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The map label for this gene is GltD [H]

Identifier: 20807067

GI number: 20807067

Start: 570973

End: 572367

Strand: Direct

Name: GltD [H]

Synonym: TTE0567

Alternate gene names: 20807067

Gene position: 570973-572367 (Clockwise)

Preceding gene: 20807066

Following gene: 20807068

Centisome position: 21.23

GC content: 43.73

Gene sequence:

>1395_bases
ATGGCCGTTAAGGATAGAGTACCTATGAGAGAACAGGACCCGAAAGTGAGGATAAAGAATTTTGATGAGGTAGCGCTAGG
TTATACTGAAGAAGAAGCTATCTTAGAGGCTTCAAGGTGTTTGCAGTGCCCAAATCCTACCTGTGTGGCCGGGTGCCCCG
TCCATGTGAGAATACCTGAATTTATAAAAGCTATAACTGAAAGAAAATTTGAAGAAGCGTACAAGATAATAACCAGCACT
AACAGTCTTCCAGCCGTTTGTGGAAGAGTTTGTCCACAGGAAGAGCAGTGTGAGAAGAACTGCATTTTGAATAGAATAGG
CAAGCCCATTGCAATTGGAAGGTTGGAGAGGTTTGTAGCTGATTATGCGCTTCAGAATAACATTGAAGAGGAAGTAAAGC
CGGAGAAGAAGAACAAAAAAGTCGCCATAATAGGGAGCGGTCCTGCAGGGCTTACCTGTGCTGGAGACCTTTTGAAGATG
GGGTACGATGTTACTATTTTTGAGGCATTGCACGCTTTAGGTGGAGTTTTAACTTATGGGATTCCTGAATTTAGATTGCC
AAAAAGAATTGTGGAAGCTGAGATAGAAAGGTTAAAGAAACTGGGAGCAAAGGTAGAGACAAACGTAGTGGTAGGAAAGA
CAGTTACAATAGACGAGCTCATGGAGGAAGAAGGCTTTGAAGCGGTCTTCATTGGCACGGGAGCAGGCCTTCCGAGGTTT
ATGGGAATTCCTGGAGAGAACTTAAATGGAGTCTATTCAGCCAATGAGTTTTTGACGAGGATAAACCTCATGAAAGCCTA
TAAATTTCCGGAGTACGATACTCCTATAGCTGTGGGCAAGAGAGTGGCAGTTATAGGTGGAGGGAATGTAGCTATGGACG
CTGCCCGTTCAGCTTTAAGGCTTGAAGGGGTAGAAGAGGTTATAGTTGTATACAGGCGTTCAAAAGAAGAAATGCCAGCA
AGGGCTGAGGAAATAGAACACGCCATTGAGGAAGGAATAAAGTTTGAATTTTTGGCAAATCCAATACGAATAAACGGAAC
AGAAGACGGCTGGGTCAAGAGCATGGACGTAATAAGAATGAAGTTAGGAGAGCCAGACAGTTCAGGAAGAAGAAGGCCTA
TAGAGATACCTGGTTCAGAATTTACAATGGAAGTAGATACAGTGATCATGGCATTAGGAACTAGTCCTAACAGGCTTATA
CCCTCTACTACAAAGGATATTCAAGTTCAAAAATGGGGTGGAATAATAACAGACGAGGATGGCAGGACCTCAAGGCCAGG
TGTATTTGCCGGAGGAGATGCCGTCACTGGAGCTGCAACCGTGATTTTAGCAATGGGAGCAGGGAAAAAAGCTGCAAAAG
CGATAGATGAATATTTGAGGAGCAAAGGAGAATAA

Upstream 100 bases:

>100_bases
CTTGTAAATTTTGATTTAGCTATGACAAGGCTTAATATGTTCAAGAAGCAGGAAAAGATTTCATTAGAGCTGTATGAGAA
GGAACATGGAGGTGGTCACC

Downstream 100 bases:

>100_bases
TTATTCAAGTACGTCCCTTAAAAGGGGCGTATTTTTTAAAAAATTAGAAGGCTTACAATAAAAAGACTTTCACATGAAAA
AATTTTGTGATAAAATCCAT

Product: NADPH-dependent glutamate synthase beta chain and related oxidoreductase

