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The map label for this gene is epsC [H]

Identifier: 20807159

GI number: 20807159

Start: 669876

End: 671747

Strand: Direct

Name: epsC [H]

Synonym: TTE0668

Alternate gene names: 20807159

Gene position: 669876-671747 (Clockwise)

Preceding gene: 20807158

Following gene: 20807160

Centisome position: 24.91

GC content: 33.23

Gene sequence:

>1872_bases
ATGTGGAAAAACAAGAGAAAAATTTTATTATTGCTTATTGACATTATCCTATTGAATATAGCATATTTTCTAGCTTTTTA
TTTGCGCTTTGACTATAATATTCCCCACCAATATTTTCTCTTATACAAAAAAACCTTTTACATAGTAGTTACAGTGACTG
TCGTAACATTTATCTTTTTCAAACAATACAATAAAATCTGGAGATATGCAAGTTTACATGATATTATGGATTTAATTATT
TTTACTACCATTGGCAGCGCTATGGCTGCTTTTGTTTTACTATTTTTACAAATACATTTGCCACGTTCTATTTATCCTTT
ATACTGGTTTTTGAGTGCATTGCTAATAGGTGGAAGTCGTATTGCTTATAGAAGTTATATGGAAAATAGCAGTAAAGTTA
AAGTAAAGAATATAAAATACAAAAAAGTGTTAATAGTAGGTGCTGGAGATGCTGGGCGTATACTTGTAAGGGAGATAAAA
AATCATCCAGAAACAGGCCTTAAGCCTGTAGCAATAGTAGATGATGATGTGTCTAAATTACACAGAAGTATTGATGATGT
GCCTGTTGTGGGGAAAATTGATGATATTCAGGAAGTTATTACGGAGAAGGAAATTGATGAAGTTATTTTTGCTATCCCTT
CTGCGCCTAGAACTGTTTTGAAAAAAGTTATTGATAAATGTAGTGAAATGCGCATAAAAGTTAAGACATTGCCAGCTATT
TATGAGTTAGTTGATGGAACAATATCAATAAGTAGCATAAGGGATGTTGATATAAATGATTTGTTAGGTAGAGAACCTGT
CAAAATTGATTTAGAGGAAATAAGTAGCTACATAAAAGGTAAAAAAGTTATGGTTACAGGTGGAGGAGGGTCCATTGGGT
CTGAACTTTGCAGACAAATAGCCCGATTTTCACCCTCTCGCCTTATTATACTAGACATATACGAAAACAATATGTATGAA
GTAGAACAGGAATTAAAAAGAAAATACCCTGAACTTGATGTAATTTGCTTAGTCGCAAATATTAGAGAAGAAAAGAAGAT
AAATAAAATTTTTAGTGAGTATACTCCTGATATTGTTTTTCACGCAGCTGCTCATAAACATGTTCCACTAATGGAGGTAA
GTCCTCATGAAGCTATTAAAAACAATGTATATGGTACATTGAATCTTGTAAAAGTTTCTGACTTATATAATGTCAATCGC
TTTGTAATGATTTCGACAGATAAGGCTGTCAATCCTACGAGTGTGATGGGAGCTTCTAAGCGCATATGTGAGATGATAAT
TCAAGAATACGATAAAAAAAGTAAAACTGAGTTTGTTGCAGTGCGATTTGGAAATGTGTTGGGAAGCAATGGAAGCGTTA
TACCTCTTTTTAAAAAGCAGATTGCAGAAGGTGGACCTGTTACGGTGACTCATGAAGAAATTAAAAGATACTTTATGACA
ATACCAGAAGCTGTTCAGTTGGTTATACAAGCAGGGGCTATGGCAAAGGGCGGCGAAATATTTGTACTTGATATGGGTGA
ACCGGTTAAAATTATAGATTTAGCAAGAACGTTAATTCGGTTATCGGGTTTTGAGCCTGATGTAGATATACCTATTAAGA
TTATTGGTTTAAGACCAGGAGAGAAATTATTTGAGGAATTATTAATAAGTGATGATAAATACGTGTCGACGAAGCATGAG
AAAATTTTTATTGAAAAGCCCGTTTCTGTCGATTATGGGGATTTAATTTTAACATTGGAAAAATATAAAGATAAGATAGA
TGATATGGATGAAGATGAAATAAGAGAGTTTATAAAGTCCCTTGTGCCAGAGTATAATCCTGATTATCAGCGGTCCTTAA
TGGAAGAAGTTGCCGCTACTGAAATAGAATAG

Upstream 100 bases:

>100_bases
ACCTTTTTTCAATAAAATAACAGATGAACAAATTGATTATGTAGTCGATAAGTTAAAAGAGGCAATAAAGATATATAGTA
GGTAAATGGGAGAGATTTAT

Downstream 100 bases:

