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The map label for this gene is gatA [H]

Identifier: 20807102

GI number: 20807102

Start: 610039

End: 611505

Strand: Direct

Name: gatA [H]

Synonym: TTE0607

Alternate gene names: 20807102

Gene position: 610039-611505 (Clockwise)

Preceding gene: 20807101

Following gene: 20807103

Centisome position: 22.68

GC content: 40.63

Gene sequence:

>1467_bases
TTGGAATTGTATAGTCTGACAGTACATGAACTTAAAGAACTTCTCCATAAAAGAGAAGTAAGTGCACAAGAGGTGACAAA
ATCCTACCTTGAAAGGATAAAAGAAGTGGAGCCCAAGATAGATGCCCTTGTGACTATTACAGAAGAATTTGCACTGGAAA
GGGCTAAAGTAGCAGATGAGATGATAAAAAACGGCGAAGCAAAAGATTTAACAGGAATTCCTGTGATAATAAAAGACAAC
ATCTCTACAGAAGGCATAAGAACCACATGTTCTTCTAAAATGCTAGAAAATTACATACCGCCATACAACGCAACAGTTGT
GGAAAGGCTTTTAAATGAGGGAGTAGTTATATTAGGGAAGTCTAATTTGGACGAGTTTGCTATGGGGTCTTCAACTGAAA
ATTCCGCATTTAAAACTACGAAAAACCCGTGGGACTTGTCCCGTGTTCCAGGTGGGTCTTCTGGAGGTTCTGCAGCAGCT
GTTGCAGCAGATGAGGCTGCTTTTGCACTTGGGTCAGATACAGGAGGCTCTATAAGGCAACCGGCTTCCTTGTGCGGGGT
AGTTGGAATGAAGCCAACATATGGTTTAGTTTCTAGATACGGTTTGGTGGCTTTTGCTTCCTCTCTTGACCAGATAGGTC
CTTTCACAAAGGATGTGACAGATTGCGCGATTGTGCTAAACGCCATTGCAGGTCATGACCCTATGGATTCTACTTCTGTA
AAAATAGAAAAGCCTGATTATACCTCTTACCTTAAAGAAGACATAAAAGGTCTCAGAATAGGAGTTGCGAAGGAATTCTT
TGGAGCCGGAATTGAAGAGGGCGTAAAGGAAACAGTAGAAAAGGCTATAAAAGTGTTTGAGGATTTAGGAGCAGAAATAA
TTGATATATCTGTTCCTTATGTAGAGTATGCCCTTCCTGCCTATTACATAATCGCTTCGGCGGAAGCTAGTTCTAATTTA
GCTAGATACGATGGGATAAGGTATGGGCATATTGCGAAAAACTACGAAGATTTAGTTGATATGTACATGACAAGCAGAAG
TGAAGGTTTTGGCAAAGAGGTAAAGAGGAGAATAATGTTGGGGACATATGCATTAAGCTCAGGTTACTACGATGCTTACT
ATAAGAAGGCTTTAAAGGTGAGGACATTAATTAAAAATGACTTTGAAAGGGCTTTTGAGAAATGCGATGTCATAGTAGGT
CCTACAAGTCCTACAGTGGCTTTTAAGATCGGTGAAAGAACGAATGACCCGTTAGCTATGTACTTAGCAGATATATACAC
AGTATCTGTAAATATTGCAGGACTTCCTGCTATATCTATTCCTTGCGGACTTTCAGAGGGATTACCTGTGGGGCTTCAGA
TAATTGGCAAGCACTTTGATGAAGGCAGAATACTCAATGTGGCTTATGCTTTTGAAAAAGCGTACAAATTTGATGCCAAG
CCACAGGCCATAGGAGGTGAAAGATAA

Upstream 100 bases:

>100_bases
AAACCTTCTATGCCAAGAGAAAAAGTGTTGATGAACGCTCCTTTTACAGAGCAAGGCTGCTTTAAAGTGCCAAAGATCAT
AGAGTGAGGAGGTACGCAAA

Downstream 100 bases:

>100_bases
TGAAATACGAAGCAGTAATCGGATTAGAAGTTCATGCAGAGCTCTTGACAGACAGTAAGATATTTTGTGGATGCAGCACC
AAATTTGGCAGTGAACCAAA

Product: aspartyl/glutamyl-tRNA amidotransferase subunit A

Products: NA

Alternate protein names: Glu-ADT subunit A [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MELYSLTVHELKELLHKREVSAQEVTKSYLERIKEVEPKIDALVTITEEFALERAKVADEMIKNGEAKDLTGIPVIIKDN
ISTEGIRTTCSSKMLENYIPPYNATVVERLLNEGVVILGKSNLDEFAMGSSTENSAFKTTKNPWDLSRVPGGSSGGSAAA
VAADEAAFALGSDTGGSIRQPASLCGVVGMKPTYGLVSRYGLVAFASSLDQIGPFTKDVTDCAIVLNAIAGHDPMDSTSV
KIEKPDYTSYLKEDIKGLRIGVAKEFFGAGIEEGVKETVEKAIKVFEDLGAEIIDISVPYVEYALPAYYIIASAEASSNL
ARYDGIRYGHIAKNYEDLVDMYMTSRSEGFGKEVKRRIMLGTYALSSGYYDAYYKKALKVRTLIKNDFERAFEKCDVIVG
PTSPTVAFKIGERTNDPLAMYLADIYTVSVNIAGLPAISIPCGLSEGLPVGLQIIGKHFDEGRILNVAYAFEKAYKFDAK
PQAIGGER

Sequences:

>Translated_488_residues
MELYSLTVHELKELLHKREVSAQEVTKSYLERIKEVEPKIDALVTITEEFALERAKVADEMIKNGEAKDLTGIPVIIKDN
ISTEGIRTTCSSKMLENYIPPYNATVVERLLNEGVVILGKSNLDEFAMGSSTENSAFKTTKNPWDLSRVPGGSSGGSAAA
VAADEAAFALGSDTGGSIRQPASLCGVVGMKPTYGLVSRYGLVAFASSLDQIGPFTKDVTDCAIVLNAIAGHDPMDSTSV
KIEKPDYTSYLKEDIKGLRIGVAKEFFGAGIEEGVKETVEKAIKVFEDLGAEIIDISVPYVEYALPAYYIIASAEASSNL
ARYDGIRYGHIAKNYEDLVDMYMTSRSEGFGKEVKRRIMLGTYALSSGYYDAYYKKALKVRTLIKNDFERAFEKCDVIVG
PTSPTVAFKIGERTNDPLAMYLADIYTVSVNIAGLPAISIPCGLSEGLPVGLQIIGKHFDEGRILNVAYAFEKAYKFDAK
PQAIGGER
>Mature_488_residues
MELYSLTVHELKELLHKREVSAQEVTKSYLERIKEVEPKIDALVTITEEFALERAKVADEMIKNGEAKDLTGIPVIIKDN
ISTEGIRTTCSSKMLENYIPPYNATVVERLLNEGVVILGKSNLDEFAMGSSTENSAFKTTKNPWDLSRVPGGSSGGSAAA
VAADEAAFALGSDTGGSIRQPASLCGVVGMKPTYGLVSRYGLVAFASSLDQIGPFTKDVTDCAIVLNAIAGHDPMDSTSV
KIEKPDYTSYLKEDIKGLRIGVAKEFFGAGIEEGVKETVEKAIKVFEDLGAEIIDISVPYVEYALPAYYIIASAEASSNL
ARYDGIRYGHIAKNYEDLVDMYMTSRSEGFGKEVKRRIMLGTYALSSGYYDAYYKKALKVRTLIKNDFERAFEKCDVIVG
PTSPTVAFKIGERTNDPLAMYLADIYTVSVNIAGLPAISIPCGLSEGLPVGLQIIGKHFDEGRILNVAYAFEKAYKFDAK
PQAIGGER

Specific function: Furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu- tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activa

COG id: COG0154

COG function: function code J; Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amidase family [H]

Homologues:

Organism=Homo sapiens, GI222831590, Length=498, Percent_Identity=41.1646586345382, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI195972892, Length=500, Percent_Identity=26.2, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI166795287, Length=209, Percent_Identity=28.7081339712919, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17543272, Length=441, Percent_Identity=39.9092970521542, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17537465, Length=486, Percent_Identity=25.3086419753086, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17556264, Length=292, Percent_Identity=28.7671232876712, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71990152, Length=326, Percent_Identity=27.3006134969325, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17556278, Length=325, Percent_Identity=29.8461538461538, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556276, Length=325, Percent_Identity=29.8461538461538, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538252, Length=316, Percent_Identity=24.0506329113924, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538254, Length=330, Percent_Identity=21.8181818181818, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323950, Length=427, Percent_Identity=38.6416861826698, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6319685, Length=467, Percent_Identity=28.6937901498929, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320448, Length=534, Percent_Identity=22.8464419475655, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648113, Length=481, Percent_Identity=41.7879417879418, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24652985, Length=501, Percent_Identity=27.3453093812375, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI19922090, Length=501, Percent_Identity=27.3453093812375, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24652981, Length=501, Percent_Identity=27.3453093812375, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24652983, Length=501, Percent_Identity=27.3453093812375, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24644968, Length=497, Percent_Identity=25.9557344064386, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161078093, Length=516, Percent_Identity=28.4883720930233, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI45550774, Length=494, Percent_Identity=27.1255060728745, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648435, Length=502, Percent_Identity=26.8924302788845, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648437, Length=502, Percent_Identity=26.8924302788845, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21356731, Length=494, Percent_Identity=25.5060728744939, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24648441, Length=430, Percent_Identity=26.5116279069767, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648439, Length=430, Percent_Identity=26.5116279069767, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000120
- InterPro:   IPR020556
- InterPro:   IPR004412 [H]

Pfam domain/function: PF01425 Amidase [H]

EC number: 6.3.5.-

Molecular weight: Translated: 53139; Mature: 53139

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00571 AMIDASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYSLTVHELKELLHKREVSAQEVTKSYLERIKEVEPKIDALVTITEEFALERAKVADE
CCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHHHHH
MIKNGEAKDLTGIPVIIKDNISTEGIRTTCSSKMLENYIPPYNATVVERLLNEGVVILGK
HHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEC
SNLDEFAMGSSTENSAFKTTKNPWDLSRVPGGSSGGSAAAVAADEAAFALGSDTGGSIRQ
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHEEECCCCCCCCCC
PASLCGVVGMKPTYGLVSRYGLVAFASSLDQIGPFTKDVTDCAIVLNAIAGHDPMDSTSV
CHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEE
KIEKPDYTSYLKEDIKGLRIGVAKEFFGAGIEEGVKETVEKAIKVFEDLGAEIIDISVPY
EEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
VEYALPAYYIIASAEASSNLARYDGIRYGHIAKNYEDLVDMYMTSRSEGFGKEVKRRIML
HHHHCCCEEEEEECCCCCCHHHHCCCEECHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHH
GTYALSSGYYDAYYKKALKVRTLIKNDFERAFEKCDVIVGPTSPTVAFKIGERTNDPLAM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCCCCHHH
YLADIYTVSVNIAGLPAISIPCGLSEGLPVGLQIIGKHFDEGRILNVAYAFEKAYKFDAK
HHHHHEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCC
PQAIGGER
CCCCCCCC
>Mature Secondary Structure
MELYSLTVHELKELLHKREVSAQEVTKSYLERIKEVEPKIDALVTITEEFALERAKVADE
CCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHEEEHHHHHHHHHHHHHH
MIKNGEAKDLTGIPVIIKDNISTEGIRTTCSSKMLENYIPPYNATVVERLLNEGVVILGK
HHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEC
SNLDEFAMGSSTENSAFKTTKNPWDLSRVPGGSSGGSAAAVAADEAAFALGSDTGGSIRQ
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHEEECCCCCCCCCC
PASLCGVVGMKPTYGLVSRYGLVAFASSLDQIGPFTKDVTDCAIVLNAIAGHDPMDSTSV
CHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEE
KIEKPDYTSYLKEDIKGLRIGVAKEFFGAGIEEGVKETVEKAIKVFEDLGAEIIDISVPY
EEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCH
VEYALPAYYIIASAEASSNLARYDGIRYGHIAKNYEDLVDMYMTSRSEGFGKEVKRRIML
HHHHCCCEEEEEECCCCCCHHHHCCCEECHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHH
GTYALSSGYYDAYYKKALKVRTLIKNDFERAFEKCDVIVGPTSPTVAFKIGERTNDPLAM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCCCCHHH
YLADIYTVSVNIAGLPAISIPCGLSEGLPVGLQIIGKHFDEGRILNVAYAFEKAYKFDAK
HHHHHEEEEEEECCCCEEECCCCCCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCC
PQAIGGER
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA