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The map label for this gene is GltD2 [H]

Identifier: 20807180

GI number: 20807180

Start: 697554

End: 698954

Strand: Reverse

Name: GltD2 [H]

Synonym: TTE0693

Alternate gene names: 20807180

Gene position: 698954-697554 (Counterclockwise)

Preceding gene: 20807181

Following gene: 20807136

Centisome position: 25.99

GC content: 45.61

Gene sequence:

>1401_bases
ATGCCGTTAAATAGAAGCAAAAAGAAAACACCCATGCCTACCCAAAAGCCTGAAGTCCGCAGGCGTAATTTTAACGAAGT
AGCTTTGGGCTATTCGGAAGAGGAGGCAGTAAGTGAAGCCCAGAGGTGCCTTCAGTGTAAAAAACCAGGATGTGTTGAAG
GGTGCCCCGTTCAGGTACAAATTCCCCAGTTTATAAAGCGTATTGCAGAAAGAGATTTTGAAGGAGCTATAAAGATTATA
AAGGAAACCAACAGCTTGCCCGCCATATGTGGCAGAGTCTGTCCACAAGAAACGCAATGCGAGAAAAACTGTGTTTTGGG
CAAAGTAGGTGAACCTGTGGCCATAGGTCGCCTAGAACGGTTTGCAGCAGACTGGGAAAGAGCCAAAGGCATCCGTCCCC
CGGTAATTCCTAAAAAGCTTGGTAAAAAAGTGGCCATCATCGGTTCCGGGCCCGCCGGTCTCACCTGTGCAGGAGATTTG
GCTAAACTCGGCTACGATGTAACGATCTTTGAAGCTCTTCACAAACCCGGCGGCGTACTGGTATACGGTATTCCTGAATT
CAGGCTACCGAAAATTATAGTGGAACAAGAAGTAAAGTTTATACAACAGCTGGGCGTAGAAATTAAAACCAACATGGTTA
TGGGCAAAGTTTTAACGATAGACGACCTTTTTGAAATGGGGTATGAGGCTGTCTTTATCAGCACCGGAGCTGGCCTCCCG
AAATTTATGGGCATACCTGGTGAAAACTACCTTGGCGTGTATTCAGCCAACGAGTTTCTAACCAGGATAAACCTGATGAA
AGCCTATTCTTTTCCCAACACTGACACCCCCATAAAGGTAGGTAAAAAAGTAGCAGTAATAGGGGGTGGCAATGTAGCTA
TGGATGCAGCCAGGTCTGCCCTAAGAATGGGAGCTGACGAAGTTCATATTGTGTATCGCCGTTCTGAAGAAGAAATGCCC
GCAAGAAAAGAAGAATTCGAGAACGCTAAAGAGGAAGGTATTATATTCGATTTCCTCACAAATCCAGTGAGAATAATAGG
TAACGAAAATGGTTGGGTCAAAGGTATTGAGTGCATCCGCATGGAACTTGGAGAACCTGACGCTTCGGGTCGTCGTCGTC
CAGTTCCTATAACGGGTTCTGAATTTATTATGGATGTTGATACGATAGTAATCGCCATAGGTACTGGCCCTAATCCCCTC
CTCACAAAGACCACTGAAGGCTTAGAACTTACAAAACACGGTTATATTGCTGTCGATGAAGAGGGAAGAACTTCCAGAGA
AGGGGTATGGGCTGGAGGCGATATTGTAACGGGTTCAGCTACTGTAATTTTGGCCATGGGTGCCGGAAAAAAAGCAGCTC
GTTCCATCCATGAATACCTACAAAACAAAAAATGGCGGTAA

Upstream 100 bases:

>100_bases
AGATTGGCCACTTATAAAGAGGAAGAAAAAATTTCCCTCGAAAGATTTAATGAAGTTCATGAGTGCAAATTAATCAACAA
AATAGAAGGAGTTGATAAAG

Downstream 100 bases:

>100_bases
ACATCTTTCGATAAACTAAAGAGACGATAGCAAGTCGGTGCTGTGGAAGGACATACATCCAGCTATCGTCTCTTTTATTT
ATGAATTTATCGTTTTGCCT

Product: NADPH-dependent glutamate synthase beta chain and related oxidoreductase

