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The map label for this gene is Ysh1

Identifier: 20807203

GI number: 20807203

Start: 717577

End: 719202

Strand: Direct

Name: Ysh1

Synonym: TTE0716

Alternate gene names: NA

Gene position: 717577-719202 (Clockwise)

Preceding gene: 20807202

Following gene: 20807204

Centisome position: 26.68

GC content: 39.98

Gene sequence:

>1626_bases
GTGAAAATAACTTTTTTGGGAGCTGCTAAGGAAGTTACAGGTTCATGCTACCTTGTGGAGACGGAAAATGCCAGGTTTTT
AGTGGACTGTGGCATGTTTCAGGGTGGAGAAGTAGAAGACGAGCTAAACTATCAAGAATTTATTTTTGATATAAAAGATA
TCGATTTCGTACTTTTAACCCATGCTCATATAGACCACAGTGGCAGAATTCCTGTGCTTTACAAAAGGGGCTACAGAAAG
AGGATTTACGCAACTCATGCTACAGTTGACCTGTGCAGGTACATGCTGCCGGATAGCGGGCACATCCAGGAAATGGAAAG
CGAGTGGAAGAACAGAAAGAGGAAAAGGGCTGGAAAGCCTTTGAGGGATCCACTTTATACGGCTGAAGAGGCAGAAGAAT
CTATAAGCATATTTTATGGTGTTGACTACGGGGAAGTGATAGAGCCTGCACCTCATATAAAAGTGAGATTTAATGATGCT
GGGCATATACTTGGCTCGTCTATAATTGAGGTGTGGGTAAATGAAAAGGGAAAAGAGACTAAAATAGTGTTTTCAGGAGA
TCTAGGGAATAAAAAGGTGCCTCTTTTGAGAGATGTAACTCCTATAAATGAGGCTGATTATGTTCTCTGTGAGTCTACAT
ACGGCAATAGGATTCATGAGGAGGTCTCTGATAGGGCGAAAAGGTTGATGGAGATTATAACACGCACTATTAAAAGAGGG
GGAAATGTTATTATTCCTTCTTTTGCCGTTGGAAGGACTCAAGAGATATTATATGAGCTTCACAGGGAAAGGGATTTGTA
CAAAGATGAGATAGAATTTTTGAACAACATCCCTGTGTATGTAGACAGTCCTCTTGCCACCTCAATAACAGATGTGTTTG
CAAAGCATCCAGAGTGCTTGGATGATGAAGCGAGGGAATACATCAAAAAAGGAGAATTGCCTTTAGATTTTCCCAATTTG
CACTTTACCCACAGTGCGGAAGAGTCTAAGGCTTTGAATGAGATTAAGACGCCCATGATAATTATCTCAGCTAGCGGCAT
GTGTGAGGCAGGTAGGATAAAGCACCACCTAAAGCACAATTTATGGAGGCCGGAGTGCACAGTCCTTTTTGTTGGGTATC
AGGCAAAAGGCACTTTAGGGAGGAAACTTTTAGATGGAGAAAAAGATGTGAAGATACTTGGAGAGGATATACACGTTAAG
GCTGAAATTGAATATATTGAGAGTTTTTCAGGTCATGCCGACCAAAGAGGTATACTGGAATGGATTTCTAATTTTGAGAA
AAAGCCCAAGAAGATATTCATTGTGCACGGAGAAGACGAAGCTCAGGAAGAACTGGCTGATAAGATAGAAGCACAATTTG
GCATAGAGACTTTGATTCCATCAAGGTACGATGTTTACGATTTTGATAAGGAAGAGCTTATAAAAGGAGAGGTTGAGGAT
AAAGAAAAGTTTAAACTGGAGCTTAACAATAAATTAGAAGAGATGAAATTGAGAAGTGAAAAGGCGTTTAACAAACTTCA
GGAGATACTAGACAAGAAAGATGGAAAAGATTTAACCGGCATAATGCTTGAGATAGACAATATAAATGAAAGCCTTATGA
AGCTTTATAGGGAACTTTTGGATTGA

Upstream 100 bases:

>100_bases
AATAAAATTTTGAATAGTTTTTAATACTTTAAACACTATTCATAACCTAAGCAAATGGCTTGAAGATAACTATAATTTCT
AAAATGAAAGGGGATTTACT

Downstream 100 bases:

