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The map label for this gene is MntA [H]

Identifier: 20807173

GI number: 20807173

Start: 688659

End: 689921

Strand: Direct

Name: MntA [H]

Synonym: TTE0686

Alternate gene names: 20807173

Gene position: 688659-689921 (Clockwise)

Preceding gene: 20807172

Following gene: 20807174

Centisome position: 25.61

GC content: 36.82

Gene sequence:

>1263_bases
ATGATTACAAAAGTCAAAAATTTATTTAAAGGTGAACATCGCCCTAAACTTATGGCTTTAGATTTTATTAAATACATAGG
TCCTGGGCTACTGGTTACTGTGGGTTTTATTGACCCGGGAAATTGGGCTTCTAATGTTGCTGCAGGTTCGTCTTACGGTT
ATAAGCTTTTATGGATGGTGACTTTATCTACTATCATGCTCATTATACTCCAGCACAATGCTGCACATCTGGGTATAGTT
ACAGGTTATTGCATGTCTGAAGCTGCAACTAAGTTTTTAAAGCCTTTTACTTCGAGGTTAGTTCTTATTTCAGCTGTCTT
TGCGGCGATTTTGACGGCGATGGCAGAAATTTTAGGTGCCGCGATAGCTCTTCAAATGCTTTTTAAGATACCGATAAAGA
TAGGAAGTTTGATTACTGTTGTTTTTGTGTCATGGATGCTTTATACAAATTCCTATAAAAAGTTGGAAAAGTGGATTATA
AGTTTTGTATCTCTTATTGGCATTTCTTTTATATTTGAGCTTTCGCTAATTGATGTGAAATGGGCAGAGGTAGCTTCAAG
CTGGGTGAAACCAGAATTTCCAGCAGGTTCTATGCCTATAATTATGAGTGTGCTTGGTGCTGTTGTTATGCCCCACAATT
TGTTTTTGCACTCGGAGATAATACAAAGCAGGCAGTGGAATTTAGAAGATGAGAAAGTCATTGTGAAACAGCTTAATTAT
GAGTATTTTGACACTATCTTTTCTATGATAATAGGTTGGGGGATAAACAGTGCTATGATTATTGTTGCGGCATCGGCTTT
TTTTACCAATAATGTAACCGTAATGGAGCTTAATCAGGCACAGCAGATGTTAAAACCTCTTTTGGGAAATGCGTCAGCAG
TGGTTTTTGCTTTGGCTCTTCTTTTTGCAGGAATTTCTTCCTCTATAACAGCAGGAATGGCAGGCGGAAGTATTTTTGCG
GGGATATATGGAGAACCATATGATATACACGATGCACATACAAAAGTTGGCGTAGGAATTACATATATTTTTGCAGTGCT
AATAATATTCTTTGTAAAAAGCCCCTTTCAAGGACTAGTTTATTCGCAGATGTTTTTAAGTGTACAGCTTCCAATTACAA
TCTTTTTGCTCATTTATTTGACTTCTTCAAAAAAGATCATGGGTAAGTTTGCAAATACATTGCTTTATAAGGTATTGTTG
TGGACTATAGGAATAATAGTGACGGTTTTAAATGCGATGCTTCTTATGAGCTTTGTTGGGTGA

Upstream 100 bases:

>100_bases
CTGTGAATCACGGATCAGGACGAAGCTTTCACGAATGCCCGATTTGTGCCTCTTGCAGTTGTAAAAGGTGCAGATTAAAA
TTTTAAAATGAGGTGAACAA

Downstream 100 bases:

>100_bases
TTGATATGAATGCTTGGTCGGGCATCCTGCTTACAGTATAGCTTCCATTTGCATCGAAGTGACATACAGCTTTGAAGTGC
TTTAAAGCTACAAGAAAAAT

Product: manganese transporter NRAMP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MITKVKNLFKGEHRPKLMALDFIKYIGPGLLVTVGFIDPGNWASNVAAGSSYGYKLLWMVTLSTIMLIILQHNAAHLGIV
TGYCMSEAATKFLKPFTSRLVLISAVFAAILTAMAEILGAAIALQMLFKIPIKIGSLITVVFVSWMLYTNSYKKLEKWII
SFVSLIGISFIFELSLIDVKWAEVASSWVKPEFPAGSMPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDEKVIVKQLNY
EYFDTIFSMIIGWGINSAMIIVAASAFFTNNVTVMELNQAQQMLKPLLGNASAVVFALALLFAGISSSITAGMAGGSIFA
GIYGEPYDIHDAHTKVGVGITYIFAVLIIFFVKSPFQGLVYSQMFLSVQLPITIFLLIYLTSSKKIMGKFANTLLYKVLL
WTIGIIVTVLNAMLLMSFVG

Sequences:

>Translated_420_residues
MITKVKNLFKGEHRPKLMALDFIKYIGPGLLVTVGFIDPGNWASNVAAGSSYGYKLLWMVTLSTIMLIILQHNAAHLGIV
TGYCMSEAATKFLKPFTSRLVLISAVFAAILTAMAEILGAAIALQMLFKIPIKIGSLITVVFVSWMLYTNSYKKLEKWII
SFVSLIGISFIFELSLIDVKWAEVASSWVKPEFPAGSMPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDEKVIVKQLNY
EYFDTIFSMIIGWGINSAMIIVAASAFFTNNVTVMELNQAQQMLKPLLGNASAVVFALALLFAGISSSITAGMAGGSIFA
GIYGEPYDIHDAHTKVGVGITYIFAVLIIFFVKSPFQGLVYSQMFLSVQLPITIFLLIYLTSSKKIMGKFANTLLYKVLL
WTIGIIVTVLNAMLLMSFVG
>Mature_420_residues
MITKVKNLFKGEHRPKLMALDFIKYIGPGLLVTVGFIDPGNWASNVAAGSSYGYKLLWMVTLSTIMLIILQHNAAHLGIV
TGYCMSEAATKFLKPFTSRLVLISAVFAAILTAMAEILGAAIALQMLFKIPIKIGSLITVVFVSWMLYTNSYKKLEKWII
SFVSLIGISFIFELSLIDVKWAEVASSWVKPEFPAGSMPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDEKVIVKQLNY
EYFDTIFSMIIGWGINSAMIIVAASAFFTNNVTVMELNQAQQMLKPLLGNASAVVFALALLFAGISSSITAGMAGGSIFA
GIYGEPYDIHDAHTKVGVGITYIFAVLIIFFVKSPFQGLVYSQMFLSVQLPITIFLLIYLTSSKKIMGKFANTLLYKVLL
WTIGIIVTVLNAMLLMSFVG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=429, Percent_Identity=26.3403263403263, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI295293178, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI295293171, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI295293169, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI295293175, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI295293173, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI10835169, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI295293167, Length=431, Percent_Identity=26.4501160092807, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=31.25, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17569473, Length=376, Percent_Identity=29.2553191489362, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI193210616, Length=433, Percent_Identity=26.0969976905312, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71993856, Length=207, Percent_Identity=35.2657004830918, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71999499, Length=442, Percent_Identity=26.0180995475113, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323062, Length=403, Percent_Identity=32.0099255583127, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6321841, Length=407, Percent_Identity=31.4496314496315, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324450, Length=425, Percent_Identity=29.1764705882353, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24648607, Length=430, Percent_Identity=26.2790697674419, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281362176, Length=430, Percent_Identity=26.2790697674419, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24648609, Length=430, Percent_Identity=26.2790697674419, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45553443, Length=413, Percent_Identity=26.3922518159806, Blast_Score=121, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46240; Mature: 46240

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]