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The map label for this gene is Pdx2

Identifier: 20807304

GI number: 20807304

Start: 829079

End: 829648

Strand: Reverse

Name: Pdx2

Synonym: TTE0822

Alternate gene names: 20807304

Gene position: 829648-829079 (Counterclockwise)

Preceding gene: 20807305

Following gene: 20807302

Centisome position: 30.85

GC content: 35.44

Gene sequence:

>570_bases
TTGCGGGTAGGAGTTTTGGGAGTTCAAGGTTCTGTTAAGGAACATATGGATAAATTAAAGCTTATAAAAGGAATTGAAGC
AGTAGAGGCAAAAGATAAAGATACTCTTTTAACTCTCGATGCCCTAATTATTCCAGGTGGTGAAAGTACTGCAATAGGGA
AAATACTTGTAGATTTTGGGCTTAAAGATGCCATTTTAAAGTTAAATGAAAGGAAAGTTCCTATATGGGGTACTTGTGCA
GGCATGATACTTATGGCAAAACATATAGTTAATGATGAAAGGAGACACCTTGGAATAATGGATATTACTGTTAGACGGAA
TGCTTACGGAAGTCAGATTAACAGTTTCAAGACACGACTTATAATACCAGCAATATCTGAAAATGAGATAGAAGCGGTGT
TTATAAGAGCACCATATATAGAGAGTGTAGGGGATGGTGTTAGGATACTTGCAAAATATGAGGGTAAAATTGTTGCAGCA
CAGCAGGACAATTTACTTGCTACAGCATTTCATCCAGAACTTACAGATGATTTAAGCTTTTATAGATATTTTTTAAGGCT
TAACTCTTAA

Upstream 100 bases:

>100_bases
ATATTGGCAGAAGTTTCAGAAGGATTGGGAGAAGCGATGACCGGCATAGACATAAGGCAACTAGAAGAAAAAGATTTATA
CGCGACAAGGGGATGGTAAT

Downstream 100 bases:

>100_bases
GCCTTTTTATTTTATAGCTATGGCGGACTTTCACCGCTTAAGCTTTAGCCCATGCCGTGCGCACATAAAAATGAGGCACT
TACTTAAGTGCCTCAACAGA

Product: pyridoxine biosynthesis glutamine amidotransferase

Products: NA

Alternate protein names: Glutamine amidotransferase glutaminase subunit pdxT

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MRVGVLGVQGSVKEHMDKLKLIKGIEAVEAKDKDTLLTLDALIIPGGESTAIGKILVDFGLKDAILKLNERKVPIWGTCA
GMILMAKHIVNDERRHLGIMDITVRRNAYGSQINSFKTRLIIPAISENEIEAVFIRAPYIESVGDGVRILAKYEGKIVAA
QQDNLLATAFHPELTDDLSFYRYFLRLNS

Sequences:

>Translated_189_residues
MRVGVLGVQGSVKEHMDKLKLIKGIEAVEAKDKDTLLTLDALIIPGGESTAIGKILVDFGLKDAILKLNERKVPIWGTCA
GMILMAKHIVNDERRHLGIMDITVRRNAYGSQINSFKTRLIIPAISENEIEAVFIRAPYIESVGDGVRILAKYEGKIVAA
QQDNLLATAFHPELTDDLSFYRYFLRLNS
>Mature_189_residues
MRVGVLGVQGSVKEHMDKLKLIKGIEAVEAKDKDTLLTLDALIIPGGESTAIGKILVDFGLKDAILKLNERKVPIWGTCA
GMILMAKHIVNDERRHLGIMDITVRRNAYGSQINSFKTRLIIPAISENEIEAVFIRAPYIESVGDGVRILAKYEGKIVAA
QQDNLLATAFHPELTDDLSFYRYFLRLNS

Specific function: Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to pdxS

COG id: COG0311

COG function: function code H; Predicted glutamine amidotransferase involved in pyridoxine biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamine amidotransferase pdxT/SNO family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323995, Length=213, Percent_Identity=38.9671361502347, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323742, Length=207, Percent_Identity=38.1642512077295, Blast_Score=124, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6321048, Length=213, Percent_Identity=38.0281690140845, Blast_Score=123, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXT_THETN (Q8RBJ4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622475.1
- ProteinModelPortal:   Q8RBJ4
- SMR:   Q8RBJ4
- GeneID:   996951
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0822
- NMPDR:   fig|273068.3.peg.1072
- HOGENOM:   HBG292341
- OMA:   QGDVREH
- ProtClustDB:   CLSK900948
- BioCyc:   TTEN273068:TTE0822-MONOMER
- HAMAP:   MF_01615
- InterPro:   IPR002161
- InterPro:   IPR021196
- PIRSF:   PIRSF005639
- TIGRFAMs:   TIGR03800

Pfam domain/function: PF01174 SNO

EC number: NA

Molecular weight: Translated: 20991; Mature: 20991

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS01236 PDXT_SNO_1; PS51130 PDXT_SNO_2

Important sites: ACT_SITE 79-79 ACT_SITE 171-171 ACT_SITE 173-173 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVLGVQGSVKEHMDKLKLIKGIEAVEAKDKDTLLTLDALIIPGGESTAIGKILVDFG
CEEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHCC
LKDAILKLNERKVPIWGTCAGMILMAKHIVNDERRHLGIMDITVRRNAYGSQINSFKTRL
CHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCCCCHHHCCEEEE
IIPAISENEIEAVFIRAPYIESVGDGVRILAKYEGKIVAAQQDNLLATAFHPELTDDLSF
EEEECCCCCEEEEEEECCCHHHCCCCEEEEEEECCEEEEEECCCEEEEEECCCCCHHHHH
YRYFLRLNS
HHHEEEECC
>Mature Secondary Structure
MRVGVLGVQGSVKEHMDKLKLIKGIEAVEAKDKDTLLTLDALIIPGGESTAIGKILVDFG
CEEEEEECCCCHHHHHHHHHHHHCCHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHHCC
LKDAILKLNERKVPIWGTCAGMILMAKHIVNDERRHLGIMDITVRRNAYGSQINSFKTRL
CHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCCCCHHHCCEEEE
IIPAISENEIEAVFIRAPYIESVGDGVRILAKYEGKIVAAQQDNLLATAFHPELTDDLSF
EEEECCCCCEEEEEEECCCHHHCCCCEEEEEEECCEEEEEECCCEEEEEECCCCCHHHHH
YRYFLRLNS
HHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336