Products: L-glutamine; 2-oxoglutarate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MPLNRSKKKTPMPTQKPEVRRRNFNEVALGYSEEEAVSEAQRCLQCKKPGCVEGCPVQVQIPQFIKRIAERDFEGAIKII
KETNSLPAICGRVCPQETQCEKNCVLGKVGEPVAIGRLERFAADWERAKGIRPPVIPKKLGKKVAIIGSGPAGLTCAGDL
AKLGYDVTIFEALHKPGGVLVYGIPEFRLPKIIVEQEVKFIQQLGVEIKTNMVMGKVLTIDDLFEMGYEAVFISTGAGLP
KFMGIPGENYLGVYSANEFLTRINLMKAYSFPNTDTPIKVGKKVAVIGGGNVAMDAARSALRMGADEVHIVYRRSEEEMP
ARKEEFENAKEEGIIFDFLTNPVRIIGNENGWVKGIECIRMELGEPDASGRRRPVPITGSEFIMDVDTIVIAIGTGPNPL
LTKTTEGLELTKHGYIAVDEEGRTSREGVWAGGDIVTGSATVILAMGAGKKAARSIHEYLQNKKWR

Sequences:

>Translated_466_residues
MPLNRSKKKTPMPTQKPEVRRRNFNEVALGYSEEEAVSEAQRCLQCKKPGCVEGCPVQVQIPQFIKRIAERDFEGAIKII
KETNSLPAICGRVCPQETQCEKNCVLGKVGEPVAIGRLERFAADWERAKGIRPPVIPKKLGKKVAIIGSGPAGLTCAGDL
AKLGYDVTIFEALHKPGGVLVYGIPEFRLPKIIVEQEVKFIQQLGVEIKTNMVMGKVLTIDDLFEMGYEAVFISTGAGLP
KFMGIPGENYLGVYSANEFLTRINLMKAYSFPNTDTPIKVGKKVAVIGGGNVAMDAARSALRMGADEVHIVYRRSEEEMP
ARKEEFENAKEEGIIFDFLTNPVRIIGNENGWVKGIECIRMELGEPDASGRRRPVPITGSEFIMDVDTIVIAIGTGPNPL
LTKTTEGLELTKHGYIAVDEEGRTSREGVWAGGDIVTGSATVILAMGAGKKAARSIHEYLQNKKWR
>Mature_465_residues
PLNRSKKKTPMPTQKPEVRRRNFNEVALGYSEEEAVSEAQRCLQCKKPGCVEGCPVQVQIPQFIKRIAERDFEGAIKIIK
ETNSLPAICGRVCPQETQCEKNCVLGKVGEPVAIGRLERFAADWERAKGIRPPVIPKKLGKKVAIIGSGPAGLTCAGDLA
KLGYDVTIFEALHKPGGVLVYGIPEFRLPKIIVEQEVKFIQQLGVEIKTNMVMGKVLTIDDLFEMGYEAVFISTGAGLPK
FMGIPGENYLGVYSANEFLTRINLMKAYSFPNTDTPIKVGKKVAVIGGGNVAMDAARSALRMGADEVHIVYRRSEEEMPA
RKEEFENAKEEGIIFDFLTNPVRIIGNENGWVKGIECIRMELGEPDASGRRRPVPITGSEFIMDVDTIVIAIGTGPNPLL
TKTTEGLELTKHGYIAVDEEGRTSREGVWAGGDIVTGSATVILAMGAGKKAARSIHEYLQNKKWR

Specific function: Unknown

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=486, Percent_Identity=32.9218106995885, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI237757300, Length=121, Percent_Identity=35.5371900826446, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788811, Length=451, Percent_Identity=39.4678492239468, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI1789606, Length=459, Percent_Identity=40.0871459694989, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI87082180, Length=476, Percent_Identity=36.344537815126, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1788468, Length=447, Percent_Identity=34.8993288590604, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI1789243, Length=424, Percent_Identity=34.1981132075472, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71984108, Length=453, Percent_Identity=34.4370860927152, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17570289, Length=490, Percent_Identity=28.5714285714286, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17543860, Length=160, Percent_Identity=33.125, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320030, Length=478, Percent_Identity=29.4979079497908, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24640763, Length=459, Percent_Identity=33.1154684095861, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI18858217, Length=459, Percent_Identity=33.1154684095861, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24665547, Length=479, Percent_Identity=30.4801670146138, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24665543, Length=479, Percent_Identity=30.4801670146138, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI28574881, Length=479, Percent_Identity=30.4801670146138, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24665539, Length=479, Percent_Identity=30.4801670146138, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013027
- InterPro:   IPR012285
- InterPro:   IPR006006 [H]