Products: L-glutamine; 2-oxoglutarate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAVKDRVPMREQDPKVRIKNFDEVALGYTEEEAILEASRCLQCPNPTCVAGCPVHVRIPEFIKAITERKFEEAYKIITST
NSLPAVCGRVCPQEEQCEKNCILNRIGKPIAIGRLERFVADYALQNNIEEEVKPEKKNKKVAIIGSGPAGLTCAGDLLKM
GYDVTIFEALHALGGVLTYGIPEFRLPKRIVEAEIERLKKLGAKVETNVVVGKTVTIDELMEEEGFEAVFIGTGAGLPRF
MGIPGENLNGVYSANEFLTRINLMKAYKFPEYDTPIAVGKRVAVIGGGNVAMDAARSALRLEGVEEVIVVYRRSKEEMPA
RAEEIEHAIEEGIKFEFLANPIRINGTEDGWVKSMDVIRMKLGEPDSSGRRRPIEIPGSEFTMEVDTVIMALGTSPNRLI
PSTTKDIQVQKWGGIITDEDGRTSRPGVFAGGDAVTGAATVILAMGAGKKAAKAIDEYLRSKGE

Sequences:

>Translated_464_residues
MAVKDRVPMREQDPKVRIKNFDEVALGYTEEEAILEASRCLQCPNPTCVAGCPVHVRIPEFIKAITERKFEEAYKIITST
NSLPAVCGRVCPQEEQCEKNCILNRIGKPIAIGRLERFVADYALQNNIEEEVKPEKKNKKVAIIGSGPAGLTCAGDLLKM
GYDVTIFEALHALGGVLTYGIPEFRLPKRIVEAEIERLKKLGAKVETNVVVGKTVTIDELMEEEGFEAVFIGTGAGLPRF
MGIPGENLNGVYSANEFLTRINLMKAYKFPEYDTPIAVGKRVAVIGGGNVAMDAARSALRLEGVEEVIVVYRRSKEEMPA
RAEEIEHAIEEGIKFEFLANPIRINGTEDGWVKSMDVIRMKLGEPDSSGRRRPIEIPGSEFTMEVDTVIMALGTSPNRLI
PSTTKDIQVQKWGGIITDEDGRTSRPGVFAGGDAVTGAATVILAMGAGKKAAKAIDEYLRSKGE
>Mature_463_residues
AVKDRVPMREQDPKVRIKNFDEVALGYTEEEAILEASRCLQCPNPTCVAGCPVHVRIPEFIKAITERKFEEAYKIITSTN
SLPAVCGRVCPQEEQCEKNCILNRIGKPIAIGRLERFVADYALQNNIEEEVKPEKKNKKVAIIGSGPAGLTCAGDLLKMG
YDVTIFEALHALGGVLTYGIPEFRLPKRIVEAEIERLKKLGAKVETNVVVGKTVTIDELMEEEGFEAVFIGTGAGLPRFM
GIPGENLNGVYSANEFLTRINLMKAYKFPEYDTPIAVGKRVAVIGGGNVAMDAARSALRLEGVEEVIVVYRRSKEEMPAR
AEEIEHAIEEGIKFEFLANPIRINGTEDGWVKSMDVIRMKLGEPDSSGRRRPIEIPGSEFTMEVDTVIMALGTSPNRLIP
STTKDIQVQKWGGIITDEDGRTSRPGVFAGGDAVTGAATVILAMGAGKKAAKAIDEYLRSKGE

Specific function: Unknown

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=468, Percent_Identity=32.4786324786325, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI111118983, Length=182, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI111118981, Length=167, Percent_Identity=32.3353293413174, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI237757300, Length=119, Percent_Identity=35.2941176470588, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788811, Length=453, Percent_Identity=39.2935982339956, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1789606, Length=453, Percent_Identity=38.4105960264901, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI87082180, Length=457, Percent_Identity=38.074398249453, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI1788468, Length=441, Percent_Identity=35.827664399093, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1789243, Length=415, Percent_Identity=34.2168674698795, Blast_Score=211, Evalue=9e-56,
Organism=Caenorhabditis elegans, GI71984108, Length=450, Percent_Identity=33.3333333333333, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17570289, Length=479, Percent_Identity=28.8100208768267, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17543860, Length=166, Percent_Identity=34.3373493975904, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320030, Length=473, Percent_Identity=30.2325581395349, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24665547, Length=483, Percent_Identity=29.6066252587992, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24665543, Length=483, Percent_Identity=29.6066252587992, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI28574881, Length=483, Percent_Identity=29.6066252587992, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24665539, Length=483, Percent_Identity=29.6066252587992, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24640763, Length=447, Percent_Identity=30.8724832214765, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI18858217, Length=447, Percent_Identity=30.8724832214765, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013027
- InterPro:   IPR012285
- InterPro:   IPR006006 [H]

