSRGNVITNTEIELAKGLGHLISYQLEIADAEYQKK
HHHEEHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHEEEEECCHHHHHH
LATEAKLNALQSQINPHFLFNSLNTVISFIRTNPERARELLINLSEYFRHNLRNVGKYIT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
IEEELNNINAYLYIEKARFGDKLNVEQDVDISVLSCYMPSFILQPIVENAVKHGILPKGE
EHHHHCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RGTVKIKIKDEGDYISFYVEDDGVGMTEEELQNLFKKGVGKGAGIGLYNVNERLTVAFCK
CCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
ECALSIESKLGEGTKVSFKIPKIYLQRNDIYEEAESVNY
HHHHHHHHHCCCCCEEEEECCEEEEECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]