Pfam domain/function: PF00037 Fer4; PF07992 Pyr_redox_2 [H]

EC number: 1.4.1.13

Molecular weight: Translated: 51089; Mature: 50958

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNRSKKKTPMPTQKPEVRRRNFNEVALGYSEEEAVSEAQRCLQCKKPGCVEGCPVQVQ
CCCCCCCCCCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEE
IPQFIKRIAERDFEGAIKIIKETNSLPAICGRVCPQETQCEKNCVLGKVGEPVAIGRLER
HHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHCCEECCCCCCHHHHHHHH
FAADWERAKGIRPPVIPKKLGKKVAIIGSGPAGLTCAGDLAKLGYDVTIFEALHKPGGVL
HHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCCEECCHHHHCCCCEEEHHHHCCCCCEE
VYGIPEFRLPKIIVEQEVKFIQQLGVEIKTNMVMGKVLTIDDLFEMGYEAVFISTGAGLP
EECCCCCCCCHHHHHHHHHHHHHCCCEEEECEEECEEEEHHHHHHCCCEEEEEECCCCCH
KFMGIPGENYLGVYSANEFLTRINLMKAYSFPNTDTPIKVGKKVAVIGGGNVAMDAARSA
HHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
LRMGADEVHIVYRRSEEEMPARKEEFENAKEEGIIFDFLTNPVRIIGNENGWVKGIECIR
HHCCCCEEEEEEECCCCCCCCHHHHHHCHHHCCEEEEECCCCEEEEECCCCCCHHHHHEE
MELGEPDASGRRRPVPITGSEFIMDVDTIVIAIGTGPNPLLTKTTEGLELTKHGYIAVDE
EECCCCCCCCCCCCCCCCCCHHEEEEEEEEEEECCCCCCCEECCCCCCEEECCCEEEECC
EGRTSREGVWAGGDIVTGSATVILAMGAGKKAARSIHEYLQNKKWR
CCCCCCCCEEECCCEEECCEEEEEEECCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLNRSKKKTPMPTQKPEVRRRNFNEVALGYSEEEAVSEAQRCLQCKKPGCVEGCPVQVQ
CCCCCCCCCCCCCCCCHHHHCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEE
IPQFIKRIAERDFEGAIKIIKETNSLPAICGRVCPQETQCEKNCVLGKVGEPVAIGRLER
HHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHCCEECCCCCCHHHHHHHH
FAADWERAKGIRPPVIPKKLGKKVAIIGSGPAGLTCAGDLAKLGYDVTIFEALHKPGGVL
HHHHHHHHCCCCCCCCHHHHCCEEEEEECCCCCCEECCHHHHCCCCEEEHHHHCCCCCEE
VYGIPEFRLPKIIVEQEVKFIQQLGVEIKTNMVMGKVLTIDDLFEMGYEAVFISTGAGLP
EECCCCCCCCHHHHHHHHHHHHHCCCEEEECEEECEEEEHHHHHHCCCEEEEEECCCCCH
KFMGIPGENYLGVYSANEFLTRINLMKAYSFPNTDTPIKVGKKVAVIGGGNVAMDAARSA
HHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
LRMGADEVHIVYRRSEEEMPARKEEFENAKEEGIIFDFLTNPVRIIGNENGWVKGIECIR
HHCCCCEEEEEEECCCCCCCCHHHHHHCHHHCCEEEEECCCCEEEEECCCCCCHHHHHEE
MELGEPDASGRRRPVPITGSEFIMDVDTIVIAIGTGPNPLLTKTTEGLELTKHGYIAVDE
EECCCCCCCCCCCCCCCCCCHHEEEEEEEEEEECCCCCCCEECCCCCCEEECCCEEEECC
EGRTSREGVWAGGDIVTGSATVILAMGAGKKAARSIHEYLQNKKWR
CCCCCCCCEEECCCEEECCEEEEEEECCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-glutamate; NADP+

Specific reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955321; 9205837; 9278503 [H]