>100_bases
TTTTTGAATTTTAATAAGTGAGGAGATACGGATAATGAAAGTTTTAGTCACAGGTGGTGCAGGCTTTATAGGTTCACATA
TAGCAGATTTGTTTATTGAA

Product: nucleoside-diphosphate sugar epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MWKNKRKILLLLIDIILLNIAYFLAFYLRFDYNIPHQYFLLYKKTFYIVVTVTVVTFIFFKQYNKIWRYASLHDIMDLII
FTTIGSAMAAFVLLFLQIHLPRSIYPLYWFLSALLIGGSRIAYRSYMENSSKVKVKNIKYKKVLIVGAGDAGRILVREIK
NHPETGLKPVAIVDDDVSKLHRSIDDVPVVGKIDDIQEVITEKEIDEVIFAIPSAPRTVLKKVIDKCSEMRIKVKTLPAI
YELVDGTISISSIRDVDINDLLGREPVKIDLEEISSYIKGKKVMVTGGGGSIGSELCRQIARFSPSRLIILDIYENNMYE
VEQELKRKYPELDVICLVANIREEKKINKIFSEYTPDIVFHAAAHKHVPLMEVSPHEAIKNNVYGTLNLVKVSDLYNVNR
FVMISTDKAVNPTSVMGASKRICEMIIQEYDKKSKTEFVAVRFGNVLGSNGSVIPLFKKQIAEGGPVTVTHEEIKRYFMT
IPEAVQLVIQAGAMAKGGEIFVLDMGEPVKIIDLARTLIRLSGFEPDVDIPIKIIGLRPGEKLFEELLISDDKYVSTKHE
KIFIEKPVSVDYGDLILTLEKYKDKIDDMDEDEIREFIKSLVPEYNPDYQRSLMEEVAATEIE

Sequences:

>Translated_623_residues
MWKNKRKILLLLIDIILLNIAYFLAFYLRFDYNIPHQYFLLYKKTFYIVVTVTVVTFIFFKQYNKIWRYASLHDIMDLII
FTTIGSAMAAFVLLFLQIHLPRSIYPLYWFLSALLIGGSRIAYRSYMENSSKVKVKNIKYKKVLIVGAGDAGRILVREIK
NHPETGLKPVAIVDDDVSKLHRSIDDVPVVGKIDDIQEVITEKEIDEVIFAIPSAPRTVLKKVIDKCSEMRIKVKTLPAI
YELVDGTISISSIRDVDINDLLGREPVKIDLEEISSYIKGKKVMVTGGGGSIGSELCRQIARFSPSRLIILDIYENNMYE
VEQELKRKYPELDVICLVANIREEKKINKIFSEYTPDIVFHAAAHKHVPLMEVSPHEAIKNNVYGTLNLVKVSDLYNVNR
FVMISTDKAVNPTSVMGASKRICEMIIQEYDKKSKTEFVAVRFGNVLGSNGSVIPLFKKQIAEGGPVTVTHEEIKRYFMT
IPEAVQLVIQAGAMAKGGEIFVLDMGEPVKIIDLARTLIRLSGFEPDVDIPIKIIGLRPGEKLFEELLISDDKYVSTKHE
KIFIEKPVSVDYGDLILTLEKYKDKIDDMDEDEIREFIKSLVPEYNPDYQRSLMEEVAATEIE
>Mature_623_residues
MWKNKRKILLLLIDIILLNIAYFLAFYLRFDYNIPHQYFLLYKKTFYIVVTVTVVTFIFFKQYNKIWRYASLHDIMDLII
FTTIGSAMAAFVLLFLQIHLPRSIYPLYWFLSALLIGGSRIAYRSYMENSSKVKVKNIKYKKVLIVGAGDAGRILVREIK
NHPETGLKPVAIVDDDVSKLHRSIDDVPVVGKIDDIQEVITEKEIDEVIFAIPSAPRTVLKKVIDKCSEMRIKVKTLPAI
YELVDGTISISSIRDVDINDLLGREPVKIDLEEISSYIKGKKVMVTGGGGSIGSELCRQIARFSPSRLIILDIYENNMYE
VEQELKRKYPELDVICLVANIREEKKINKIFSEYTPDIVFHAAAHKHVPLMEVSPHEAIKNNVYGTLNLVKVSDLYNVNR
FVMISTDKAVNPTSVMGASKRICEMIIQEYDKKSKTEFVAVRFGNVLGSNGSVIPLFKKQIAEGGPVTVTHEEIKRYFMT
IPEAVQLVIQAGAMAKGGEIFVLDMGEPVKIIDLARTLIRLSGFEPDVDIPIKIIGLRPGEKLFEELLISDDKYVSTKHE
KIFIEKPVSVDYGDLILTLEKYKDKIDDMDEDEIREFIKSLVPEYNPDYQRSLMEEVAATEIE