>100_bases
GAATGCTTCCGGGCATTCTTTTTTTATATTTAAGGGCTTATTGCTCCCGCTTTCAAAATGTGATATAATATAATTGCACT
TTGATAAGCTTTACATCAAA

Product: RNA processing exonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKITFLGAAKEVTGSCYLVETENARFLVDCGMFQGGEVEDELNYQEFIFDIKDIDFVLLTHAHIDHSGRIPVLYKRGYRK
RIYATHATVDLCRYMLPDSGHIQEMESEWKNRKRKRAGKPLRDPLYTAEEAEESISIFYGVDYGEVIEPAPHIKVRFNDA
GHILGSSIIEVWVNEKGKETKIVFSGDLGNKKVPLLRDVTPINEADYVLCESTYGNRIHEEVSDRAKRLMEIITRTIKRG
GNVIIPSFAVGRTQEILYELHRERDLYKDEIEFLNNIPVYVDSPLATSITDVFAKHPECLDDEAREYIKKGELPLDFPNL
HFTHSAEESKALNEIKTPMIIISASGMCEAGRIKHHLKHNLWRPECTVLFVGYQAKGTLGRKLLDGEKDVKILGEDIHVK
AEIEYIESFSGHADQRGILEWISNFEKKPKKIFIVHGEDEAQEELADKIEAQFGIETLIPSRYDVYDFDKEELIKGEVED
KEKFKLELNNKLEEMKLRSEKAFNKLQEILDKKDGKDLTGIMLEIDNINESLMKLYRELLD

Sequences:

>Translated_541_residues
MKITFLGAAKEVTGSCYLVETENARFLVDCGMFQGGEVEDELNYQEFIFDIKDIDFVLLTHAHIDHSGRIPVLYKRGYRK
RIYATHATVDLCRYMLPDSGHIQEMESEWKNRKRKRAGKPLRDPLYTAEEAEESISIFYGVDYGEVIEPAPHIKVRFNDA
GHILGSSIIEVWVNEKGKETKIVFSGDLGNKKVPLLRDVTPINEADYVLCESTYGNRIHEEVSDRAKRLMEIITRTIKRG
GNVIIPSFAVGRTQEILYELHRERDLYKDEIEFLNNIPVYVDSPLATSITDVFAKHPECLDDEAREYIKKGELPLDFPNL
HFTHSAEESKALNEIKTPMIIISASGMCEAGRIKHHLKHNLWRPECTVLFVGYQAKGTLGRKLLDGEKDVKILGEDIHVK
AEIEYIESFSGHADQRGILEWISNFEKKPKKIFIVHGEDEAQEELADKIEAQFGIETLIPSRYDVYDFDKEELIKGEVED
KEKFKLELNNKLEEMKLRSEKAFNKLQEILDKKDGKDLTGIMLEIDNINESLMKLYRELLD
>Mature_541_residues
MKITFLGAAKEVTGSCYLVETENARFLVDCGMFQGGEVEDELNYQEFIFDIKDIDFVLLTHAHIDHSGRIPVLYKRGYRK
RIYATHATVDLCRYMLPDSGHIQEMESEWKNRKRKRAGKPLRDPLYTAEEAEESISIFYGVDYGEVIEPAPHIKVRFNDA
GHILGSSIIEVWVNEKGKETKIVFSGDLGNKKVPLLRDVTPINEADYVLCESTYGNRIHEEVSDRAKRLMEIITRTIKRG
GNVIIPSFAVGRTQEILYELHRERDLYKDEIEFLNNIPVYVDSPLATSITDVFAKHPECLDDEAREYIKKGELPLDFPNL
HFTHSAEESKALNEIKTPMIIISASGMCEAGRIKHHLKHNLWRPECTVLFVGYQAKGTLGRKLLDGEKDVKILGEDIHVK
AEIEYIESFSGHADQRGILEWISNFEKKPKKIFIVHGEDEAQEELADKIEAQFGIETLIPSRYDVYDFDKEELIKGEVED
KEKFKLELNNKLEEMKLRSEKAFNKLQEILDKKDGKDLTGIMLEIDNINESLMKLYRELLD

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=533, Percent_Identity=28.3302063789869, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI33300633, Length=479, Percent_Identity=25.8872651356994, Blast_Score=167, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI32566029, Length=465, Percent_Identity=29.0322580645161, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32564696, Length=479, Percent_Identity=26.9311064718163, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323307, Length=489, Percent_Identity=25.1533742331288, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24648013, Length=458, Percent_Identity=27.7292576419214, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21358523, Length=481, Percent_Identity=27.8586278586279, Blast_Score=159, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 62276; Mature: 62276

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITFLGAAKEVTGSCYLVETENARFLVDCGMFQGGEVEDELNYQEFIFDIKDIDFVLLT
CEEEEEECCHHCCCCEEEEEECCCEEEEEECCCCCCCCCHHCCHHHHHHHHCCCCEEEEE
HAHIDHSGRIPVLYKRGYRKRIYATHATVDLCRYMLPDSGHIQEMESEWKNRKRKRAGKP
EEECCCCCCCCEEECCCCCEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
LRDPLYTAEEAEESISIFYGVDYGEVIEPAPHIKVRFNDAGHILGSSIIEVWVNEKGKET
CCCCCCCHHHHHCCEEEEEECCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEE
KIVFSGDLGNKKVPLLRDVTPINEADYVLCESTYGNRIHEEVSDRAKRLMEIITRTIKRG
EEEEECCCCCCCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GNVIIPSFAVGRTQEILYELHRERDLYKDEIEFLNNIPVYVDSPLATSITDVFAKHPECL
CCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCCC
DDEAREYIKKGELPLDFPNLHFTHSAEESKALNEIKTPMIIISASGMCEAGRIKHHLKHN
CHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHC
LWRPECTVLFVGYQAKGTLGRKLLDGEKDVKILGEDIHVKAEIEYIESFSGHADQRGILE
CCCCCEEEEEEEEECCCCHHHHHHCCCCCEEEECCCEEEEEEHHHHHHCCCCCCCHHHHH
WISNFEKKPKKIFIVHGEDEAQEELADKIEAQFGIETLIPSRYDVYDFDKEELIKGEVED
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHHCCCCCC
KEKFKLELNNKLEEMKLRSEKAFNKLQEILDKKDGKDLTGIMLEIDNINESLMKLYRELL
CHHEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHC
D
C
>Mature Secondary Structure
MKITFLGAAKEVTGSCYLVETENARFLVDCGMFQGGEVEDELNYQEFIFDIKDIDFVLLT
CEEEEEECCHHCCCCEEEEEECCCEEEEEECCCCCCCCCHHCCHHHHHHHHCCCCEEEEE
HAHIDHSGRIPVLYKRGYRKRIYATHATVDLCRYMLPDSGHIQEMESEWKNRKRKRAGKP
EEECCCCCCCCEEECCCCCEEEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
LRDPLYTAEEAEESISIFYGVDYGEVIEPAPHIKVRFNDAGHILGSSIIEVWVNEKGKET
CCCCCCCHHHHHCCEEEEEECCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEE
KIVFSGDLGNKKVPLLRDVTPINEADYVLCESTYGNRIHEEVSDRAKRLMEIITRTIKRG
EEEEECCCCCCCCCCEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GNVIIPSFAVGRTQEILYELHRERDLYKDEIEFLNNIPVYVDSPLATSITDVFAKHPECL
CCEEECCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCCCC
DDEAREYIKKGELPLDFPNLHFTHSAEESKALNEIKTPMIIISASGMCEAGRIKHHLKHN
CHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHC
LWRPECTVLFVGYQAKGTLGRKLLDGEKDVKILGEDIHVKAEIEYIESFSGHADQRGILE
CCCCCEEEEEEEEECCCCHHHHHHCCCCCEEEECCCEEEEEEHHHHHHCCCCCCCHHHHH
WISNFEKKPKKIFIVHGEDEAQEELADKIEAQFGIETLIPSRYDVYDFDKEELIKGEVED
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHHCCCCCC
KEKFKLELNNKLEEMKLRSEKAFNKLQEILDKKDGKDLTGIMLEIDNINESLMKLYRELL
CHHEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA