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The map label for this gene is ndk

Identifier: 20807233

GI number: 20807233

Start: 750558

End: 750977

Strand: Reverse

Name: ndk

Synonym: TTE0747

Alternate gene names: 20807233

Gene position: 750977-750558 (Counterclockwise)

Preceding gene: 20807234

Following gene: 20807225

Centisome position: 27.92

GC content: 41.67

Gene sequence:

>420_bases
TTGATTTTTATGGAAGTGACTTTGGCTATTGTAAAGCCGGATGGAGTAAAGAGGGGTCTTATAGGGGAAATACTGAAAAG
ATATGAAAACAAGGGGTTAAGGCTTAAAGCCGCAAAAGTAGTCACACCTTCAATTGAACTTCTGGAAAAACACTATGAGG
AGCACAAAGGAAAGCCTTTTTTTAAGCCTTTGATAGAGTACATGTCTTCAGGTCCCGTTTTTGCAATGGTCCTTGAAGGA
GAGAACGCTGTAAAACTGGTGAGAATGATAAACGGAGCGACAAAAGTGGAAGATGCTCTCCCTGGCACTATACGAGGAGA
CTTTGCTTCCAGCACCACTTACAATGTGGTGCACGGTTCAGACAGTGTGGAATCTGCAAAAAGAGAAATAGCATTATGGT
TTCCTGAACTCATCCTTTAA

Upstream 100 bases:

>100_bases
TGAGGGCAATTAAAGAAGCATACATAGTTGCAGGAATTTTTTCTGTAATCTGCGCCTTTACTTCTCTTGTCAGAGACAAT
ATCAAAATACAAAGAAAGGA

Downstream 100 bases:

>100_bases
AATTAAAAGCTGTGGCAAATTTTTTCTTCCTGCCACAGCTTTTAATTTACTCTTCTTTTCTCAAATGAGGGATTATGTAG
GCTGTGTAAAGATTGTTGAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MIFMEVTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVVTPSIELLEKHYEEHKGKPFFKPLIEYMSSGPVFAMVLEG
ENAVKLVRMINGATKVEDALPGTIRGDFASSTTYNVVHGSDSVESAKREIALWFPELIL

Sequences:

>Translated_139_residues
MIFMEVTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVVTPSIELLEKHYEEHKGKPFFKPLIEYMSSGPVFAMVLEG
ENAVKLVRMINGATKVEDALPGTIRGDFASSTTYNVVHGSDSVESAKREIALWFPELIL
>Mature_139_residues
MIFMEVTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVVTPSIELLEKHYEEHKGKPFFKPLIEYMSSGPVFAMVLEG
ENAVKLVRMINGATKVEDALPGTIRGDFASSTTYNVVHGSDSVESAKREIALWFPELIL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=130, Percent_Identity=56.1538461538462, Blast_Score=151, Evalue=2e-37,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=54.7445255474453, Blast_Score=151, Evalue=2e-37,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=54.7445255474453, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=54.7445255474453, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=54.7445255474453, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=54.7445255474453, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=54.7445255474453, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=54.7445255474453, Blast_Score=150, Evalue=3e-37,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=50.7692307692308, Blast_Score=140, Evalue=4e-34,
Organism=Homo sapiens, GI5031951, Length=139, Percent_Identity=39.568345323741, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=31.8518518518519, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI4505413, Length=142, Percent_Identity=34.5070422535211, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=31.8518518518519, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=32.3741007194245, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI148839372, Length=136, Percent_Identity=33.0882352941176, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=48.8721804511278, Blast_Score=134, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=53.6764705882353, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17507605, Length=89, Percent_Identity=48.314606741573, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=54.6153846153846, Blast_Score=146, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45549037, Length=132, Percent_Identity=56.8181818181818, Blast_Score=156, Evalue=4e-39,
Organism=Drosophila melanogaster, GI18860097, Length=137, Percent_Identity=37.956204379562, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_THETN (Q8RBR5)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622404.1
- ProteinModelPortal:   Q8RBR5
- SMR:   Q8RBR5
- GeneID:   996877
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0747
- NMPDR:   fig|273068.3.peg.765
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   TTEN273068:TTE0747-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15461; Mature: 15461

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 118-118 BINDING 12-12 BINDING 60-60 BINDING 88-88 BINDING 94-94 BINDING 105-105 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFMEVTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVVTPSIELLEKHYEEHKGKPF
CEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCH
FKPLIEYMSSGPVFAMVLEGENAVKLVRMINGATKVEDALPGTIRGDFASSTTYNVVHGS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCEEEEEECC
DSVESAKREIALWFPELIL
CHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFMEVTLAIVKPDGVKRGLIGEILKRYENKGLRLKAAKVVTPSIELLEKHYEEHKGKPF
CEEEEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCH
FKPLIEYMSSGPVFAMVLEGENAVKLVRMINGATKVEDALPGTIRGDFASSTTYNVVHGS
HHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCEEEEEECC
DSVESAKREIALWFPELIL
CHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336