Specific function: Involved in biofilm formation [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=290, Percent_Identity=26.8965517241379, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568069, Length=283, Percent_Identity=25.4416961130742, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 71056; Mature: 71056

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKNKRKILLLLIDIILLNIAYFLAFYLRFDYNIPHQYFLLYKKTFYIVVTVTVVTFIFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEHHHHEEHHHHHHHHHHH
KQYNKIWRYASLHDIMDLIIFTTIGSAMAAFVLLFLQIHLPRSIYPLYWFLSALLIGGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCH
IAYRSYMENSSKVKVKNIKYKKVLIVGAGDAGRILVREIKNHPETGLKPVAIVDDDVSKL
HHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECHHHHHH
HRSIDDVPVVGKIDDIQEVITEKEIDEVIFAIPSAPRTVLKKVIDKCSEMRIKVKTLPAI
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEEEHHHHH
YELVDGTISISSIRDVDINDLLGREPVKIDLEEISSYIKGKKVMVTGGGGSIGSELCRQI
HHHHCCCEEECCCCCCCHHHHCCCCCCEEEHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
ARFSPSRLIILDIYENNMYEVEQELKRKYPELDVICLVANIREEKKINKIFSEYTPDIVF
HHCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEE
HAAAHKHVPLMEVSPHEAIKNNVYGTLNLVKVSDLYNVNRFVMISTDKAVNPTSVMGASK
EECCCCCCCEEECCCHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHH
RICEMIIQEYDKKSKTEFVAVRFGNVLGSNGSVIPLFKKQIAEGGPVTVTHEEIKRYFMT
HHHHHHHHHHCCCCCCEEEEEEECHHCCCCCCEEHHHHHHHCCCCCEEEEHHHHHHHHHH
IPEAVQLVIQAGAMAKGGEIFVLDMGEPVKIIDLARTLIRLSGFEPDVDIPIKIIGLRPG
HHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
EKLFEELLISDDKYVSTKHEKIFIEKPVSVDYGDLILTLEKYKDKIDDMDEDEIREFIKS
HHHHHHHHCCCCCEECCCCCEEEEECCCCCCCCHHEEEHHHHHHHCCCCCHHHHHHHHHH
LVPEYNPDYQRSLMEEVAATEIE
HCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWKNKRKILLLLIDIILLNIAYFLAFYLRFDYNIPHQYFLLYKKTFYIVVTVTVVTFIFF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEHHHHEEHHHHHHHHHHH
KQYNKIWRYASLHDIMDLIIFTTIGSAMAAFVLLFLQIHLPRSIYPLYWFLSALLIGGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCH
IAYRSYMENSSKVKVKNIKYKKVLIVGAGDAGRILVREIKNHPETGLKPVAIVDDDVSKL
HHHHHHHCCCCCEEEEEEEEEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECHHHHHH
HRSIDDVPVVGKIDDIQEVITEKEIDEVIFAIPSAPRTVLKKVIDKCSEMRIKVKTLPAI
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEEEHHHHH
YELVDGTISISSIRDVDINDLLGREPVKIDLEEISSYIKGKKVMVTGGGGSIGSELCRQI
HHHHCCCEEECCCCCCCHHHHCCCCCCEEEHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
ARFSPSRLIILDIYENNMYEVEQELKRKYPELDVICLVANIREEKKINKIFSEYTPDIVF
HHCCCCEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCEE
HAAAHKHVPLMEVSPHEAIKNNVYGTLNLVKVSDLYNVNRFVMISTDKAVNPTSVMGASK
EECCCCCCCEEECCCHHHHHCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHHHH
RICEMIIQEYDKKSKTEFVAVRFGNVLGSNGSVIPLFKKQIAEGGPVTVTHEEIKRYFMT
HHHHHHHHHHCCCCCCEEEEEEECHHCCCCCCEEHHHHHHHCCCCCEEEEHHHHHHHHHH
IPEAVQLVIQAGAMAKGGEIFVLDMGEPVKIIDLARTLIRLSGFEPDVDIPIKIIGLRPG
HHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCC
EKLFEELLISDDKYVSTKHEKIFIEKPVSVDYGDLILTLEKYKDKIDDMDEDEIREFIKS
HHHHHHHHCCCCCEECCCCCEEEEECCCCCCCCHHEEEHHHHHHHCCCCCHHHHHHHHHH
LVPEYNPDYQRSLMEEVAATEIE
HCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969506; 9384377 [H]