Pfam domain/function: PF00037 Fer4; PF07992 Pyr_redox_2 [H]

EC number: 1.4.1.13

Molecular weight: Translated: 50787; Mature: 50656

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKDRVPMREQDPKVRIKNFDEVALGYTEEEAILEASRCLQCPNPTCVAGCPVHVRIPE
CCCCCCCCCCCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCEEEECHH
FIKAITERKFEEAYKIITSTNSLPAVCGRVCPQEEQCEKNCILNRIGKPIAIGRLERFVA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
DYALQNNIEEEVKPEKKNKKVAIIGSGPAGLTCAGDLLKMGYDVTIFEALHALGGVLTYG
HHHHHCCCHHHCCCCCCCCEEEEEECCCCCCEEHHHHHHCCCCCHHHHHHHHHHHHHHCC
IPEFRLPKRIVEAEIERLKKLGAKVETNVVVGKTVTIDELMEEEGFEAVFIGTGAGLPRF
CCCHHHHHHHHHHHHHHHHHHCCCEECCEEEECEEEHHHHHHHCCCCEEEEECCCCCCHH
MGIPGENLNGVYSANEFLTRINLMKAYKFPEYDTPIAVGKRVAVIGGGNVAMDAARSALR
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCHHHHHHHHHHH
LEGVEEVIVVYRRSKEEMPARAEEIEHAIEEGIKFEFLANPIRINGTEDGWVKSMDVIRM
HCCHHHHHHHHHHCHHCCCHHHHHHHHHHHCCCEEEEECCCEEECCCCCCHHHHHHHHHH
KLGEPDSSGRRRPIEIPGSEFTMEVDTVIMALGTSPNRLIPSTTKDIQVQKWGGIITDED
HCCCCCCCCCCCCEECCCCCEEEEHHHEEEEECCCCCCCCCCCCCCEEEEECCCEEECCC
GRTSRPGVFAGGDAVTGAATVILAMGAGKKAAKAIDEYLRSKGE
CCCCCCCEEECCCCHHHHHHEEEEECCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AVKDRVPMREQDPKVRIKNFDEVALGYTEEEAILEASRCLQCPNPTCVAGCPVHVRIPE
CCCCCCCCCCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCEEECCCEEEECHH
FIKAITERKFEEAYKIITSTNSLPAVCGRVCPQEEQCEKNCILNRIGKPIAIGRLERFVA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
DYALQNNIEEEVKPEKKNKKVAIIGSGPAGLTCAGDLLKMGYDVTIFEALHALGGVLTYG
HHHHHCCCHHHCCCCCCCCEEEEEECCCCCCEEHHHHHHCCCCCHHHHHHHHHHHHHHCC
IPEFRLPKRIVEAEIERLKKLGAKVETNVVVGKTVTIDELMEEEGFEAVFIGTGAGLPRF
CCCHHHHHHHHHHHHHHHHHHCCCEECCEEEECEEEHHHHHHHCCCCEEEEECCCCCCHH
MGIPGENLNGVYSANEFLTRINLMKAYKFPEYDTPIAVGKRVAVIGGGNVAMDAARSALR
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCHHHHHHHHHHH
LEGVEEVIVVYRRSKEEMPARAEEIEHAIEEGIKFEFLANPIRINGTEDGWVKSMDVIRM
HCCHHHHHHHHHHCHHCCCHHHHHHHHHHHCCCEEEEECCCEEECCCCCCHHHHHHHHHH
KLGEPDSSGRRRPIEIPGSEFTMEVDTVIMALGTSPNRLIPSTTKDIQVQKWGGIITDED
HCCCCCCCCCCCCEECCCCCEEEEHHHEEEEECCCCCCCCCCCCCCEEEEECCCEEECCC
GRTSRPGVFAGGDAVTGAATVILAMGAGKKAAKAIDEYLRSKGE
CCCCCCCEEECCCCHHHHHHEEEEECCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-glutamate; NADP+

Specific reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955321; 9205837; 9278503 [H]